Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study.
Identifieur interne : 001391 ( Main/Corpus ); précédent : 001390; suivant : 001392Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study.
Auteurs : Yao Huang ; Zhe Chen ; Yu Wang ; Liang Han ; Kai Qin ; Wenya Huang ; Ying Huang ; Hui Wang ; Pan Shen ; Xin Ba ; Weiji Lin ; Hui Dong ; Mingmin Zhang ; Shenghao TuSource :
- Annals of the rheumatic diseases [ 1468-2060 ] ; 2020.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Autoimmune Diseases (epidemiology), Autoimmune Diseases (virology), Betacoronavirus (MeSH), COVID-19 (MeSH), China (epidemiology), Comorbidity (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (immunology), Coronavirus Infections (virology), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Inpatients (statistics & numerical data), Intensive Care Units (statistics & numerical data), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (immunology), Pneumonia, Viral (virology), Retrospective Studies (MeSH), SARS-CoV-2 (MeSH), Young Adult (MeSH).
- MESH :
- geographic , epidemiology : China.
- epidemiology : Autoimmune Diseases, Coronavirus Infections, Pneumonia, Viral.
- immunology : Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Hospitalization, Inpatients, Intensive Care Units.
- virology : Autoimmune Diseases, Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Adult, Aged, Betacoronavirus, COVID-19, Comorbidity, Female, Humans, Male, Middle Aged, Pandemics, Retrospective Studies, SARS-CoV-2, Young Adult.
Abstract
OBJECTIVES
Increasing data about COVID-19 have been acquired from the general population. We aim to further evaluate the clinical characteristics of COVID-19 in patients with systemic autoimmune diseases (AIDs).
METHODS
We included all confirmed inpatients with COVID-19 and systemic AIDs in Wuhan Tongji Hospital from 29 January to 8 March 2020. We retrospectively collected and analysed information on epidemiology of 1255 inpatients and additional clinical characteristics of patients with systemic AIDs. Outcomes were followed up until 16 April 2020.
RESULTS
Of the 1255 patients with COVID-19, the median age was 64.0 years and 53.1% were male. More than half (63.0%) had chronic comorbidities. The proportions of elderly, male and patients with comorbidities were significantly higher in intensive care unit (ICU) than in the general ward (p<0.001). 17 (0.61%) patients with systemic AIDs were further screened and analysed from 2804 inpatients. The median age was 64.0 years and 82.4% were female. All patients were living in Wuhan and two family clusters were found. 1 (5.9%) patient was admitted to ICU and one died. 10 (62.5%) of 16 patients changed or stopped their anti-AIDs treatments during hospitalisation, and 5 of them felt that the disease had worsened after the quarantine.
CONCLUSIONS
Older males with chronic comorbidities are more vulnerable to severe COVID-19. The lower proportion of COVID-19 in patients with systemic AIDs needs more high-quality human clinical trials and in-depth mechanism researches. Of note, the withdrawal of anti-AIDs treatments during hospitalisation can lead to flares of diseases.
DOI: 10.1136/annrheumdis-2020-217425
PubMed: 32546598
PubMed Central: PMC7316114
Links to Exploration step
pubmed:32546598Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study.</title><author><name sortKey="Huang, Yao" sort="Huang, Yao" uniqKey="Huang Y" first="Yao" last="Huang">Yao Huang</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Zhe" sort="Chen, Zhe" uniqKey="Chen Z" first="Zhe" last="Chen">Zhe Chen</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Liang" sort="Han, Liang" uniqKey="Han L" first="Liang" last="Han">Liang Han</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Kai" sort="Qin, Kai" uniqKey="Qin K" first="Kai" last="Qin">Kai Qin</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Wenya" sort="Huang, Wenya" uniqKey="Huang W" first="Wenya" last="Huang">Wenya Huang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Ying" sort="Huang, Ying" uniqKey="Huang Y" first="Ying" last="Huang">Ying Huang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hui" sort="Wang, Hui" uniqKey="Wang H" first="Hui" last="Wang">Hui Wang</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shen, Pan" sort="Shen, Pan" uniqKey="Shen P" first="Pan" last="Shen">Pan Shen</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ba, Xin" sort="Ba, Xin" uniqKey="Ba X" first="Xin" last="Ba">Xin Ba</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Weiji" sort="Lin, Weiji" uniqKey="Lin W" first="Weiji" last="Lin">Weiji Lin</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Dong, Hui" sort="Dong, Hui" uniqKey="Dong H" first="Hui" last="Dong">Hui Dong</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Mingmin" sort="Zhang, Mingmin" uniqKey="Zhang M" first="Mingmin" last="Zhang">Mingmin Zhang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, Shenghao" sort="Tu, Shenghao" uniqKey="Tu S" first="Shenghao" last="Tu">Shenghao Tu</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China shtu@tjh.tjmu.edu.cn.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32546598</idno><idno type="pmid">32546598</idno><idno type="doi">10.1136/annrheumdis-2020-217425</idno><idno type="pmc">PMC7316114</idno><idno type="wicri:Area/Main/Corpus">001391</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001391</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study.</title><author><name sortKey="Huang, Yao" sort="Huang, Yao" uniqKey="Huang Y" first="Yao" last="Huang">Yao Huang</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Zhe" sort="Chen, Zhe" uniqKey="Chen Z" first="Zhe" last="Chen">Zhe Chen</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Liang" sort="Han, Liang" uniqKey="Han L" first="Liang" last="Han">Liang Han</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Kai" sort="Qin, Kai" uniqKey="Qin K" first="Kai" last="Qin">Kai Qin</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Wenya" sort="Huang, Wenya" uniqKey="Huang W" first="Wenya" last="Huang">Wenya Huang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Ying" sort="Huang, Ying" uniqKey="Huang Y" first="Ying" last="Huang">Ying Huang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hui" sort="Wang, Hui" uniqKey="Wang H" first="Hui" last="Wang">Hui Wang</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shen, Pan" sort="Shen, Pan" uniqKey="Shen P" first="Pan" last="Shen">Pan Shen</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ba, Xin" sort="Ba, Xin" uniqKey="Ba X" first="Xin" last="Ba">Xin Ba</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Weiji" sort="Lin, Weiji" uniqKey="Lin W" first="Weiji" last="Lin">Weiji Lin</name><affiliation><nlm:affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Dong, Hui" sort="Dong, Hui" uniqKey="Dong H" first="Hui" last="Dong">Hui Dong</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Mingmin" sort="Zhang, Mingmin" uniqKey="Zhang M" first="Mingmin" last="Zhang">Mingmin Zhang</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, Shenghao" sort="Tu, Shenghao" uniqKey="Tu S" first="Shenghao" last="Tu">Shenghao Tu</name><affiliation><nlm:affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China shtu@tjh.tjmu.edu.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of the rheumatic diseases</title><idno type="eISSN">1468-2060</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Autoimmune Diseases (epidemiology)</term><term>Autoimmune Diseases (virology)</term><term>Betacoronavirus (MeSH)</term><term>COVID-19 (MeSH)</term><term>China (epidemiology)</term><term>Comorbidity (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Inpatients (statistics & numerical data)</term><term>Intensive Care Units (statistics & numerical data)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (immunology)</term><term>Pneumonia, Viral (virology)</term><term>Retrospective Studies (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Autoimmune Diseases</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term><term>Inpatients</term><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Autoimmune Diseases</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Betacoronavirus</term><term>COVID-19</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>SARS-CoV-2</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Increasing data about COVID-19 have been acquired from the general population. We aim to further evaluate the clinical characteristics of COVID-19 in patients with systemic autoimmune diseases (AIDs).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We included all confirmed inpatients with COVID-19 and systemic AIDs in Wuhan Tongji Hospital from 29 January to 8 March 2020. We retrospectively collected and analysed information on epidemiology of 1255 inpatients and additional clinical characteristics of patients with systemic AIDs. Outcomes were followed up until 16 April 2020.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Of the 1255 patients with COVID-19, the median age was 64.0 years and 53.1% were male. More than half (63.0%) had chronic comorbidities. The proportions of elderly, male and patients with comorbidities were significantly higher in intensive care unit (ICU) than in the general ward (p<0.001). 17 (0.61%) patients with systemic AIDs were further screened and analysed from 2804 inpatients. The median age was 64.0 years and 82.4% were female. All patients were living in Wuhan and two family clusters were found. 1 (5.9%) patient was admitted to ICU and one died. 10 (62.5%) of 16 patients changed or stopped their anti-AIDs treatments during hospitalisation, and 5 of them felt that the disease had worsened after the quarantine.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Older males with chronic comorbidities are more vulnerable to severe COVID-19. The lower proportion of COVID-19 in patients with systemic AIDs needs more high-quality human clinical trials and in-depth mechanism researches. Of note, the withdrawal of anti-AIDs treatments during hospitalisation can lead to flares of diseases.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32546598</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2060</ISSN><JournalIssue CitedMedium="Internet"><Volume>79</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Annals of the rheumatic diseases</Title><ISOAbbreviation>Ann Rheum Dis</ISOAbbreviation></Journal><ArticleTitle>Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study.</ArticleTitle><Pagination><MedlinePgn>1163-1169</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/annrheumdis-2020-217425</ELocationID><Abstract><AbstractText Label="OBJECTIVES">Increasing data about COVID-19 have been acquired from the general population. We aim to further evaluate the clinical characteristics of COVID-19 in patients with systemic autoimmune diseases (AIDs).</AbstractText><AbstractText Label="METHODS">We included all confirmed inpatients with COVID-19 and systemic AIDs in Wuhan Tongji Hospital from 29 January to 8 March 2020. We retrospectively collected and analysed information on epidemiology of 1255 inpatients and additional clinical characteristics of patients with systemic AIDs. Outcomes were followed up until 16 April 2020.</AbstractText><AbstractText Label="RESULTS">Of the 1255 patients with COVID-19, the median age was 64.0 years and 53.1% were male. More than half (63.0%) had chronic comorbidities. The proportions of elderly, male and patients with comorbidities were significantly higher in intensive care unit (ICU) than in the general ward (p<0.001). 17 (0.61%) patients with systemic AIDs were further screened and analysed from 2804 inpatients. The median age was 64.0 years and 82.4% were female. All patients were living in Wuhan and two family clusters were found. 1 (5.9%) patient was admitted to ICU and one died. 10 (62.5%) of 16 patients changed or stopped their anti-AIDs treatments during hospitalisation, and 5 of them felt that the disease had worsened after the quarantine.</AbstractText><AbstractText Label="CONCLUSIONS">Older males with chronic comorbidities are more vulnerable to severe COVID-19. The lower proportion of COVID-19 in patients with systemic AIDs needs more high-quality human clinical trials and in-depth mechanism researches. Of note, the withdrawal of anti-AIDs treatments during hospitalisation can lead to flares of diseases.</AbstractText><CopyrightInformation>© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Huang</LastName><ForeName>Yao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Chen</LastName><ForeName>Zhe</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Kai</ForeName><Initials>K</Initials><Identifier Source="ORCID">0000-0002-6180-7890</Identifier><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Wenya</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hui</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0001-9651-2729</Identifier><AffiliationInfo><Affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Pan</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ba</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Weiji</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Mingmin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>Shenghao</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0001-8530-270X</Identifier><AffiliationInfo><Affiliation>Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China shtu@tjh.tjmu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Rheum Dis</MedlineTA><NlmUniqueID>0372355</NlmUniqueID><ISSNLinking>0003-4967</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nat Rev Rheumatol. 2020 Aug;16(8):407</RefSource><PMID Version="1">32620941</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001327" MajorTopicYN="N">Autoimmune Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus 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