Unusual Early Recovery of a Critical COVID-19 Patient After Administration of Intravenous Vitamin C.
Identifieur interne : 001065 ( Main/Corpus ); précédent : 001064; suivant : 001066Unusual Early Recovery of a Critical COVID-19 Patient After Administration of Intravenous Vitamin C.
Auteurs : Hafiz Muhammad Waqas Khan ; Niraj Parikh ; Shady Maher Megala ; George Silviu PredeteanuSource :
- The American journal of case reports [ 1941-5923 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Ascorbic Acid (administration & dosage), Betacoronavirus (MeSH), COVID-19 (MeSH), Coronavirus Infections (therapy), Female (MeSH), Humans (MeSH), Infusions, Intravenous (MeSH), Pandemics (MeSH), Pneumonia, Viral (therapy), Recovery of Function (MeSH), Respiration, Artificial (methods), SARS-CoV-2 (MeSH), Vitamins (administration & dosage).
- MESH :
- chemical , administration & dosage : Ascorbic Acid, Vitamins.
- methods : Respiration, Artificial.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Aged, Betacoronavirus, COVID-19, Female, Humans, Infusions, Intravenous, Pandemics, Recovery of Function, SARS-CoV-2.
Abstract
BACKGROUND Coronavirus disease 2019 (COVID-19) continues to spread, with confirmed cases now in more than 200 countries. Thus far there are no proven therapeutic options to treat COVID-19. We report a case of COVID-19 with acute respiratory distress syndrome who was treated with high-dose vitamin C infusion and was the first case to have early recovery from the disease at our institute. CASE REPORT A 74-year-old woman with no recent sick contacts or travel history presented with fever, cough, and shortness of breath. Her vital signs were normal except for oxygen saturation of 87% and bilateral rhonchi on lung auscultation. Chest radiography revealed air space opacity in the right upper lobe, suspicious for pneumonia. A nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 came back positive while the patient was in the airborne-isolation unit. Laboratory data showed lymphopenia and elevated lactate dehydrogenase, ferritin, and interleukin-6. The patient was initially started on oral hydroxychloroquine and azithromycin. On day 6, she developed ARDS and septic shock, for which mechanical ventilation and pressor support were started, along with infusion of high-dose intravenous vitamin C. The patient improved clinically and was able to be taken off mechanical ventilation within 5 days. CONCLUSIONS This report highlights the potential benefits of high-dose intravenous vitamin C in critically ill COVID-19 patients in terms of rapid recovery and shortened length of mechanical ventilation and ICU stay. Further studies will elaborate on the efficacy of intravenous vitamin C in critically ill COVID-19.
DOI: 10.12659/AJCR.925521
PubMed: 32709838
PubMed Central: PMC7405920
Links to Exploration step
pubmed:32709838Le document en format XML
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<author><name sortKey="Waqas Khan, Hafiz Muhammad" sort="Waqas Khan, Hafiz Muhammad" uniqKey="Waqas Khan H" first="Hafiz Muhammad" last="Waqas Khan">Hafiz Muhammad Waqas Khan</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Disease, McLaren-Flint/Michigan State University, Flint, MI, USA.</nlm:affiliation>
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<author><name sortKey="Parikh, Niraj" sort="Parikh, Niraj" uniqKey="Parikh N" first="Niraj" last="Parikh">Niraj Parikh</name>
<affiliation><nlm:affiliation>Department of Pulmonary and Critical Care, McLaren-Flint/Michigan State University, Flint, MI, USA.</nlm:affiliation>
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<term>Coronavirus Infections (therapy)</term>
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<term>Infusions, Intravenous (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (therapy)</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND Coronavirus disease 2019 (COVID-19) continues to spread, with confirmed cases now in more than 200 countries. Thus far there are no proven therapeutic options to treat COVID-19. We report a case of COVID-19 with acute respiratory distress syndrome who was treated with high-dose vitamin C infusion and was the first case to have early recovery from the disease at our institute. CASE REPORT A 74-year-old woman with no recent sick contacts or travel history presented with fever, cough, and shortness of breath. Her vital signs were normal except for oxygen saturation of 87% and bilateral rhonchi on lung auscultation. Chest radiography revealed air space opacity in the right upper lobe, suspicious for pneumonia. A nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 came back positive while the patient was in the airborne-isolation unit. Laboratory data showed lymphopenia and elevated lactate dehydrogenase, ferritin, and interleukin-6. The patient was initially started on oral hydroxychloroquine and azithromycin. On day 6, she developed ARDS and septic shock, for which mechanical ventilation and pressor support were started, along with infusion of high-dose intravenous vitamin C. The patient improved clinically and was able to be taken off mechanical ventilation within 5 days. CONCLUSIONS This report highlights the potential benefits of high-dose intravenous vitamin C in critically ill COVID-19 patients in terms of rapid recovery and shortened length of mechanical ventilation and ICU stay. Further studies will elaborate on the efficacy of intravenous vitamin C in critically ill COVID-19.</div>
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<Abstract><AbstractText>BACKGROUND Coronavirus disease 2019 (COVID-19) continues to spread, with confirmed cases now in more than 200 countries. Thus far there are no proven therapeutic options to treat COVID-19. We report a case of COVID-19 with acute respiratory distress syndrome who was treated with high-dose vitamin C infusion and was the first case to have early recovery from the disease at our institute. CASE REPORT A 74-year-old woman with no recent sick contacts or travel history presented with fever, cough, and shortness of breath. Her vital signs were normal except for oxygen saturation of 87% and bilateral rhonchi on lung auscultation. Chest radiography revealed air space opacity in the right upper lobe, suspicious for pneumonia. A nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 came back positive while the patient was in the airborne-isolation unit. Laboratory data showed lymphopenia and elevated lactate dehydrogenase, ferritin, and interleukin-6. The patient was initially started on oral hydroxychloroquine and azithromycin. On day 6, she developed ARDS and septic shock, for which mechanical ventilation and pressor support were started, along with infusion of high-dose intravenous vitamin C. The patient improved clinically and was able to be taken off mechanical ventilation within 5 days. CONCLUSIONS This report highlights the potential benefits of high-dose intravenous vitamin C in critically ill COVID-19 patients in terms of rapid recovery and shortened length of mechanical ventilation and ICU stay. Further studies will elaborate on the efficacy of intravenous vitamin C in critically ill COVID-19.</AbstractText>
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