The rationale for Low-Molecular Weight Heparin (LMWH) use in SARS-CoV-2 infection
Identifieur interne : 001420 ( Main/Corpus ); précédent : 001419; suivant : 001421The rationale for Low-Molecular Weight Heparin (LMWH) use in SARS-CoV-2 infection
Auteurs : Giovanni Di PerriSource :
- Le infezioni in medicina [ 1124-9390 ] ; 2020.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (therapeutic use), Alanine (analogs & derivatives), Alanine (therapeutic use), Anticoagulants (administration & dosage), Anticoagulants (therapeutic use), Antiviral Agents (administration & dosage), Antiviral Agents (therapeutic use), Biomarkers (MeSH), COVID-19 (MeSH), Coronavirus Infections (blood), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Coronavirus Infections (physiopathology), Critical Care (methods), Disease Management (MeSH), Double-Blind Method (MeSH), Drug Combinations (MeSH), Drug Therapy, Combination (MeSH), Embolism (epidemiology), Embolism (prevention & control), Endothelium, Vascular (physiopathology), Heparin, Low-Molecular-Weight (administration & dosage), Heparin, Low-Molecular-Weight (therapeutic use), Humans (MeSH), Hydroxychloroquine (therapeutic use), Interferon beta-1b (therapeutic use), Lopinavir (therapeutic use), Macrophage Activation (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (complications), Pneumonia, Viral (drug therapy), Pneumonia, Viral (physiopathology), Pulmonary Fibrosis (etiology), Pulmonary Fibrosis (prevention & control), Randomized Controlled Trials as Topic (MeSH), Ritonavir (therapeutic use), Thromboembolism (epidemiology), Thromboembolism (prevention & control), Thrombophilia (blood), Thrombophilia (drug therapy), Thrombophilia (etiology), Thrombosis (epidemiology), Thrombosis (prevention & control).
- MESH :
- chemical , administration & dosage : Anticoagulants, Antiviral Agents, Heparin, Low-Molecular-Weight.
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Anticoagulants, Antiviral Agents, Heparin, Low-Molecular-Weight, Hydroxychloroquine, Interferon beta-1b, Lopinavir, Ritonavir.
- chemical : Biomarkers, Drug Combinations.
- blood : Coronavirus Infections, Pneumonia, Viral, Thrombophilia.
- complications : Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections, Pneumonia, Viral, Thrombophilia.
- epidemiology : Embolism, Thromboembolism, Thrombosis.
- etiology : Pulmonary Fibrosis, Thrombophilia.
- methods : Critical Care.
- physiopathology : Coronavirus Infections, Endothelium, Vascular, Pneumonia, Viral.
- prevention & control : Embolism, Pulmonary Fibrosis, Thromboembolism, Thrombosis.
- COVID-19, Disease Management, Double-Blind Method, Drug Therapy, Combination, Humans, Macrophage Activation, Pandemics, Randomized Controlled Trials as Topic.
Abstract
In spite of many ongoing attempts to repurpose existing antivirals, no drugs have emerged yet with the desirable activity against SARS-CoV-2. Hydroxychloroquine, lopinavir/ritonavir, remdesivir, umifenovir, favipiravir, ribavirin and beta-interferon-1 gave rise to variable but still inconsistent proof of clinical efficacy in the treatment of COVID-19. Pathogenetic studies have shown significant differences between commonly defined viral pneumonia and COVID-19 pulmonary disease. In severe forms, immune/inflammatory alterations reminiscent of disease forms like Macrophage Activation Syndrome (MAS) have been described, and therapeutic options other than anti-infective have been proposed and implemented, such as anti-inflammatory and anticoagulative agents. The thrombotic phenomena described in the pulmonary vascular bed of patients with severe COVID-19 suggest the administration of low-molecular weight heparin (LMWH) as standard measure in hospitalized patients with COVID-19.
PubMed: 32532939
Links to Exploration step
pubmed:32532939Le document en format XML
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<author><name sortKey="Di Perri, Giovanni" sort="Di Perri, Giovanni" uniqKey="Di Perri G" first="Giovanni" last="Di Perri">Giovanni Di Perri</name>
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<term>Adenosine Monophosphate (therapeutic use)</term>
<term>Alanine (analogs & derivatives)</term>
<term>Alanine (therapeutic use)</term>
<term>Anticoagulants (administration & dosage)</term>
<term>Anticoagulants (therapeutic use)</term>
<term>Antiviral Agents (administration & dosage)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Biomarkers (MeSH)</term>
<term>COVID-19 (MeSH)</term>
<term>Coronavirus Infections (blood)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (physiopathology)</term>
<term>Critical Care (methods)</term>
<term>Disease Management (MeSH)</term>
<term>Double-Blind Method (MeSH)</term>
<term>Drug Combinations (MeSH)</term>
<term>Drug Therapy, Combination (MeSH)</term>
<term>Embolism (epidemiology)</term>
<term>Embolism (prevention & control)</term>
<term>Endothelium, Vascular (physiopathology)</term>
<term>Heparin, Low-Molecular-Weight (administration & dosage)</term>
<term>Heparin, Low-Molecular-Weight (therapeutic use)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Interferon beta-1b (therapeutic use)</term>
<term>Lopinavir (therapeutic use)</term>
<term>Macrophage Activation (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (blood)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Pulmonary Fibrosis (etiology)</term>
<term>Pulmonary Fibrosis (prevention & control)</term>
<term>Randomized Controlled Trials as Topic (MeSH)</term>
<term>Ritonavir (therapeutic use)</term>
<term>Thromboembolism (epidemiology)</term>
<term>Thromboembolism (prevention & control)</term>
<term>Thrombophilia (blood)</term>
<term>Thrombophilia (drug therapy)</term>
<term>Thrombophilia (etiology)</term>
<term>Thrombosis (epidemiology)</term>
<term>Thrombosis (prevention & control)</term>
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<term>Antiviral Agents</term>
<term>Heparin, Low-Molecular-Weight</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
<term>Anticoagulants</term>
<term>Antiviral Agents</term>
<term>Heparin, Low-Molecular-Weight</term>
<term>Hydroxychloroquine</term>
<term>Interferon beta-1b</term>
<term>Lopinavir</term>
<term>Ritonavir</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term>
<term>Drug Combinations</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Thrombophilia</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Thrombophilia</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Embolism</term>
<term>Thromboembolism</term>
<term>Thrombosis</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pulmonary Fibrosis</term>
<term>Thrombophilia</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Critical Care</term>
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<term>Pneumonia, Viral</term>
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<term>Thromboembolism</term>
<term>Thrombosis</term>
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<keywords scheme="MESH" xml:lang="en"><term>COVID-19</term>
<term>Disease Management</term>
<term>Double-Blind Method</term>
<term>Drug Therapy, Combination</term>
<term>Humans</term>
<term>Macrophage Activation</term>
<term>Pandemics</term>
<term>Randomized Controlled Trials as Topic</term>
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<front><div type="abstract" xml:lang="en">In spite of many ongoing attempts to repurpose existing antivirals, no drugs have emerged yet with the desirable activity against SARS-CoV-2. Hydroxychloroquine, lopinavir/ritonavir, remdesivir, umifenovir, favipiravir, ribavirin and beta-interferon-1 gave rise to variable but still inconsistent proof of clinical efficacy in the treatment of COVID-19. Pathogenetic studies have shown significant differences between commonly defined viral pneumonia and COVID-19 pulmonary disease. In severe forms, immune/inflammatory alterations reminiscent of disease forms like Macrophage Activation Syndrome (MAS) have been described, and therapeutic options other than anti-infective have been proposed and implemented, such as anti-inflammatory and anticoagulative agents. The thrombotic phenomena described in the pulmonary vascular bed of patients with severe COVID-19 suggest the administration of low-molecular weight heparin (LMWH) as standard measure in hospitalized patients with COVID-19.</div>
</front>
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<Title>Le infezioni in medicina</Title>
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<Abstract><AbstractText>In spite of many ongoing attempts to repurpose existing antivirals, no drugs have emerged yet with the desirable activity against SARS-CoV-2. Hydroxychloroquine, lopinavir/ritonavir, remdesivir, umifenovir, favipiravir, ribavirin and beta-interferon-1 gave rise to variable but still inconsistent proof of clinical efficacy in the treatment of COVID-19. Pathogenetic studies have shown significant differences between commonly defined viral pneumonia and COVID-19 pulmonary disease. In severe forms, immune/inflammatory alterations reminiscent of disease forms like Macrophage Activation Syndrome (MAS) have been described, and therapeutic options other than anti-infective have been proposed and implemented, such as anti-inflammatory and anticoagulative agents. The thrombotic phenomena described in the pulmonary vascular bed of patients with severe COVID-19 suggest the administration of low-molecular weight heparin (LMWH) as standard measure in hospitalized patients with COVID-19.</AbstractText>
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