Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry.
Identifieur interne : 001276 ( Main/Corpus ); précédent : 001275; suivant : 001277Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry.
Auteurs : Aitor Uribarri ; Iván J. Nú Ez-Gil ; Alvaro Aparisi ; Victor M. Becerra-Mu Oz ; Gisela Feltes ; Daniela Trabattoni ; Inmaculada Fernández-Rozas ; María C. Viana-Llamas ; Martino Pepe ; Enrico Cerrato ; Thamar Capel-Astrua ; Rodolfo Romero ; Alex F. Castro-Mejía ; Ibrahim El-Battrawy ; Javier L Pez-País ; Fabrizio D'Ascenzo ; Oscar Fabregat-Andres ; Alfredo Bardají ; Sergio Raposeiras-Roubin ; Francisco Marín ; Antonio Fernández-Ortiz ; Carlos Macaya ; Vicente EstradaSource :
- Journal of nephrology [ 1724-6059 ] ; 2020.
English descriptors
- KwdEn :
- Acute Kidney Injury (epidemiology), Aged (MeSH), Aged, 80 and over (MeSH), Angiotensin-Converting Enzyme 2 (MeSH), Betacoronavirus (MeSH), COVID-19 (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (physiopathology), Coronavirus Infections (therapy), Female (MeSH), Glomerular Filtration Rate (physiology), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Peptidyl-Dipeptidase A (physiology), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (physiopathology), Pneumonia, Viral (therapy), Registries (MeSH), Risk Assessment (MeSH), SARS-CoV-2 (MeSH).
- MESH :
- chemical , physiology : Peptidyl-Dipeptidase A.
- chemical : Angiotensin-Converting Enzyme 2.
- epidemiology : Acute Kidney Injury, Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- physiology : Glomerular Filtration Rate.
- physiopathology : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Aged, Aged, 80 and over, Betacoronavirus, COVID-19, Female, Humans, Male, Middle Aged, Pandemics, Registries, Risk Assessment, SARS-CoV-2.
Abstract
BACKGROUND
Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite its international aggressive extension, with a significant morbidity and mortality, the impact of renal function on its prognosis is uncertain.
METHODS
Analysis from the international HOPE-Registry (NCT04334291). The objective was to evaluate the association between kidney failure severity on admission with the mortality of patients with SARS-CoV-2 infection. Patients were categorized in 3 groups according to the estimated glomerular filtration rate on admission (eGFR > 60 mL/min/1.73 m
RESULTS
758 patients were included: mean age was 66 ± 18 years, and 58.6% of patient were male. Only 8.5% of patients had a history of chronic kidney disease (CKD); however, 30% of patients had kidney dysfunction upon admission (eGFR < 60 mL/min/1.73 m
CONCLUSIONS
Renal failure on admission in patients with SARS-CoV-2 infection is frequent and is associated with a greater number of complications and in-hospital mortality. Our data comes from a multicenter registry and therefore does not allow to have a precise mortality risk assessment. More studies are needed to confirm these findings.
DOI: 10.1007/s40620-020-00790-5
PubMed: 32602006
PubMed Central: PMC7322375
Links to Exploration step
pubmed:32602006Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry.</title><author><name sortKey="Uribarri, Aitor" sort="Uribarri, Aitor" uniqKey="Uribarri A" first="Aitor" last="Uribarri">Aitor Uribarri</name><affiliation><nlm:affiliation>Instituto de Ciencias del Corazón (ICICOR), CIBER-CV, Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal 3, 47005, Valladolid, Spain. auribarrig@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Nu Ez Gil, Ivan J" sort="Nu Ez Gil, Ivan J" uniqKey="Nu Ez Gil I" first="Iván J" last="Nú Ez-Gil">Iván J. Nú Ez-Gil</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aparisi, Alvaro" sort="Aparisi, Alvaro" uniqKey="Aparisi A" first="Alvaro" last="Aparisi">Alvaro Aparisi</name><affiliation><nlm:affiliation>Instituto de Ciencias del Corazón (ICICOR), CIBER-CV, Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal 3, 47005, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becerra Mu Oz, Victor M" sort="Becerra Mu Oz, Victor M" uniqKey="Becerra Mu Oz V" first="Victor M" last="Becerra-Mu Oz">Victor M. Becerra-Mu Oz</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Feltes, Gisela" sort="Feltes, Gisela" uniqKey="Feltes G" first="Gisela" last="Feltes">Gisela Feltes</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Trabattoni, Daniela" sort="Trabattoni, Daniela" uniqKey="Trabattoni D" first="Daniela" last="Trabattoni">Daniela Trabattoni</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rozas, Inmaculada" sort="Fernandez Rozas, Inmaculada" uniqKey="Fernandez Rozas I" first="Inmaculada" last="Fernández-Rozas">Inmaculada Fernández-Rozas</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Viana Llamas, Maria C" sort="Viana Llamas, Maria C" uniqKey="Viana Llamas M" first="María C" last="Viana-Llamas">María C. Viana-Llamas</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pepe, Martino" sort="Pepe, Martino" uniqKey="Pepe M" first="Martino" last="Pepe">Martino Pepe</name><affiliation><nlm:affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cerrato, Enrico" sort="Cerrato, Enrico" uniqKey="Cerrato E" first="Enrico" last="Cerrato">Enrico Cerrato</name><affiliation><nlm:affiliation>San Luigi Gonzaga University Hospital, Rivoli, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Capel Astrua, Thamar" sort="Capel Astrua, Thamar" uniqKey="Capel Astrua T" first="Thamar" last="Capel-Astrua">Thamar Capel-Astrua</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Romero, Rodolfo" sort="Romero, Rodolfo" uniqKey="Romero R" first="Rodolfo" last="Romero">Rodolfo Romero</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Castro Mejia, Alex F" sort="Castro Mejia, Alex F" uniqKey="Castro Mejia A" first="Alex F" last="Castro-Mejía">Alex F. Castro-Mejía</name><affiliation><nlm:affiliation>Hospital General del norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</nlm:affiliation></affiliation></author><author><name sortKey="El Battrawy, Ibrahim" sort="El Battrawy, Ibrahim" uniqKey="El Battrawy I" first="Ibrahim" last="El-Battrawy">Ibrahim El-Battrawy</name><affiliation><nlm:affiliation>First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Pais, Javier" sort="L Pez Pais, Javier" uniqKey="L Pez Pais J" first="Javier" last="L Pez-País">Javier L Pez-País</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="D Ascenzo, Fabrizio" sort="D Ascenzo, Fabrizio" uniqKey="D Ascenzo F" first="Fabrizio" last="D'Ascenzo">Fabrizio D'Ascenzo</name><affiliation><nlm:affiliation>San Giovanni Battista, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat Andres, Oscar" sort="Fabregat Andres, Oscar" uniqKey="Fabregat Andres O" first="Oscar" last="Fabregat-Andres">Oscar Fabregat-Andres</name><affiliation><nlm:affiliation>Hospital IMED, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bardaji, Alfredo" sort="Bardaji, Alfredo" uniqKey="Bardaji A" first="Alfredo" last="Bardají">Alfredo Bardají</name><affiliation><nlm:affiliation>University Hospital Joan XXIII, Tarragona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Raposeiras Roubin, Sergio" sort="Raposeiras Roubin, Sergio" uniqKey="Raposeiras Roubin S" first="Sergio" last="Raposeiras-Roubin">Sergio Raposeiras-Roubin</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marin, Francisco" sort="Marin, Francisco" uniqKey="Marin F" first="Francisco" last="Marín">Francisco Marín</name><affiliation><nlm:affiliation>Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, CIBERCV, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ortiz, Antonio" sort="Fernandez Ortiz, Antonio" uniqKey="Fernandez Ortiz A" first="Antonio" last="Fernández-Ortiz">Antonio Fernández-Ortiz</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Estrada, Vicente" sort="Estrada, Vicente" uniqKey="Estrada V" first="Vicente" last="Estrada">Vicente Estrada</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32602006</idno><idno type="pmid">32602006</idno><idno type="doi">10.1007/s40620-020-00790-5</idno><idno type="pmc">PMC7322375</idno><idno type="wicri:Area/Main/Corpus">001276</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001276</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry.</title><author><name sortKey="Uribarri, Aitor" sort="Uribarri, Aitor" uniqKey="Uribarri A" first="Aitor" last="Uribarri">Aitor Uribarri</name><affiliation><nlm:affiliation>Instituto de Ciencias del Corazón (ICICOR), CIBER-CV, Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal 3, 47005, Valladolid, Spain. auribarrig@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Nu Ez Gil, Ivan J" sort="Nu Ez Gil, Ivan J" uniqKey="Nu Ez Gil I" first="Iván J" last="Nú Ez-Gil">Iván J. Nú Ez-Gil</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aparisi, Alvaro" sort="Aparisi, Alvaro" uniqKey="Aparisi A" first="Alvaro" last="Aparisi">Alvaro Aparisi</name><affiliation><nlm:affiliation>Instituto de Ciencias del Corazón (ICICOR), CIBER-CV, Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal 3, 47005, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becerra Mu Oz, Victor M" sort="Becerra Mu Oz, Victor M" uniqKey="Becerra Mu Oz V" first="Victor M" last="Becerra-Mu Oz">Victor M. Becerra-Mu Oz</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Feltes, Gisela" sort="Feltes, Gisela" uniqKey="Feltes G" first="Gisela" last="Feltes">Gisela Feltes</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Trabattoni, Daniela" sort="Trabattoni, Daniela" uniqKey="Trabattoni D" first="Daniela" last="Trabattoni">Daniela Trabattoni</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rozas, Inmaculada" sort="Fernandez Rozas, Inmaculada" uniqKey="Fernandez Rozas I" first="Inmaculada" last="Fernández-Rozas">Inmaculada Fernández-Rozas</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Viana Llamas, Maria C" sort="Viana Llamas, Maria C" uniqKey="Viana Llamas M" first="María C" last="Viana-Llamas">María C. Viana-Llamas</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pepe, Martino" sort="Pepe, Martino" uniqKey="Pepe M" first="Martino" last="Pepe">Martino Pepe</name><affiliation><nlm:affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cerrato, Enrico" sort="Cerrato, Enrico" uniqKey="Cerrato E" first="Enrico" last="Cerrato">Enrico Cerrato</name><affiliation><nlm:affiliation>San Luigi Gonzaga University Hospital, Rivoli, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Capel Astrua, Thamar" sort="Capel Astrua, Thamar" uniqKey="Capel Astrua T" first="Thamar" last="Capel-Astrua">Thamar Capel-Astrua</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Romero, Rodolfo" sort="Romero, Rodolfo" uniqKey="Romero R" first="Rodolfo" last="Romero">Rodolfo Romero</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Castro Mejia, Alex F" sort="Castro Mejia, Alex F" uniqKey="Castro Mejia A" first="Alex F" last="Castro-Mejía">Alex F. Castro-Mejía</name><affiliation><nlm:affiliation>Hospital General del norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</nlm:affiliation></affiliation></author><author><name sortKey="El Battrawy, Ibrahim" sort="El Battrawy, Ibrahim" uniqKey="El Battrawy I" first="Ibrahim" last="El-Battrawy">Ibrahim El-Battrawy</name><affiliation><nlm:affiliation>First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Pais, Javier" sort="L Pez Pais, Javier" uniqKey="L Pez Pais J" first="Javier" last="L Pez-País">Javier L Pez-País</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="D Ascenzo, Fabrizio" sort="D Ascenzo, Fabrizio" uniqKey="D Ascenzo F" first="Fabrizio" last="D'Ascenzo">Fabrizio D'Ascenzo</name><affiliation><nlm:affiliation>San Giovanni Battista, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat Andres, Oscar" sort="Fabregat Andres, Oscar" uniqKey="Fabregat Andres O" first="Oscar" last="Fabregat-Andres">Oscar Fabregat-Andres</name><affiliation><nlm:affiliation>Hospital IMED, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bardaji, Alfredo" sort="Bardaji, Alfredo" uniqKey="Bardaji A" first="Alfredo" last="Bardají">Alfredo Bardají</name><affiliation><nlm:affiliation>University Hospital Joan XXIII, Tarragona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Raposeiras Roubin, Sergio" sort="Raposeiras Roubin, Sergio" uniqKey="Raposeiras Roubin S" first="Sergio" last="Raposeiras-Roubin">Sergio Raposeiras-Roubin</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marin, Francisco" sort="Marin, Francisco" uniqKey="Marin F" first="Francisco" last="Marín">Francisco Marín</name><affiliation><nlm:affiliation>Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, CIBERCV, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ortiz, Antonio" sort="Fernandez Ortiz, Antonio" uniqKey="Fernandez Ortiz A" first="Antonio" last="Fernández-Ortiz">Antonio Fernández-Ortiz</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Estrada, Vicente" sort="Estrada, Vicente" uniqKey="Estrada V" first="Vicente" last="Estrada">Vicente Estrada</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of nephrology</title><idno type="eISSN">1724-6059</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (epidemiology)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Angiotensin-Converting Enzyme 2 (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>COVID-19 (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (physiopathology)</term><term>Coronavirus Infections (therapy)</term><term>Female (MeSH)</term><term>Glomerular Filtration Rate (physiology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Peptidyl-Dipeptidase A (physiology)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (physiopathology)</term><term>Pneumonia, Viral (therapy)</term><term>Registries (MeSH)</term><term>Risk Assessment (MeSH)</term><term>SARS-CoV-2 (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Angiotensin-Converting Enzyme 2</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Acute Kidney Injury</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Glomerular Filtration Rate</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>COVID-19</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Registries</term><term>Risk Assessment</term><term>SARS-CoV-2</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite its international aggressive extension, with a significant morbidity and mortality, the impact of renal function on its prognosis is uncertain.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Analysis from the international HOPE-Registry (NCT04334291). The objective was to evaluate the association between kidney failure severity on admission with the mortality of patients with SARS-CoV-2 infection. Patients were categorized in 3 groups according to the estimated glomerular filtration rate on admission (eGFR > 60 mL/min/1.73 m</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>758 patients were included: mean age was 66 ± 18 years, and 58.6% of patient were male. Only 8.5% of patients had a history of chronic kidney disease (CKD); however, 30% of patients had kidney dysfunction upon admission (eGFR < 60 mL/min/1.73 m</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Renal failure on admission in patients with SARS-CoV-2 infection is frequent and is associated with a greater number of complications and in-hospital mortality. Our data comes from a multicenter registry and therefore does not allow to have a precise mortality risk assessment. More studies are needed to confirm these findings.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32602006</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1724-6059</ISSN><JournalIssue CitedMedium="Internet"><Volume>33</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>08</Month></PubDate></JournalIssue><Title>Journal of nephrology</Title><ISOAbbreviation>J Nephrol</ISOAbbreviation></Journal><ArticleTitle>Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry.</ArticleTitle><Pagination><MedlinePgn>737-745</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s40620-020-00790-5</ELocationID><Abstract><AbstractText Label="BACKGROUND">Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite its international aggressive extension, with a significant morbidity and mortality, the impact of renal function on its prognosis is uncertain.</AbstractText><AbstractText Label="METHODS">Analysis from the international HOPE-Registry (NCT04334291). The objective was to evaluate the association between kidney failure severity on admission with the mortality of patients with SARS-CoV-2 infection. Patients were categorized in 3 groups according to the estimated glomerular filtration rate on admission (eGFR > 60 mL/min/1.73 m<sup>2</sup>, eGFR 30-60 mL/min/1.73 m<sup>2</sup> and eGFR < 30 mL/min/1.73 m<sup>2</sup>).</AbstractText><AbstractText Label="RESULTS">758 patients were included: mean age was 66 ± 18 years, and 58.6% of patient were male. Only 8.5% of patients had a history of chronic kidney disease (CKD); however, 30% of patients had kidney dysfunction upon admission (eGFR < 60 mL/min/1.73 m<sup>2</sup>). These patients received less frequently pharmacological treatment with hydroxychloroquine or antivirals and had a greater number of complications such as sepsis (11.9% vs 26.4% vs 40.8%, p < 0.001) and respiratory failure (35.4% vs 72.2% vs 62.0%, p < 0.001) as well as a higher in-hospital mortality rate (eGFR > 60 vs eGFR 30-60 vs and eGFR < 30, 18.4% vs 56.5% vs 65.5%, p < 0.001). In multivariate analysis: age, hypertension, renal function, 0<sup>2</sup> saturation < 92% and lactate dehydrogenase elevation on admission independently predicted all-cause mortality.</AbstractText><AbstractText Label="CONCLUSIONS">Renal failure on admission in patients with SARS-CoV-2 infection is frequent and is associated with a greater number of complications and in-hospital mortality. Our data comes from a multicenter registry and therefore does not allow to have a precise mortality risk assessment. More studies are needed to confirm these findings.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Uribarri</LastName><ForeName>Aitor</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-6911-7480</Identifier><AffiliationInfo><Affiliation>Instituto de Ciencias del Corazón (ICICOR), CIBER-CV, Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal 3, 47005, Valladolid, Spain. auribarrig@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Núñez-Gil</LastName><ForeName>Iván J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aparisi</LastName><ForeName>Alvaro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Instituto de Ciencias del Corazón (ICICOR), CIBER-CV, Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal 3, 47005, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becerra-Muñoz</LastName><ForeName>Victor M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feltes</LastName><ForeName>Gisela</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trabattoni</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Rozas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Hospital Severo Ochoa, Leganés, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viana-Llamas</LastName><ForeName>María C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pepe</LastName><ForeName>Martino</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerrato</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>San Luigi Gonzaga University Hospital, Rivoli, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capel-Astrua</LastName><ForeName>Thamar</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Hospital Virgen del Mar, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>Rodolfo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hospital Universitario Getafe, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castro-Mejía</LastName><ForeName>Alex F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Hospital General del norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Battrawy</LastName><ForeName>Ibrahim</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-País</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Complejo Hospitalario Universitario de Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Ascenzo</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>San Giovanni Battista, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fabregat-Andres</LastName><ForeName>Oscar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Hospital IMED, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bardají</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University Hospital Joan XXIII, Tarragona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raposeiras-Roubin</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marín</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, CIBERCV, Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Ortiz</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macaya</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Estrada</LastName><ForeName>Vicente</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>HOPE COVID-19 Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT04334291</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>J Nephrol</MedlineTA><NlmUniqueID>9012268</NlmUniqueID><ISSNLinking>1121-8428</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.23</RegistryNumber><NameOfSubstance UI="C000705307">ACE2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 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MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="Y">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword 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