Recommendations for the measurement of the QT interval during the use of drugs for COVID-19 infection treatment. Updatable in accordance with the availability of new evidence.
Identifieur interne : 001675 ( Main/Corpus ); précédent : 001674; suivant : 001676Recommendations for the measurement of the QT interval during the use of drugs for COVID-19 infection treatment. Updatable in accordance with the availability of new evidence.
Auteurs : Enrique Asensio ; Rafael Acunzo ; William Uribe ; Eduardo B. Saad ; Luis C. SáenzSource :
- Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing [ 1572-8595 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Antimalarials (administration & dosage), Antimalarials (adverse effects), Arrhythmias, Cardiac (chemically induced), Arrhythmias, Cardiac (epidemiology), Azithromycin (administration & dosage), Azithromycin (adverse effects), COVID-19 (MeSH), Chloroquine (administration & dosage), Chloroquine (adverse effects), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Dose-Response Relationship, Drug (MeSH), Electrocardiography (MeSH), Female (MeSH), Humans (MeSH), Hydroxychloroquine (administration & dosage), Hydroxychloroquine (adverse effects), Incidence (MeSH), Long QT Syndrome (chemically induced), Long QT Syndrome (diagnostic imaging), Male (MeSH), Middle Aged (MeSH), Pandemics (prevention & control), Pandemics (statistics & numerical data), Pneumonia, Viral (diagnosis), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Practice Guidelines as Topic (MeSH), Prognosis (MeSH), Risk Assessment (MeSH).
- MESH :
- chemical , administration & dosage : Antimalarials, Azithromycin, Chloroquine, Hydroxychloroquine.
- chemical , adverse effects : Antimalarials, Azithromycin, Chloroquine, Hydroxychloroquine.
- chemically induced : Arrhythmias, Cardiac, Long QT Syndrome.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- diagnostic imaging : Long QT Syndrome.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Arrhythmias, Cardiac, Coronavirus Infections, Pneumonia, Viral.
- prevention & control : Pandemics.
- statistics & numerical data : Pandemics.
- Adult, Aged, COVID-19, Dose-Response Relationship, Drug, Electrocardiography, Female, Humans, Incidence, Male, Middle Aged, Practice Guidelines as Topic, Prognosis, Risk Assessment.
Abstract
COVID-19 infection has shown rapid growth worldwide, and different therapies have been proposed for treatment, in particular, the combination of immune response modulating drugs such as chloroquine and hydroxychloroquine (antimalarials) alone or in combination with azithromycin. Although the clinical evidence supporting their use is scarce, the off label use of these drugs has spread very quickly in face of the progression of the epidemic and the high mortality rate in susceptible populations. However, these medications can pathologically prolong the QT interval and lead to malignant ventricular arrhythmias such that organized guidance on QT evaluation and management strategies are important to reduce morbidity associated with the potential large-scale use.
DOI: 10.1007/s10840-020-00765-3
PubMed: 32418181
PubMed Central: PMC7229438
Links to Exploration step
pubmed:32418181Le document en format XML
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Updatable in accordance with the availability of new evidence.</title><author><name sortKey="Asensio, Enrique" sort="Asensio, Enrique" uniqKey="Asensio E" first="Enrique" last="Asensio">Enrique Asensio</name><affiliation><nlm:affiliation>Division of Internal Medicine, Hospital H, Querétaro, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Acunzo, Rafael" sort="Acunzo, Rafael" uniqKey="Acunzo R" first="Rafael" last="Acunzo">Rafael Acunzo</name><affiliation><nlm:affiliation>Division of Cardiology, Hospital Ramos Mejía, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Uribe, William" sort="Uribe, William" uniqKey="Uribe W" first="William" last="Uribe">William Uribe</name><affiliation><nlm:affiliation>CES Cardiología, Medellín, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Saad, Eduardo B" sort="Saad, Eduardo B" uniqKey="Saad E" first="Eduardo B" last="Saad">Eduardo B. Saad</name><affiliation><nlm:affiliation>Arrhythmias Service, Hospital Pró-Cardíaco, Río de Janeiro, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Saenz, Luis C" sort="Saenz, Luis C" uniqKey="Saenz L" first="Luis C" last="Sáenz">Luis C. Sáenz</name><affiliation><nlm:affiliation>International Center of Arrhythmias, Fundación CardioInfantilI-Instituto de Cardiología, Bogotá, Colombia. lcsaenz@cardioinfantil.org.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32418181</idno><idno type="pmid">32418181</idno><idno type="doi">10.1007/s10840-020-00765-3</idno><idno type="pmc">PMC7229438</idno><idno type="wicri:Area/Main/Corpus">001675</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001675</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Recommendations for the measurement of the QT interval during the use of drugs for COVID-19 infection treatment. Updatable in accordance with the availability of new evidence.</title><author><name sortKey="Asensio, Enrique" sort="Asensio, Enrique" uniqKey="Asensio E" first="Enrique" last="Asensio">Enrique Asensio</name><affiliation><nlm:affiliation>Division of Internal Medicine, Hospital H, Querétaro, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Acunzo, Rafael" sort="Acunzo, Rafael" uniqKey="Acunzo R" first="Rafael" last="Acunzo">Rafael Acunzo</name><affiliation><nlm:affiliation>Division of Cardiology, Hospital Ramos Mejía, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Uribe, William" sort="Uribe, William" uniqKey="Uribe W" first="William" last="Uribe">William Uribe</name><affiliation><nlm:affiliation>CES Cardiología, Medellín, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Saad, Eduardo B" sort="Saad, Eduardo B" uniqKey="Saad E" first="Eduardo B" last="Saad">Eduardo B. Saad</name><affiliation><nlm:affiliation>Arrhythmias Service, Hospital Pró-Cardíaco, Río de Janeiro, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Saenz, Luis C" sort="Saenz, Luis C" uniqKey="Saenz L" first="Luis C" last="Sáenz">Luis C. Sáenz</name><affiliation><nlm:affiliation>International Center of Arrhythmias, Fundación CardioInfantilI-Instituto de Cardiología, Bogotá, Colombia. lcsaenz@cardioinfantil.org.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing</title><idno type="eISSN">1572-8595</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Antimalarials (administration & dosage)</term><term>Antimalarials (adverse effects)</term><term>Arrhythmias, Cardiac (chemically induced)</term><term>Arrhythmias, Cardiac (epidemiology)</term><term>Azithromycin (administration & dosage)</term><term>Azithromycin (adverse effects)</term><term>COVID-19 (MeSH)</term><term>Chloroquine (administration & dosage)</term><term>Chloroquine (adverse effects)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Electrocardiography (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (administration & dosage)</term><term>Hydroxychloroquine (adverse effects)</term><term>Incidence (MeSH)</term><term>Long QT Syndrome (chemically induced)</term><term>Long QT Syndrome (diagnostic imaging)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (prevention & control)</term><term>Pandemics (statistics & numerical data)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (epidemiology)</term><term>Practice Guidelines as Topic (MeSH)</term><term>Prognosis (MeSH)</term><term>Risk Assessment (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antimalarials</term><term>Azithromycin</term><term>Chloroquine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antimalarials</term><term>Azithromycin</term><term>Chloroquine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Arrhythmias, Cardiac</term><term>Long QT Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Long QT Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Arrhythmias, Cardiac</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>COVID-19</term><term>Dose-Response Relationship, Drug</term><term>Electrocardiography</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Practice Guidelines as Topic</term><term>Prognosis</term><term>Risk Assessment</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">COVID-19 infection has shown rapid growth worldwide, and different therapies have been proposed for treatment, in particular, the combination of immune response modulating drugs such as chloroquine and hydroxychloroquine (antimalarials) alone or in combination with azithromycin. Although the clinical evidence supporting their use is scarce, the off label use of these drugs has spread very quickly in face of the progression of the epidemic and the high mortality rate in susceptible populations. However, these medications can pathologically prolong the QT interval and lead to malignant ventricular arrhythmias such that organized guidance on QT evaluation and management strategies are important to reduce morbidity associated with the potential large-scale use.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32418181</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>11</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1572-8595</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing</Title><ISOAbbreviation>J Interv Card Electrophysiol</ISOAbbreviation></Journal><ArticleTitle>Recommendations for the measurement of the QT interval during the use of drugs for COVID-19 infection treatment. Updatable in accordance with the availability of new evidence.</ArticleTitle><Pagination><MedlinePgn>315-320</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10840-020-00765-3</ELocationID><Abstract><AbstractText>COVID-19 infection has shown rapid growth worldwide, and different therapies have been proposed for treatment, in particular, the combination of immune response modulating drugs such as chloroquine and hydroxychloroquine (antimalarials) alone or in combination with azithromycin. Although the clinical evidence supporting their use is scarce, the off label use of these drugs has spread very quickly in face of the progression of the epidemic and the high mortality rate in susceptible populations. However, these medications can pathologically prolong the QT interval and lead to malignant ventricular arrhythmias such that organized guidance on QT evaluation and management strategies are important to reduce morbidity associated with the potential large-scale use.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Asensio</LastName><ForeName>Enrique</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Internal Medicine, Hospital H, Querétaro, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Acunzo</LastName><ForeName>Rafael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cardiology, Hospital Ramos Mejía, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uribe</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>CES Cardiología, Medellín, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saad</LastName><ForeName>Eduardo B</ForeName><Initials>EB</Initials><AffiliationInfo><Affiliation>Arrhythmias Service, Hospital Pró-Cardíaco, Río de Janeiro, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sáenz</LastName><ForeName>Luis C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>International Center of Arrhythmias, Fundación CardioInfantilI-Instituto de Cardiología, Bogotá, Colombia. lcsaenz@cardioinfantil.org.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Interv Card Electrophysiol</MedlineTA><NlmUniqueID>9708966</NlmUniqueID><ISSNLinking>1383-875X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>83905-01-5</RegistryNumber><NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" 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interval</Keyword><Keyword MajorTopicYN="N">Torsade de pointes</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32418181</ArticleId><ArticleId IdType="doi">10.1007/s10840-020-00765-3</ArticleId><ArticleId IdType="pii">10.1007/s10840-020-00765-3</ArticleId><ArticleId 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