A Perspective on Emerging Therapeutic Interventions for COVID-19.
Identifieur interne : 001029 ( Main/Corpus ); précédent : 001028; suivant : 001030A Perspective on Emerging Therapeutic Interventions for COVID-19.
Auteurs : Muhammad Torequl Islam ; Md Nasiruddin ; Ishaq N. Khan ; Siddhartha Kumar Mishra ; Md Kudrat-E-Zahan ; Thoufiqul Alam Riaz ; Eunus S. Ali ; M Safiur Rahman ; Mohammad S. Mubarak ; Miquel Martorell ; William C. Cho ; Daniela Calina ; Anca Oana Docea ; Javad Sharifi-RadSource :
- Frontiers in public health [ 2296-2565 ] ; 2020.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (therapeutic use), Alanine (analogs & derivatives), Alanine (therapeutic use), Antimalarials (therapeutic use), Antiviral Agents (therapeutic use), COVID-19 (physiopathology), COVID-19 (therapy), COVID-19 (transmission), Humans (MeSH), Hydroxychloroquine (therapeutic use), Public Health (MeSH), Vaccines (MeSH), Virus Replication (MeSH).
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Antimalarials, Antiviral Agents, Hydroxychloroquine.
- physiopathology : COVID-19.
- therapy : COVID-19.
- transmission : COVID-19.
- Humans, Public Health, Vaccines, Virus Replication.
Abstract
Coronaviruses are enveloped positive-sense RNA viruses with an unusual large RNA genome and a unique replication mechanism, which are characterized by club-like spikes that protrude from their surface. An outbreak of a novel coronavirus 2019 infection has posed significant threat to the health and economies in the whole world. This article reviewed the viral replication, pathogenicity, prevention and treatment strategies. With a lack of approved treatment options for this virus, alternative approaches to control the spread of disease is in urgent need. This article also covers some management strategies which may be applied to this virus outbreak. Ongoing clinical studies related to possible treatments for COVID-19, potential vaccines, and alternative medication such as natural compounds are also discussed.
DOI: 10.3389/fpubh.2020.00281
PubMed: 32733837
PubMed Central: PMC7362761
Links to Exploration step
pubmed:32733837Le document en format XML
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<front><div type="abstract" xml:lang="en">Coronaviruses are enveloped positive-sense RNA viruses with an unusual large RNA genome and a unique replication mechanism, which are characterized by club-like spikes that protrude from their surface. An outbreak of a novel coronavirus 2019 infection has posed significant threat to the health and economies in the whole world. This article reviewed the viral replication, pathogenicity, prevention and treatment strategies. With a lack of approved treatment options for this virus, alternative approaches to control the spread of disease is in urgent need. This article also covers some management strategies which may be applied to this virus outbreak. Ongoing clinical studies related to possible treatments for COVID-19, potential vaccines, and alternative medication such as natural compounds are also discussed.</div>
</front>
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<Abstract><AbstractText>Coronaviruses are enveloped positive-sense RNA viruses with an unusual large RNA genome and a unique replication mechanism, which are characterized by club-like spikes that protrude from their surface. An outbreak of a novel coronavirus 2019 infection has posed significant threat to the health and economies in the whole world. This article reviewed the viral replication, pathogenicity, prevention and treatment strategies. With a lack of approved treatment options for this virus, alternative approaches to control the spread of disease is in urgent need. This article also covers some management strategies which may be applied to this virus outbreak. Ongoing clinical studies related to possible treatments for COVID-19, potential vaccines, and alternative medication such as natural compounds are also discussed.</AbstractText>
<CopyrightInformation>Copyright © 2020 Torequl Islam, Nasiruddin, Khan, Mishra, Kudrat-E-Zahan, Alam Riaz, Ali, Rahman, Mubarak, Martorell, Cho, Calina, Docea and Sharifi-Rad.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Torequl Islam</LastName>
<ForeName>Muhammad</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Nasiruddin</LastName>
<ForeName>Md</ForeName>
<Initials>M</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Khan</LastName>
<ForeName>Ishaq N</ForeName>
<Initials>IN</Initials>
<AffiliationInfo><Affiliation>Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mishra</LastName>
<ForeName>Siddhartha Kumar</ForeName>
<Initials>SK</Initials>
<AffiliationInfo><Affiliation>Cancer Biology Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar, India.</Affiliation>
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<Author ValidYN="Y"><LastName>Kudrat-E-Zahan</LastName>
<ForeName>Md</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Rajshahi University, Rajshahi, Bangladesh.</Affiliation>
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<Author ValidYN="Y"><LastName>Alam Riaz</LastName>
<ForeName>Thoufiqul</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, School of Medicine, Institute of New Drug Development, Jeonbuk National University, Jeonju, South Korea.</Affiliation>
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</AffiliationInfo>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Martorell</LastName>
<ForeName>Miquel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Healthy Living, University of Concepción, Concepción, Chile.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cho</LastName>
<ForeName>William C</ForeName>
<Initials>WC</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Calina</LastName>
<ForeName>Daniela</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.</Affiliation>
</AffiliationInfo>
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<ForeName>Anca Oana</ForeName>
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<AffiliationInfo><Affiliation>Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.</Affiliation>
</AffiliationInfo>
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<ForeName>Javad</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</Affiliation>
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