CovidChloroV1, Main, Corpus, bibRecord, 001731

An Update on Current Therapeutic Drugs Treating COVID-19.

Identifieur interne : 001731 ( Main/Corpus ); précédent : 001730; suivant : 001732

An Update on Current Therapeutic Drugs Treating COVID-19.

Auteurs : Renyi Wu ; Lujing Wang ; Hsiao-Chen Dina Kuo ; Ahmad Shannar ; Rebecca Peter ; Pochung Jordan Chou ; Shanyi Li ; Rasika Hudlikar ; Xia Liu ; Zhigang Liu ; George J. Poiani ; Louis Amorosa ; Luigi Brunetti ; Ah-Ng Kong

Source :

Current pharmacology reports [ 2198-641X ] ; 2020.

RBID : pubmed:32395418

Abstract

The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. These drugs and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir), and supporting agents (Ascorbic acid, Azithromycin, Corticosteroids, Nitric oxide, IL-6 antagonists), among others. We hope that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.

DOI: 10.1007/s40495-020-00216-7
PubMed: 32395418
PubMed Central: PMC7211915

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pubmed:32395418

Le document en format XML

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<author><name sortKey="Kong, Ah Ng" sort="Kong, Ah Ng" uniqKey="Kong A" first="Ah-Ng" last="Kong">Ah-Ng Kong</name>
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<author><name sortKey="Kuo, Hsiao Chen Dina" sort="Kuo, Hsiao Chen Dina" uniqKey="Kuo H" first="Hsiao-Chen Dina" last="Kuo">Hsiao-Chen Dina Kuo</name>
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<author><name sortKey="Shannar, Ahmad" sort="Shannar, Ahmad" uniqKey="Shannar A" first="Ahmad" last="Shannar">Ahmad Shannar</name>
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<author><name sortKey="Chou, Pochung Jordan" sort="Chou, Pochung Jordan" uniqKey="Chou P" first="Pochung Jordan" last="Chou">Pochung Jordan Chou</name>
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<author><name sortKey="Li, Shanyi" sort="Li, Shanyi" uniqKey="Li S" first="Shanyi" last="Li">Shanyi Li</name>
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<author><name sortKey="Liu, Xia" sort="Liu, Xia" uniqKey="Liu X" first="Xia" last="Liu">Xia Liu</name>
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<affiliation><nlm:affiliation>2Department of Pharmacology, School of Basic Medical Science, Lanzhou University, Lanzhou, 730000 China.</nlm:affiliation>
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<author><name sortKey="Liu, Zhigang" sort="Liu, Zhigang" uniqKey="Liu Z" first="Zhigang" last="Liu">Zhigang Liu</name>
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<author><name sortKey="Poiani, George J" sort="Poiani, George J" uniqKey="Poiani G" first="George J" last="Poiani">George J. Poiani</name>
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<author><name sortKey="Brunetti, Luigi" sort="Brunetti, Luigi" uniqKey="Brunetti L" first="Luigi" last="Brunetti">Luigi Brunetti</name>
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<front><div type="abstract" xml:lang="en">The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. These drugs and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir), and supporting agents (Ascorbic acid, Azithromycin, Corticosteroids, Nitric oxide, IL-6 antagonists), among others. We hope that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.</div>
</front>
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<Title>Current pharmacology reports</Title>
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<ArticleTitle>An Update on Current Therapeutic Drugs Treating COVID-19.</ArticleTitle>
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<Abstract><AbstractText>The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. These drugs and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir), and supporting agents (Ascorbic acid, Azithromycin, Corticosteroids, Nitric oxide, IL-6 antagonists), among others. We hope that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.</AbstractText>
<CopyrightInformation>© Springer Nature Switzerland AG 2020.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Renyi</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Lujing</ForeName>
<Initials>L</Initials>
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<Author ValidYN="Y"><LastName>Kuo</LastName>
<ForeName>Hsiao-Chen Dina</ForeName>
<Initials>HD</Initials>
<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Shannar</LastName>
<ForeName>Ahmad</ForeName>
<Initials>A</Initials>
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<Author ValidYN="Y"><LastName>Peter</LastName>
<ForeName>Rebecca</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Chou</LastName>
<ForeName>Pochung Jordan</ForeName>
<Initials>PJ</Initials>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Shanyi</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Hudlikar</LastName>
<ForeName>Rasika</ForeName>
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<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Xia</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<AffiliationInfo><Affiliation>2Department of Pharmacology, School of Basic Medical Science, Lanzhou University, Lanzhou, 730000 China.</Affiliation>
<Identifier Source="GRID">grid.32566.34</Identifier>
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<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Zhigang</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<AffiliationInfo><Affiliation>3Department of Food and Pharmaceutical Engineering, Guiyang University, Guiyang, 550005 China.</Affiliation>
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<Author ValidYN="Y"><LastName>Poiani</LastName>
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<Initials>GJ</Initials>
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<Author ValidYN="Y"><LastName>Amorosa</LastName>
<ForeName>Louis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>5Robert Wood Johnson Medical School, New Brunswick, NJ 08901 USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Brunetti</LastName>
<ForeName>Luigi</ForeName>
<Initials>L</Initials>
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<AffiliationInfo><Affiliation>6Department of Pharmacy Practice, Ernest Mario School of Pharmacy, Piscataway, NJ 08854 USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Kong</LastName>
<ForeName>Ah-Ng</ForeName>
<Initials>AN</Initials>
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<AffiliationInfo><Affiliation>1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.</Affiliation>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Expert Opin Biol Ther. 2020 Oct;20(10):1111-1116</RefSource>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anakinra</Keyword>
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<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Chloroquine</Keyword>
<Keyword MajorTopicYN="N">Convalescent plasma</Keyword>
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<Keyword MajorTopicYN="N">Nitric oxide</Keyword>
<Keyword MajorTopicYN="N">Oseltamivir</Keyword>
<Keyword MajorTopicYN="N">Remdesivir</Keyword>
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<Keyword MajorTopicYN="N">Sarilumab</Keyword>
<Keyword MajorTopicYN="N">Sirolimus</Keyword>
<Keyword MajorTopicYN="N">Tocilizumab</Keyword>
<Keyword MajorTopicYN="N">Traditional Chinese Medicine</Keyword>
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	Serveur d'exploration COVID et hydrochloroquine
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Serveur d'exploration COVID et hydrochloroquine

An Update on Current Therapeutic Drugs Treating COVID-19.

An Update on Current Therapeutic Drugs Treating COVID-19.

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