Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19).
Identifieur interne : 001799 ( Main/Corpus ); précédent : 001798; suivant : 001800Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19).
Auteurs : Katelyn A. Pastick ; Elizabeth C. Okafor ; Fan Wang ; Sarah M. Lofgren ; Caleb P. Skipper ; Melanie R. Nicol ; Matthew F. Pullen ; Radha Rajasingham ; Emily G. Mcdonald ; Todd C. Lee ; Ilan S. Schwartz ; Lauren E. Kelly ; Sylvain A. Lother ; Oriol Mitjà ; Emili Letang ; Mahsa Abassi ; David R. BoulwareSource :
- Open forum infectious diseases [ 2328-8957 ] ; 2020.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. While there is a growing body of scientific data, there is also concern for harm, particularly QTc prolongation and cardiac arrhythmias. Here, we perform a rapid narrative review and discuss the strengths and limitations of existing in vitro and clinical studies. We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines.
DOI: 10.1093/ofid/ofaa130
PubMed: 32363212
PubMed Central: PMC7184359
Links to Exploration step
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<author><name sortKey="Letang, Emili" sort="Letang, Emili" uniqKey="Letang E" first="Emili" last="Letang">Emili Letang</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, Hospital del Mar/Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>ISGlobal, Barcelona Institute for Global Health, Universitat de Barcelona, Barcelona, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Abassi, Mahsa" sort="Abassi, Mahsa" uniqKey="Abassi M" first="Mahsa" last="Abassi">Mahsa Abassi</name>
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<author><name sortKey="Kelly, Lauren E" sort="Kelly, Lauren E" uniqKey="Kelly L" first="Lauren E" last="Kelly">Lauren E. Kelly</name>
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<affiliation><nlm:affiliation>Department of Infectious Diseases, Hospital del Mar/Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>ISGlobal, Barcelona Institute for Global Health, Universitat de Barcelona, Barcelona, Spain.</nlm:affiliation>
</affiliation>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. While there is a growing body of scientific data, there is also concern for harm, particularly QTc prolongation and cardiac arrhythmias. Here, we perform a rapid narrative review and discuss the strengths and limitations of existing <i>in vitro</i>
and clinical studies. We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines.</div>
</front>
</TEI>
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<Abstract><AbstractText>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. While there is a growing body of scientific data, there is also concern for harm, particularly QTc prolongation and cardiac arrhythmias. Here, we perform a rapid narrative review and discuss the strengths and limitations of existing <i>in vitro</i>
and clinical studies. We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines.</AbstractText>
<CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pastick</LastName>
<ForeName>Katelyn A</ForeName>
<Initials>KA</Initials>
<Identifier Source="ORCID">0000-0002-1306-1713</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Okafor</LastName>
<ForeName>Elizabeth C</ForeName>
<Initials>EC</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Fan</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lofgren</LastName>
<ForeName>Sarah M</ForeName>
<Initials>SM</Initials>
<Identifier Source="ORCID">0000-0001-6717-2614</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
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<Author ValidYN="Y"><LastName>Pullen</LastName>
<ForeName>Matthew F</ForeName>
<Initials>MF</Initials>
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<AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
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<Author ValidYN="Y"><LastName>Rajasingham</LastName>
<ForeName>Radha</ForeName>
<Initials>R</Initials>
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<ForeName>Emily G</ForeName>
<Initials>EG</Initials>
<AffiliationInfo><Affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Canada.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Todd C</ForeName>
<Initials>TC</Initials>
<AffiliationInfo><Affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schwartz</LastName>
<ForeName>Ilan S</ForeName>
<Initials>IS</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kelly</LastName>
<ForeName>Lauren E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics and Child Health, Department of Pharmacology, University of Manitoba, Winnipeg, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lother</LastName>
<ForeName>Sylvain A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Sections of Critical Care and Infectious Diseases, University of Manitoba, Winnipeg, Canada.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Mitjà</LastName>
<ForeName>Oriol</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Fight AIDS and Inf Dis Foundation, Hospital Germans Trias i Pujol, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Letang</LastName>
<ForeName>Emili</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital del Mar/Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>ISGlobal, Barcelona Institute for Global Health, Universitat de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abassi</LastName>
<ForeName>Mahsa</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Boulware</LastName>
<ForeName>David R</ForeName>
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<AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota.</Affiliation>
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