Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019.
Identifieur interne : 001284 ( Main/Corpus ); précédent : 001283; suivant : 001285Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019.
Auteurs : Boghuma K. Titanji ; Monica M. Farley ; Ashish Mehta ; Randi Connor-Schuler ; Abeer Moanna ; Sushma K. Cribbs ; Jesse O'Shea ; Kathryn Desilva ; Bonnie Chan ; Alex Edwards ; Christina Gavegnano ; Raymond F. Schinazi ; Vincent C. MarconiSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2021.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- chemical : Azetidines, Purines, Pyrazoles, Sulfonamides.
- drug therapy : COVID-19.
- Humans, Retrospective Studies, SARS-CoV-2, Treatment Outcome.
Abstract
Hyperinflammation is associated with increased mortality in coronavirus disease 2019 (COVID-19). In this retrospective, uncontrolled patient cohort with moderate -severe COVID-19, treatment with baricitinib plus hydroxychloroquine was associated with recovery in 11 of 15 patients. Baricitinib for the treatment of COVID-19 should be further investigated in randomized, controlled clinical trials.
DOI: 10.1093/cid/ciaa879
PubMed: 32597466
PubMed Central: PMC7337637
Links to Exploration step
pubmed:32597466Le document en format XML
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Titanji</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Farley, Monica M" sort="Farley, Monica M" uniqKey="Farley M" first="Monica M" last="Farley">Monica M. Farley</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mehta, Ashish" sort="Mehta, Ashish" uniqKey="Mehta A" first="Ashish" last="Mehta">Ashish Mehta</name><affiliation><nlm:affiliation>Pulmonary Medicine, Atlanta Veterans Affairs Medical Center, Department of Medicine, Decatur, Georgia, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Connor Schuler, Randi" sort="Connor Schuler, Randi" uniqKey="Connor Schuler R" first="Randi" last="Connor-Schuler">Randi Connor-Schuler</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Moanna, Abeer" sort="Moanna, Abeer" uniqKey="Moanna A" first="Abeer" last="Moanna">Abeer Moanna</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cribbs, Sushma K" sort="Cribbs, Sushma K" uniqKey="Cribbs S" first="Sushma K" last="Cribbs">Sushma K. Cribbs</name><affiliation><nlm:affiliation>Pulmonary Medicine, Atlanta Veterans Affairs Medical Center, Department of Medicine, Decatur, Georgia, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="O Shea, Jesse" sort="O Shea, Jesse" uniqKey="O Shea J" first="Jesse" last="O'Shea">Jesse O'Shea</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Desilva, Kathryn" sort="Desilva, Kathryn" uniqKey="Desilva K" first="Kathryn" last="Desilva">Kathryn Desilva</name><affiliation><nlm:affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Bonnie" sort="Chan, Bonnie" uniqKey="Chan B" first="Bonnie" last="Chan">Bonnie Chan</name><affiliation><nlm:affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Edwards, Alex" sort="Edwards, Alex" uniqKey="Edwards A" first="Alex" last="Edwards">Alex Edwards</name><affiliation><nlm:affiliation>Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gavegnano, Christina" sort="Gavegnano, Christina" uniqKey="Gavegnano C" first="Christina" last="Gavegnano">Christina Gavegnano</name><affiliation><nlm:affiliation>Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schinazi, Raymond F" sort="Schinazi, Raymond F" uniqKey="Schinazi R" first="Raymond F" last="Schinazi">Raymond F. Schinazi</name><affiliation><nlm:affiliation>Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Marconi, Vincent C" sort="Marconi, Vincent C" uniqKey="Marconi V" first="Vincent C" last="Marconi">Vincent C. Marconi</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term><term>Azetidines (MeSH)</term><term>COVID-19 (drug therapy)</term><term>Humans (MeSH)</term><term>Purines (MeSH)</term><term>Pyrazoles (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Sulfonamides (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Azetidines</term><term>Purines</term><term>Pyrazoles</term><term>Sulfonamides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Retrospective Studies</term><term>SARS-CoV-2</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyperinflammation is associated with increased mortality in coronavirus disease 2019 (COVID-19). In this retrospective, uncontrolled patient cohort with moderate -severe COVID-19, treatment with baricitinib plus hydroxychloroquine was associated with recovery in 11 of 15 patients. Baricitinib for the treatment of COVID-19 should be further investigated in randomized, controlled clinical trials.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">32597466</PMID><DateCompleted><Year>2021</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2021</Year><Month>04</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><Volume>72</Volume><Issue>7</Issue><PubDate><Year>2021</Year><Month>04</Month><Day>08</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019.</ArticleTitle><Pagination><MedlinePgn>1247-1250</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa879</ELocationID><Abstract><AbstractText>Hyperinflammation is associated with increased mortality in coronavirus disease 2019 (COVID-19). In this retrospective, uncontrolled patient cohort with moderate -severe COVID-19, treatment with baricitinib plus hydroxychloroquine was associated with recovery in 11 of 15 patients. Baricitinib for the treatment of COVID-19 should be further investigated in randomized, controlled clinical trials.</AbstractText><CopyrightInformation>Published by Oxford University Press for the Infectious Diseases Society of America 2020.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Titanji</LastName><ForeName>Boghuma K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farley</LastName><ForeName>Monica M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mehta</LastName><ForeName>Ashish</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Pulmonary Medicine, Atlanta Veterans Affairs Medical Center, Department of Medicine, Decatur, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Connor-Schuler</LastName><ForeName>Randi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moanna</LastName><ForeName>Abeer</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cribbs</LastName><ForeName>Sushma K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Pulmonary Medicine, Atlanta Veterans Affairs Medical Center, Department of Medicine, Decatur, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Shea</LastName><ForeName>Jesse</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeSilva</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Bonnie</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gavegnano</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schinazi</LastName><ForeName>Raymond F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marconi</LastName><ForeName>Vincent C</ForeName><Initials>VC</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infectious Diseases, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001384">Azetidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011687">Purines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011720">Pyrazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013449">Sulfonamides</NameOfSubstance></Chemical><Chemical><RegistryNumber>ISP4442I3Y</RegistryNumber><NameOfSubstance UI="C000596027">baricitinib</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001384" MajorTopicYN="N">Azetidines</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="Y">COVID-19</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011687" 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