SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches-Insights into Chemical Structure-Biological Activity and Toxicological Screening.
Identifieur interne : 001218 ( Main/Corpus ); précédent : 001217; suivant : 001219SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches-Insights into Chemical Structure-Biological Activity and Toxicological Screening.
Auteurs : Cristina Adriana Dehelean ; Voichita Lazureanu ; Dorina Coricovac ; Marius Mioc ; Roxana Oancea ; Iasmina Marcovici ; Iulia Pinzaru ; Codruta Soica ; Aristidis M. Tsatsakis ; Octavian CretuSource :
- Journal of clinical medicine [ 2077-0383 ] ; 2020.
Abstract
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic represents the primary public health concern nowadays, and great efforts are made worldwide for efficient management of this crisis. Considerable scientific progress was recorded regarding SARS-CoV-2 infection in terms of genomic structure, diagnostic tools, viral transmission, mechanism of viral infection, symptomatology, clinical impact, and complications, but these data evolve constantly. Up to date, neither an effective vaccine nor SARS-CoV-2 specific antiviral agents have been approved, but significant advances were enlisted in this direction by investigating repurposed approved drugs (ongoing clinical trials) or developing innovative antiviral drugs (preclinical and clinical studies). This review presents a thorough analysis of repurposed drug admitted for compassionate use from a chemical structure-biological activity perspective highlighting the ADME (absorption, distribution, metabolism, and excretion) properties and the toxicophore groups linked to potential adverse effects. A detailed pharmacological description of the novel potential anti-COVID-19 therapeutics was also included. In addition, a comprehensible overview of SARS-CoV-2 infection in terms of general description and structure, mechanism of viral infection, and clinical impact was portrayed.
DOI: 10.3390/jcm9072084
PubMed: 32630746
PubMed Central: PMC7409030
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pubmed:32630746Le document en format XML
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Tsatsakis</name><affiliation><nlm:affiliation>Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003 Crete, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Cretu, Octavian" sort="Cretu, Octavian" uniqKey="Cretu O" first="Octavian" last="Cretu">Octavian Cretu</name><affiliation><nlm:affiliation>Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of clinical medicine</title><idno type="ISSN">2077-0383</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic represents the primary public health concern nowadays, and great efforts are made worldwide for efficient management of this crisis. Considerable scientific progress was recorded regarding SARS-CoV-2 infection in terms of genomic structure, diagnostic tools, viral transmission, mechanism of viral infection, symptomatology, clinical impact, and complications, but these data evolve constantly. Up to date, neither an effective vaccine nor SARS-CoV-2 specific antiviral agents have been approved, but significant advances were enlisted in this direction by investigating repurposed approved drugs (ongoing clinical trials) or developing innovative antiviral drugs (preclinical and clinical studies). This review presents a thorough analysis of repurposed drug admitted for compassionate use from a chemical structure-biological activity perspective highlighting the ADME (absorption, distribution, metabolism, and excretion) properties and the toxicophore groups linked to potential adverse effects. A detailed pharmacological description of the novel potential anti-COVID-19 therapeutics was also included. In addition, a comprehensible overview of SARS-CoV-2 infection in terms of general description and structure, mechanism of viral infection, and clinical impact was portrayed.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32630746</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2077-0383</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>02</Day></PubDate></JournalIssue><Title>Journal of clinical medicine</Title><ISOAbbreviation>J Clin Med</ISOAbbreviation></Journal><ArticleTitle>SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches-Insights into Chemical Structure-Biological Activity and Toxicological Screening.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E2084</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/jcm9072084</ELocationID><Abstract><AbstractText>SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic represents the primary public health concern nowadays, and great efforts are made worldwide for efficient management of this crisis. Considerable scientific progress was recorded regarding SARS-CoV-2 infection in terms of genomic structure, diagnostic tools, viral transmission, mechanism of viral infection, symptomatology, clinical impact, and complications, but these data evolve constantly. Up to date, neither an effective vaccine nor SARS-CoV-2 specific antiviral agents have been approved, but significant advances were enlisted in this direction by investigating repurposed approved drugs (ongoing clinical trials) or developing innovative antiviral drugs (preclinical and clinical studies). This review presents a thorough analysis of repurposed drug admitted for compassionate use from a chemical structure-biological activity perspective highlighting the ADME (absorption, distribution, metabolism, and excretion) properties and the toxicophore groups linked to potential adverse effects. A detailed pharmacological description of the novel potential anti-COVID-19 therapeutics was also included. In addition, a comprehensible overview of SARS-CoV-2 infection in terms of general description and structure, mechanism of viral infection, and clinical impact was portrayed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dehelean</LastName><ForeName>Cristina Adriana</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lazureanu</LastName><ForeName>Voichita</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>"Dr. Victor Babes" Clinical Hospital for Infectious Diseases and Pneumophthisiology, 300310 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coricovac</LastName><ForeName>Dorina</ForeName><Initials>D</Initials><Identifier Source="ORCID">0000-0002-5760-8872</Identifier><AffiliationInfo><Affiliation>Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mioc</LastName><ForeName>Marius</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oancea</LastName><ForeName>Roxana</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Faculty of Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcovici</LastName><ForeName>Iasmina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinzaru</LastName><ForeName>Iulia</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0003-2295-1926</Identifier><AffiliationInfo><Affiliation>Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soica</LastName><ForeName>Codruta</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsatsakis</LastName><ForeName>Aristidis M</ForeName><Initials>AM</Initials><Identifier Source="ORCID">0000-0003-3824-2462</Identifier><AffiliationInfo><Affiliation>Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003 Crete, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cretu</LastName><ForeName>Octavian</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>J Clin 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IdType="pubmed">32275812</ArticleId></ArticleIdList></Reference><Reference><Citation>Infez Med. 2020 Ahead of print Jun 1;28(2):143-152</Citation><ArticleIdList><ArticleId IdType="pubmed">32275256</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Microbes Infect. 2020 Dec;9(1):382-385</Citation><ArticleIdList><ArticleId IdType="pubmed">32065055</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Med. 2020 Aug;46(2):467-488</Citation><ArticleIdList><ArticleId IdType="pubmed">32468014</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pediatr. 2020 Jul;179(7):1029-1046</Citation><ArticleIdList><ArticleId IdType="pubmed">32424745</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Pharm Sin B. 2020 May;10(5):766-788</Citation><ArticleIdList><ArticleId IdType="pubmed">32292689</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2020 May - Jun;35:101647</Citation><ArticleIdList><ArticleId IdType="pubmed">32247927</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Ther. 2010 Oct;128(1):119-28</Citation><ArticleIdList><ArticleId IdType="pubmed">20599443</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Microbiol. 2020 Apr 23;58(5):</Citation><ArticleIdList><ArticleId IdType="pubmed">32161092</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2020 Jun 1;130(6):2757-2765</Citation><ArticleIdList><ArticleId IdType="pubmed">32254064</ArticleId></ArticleIdList></Reference><Reference><Citation>J Antimicrob Chemother. 2020 Jul 1;75(7):1667-1670</Citation><ArticleIdList><ArticleId IdType="pubmed">32196083</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Immunopharmacol. 2020 Aug;85:106688</Citation><ArticleIdList><ArticleId IdType="pubmed">32544867</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Klin Intensivmed Notfmed. 2020 Apr 14;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32291505</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 30;395(10238):1695-1704</Citation><ArticleIdList><ArticleId IdType="pubmed">32401715</ArticleId></ArticleIdList></Reference><Reference><Citation>Viruses. 2020 Apr 06;12(4):</Citation><ArticleIdList><ArticleId IdType="pubmed">32268515</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Pharmacol Ther. 2020 Apr 23;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32324898</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2020 Jun;178:104793</Citation><ArticleIdList><ArticleId IdType="pubmed">32283108</ArticleId></ArticleIdList></Reference><Reference><Citation>J Antimicrob Chemother. 2010 Apr;65 Suppl 2:ii5-ii10</Citation><ArticleIdList><ArticleId IdType="pubmed">20215135</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):470-473</Citation><ArticleIdList><ArticleId IdType="pubmed">31986257</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Discov Ther. 2020;14(1):58-60</Citation><ArticleIdList><ArticleId IdType="pubmed">32147628</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2015 Mar;89(5):2931-43</Citation><ArticleIdList><ArticleId IdType="pubmed">25552710</ArticleId></ArticleIdList></Reference><Reference><Citation>Mil Med Res. 2020 Mar 13;7(1):11</Citation><ArticleIdList><ArticleId IdType="pubmed">32169119</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 May 22;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32445440</ArticleId></ArticleIdList></Reference><Reference><Citation>Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219</Citation><ArticleIdList><ArticleId IdType="pubmed">32391667</ArticleId></ArticleIdList></Reference><Reference><Citation>Virol Sin. 2020 Jun;35(3):266-271</Citation><ArticleIdList><ArticleId IdType="pubmed">32125642</ArticleId></ArticleIdList></Reference><Reference><Citation>Acad Emerg Med. 2020 Jun;27(6):493-504</Citation><ArticleIdList><ArticleId IdType="pubmed">32359203</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2020 Apr;80(4):469-496</Citation><ArticleIdList><ArticleId IdType="pubmed">32092392</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Pharmacol Ther. 2020 Aug;108(2):242-247</Citation><ArticleIdList><ArticleId IdType="pubmed">32246834</ArticleId></ArticleIdList></Reference><Reference><Citation>Postgrad Med. 2020 Jun 21;:1-10</Citation><ArticleIdList><ArticleId IdType="pubmed">32496926</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation><ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId></ArticleIdList></Reference><Reference><Citation>Gene Rep. 2020 Jun;19:100682</Citation><ArticleIdList><ArticleId IdType="pubmed">32300673</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation><ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId></ArticleIdList></Reference><Reference><Citation>ACS Cent Sci. 2020 Mar 25;6(3):315-331</Citation><ArticleIdList><ArticleId IdType="pubmed">32226821</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Otolaryngol. 2020 Jun 2;41(5):102581</Citation><ArticleIdList><ArticleId IdType="pubmed">32563019</ArticleId></ArticleIdList></Reference><Reference><Citation>Asian Pac J Allergy Immunol. 2020 Mar;38(1):10-18</Citation><ArticleIdList><ArticleId IdType="pubmed">32134278</ArticleId></ArticleIdList></Reference><Reference><Citation>FASEB J. 2020 May;34(5):6027-6037</Citation><ArticleIdList><ArticleId IdType="pubmed">32350928</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation><ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId></ArticleIdList></Reference><Reference><Citation>J Adv Res. 2020 Mar 16;24:91-98</Citation><ArticleIdList><ArticleId IdType="pubmed">32257431</ArticleId></ArticleIdList></Reference><Reference><Citation>Biosci Trends. 2020 Mar 16;14(1):72-73</Citation><ArticleIdList><ArticleId IdType="pubmed">32074550</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2020 Apr 16;181(2):281-292.e6</Citation><ArticleIdList><ArticleId IdType="pubmed">32155444</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Virol. 2016 Sep 29;3(1):237-261</Citation><ArticleIdList><ArticleId IdType="pubmed">27578435</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 16;395(10236):1569-1578</Citation><ArticleIdList><ArticleId IdType="pubmed">32423584</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Chem. 2007 Aug 23;50(17):4087-95</Citation><ArticleIdList><ArticleId IdType="pubmed">17663539</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2017 Mar 06;7:43395</Citation><ArticleIdList><ArticleId IdType="pubmed">28262699</ArticleId></ArticleIdList></Reference><Reference><Citation>Thorax. 2004 Mar;59(3):252-6</Citation><ArticleIdList><ArticleId IdType="pubmed">14985565</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Discov. 2020 Mar 18;6:16</Citation><ArticleIdList><ArticleId IdType="pubmed">32194981</ArticleId></ArticleIdList></Reference><Reference><Citation>Open Forum Infect Dis. 2020 Apr 15;7(4):ofaa130</Citation><ArticleIdList><ArticleId IdType="pubmed">32363212</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2020 May;46(5):846-848</Citation><ArticleIdList><ArticleId IdType="pubmed">32125452</ArticleId></ArticleIdList></Reference><Reference><Citation>Pathogens. 2020 Mar 04;9(3):</Citation><ArticleIdList><ArticleId IdType="pubmed">32143502</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Infect Dis. 2020 Aug;97:225-229</Citation><ArticleIdList><ArticleId IdType="pubmed">32535302</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Biochem Biophys. 2008 Apr 1;472(1):34-42</Citation><ArticleIdList><ArticleId IdType="pubmed">18275836</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Surg. 2020 Apr;76:71-76</Citation><ArticleIdList><ArticleId IdType="pubmed">32112977</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2017 Mar 03;7:42717</Citation><ArticleIdList><ArticleId IdType="pubmed">28256516</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2020 Mar 27;367(6485):1412-1413</Citation><ArticleIdList><ArticleId IdType="pubmed">32217705</ArticleId></ArticleIdList></Reference><Reference><Citation>J Phys Chem B. 2020 Aug 13;124(32):6955-6962</Citation><ArticleIdList><ArticleId IdType="pubmed">32521159</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2020 Jun 4;135(23):2033-2040</Citation><ArticleIdList><ArticleId IdType="pubmed">32339221</ArticleId></ArticleIdList></Reference><Reference><Citation>Life Sci. 2020 May 1;248:117477</Citation><ArticleIdList><ArticleId IdType="pubmed">32119961</ArticleId></ArticleIdList></Reference><Reference><Citation>Viruses. 2019 Apr 04;11(4):</Citation><ArticleIdList><ArticleId IdType="pubmed">30987343</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 May;581(7807):221-224</Citation><ArticleIdList><ArticleId IdType="pubmed">32225175</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 Apr 16;:1-6</Citation><ArticleIdList><ArticleId IdType="pubmed">32248766</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2020 Jun 12;24(1):335</Citation><ArticleIdList><ArticleId IdType="pubmed">32532353</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Infect Dis. 2020 May;94:44-48</Citation><ArticleIdList><ArticleId IdType="pubmed">32171952</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Heart J Acute Cardiovasc Care. 2020 Apr;9(3):215-221</Citation><ArticleIdList><ArticleId IdType="pubmed">32372695</ArticleId></ArticleIdList></Reference><Reference><Citation>mBio. 2018 Mar 6;9(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">29511076</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Chem. 2000 Jun;7(6):663-72</Citation><ArticleIdList><ArticleId IdType="pubmed">10702632</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmaceuticals (Basel). 2020 May 14;13(5):</Citation><ArticleIdList><ArticleId IdType="pubmed">32423027</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Med (Lausanne). 2015 Feb 04;2:4</Citation><ArticleIdList><ArticleId IdType="pubmed">25699258</ArticleId></ArticleIdList></Reference><Reference><Citation>Planta Med. 2018 Jan;84(1):8-19</Citation><ArticleIdList><ArticleId IdType="pubmed">29202513</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2020 Apr 1;130(4):1545-1548</Citation><ArticleIdList><ArticleId IdType="pubmed">32167489</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Rev Med Pharmacol Sci. 2020 Apr;24(8):4539-4547</Citation><ArticleIdList><ArticleId IdType="pubmed">32373993</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 May 5;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32369191</ArticleId></ArticleIdList></Reference><Reference><Citation>J Integr Med. 2020 Mar;18(2):152-158</Citation><ArticleIdList><ArticleId IdType="pubmed">32113846</ArticleId></ArticleIdList></Reference><Reference><Citation>Drugs Context. 2020 Apr 28;9:</Citation><ArticleIdList><ArticleId IdType="pubmed">32373183</ArticleId></ArticleIdList></Reference><Reference><Citation>Engineering (Beijing). 2020 Mar 18;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32346491</ArticleId></ArticleIdList></Reference><Reference><Citation>Life Sci. 2020 Jul 15;253:117592</Citation><ArticleIdList><ArticleId IdType="pubmed">32222463</ArticleId></ArticleIdList></Reference><Reference><Citation>Virol J. 2005 Aug 22;2:69</Citation><ArticleIdList><ArticleId IdType="pubmed">16115318</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Transl Hepatol. 2020 Mar 28;8(1):13-17</Citation><ArticleIdList><ArticleId IdType="pubmed">32274341</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Jun;92(6):548-551</Citation><ArticleIdList><ArticleId IdType="pubmed">32096567</ArticleId></ArticleIdList></Reference><Reference><Citation>Asia Pac J Ophthalmol (Phila). 2020 Mar-Apr;9(2):85-87</Citation><ArticleIdList><ArticleId IdType="pubmed">32349115</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Mar 26;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32219882</ArticleId></ArticleIdList></Reference><Reference><Citation>Autoimmun Rev. 2020 Jul;19(7):102566</Citation><ArticleIdList><ArticleId IdType="pubmed">32380315</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Surg. 2020 May;77:206-216</Citation><ArticleIdList><ArticleId IdType="pubmed">32289472</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 Apr 15;:1-11</Citation><ArticleIdList><ArticleId IdType="pubmed">32238078</ArticleId></ArticleIdList></Reference><Reference><Citation>Basic Res Cardiol. 2020 Apr 10;115(3):32</Citation><ArticleIdList><ArticleId IdType="pubmed">32277299</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Med (Berl). 2002 Feb;80(2):86-95</Citation><ArticleIdList><ArticleId IdType="pubmed">11907645</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2019 Jun 6;133(23):2465-2477</Citation><ArticleIdList><ArticleId IdType="pubmed">30992265</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2020 Mar 27;367(6485):1444-1448</Citation><ArticleIdList><ArticleId IdType="pubmed">32132184</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2020 Mar 11;27(3):325-328</Citation><ArticleIdList><ArticleId IdType="pubmed">32035028</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2020 Jun 26;368(6498):1499-1504</Citation><ArticleIdList><ArticleId IdType="pubmed">32358203</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Apr;55(4):105932</Citation><ArticleIdList><ArticleId IdType="pubmed">32145363</ArticleId></ArticleIdList></Reference><Reference><Citation>Aliment Pharmacol Ther. 2020 May;51(9):843-851</Citation><ArticleIdList><ArticleId IdType="pubmed">32222988</ArticleId></ArticleIdList></Reference><Reference><Citation>One Health. 2020 Mar 27;9:100128</Citation><ArticleIdList><ArticleId IdType="pubmed">32258351</ArticleId></ArticleIdList></Reference><Reference><Citation>J Thromb Haemost. 2020 May;18(5):1094-1099</Citation><ArticleIdList><ArticleId IdType="pubmed">32220112</ArticleId></ArticleIdList></Reference><Reference><Citation>Mil Med Res. 2020 Apr 20;7(1):19</Citation><ArticleIdList><ArticleId IdType="pubmed">32307014</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomol Ther (Seoul). 2015 Jul;23(4):345-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26157551</ArticleId></ArticleIdList></Reference><Reference><Citation>Neth Heart J. 2020 Jul;28(7-8):406-409</Citation><ArticleIdList><ArticleId IdType="pubmed">32350818</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2018 Jun 2;500(2):365-369</Citation><ArticleIdList><ArticleId IdType="pubmed">29660337</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):2006-2011</Citation><ArticleIdList><ArticleId IdType="pubmed">32141569</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Infect. 2020 Jul;26(7):880-894</Citation><ArticleIdList><ArticleId IdType="pubmed">32360444</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Transl Hepatol. 2020 Mar 28;8(1):18-24</Citation><ArticleIdList><ArticleId IdType="pubmed">32274342</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Med. 2020 Jul;46(1):3-16</Citation><ArticleIdList><ArticleId IdType="pubmed">32377694</ArticleId></ArticleIdList></Reference><Reference><Citation>J Microbiol Immunol Infect. 2020 Jun;53(3):404-412</Citation><ArticleIdList><ArticleId IdType="pubmed">32173241</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2020 Aug;26(8):1205-1211</Citation><ArticleIdList><ArticleId IdType="pubmed">32546824</ArticleId></ArticleIdList></Reference><Reference><Citation>J Heart Lung Transplant. 2020 May;39(5):405-407</Citation><ArticleIdList><ArticleId IdType="pubmed">32362390</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2020 Apr 16;181(2):223-227</Citation><ArticleIdList><ArticleId IdType="pubmed">32220310</ArticleId></ArticleIdList></Reference><Reference><Citation>Gut. 2020 Jul;69(7):1335-1342</Citation><ArticleIdList><ArticleId IdType="pubmed">32303609</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Apr;55(4):105933</Citation><ArticleIdList><ArticleId IdType="pubmed">32147516</ArticleId></ArticleIdList></Reference><Reference><Citation>Antivir Chem Chemother. 2012 Sep 25;23(1):1-12</Citation><ArticleIdList><ArticleId IdType="pubmed">22592135</ArticleId></ArticleIdList></Reference><Reference><Citation>J Microbiol Immunol Infect. 2020 Mar 31;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32265180</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2020 May 15;295(20):6785-6797</Citation><ArticleIdList><ArticleId IdType="pubmed">32284326</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2006 Feb;6(2):67-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16439323</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Sci. 2020 Apr 10;21(7):</Citation><ArticleIdList><ArticleId IdType="pubmed">32290293</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 May;581(7807):215-220</Citation><ArticleIdList><ArticleId IdType="pubmed">32225176</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation><ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2020 May 14;181(4):894-904.e9</Citation><ArticleIdList><ArticleId IdType="pubmed">32275855</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Jun 21;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32562541</ArticleId></ArticleIdList></Reference><Reference><Citation>Heart Rhythm. 2020 May 5;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32380291</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Med. 2020 Jun;45(6):1631-1643</Citation><ArticleIdList><ArticleId IdType="pubmed">32236624</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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