Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.
Identifieur interne : 001215 ( Main/Corpus ); précédent : 001214; suivant : 001216Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.
Auteurs : Rafael San-Juan ; Patricia Barbero ; Mario Fernández-Ruiz ; Francisco L Pez-Medrano ; Manuel Lizasoáin ; Pilar Hernández-Jiménez ; José Tiago Silva ; María Ruiz-Ruig Mez ; Laura Corbella ; Isabel Rodríguez-Goncer ; María Dolores Folgueira ; Antonio Lalueza ; Emma Batllori ; Inma Mejía ; Laura Forcén ; Carlos Lumbreras ; Antonio García-Burguillo ; Alberto Galindo ; José María AguadoSource :
- EClinicalMedicine [ 2589-5370 ] ; 2020.
Abstract
Background
Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.
Methods
Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.
Findings
COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%;
Interpretation
Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.
Funding
Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.
DOI: 10.1016/j.eclinm.2020.100407
PubMed: 32632417
PubMed Central: PMC7295514
Links to Exploration step
pubmed:32632417Le document en format XML
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<author><name sortKey="San Juan, Rafael" sort="San Juan, Rafael" uniqKey="San Juan R" first="Rafael" last="San-Juan">Rafael San-Juan</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Barbero, Patricia" sort="Barbero, Patricia" uniqKey="Barbero P" first="Patricia" last="Barbero">Patricia Barbero</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Fernandez Ruiz, Mario" sort="Fernandez Ruiz, Mario" uniqKey="Fernandez Ruiz M" first="Mario" last="Fernández-Ruiz">Mario Fernández-Ruiz</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="L Pez Medrano, Francisco" sort="L Pez Medrano, Francisco" uniqKey="L Pez Medrano F" first="Francisco" last="L Pez-Medrano">Francisco L Pez-Medrano</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Lizasoain, Manuel" sort="Lizasoain, Manuel" uniqKey="Lizasoain M" first="Manuel" last="Lizasoáin">Manuel Lizasoáin</name>
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<author><name sortKey="Hernandez Jimenez, Pilar" sort="Hernandez Jimenez, Pilar" uniqKey="Hernandez Jimenez P" first="Pilar" last="Hernández-Jiménez">Pilar Hernández-Jiménez</name>
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<author><name sortKey="Silva, Jose Tiago" sort="Silva, Jose Tiago" uniqKey="Silva J" first="José Tiago" last="Silva">José Tiago Silva</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Ruiz Ruig Mez, Maria" sort="Ruiz Ruig Mez, Maria" uniqKey="Ruiz Ruig Mez M" first="María" last="Ruiz-Ruig Mez">María Ruiz-Ruig Mez</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Corbella, Laura" sort="Corbella, Laura" uniqKey="Corbella L" first="Laura" last="Corbella">Laura Corbella</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Rodriguez Goncer, Isabel" sort="Rodriguez Goncer, Isabel" uniqKey="Rodriguez Goncer I" first="Isabel" last="Rodríguez-Goncer">Isabel Rodríguez-Goncer</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Folgueira, Maria Dolores" sort="Folgueira, Maria Dolores" uniqKey="Folgueira M" first="María Dolores" last="Folgueira">María Dolores Folgueira</name>
<affiliation><nlm:affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Lalueza, Antonio" sort="Lalueza, Antonio" uniqKey="Lalueza A" first="Antonio" last="Lalueza">Antonio Lalueza</name>
<affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Batllori, Emma" sort="Batllori, Emma" uniqKey="Batllori E" first="Emma" last="Batllori">Emma Batllori</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Mejia, Inma" sort="Mejia, Inma" uniqKey="Mejia I" first="Inma" last="Mejía">Inma Mejía</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Forcen, Laura" sort="Forcen, Laura" uniqKey="Forcen L" first="Laura" last="Forcén">Laura Forcén</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Lumbreras, Carlos" sort="Lumbreras, Carlos" uniqKey="Lumbreras C" first="Carlos" last="Lumbreras">Carlos Lumbreras</name>
<affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Garcia Burguillo, Antonio" sort="Garcia Burguillo, Antonio" uniqKey="Garcia Burguillo A" first="Antonio" last="García-Burguillo">Antonio García-Burguillo</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Galindo, Alberto" sort="Galindo, Alberto" uniqKey="Galindo A" first="Alberto" last="Galindo">Alberto Galindo</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Aguado, Jose Maria" sort="Aguado, Jose Maria" uniqKey="Aguado J" first="José María" last="Aguado">José María Aguado</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.</title>
<author><name sortKey="San Juan, Rafael" sort="San Juan, Rafael" uniqKey="San Juan R" first="Rafael" last="San-Juan">Rafael San-Juan</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Barbero, Patricia" sort="Barbero, Patricia" uniqKey="Barbero P" first="Patricia" last="Barbero">Patricia Barbero</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Fernandez Ruiz, Mario" sort="Fernandez Ruiz, Mario" uniqKey="Fernandez Ruiz M" first="Mario" last="Fernández-Ruiz">Mario Fernández-Ruiz</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="L Pez Medrano, Francisco" sort="L Pez Medrano, Francisco" uniqKey="L Pez Medrano F" first="Francisco" last="L Pez-Medrano">Francisco L Pez-Medrano</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Lizasoain, Manuel" sort="Lizasoain, Manuel" uniqKey="Lizasoain M" first="Manuel" last="Lizasoáin">Manuel Lizasoáin</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hernandez Jimenez, Pilar" sort="Hernandez Jimenez, Pilar" uniqKey="Hernandez Jimenez P" first="Pilar" last="Hernández-Jiménez">Pilar Hernández-Jiménez</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Silva, Jose Tiago" sort="Silva, Jose Tiago" uniqKey="Silva J" first="José Tiago" last="Silva">José Tiago Silva</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ruiz Ruig Mez, Maria" sort="Ruiz Ruig Mez, Maria" uniqKey="Ruiz Ruig Mez M" first="María" last="Ruiz-Ruig Mez">María Ruiz-Ruig Mez</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Corbella, Laura" sort="Corbella, Laura" uniqKey="Corbella L" first="Laura" last="Corbella">Laura Corbella</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rodriguez Goncer, Isabel" sort="Rodriguez Goncer, Isabel" uniqKey="Rodriguez Goncer I" first="Isabel" last="Rodríguez-Goncer">Isabel Rodríguez-Goncer</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Folgueira, Maria Dolores" sort="Folgueira, Maria Dolores" uniqKey="Folgueira M" first="María Dolores" last="Folgueira">María Dolores Folgueira</name>
<affiliation><nlm:affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lalueza, Antonio" sort="Lalueza, Antonio" uniqKey="Lalueza A" first="Antonio" last="Lalueza">Antonio Lalueza</name>
<affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Batllori, Emma" sort="Batllori, Emma" uniqKey="Batllori E" first="Emma" last="Batllori">Emma Batllori</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mejia, Inma" sort="Mejia, Inma" uniqKey="Mejia I" first="Inma" last="Mejía">Inma Mejía</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Forcen, Laura" sort="Forcen, Laura" uniqKey="Forcen L" first="Laura" last="Forcén">Laura Forcén</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lumbreras, Carlos" sort="Lumbreras, Carlos" uniqKey="Lumbreras C" first="Carlos" last="Lumbreras">Carlos Lumbreras</name>
<affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garcia Burguillo, Antonio" sort="Garcia Burguillo, Antonio" uniqKey="Garcia Burguillo A" first="Antonio" last="García-Burguillo">Antonio García-Burguillo</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Galindo, Alberto" sort="Galindo, Alberto" uniqKey="Galindo A" first="Alberto" last="Galindo">Alberto Galindo</name>
<affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aguado, Jose Maria" sort="Aguado, Jose Maria" uniqKey="Aguado J" first="José María" last="Aguado">José María Aguado</name>
<affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation>
</affiliation>
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<imprint><date when="2020" type="published">2020</date>
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<front><div type="abstract" xml:lang="en"><p><b>Background</b>
</p>
<p>Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Methods</b>
</p>
<p>Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Findings</b>
</p>
<p>COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%; </p>
</div>
<div type="abstract" xml:lang="en"><p><b>Interpretation</b>
</p>
<p>Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Funding</b>
</p>
<p>Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32632417</PMID>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2589-5370</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<PubDate><Year>2020</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>EClinicalMedicine</Title>
<ISOAbbreviation>EClinicalMedicine</ISOAbbreviation>
</Journal>
<ArticleTitle>Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.</ArticleTitle>
<Pagination><MedlinePgn>100407</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.eclinm.2020.100407</ELocationID>
<Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.</AbstractText>
<AbstractText Label="Methods" NlmCategory="UNASSIGNED">Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.</AbstractText>
<AbstractText Label="Findings" NlmCategory="UNASSIGNED">COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%; <i>P</i>
-value = 0·003) and serum C-reactive protein (CRP) levels >10 mg/dL (33·0% vs. 0·0%; <i>P</i>
-value = 0·05) at admission than those with no oxygen requirements.</AbstractText>
<AbstractText Label="Interpretation" NlmCategory="UNASSIGNED">Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.</AbstractText>
<AbstractText Label="Funding" NlmCategory="UNASSIGNED">Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.</AbstractText>
<CopyrightInformation>© 2020 The Author(s).</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>San-Juan</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barbero</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fernández-Ruiz</LastName>
<ForeName>Mario</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>López-Medrano</LastName>
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<Initials>F</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Lizasoáin</LastName>
<ForeName>Manuel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hernández-Jiménez</LastName>
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<Initials>P</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Silva</LastName>
<ForeName>José Tiago</ForeName>
<Initials>JT</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ruiz-Ruigómez</LastName>
<ForeName>María</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Corbella</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodríguez-Goncer</LastName>
<ForeName>Isabel</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Folgueira</LastName>
<ForeName>María Dolores</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lalueza</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Batllori</LastName>
<ForeName>Emma</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Inma</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lumbreras</LastName>
<ForeName>Carlos</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-Burguillo</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Galindo</LastName>
<ForeName>Alberto</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aguado</LastName>
<ForeName>José María</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation>
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<Language>eng</Language>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>06</Month>
<Day>15</Day>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>EClinicalMedicine</MedlineTA>
<NlmUniqueID>101733727</NlmUniqueID>
<ISSNLinking>2589-5370</ISSNLinking>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ALT, alanine aminotransferase</Keyword>
<Keyword MajorTopicYN="N">ARDS, acute respiratory distress syndrome</Keyword>
<Keyword MajorTopicYN="N">AST, aspartate aminotransferase</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">COVID-19, coronavirus disease 2019</Keyword>
<Keyword MajorTopicYN="N">CRP, C-reactive protein</Keyword>
<Keyword MajorTopicYN="N">CT, computerized tomography</Keyword>
<Keyword MajorTopicYN="N">Coronavirus</Keyword>
<Keyword MajorTopicYN="N">HCQ, hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="N">ICU, intensive care unit</Keyword>
<Keyword MajorTopicYN="N">IFN-β, interferon-β</Keyword>
<Keyword MajorTopicYN="N">IMV, invasive mechanical ventilation</Keyword>
<Keyword MajorTopicYN="N">IQR, interquartile range</Keyword>
<Keyword MajorTopicYN="N">IV, intravenous</Keyword>
<Keyword MajorTopicYN="N">LPV/r, lopinavir/ritonavir</Keyword>
<Keyword MajorTopicYN="N">Pneumonia</Keyword>
<Keyword MajorTopicYN="N">Pregnancy</Keyword>
<Keyword MajorTopicYN="N">RT-PCR, reverse transcription polymerase chain reaction</Keyword>
<Keyword MajorTopicYN="N">Risk stratification</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2, severe acute respiratory syndrome coronavirus 2</Keyword>
<Keyword MajorTopicYN="N">TCZ, tocilizumab</Keyword>
<Keyword MajorTopicYN="N">URTI, upper respiratory tract infection</Keyword>
<Keyword MajorTopicYN="N">ePaO2/FiO2, estimated arterial oxygen/fraction of inspired oxygen ratio</Keyword>
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<Month>05</Month>
<Day>19</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>05</Month>
<Day>21</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>7</Month>
<Day>8</Day>
<Hour>6</Hour>
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<Month>7</Month>
<Day>8</Day>
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<Month>7</Month>
<Day>8</Day>
<Hour>6</Hour>
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