Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.
Identifieur interne : 001215 ( Main/Corpus ); précédent : 001214; suivant : 001216Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.
Auteurs : Rafael San-Juan ; Patricia Barbero ; Mario Fernández-Ruiz ; Francisco L Pez-Medrano ; Manuel Lizasoáin ; Pilar Hernández-Jiménez ; José Tiago Silva ; María Ruiz-Ruig Mez ; Laura Corbella ; Isabel Rodríguez-Goncer ; María Dolores Folgueira ; Antonio Lalueza ; Emma Batllori ; Inma Mejía ; Laura Forcén ; Carlos Lumbreras ; Antonio García-Burguillo ; Alberto Galindo ; José María AguadoSource :
- EClinicalMedicine [ 2589-5370 ] ; 2020.
Abstract
Background
Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.
Methods
Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.
Findings
COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%;
Interpretation
Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.
Funding
Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.
DOI: 10.1016/j.eclinm.2020.100407
PubMed: 32632417
PubMed Central: PMC7295514
Links to Exploration step
pubmed:32632417Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.</title><author><name sortKey="San Juan, Rafael" sort="San Juan, Rafael" uniqKey="San Juan R" first="Rafael" last="San-Juan">Rafael San-Juan</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Barbero, Patricia" sort="Barbero, Patricia" uniqKey="Barbero P" first="Patricia" last="Barbero">Patricia Barbero</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ruiz, Mario" sort="Fernandez Ruiz, Mario" uniqKey="Fernandez Ruiz M" first="Mario" last="Fernández-Ruiz">Mario Fernández-Ruiz</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Medrano, Francisco" sort="L Pez Medrano, Francisco" uniqKey="L Pez Medrano F" first="Francisco" last="L Pez-Medrano">Francisco L Pez-Medrano</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lizasoain, Manuel" sort="Lizasoain, Manuel" uniqKey="Lizasoain M" first="Manuel" last="Lizasoáin">Manuel Lizasoáin</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Hernandez Jimenez, Pilar" sort="Hernandez Jimenez, Pilar" uniqKey="Hernandez Jimenez P" first="Pilar" last="Hernández-Jiménez">Pilar Hernández-Jiménez</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Silva, Jose Tiago" sort="Silva, Jose Tiago" uniqKey="Silva J" first="José Tiago" last="Silva">José Tiago Silva</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz Ruig Mez, Maria" sort="Ruiz Ruig Mez, Maria" uniqKey="Ruiz Ruig Mez M" first="María" last="Ruiz-Ruig Mez">María Ruiz-Ruig Mez</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Corbella, Laura" sort="Corbella, Laura" uniqKey="Corbella L" first="Laura" last="Corbella">Laura Corbella</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Goncer, Isabel" sort="Rodriguez Goncer, Isabel" uniqKey="Rodriguez Goncer I" first="Isabel" last="Rodríguez-Goncer">Isabel Rodríguez-Goncer</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Folgueira, Maria Dolores" sort="Folgueira, Maria Dolores" uniqKey="Folgueira M" first="María Dolores" last="Folgueira">María Dolores Folgueira</name><affiliation><nlm:affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lalueza, Antonio" sort="Lalueza, Antonio" uniqKey="Lalueza A" first="Antonio" last="Lalueza">Antonio Lalueza</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Batllori, Emma" sort="Batllori, Emma" uniqKey="Batllori E" first="Emma" last="Batllori">Emma Batllori</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mejia, Inma" sort="Mejia, Inma" uniqKey="Mejia I" first="Inma" last="Mejía">Inma Mejía</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Forcen, Laura" sort="Forcen, Laura" uniqKey="Forcen L" first="Laura" last="Forcén">Laura Forcén</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lumbreras, Carlos" sort="Lumbreras, Carlos" uniqKey="Lumbreras C" first="Carlos" last="Lumbreras">Carlos Lumbreras</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Burguillo, Antonio" sort="Garcia Burguillo, Antonio" uniqKey="Garcia Burguillo A" first="Antonio" last="García-Burguillo">Antonio García-Burguillo</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Galindo, Alberto" sort="Galindo, Alberto" uniqKey="Galindo A" first="Alberto" last="Galindo">Alberto Galindo</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aguado, Jose Maria" sort="Aguado, Jose Maria" uniqKey="Aguado J" first="José María" last="Aguado">José María Aguado</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32632417</idno><idno type="pmid">32632417</idno><idno type="doi">10.1016/j.eclinm.2020.100407</idno><idno type="pmc">PMC7295514</idno><idno type="wicri:Area/Main/Corpus">001215</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001215</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.</title><author><name sortKey="San Juan, Rafael" sort="San Juan, Rafael" uniqKey="San Juan R" first="Rafael" last="San-Juan">Rafael San-Juan</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Barbero, Patricia" sort="Barbero, Patricia" uniqKey="Barbero P" first="Patricia" last="Barbero">Patricia Barbero</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ruiz, Mario" sort="Fernandez Ruiz, Mario" uniqKey="Fernandez Ruiz M" first="Mario" last="Fernández-Ruiz">Mario Fernández-Ruiz</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Medrano, Francisco" sort="L Pez Medrano, Francisco" uniqKey="L Pez Medrano F" first="Francisco" last="L Pez-Medrano">Francisco L Pez-Medrano</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lizasoain, Manuel" sort="Lizasoain, Manuel" uniqKey="Lizasoain M" first="Manuel" last="Lizasoáin">Manuel Lizasoáin</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Hernandez Jimenez, Pilar" sort="Hernandez Jimenez, Pilar" uniqKey="Hernandez Jimenez P" first="Pilar" last="Hernández-Jiménez">Pilar Hernández-Jiménez</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Silva, Jose Tiago" sort="Silva, Jose Tiago" uniqKey="Silva J" first="José Tiago" last="Silva">José Tiago Silva</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz Ruig Mez, Maria" sort="Ruiz Ruig Mez, Maria" uniqKey="Ruiz Ruig Mez M" first="María" last="Ruiz-Ruig Mez">María Ruiz-Ruig Mez</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Corbella, Laura" sort="Corbella, Laura" uniqKey="Corbella L" first="Laura" last="Corbella">Laura Corbella</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Goncer, Isabel" sort="Rodriguez Goncer, Isabel" uniqKey="Rodriguez Goncer I" first="Isabel" last="Rodríguez-Goncer">Isabel Rodríguez-Goncer</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Folgueira, Maria Dolores" sort="Folgueira, Maria Dolores" uniqKey="Folgueira M" first="María Dolores" last="Folgueira">María Dolores Folgueira</name><affiliation><nlm:affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lalueza, Antonio" sort="Lalueza, Antonio" uniqKey="Lalueza A" first="Antonio" last="Lalueza">Antonio Lalueza</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Batllori, Emma" sort="Batllori, Emma" uniqKey="Batllori E" first="Emma" last="Batllori">Emma Batllori</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mejia, Inma" sort="Mejia, Inma" uniqKey="Mejia I" first="Inma" last="Mejía">Inma Mejía</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Forcen, Laura" sort="Forcen, Laura" uniqKey="Forcen L" first="Laura" last="Forcén">Laura Forcén</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lumbreras, Carlos" sort="Lumbreras, Carlos" uniqKey="Lumbreras C" first="Carlos" last="Lumbreras">Carlos Lumbreras</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Burguillo, Antonio" sort="Garcia Burguillo, Antonio" uniqKey="Garcia Burguillo A" first="Antonio" last="García-Burguillo">Antonio García-Burguillo</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Galindo, Alberto" sort="Galindo, Alberto" uniqKey="Galindo A" first="Alberto" last="Galindo">Alberto Galindo</name><affiliation><nlm:affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aguado, Jose Maria" sort="Aguado, Jose Maria" uniqKey="Aguado J" first="José María" last="Aguado">José María Aguado</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">EClinicalMedicine</title><idno type="eISSN">2589-5370</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.</p></div><div type="abstract" xml:lang="en"><p><b>Findings</b></p><p>COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%; </p></div><div type="abstract" xml:lang="en"><p><b>Interpretation</b></p><p>Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.</p></div><div type="abstract" xml:lang="en"><p><b>Funding</b></p><p>Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32632417</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2589-5370</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><PubDate><Year>2020</Year><Month>Jun</Month></PubDate></JournalIssue><Title>EClinicalMedicine</Title><ISOAbbreviation>EClinicalMedicine</ISOAbbreviation></Journal><ArticleTitle>Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.</ArticleTitle><Pagination><MedlinePgn>100407</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.eclinm.2020.100407</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.</AbstractText><AbstractText Label="Findings" NlmCategory="UNASSIGNED">COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%; <i>P</i>-value = 0·003) and serum C-reactive protein (CRP) levels >10 mg/dL (33·0% vs. 0·0%; <i>P</i>-value = 0·05) at admission than those with no oxygen requirements.</AbstractText><AbstractText Label="Interpretation" NlmCategory="UNASSIGNED">Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.</AbstractText><AbstractText Label="Funding" NlmCategory="UNASSIGNED">Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.</AbstractText><CopyrightInformation>© 2020 The Author(s).</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>San-Juan</LastName><ForeName>Rafael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbero</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Ruiz</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Medrano</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lizasoáin</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández-Jiménez</LastName><ForeName>Pilar</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silva</LastName><ForeName>José Tiago</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruiz-Ruigómez</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corbella</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Goncer</LastName><ForeName>Isabel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Folgueira</LastName><ForeName>María Dolores</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lalueza</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Batllori</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mejía</LastName><ForeName>Inma</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forcén</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lumbreras</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Burguillo</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galindo</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Perinatal Medicine, Obstetrics and Gynaecology Department, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aguado</LastName><ForeName>José María</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>EClinicalMedicine</MedlineTA><NlmUniqueID>101733727</NlmUniqueID><ISSNLinking>2589-5370</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ALT, alanine aminotransferase</Keyword><Keyword MajorTopicYN="N">ARDS, acute respiratory distress syndrome</Keyword><Keyword MajorTopicYN="N">AST, aspartate aminotransferase</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">COVID-19, coronavirus disease 2019</Keyword><Keyword MajorTopicYN="N">CRP, C-reactive protein</Keyword><Keyword MajorTopicYN="N">CT, computerized tomography</Keyword><Keyword 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