COVID-19 pandemic: an overview of epidemiology, pathogenesis, diagnostics and potential vaccines and therapeutics.
Identifieur interne : 001724 ( Main/Corpus ); précédent : 001723; suivant : 001725COVID-19 pandemic: an overview of epidemiology, pathogenesis, diagnostics and potential vaccines and therapeutics.
Auteurs : Haneen Amawi ; Ghina'A I. Abu Deiab ; Alaa A. A Aljabali ; Kamal Dua ; Murtaza M. TambuwalaSource :
- Therapeutic delivery [ 2041-6008 ] ; 2020.
English descriptors
- KwdEn :
- Antiviral Agents (therapeutic use), Betacoronavirus (genetics), COVID-19 (MeSH), COVID-19 Testing (MeSH), COVID-19 Vaccines (MeSH), Clinical Laboratory Techniques (MeSH), Coronavirus (genetics), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (therapy), Disease Progression (MeSH), Humans (MeSH), Pandemics (prevention & control), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (prevention & control), Pneumonia, Viral (therapy), RNA, Viral (MeSH), SARS-CoV-2 (MeSH), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , genetics : Viral Vaccines.
- chemical , immunology : Viral Vaccines.
- chemical , therapeutic use : Antiviral Agents.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus, Coronavirus, Coronavirus Infections.
- immunology : Coronavirus Infections.
- prevention & control : Coronavirus Infections, Pandemics, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- COVID-19, COVID-19 Testing, COVID-19 Vaccines, Clinical Laboratory Techniques, Disease Progression, Humans, RNA, Viral, SARS-CoV-2.
Abstract
At the time of writing this review, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) has infected more than 2,355,853 patients and resulted in more than 164,656 deaths worldwide (as of 20 April 2020). This review highlights the preventive measures, available clinical therapies and the potential of vaccine development against SARS-CoV-2 by taking into consideration the strong genetic similarities of the 2003 epidemic SARS-CoV. Recent studies are investigating the repurposing of US FDA-approved drugs as there is no available vaccine yet with many attempts under clinical evaluation. Several antivirals, antimalarials and immunomodulators that have shown activity against SARS-CoV and Middle East coronavirus respiratory syndromes are being evaluated. In particular, hydroxychloroquine, remdesivir, favipiravir, arbidol, tocilizumab and bevacizumab have shown promising results. The main aim of this review is to provide an overview of this pandemic and where we currently stand.
DOI: 10.4155/tde-2020-0035
PubMed: 32397911
PubMed Central: PMC7222554
Links to Exploration step
pubmed:32397911Le document en format XML
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Abu Deiab</name><affiliation><nlm:affiliation>Faculty of Pharmacy, Department of Medicinal Chemistry & Pharmacognosy, Yarmouk University, Irbid-Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="A Aljabali, Alaa A" sort="A Aljabali, Alaa A" uniqKey="A Aljabali A" first="Alaa A" last="A Aljabali">Alaa A. A Aljabali</name><affiliation><nlm:affiliation>Faculty of Pharmacy, Department of Pharmaceutics & Pharmaceutical Technology, Yarmouk University, Irbid-Jordan.</nlm:affiliation></affiliation></author><author><name sortKey="Dua, Kamal" sort="Dua, Kamal" uniqKey="Dua K" first="Kamal" last="Dua">Kamal Dua</name><affiliation><nlm:affiliation>Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tambuwala, Murtaza M" sort="Tambuwala, Murtaza M" uniqKey="Tambuwala M" first="Murtaza M" last="Tambuwala">Murtaza M. Tambuwala</name><affiliation><nlm:affiliation>School of Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Therapeutic delivery</title><idno type="eISSN">2041-6008</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term><term>Betacoronavirus (genetics)</term><term>COVID-19 (MeSH)</term><term>COVID-19 Testing (MeSH)</term><term>COVID-19 Vaccines (MeSH)</term><term>Clinical Laboratory Techniques (MeSH)</term><term>Coronavirus (genetics)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (genetics)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Coronavirus Infections (therapy)</term><term>Disease Progression (MeSH)</term><term>Humans (MeSH)</term><term>Pandemics (prevention & control)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (prevention & control)</term><term>Pneumonia, Viral (therapy)</term><term>RNA, Viral (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term><term>Pandemics</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>COVID-19</term><term>COVID-19 Testing</term><term>COVID-19 Vaccines</term><term>Clinical Laboratory Techniques</term><term>Disease Progression</term><term>Humans</term><term>RNA, Viral</term><term>SARS-CoV-2</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">At the time of writing this review, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) has infected more than 2,355,853 patients and resulted in more than 164,656 deaths worldwide (as of 20 April 2020). This review highlights the preventive measures, available clinical therapies and the potential of vaccine development against SARS-CoV-2 by taking into consideration the strong genetic similarities of the 2003 epidemic SARS-CoV. Recent studies are investigating the repurposing of US FDA-approved drugs as there is no available vaccine yet with many attempts under clinical evaluation. Several antivirals, antimalarials and immunomodulators that have shown activity against SARS-CoV and Middle East coronavirus respiratory syndromes are being evaluated. In particular, hydroxychloroquine, remdesivir, favipiravir, arbidol, tocilizumab and bevacizumab have shown promising results. The main aim of this review is to provide an overview of this pandemic and where we currently stand.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32397911</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>22</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2041-6008</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>04</Month></PubDate></JournalIssue><Title>Therapeutic delivery</Title><ISOAbbreviation>Ther Deliv</ISOAbbreviation></Journal><ArticleTitle>COVID-19 pandemic: an overview of epidemiology, pathogenesis, diagnostics and potential vaccines and therapeutics.</ArticleTitle><Pagination><MedlinePgn>245-268</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4155/tde-2020-0035</ELocationID><Abstract><AbstractText>At the time of writing this review, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) has infected more than 2,355,853 patients and resulted in more than 164,656 deaths worldwide (as of 20 April 2020). This review highlights the preventive measures, available clinical therapies and the potential of vaccine development against SARS-CoV-2 by taking into consideration the strong genetic similarities of the 2003 epidemic SARS-CoV. Recent studies are investigating the repurposing of US FDA-approved drugs as there is no available vaccine yet with many attempts under clinical evaluation. Several antivirals, antimalarials and immunomodulators that have shown activity against SARS-CoV and Middle East coronavirus respiratory syndromes are being evaluated. In particular, hydroxychloroquine, remdesivir, favipiravir, arbidol, tocilizumab and bevacizumab have shown promising results. 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