Systemic immunosuppression in times of COVID-19: Do we need to rethink our standards?
Identifieur interne : 000F98 ( Main/Corpus ); précédent : 000F97; suivant : 000F99Systemic immunosuppression in times of COVID-19: Do we need to rethink our standards?
Auteurs : Stephan Grabbe ; Stefan Beissert ; Alexander EnkSource :
- Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [ 1610-0387 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antiviral Agents, Chloroquine, Doxycycline, Hydroxychloroquine.
- adverse effects : Immunosuppression.
- drug therapy : COVID-19.
- immunology : COVID-19.
- Humans.
Abstract
The current SARS-CoV-2 pandemic particularly endangers older people with pre-existing cardiopulmonary and metabolic conditions. However, it is also currently under discussion whether patients under immunosuppressive therapy also have a higher risk of suffering a severe course of the COVID-19 disease. In principle though, there is currently no data available for a general reduction or pause of immunosuppression in patients with autoimmune diseases because of the SARS-CoV-2 pandemic. However, since there is currently neither an effective therapy nor corresponding vaccination protection, the indication for a prolonged immunosuppressive therapy should be made with special care. In particular, immunotherapeutic agents that produce long-term effects (e.g., rituximab) should be used with special caution. In contrast, immunomodulating substances that do not suppress antiviral immunity (e.g. systemic immunoglobulins, doxycycline), or that have intrinsic effects on SARS-CoV-2 (calcineurin inhibitors, chloroquine, hydroxychloroquine) may be useful alternatives.
DOI: 10.1111/ddg.14194
PubMed: 32743938
PubMed Central: PMC7436367
Links to Exploration step
pubmed:32743938Le document en format XML
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<author><name sortKey="Grabbe, Stephan" sort="Grabbe, Stephan" uniqKey="Grabbe S" first="Stephan" last="Grabbe">Stephan Grabbe</name>
<affiliation><nlm:affiliation>Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.</nlm:affiliation>
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<author><name sortKey="Beissert, Stefan" sort="Beissert, Stefan" uniqKey="Beissert S" first="Stefan" last="Beissert">Stefan Beissert</name>
<affiliation><nlm:affiliation>Department of Dermatology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.</nlm:affiliation>
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<term>COVID-19 (drug therapy)</term>
<term>COVID-19 (immunology)</term>
<term>Chloroquine (pharmacology)</term>
<term>Doxycycline (pharmacology)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (pharmacology)</term>
<term>Immunosuppression (adverse effects)</term>
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<front><div type="abstract" xml:lang="en">The current SARS-CoV-2 pandemic particularly endangers older people with pre-existing cardiopulmonary and metabolic conditions. However, it is also currently under discussion whether patients under immunosuppressive therapy also have a higher risk of suffering a severe course of the COVID-19 disease. In principle though, there is currently no data available for a general reduction or pause of immunosuppression in patients with autoimmune diseases because of the SARS-CoV-2 pandemic. However, since there is currently neither an effective therapy nor corresponding vaccination protection, the indication for a prolonged immunosuppressive therapy should be made with special care. In particular, immunotherapeutic agents that produce long-term effects (e.g., rituximab) should be used with special caution. In contrast, immunomodulating substances that do not suppress antiviral immunity (e.g. systemic immunoglobulins, doxycycline), or that have intrinsic effects on SARS-CoV-2 (calcineurin inhibitors, chloroquine, hydroxychloroquine) may be useful alternatives.</div>
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<Abstract><AbstractText>The current SARS-CoV-2 pandemic particularly endangers older people with pre-existing cardiopulmonary and metabolic conditions. However, it is also currently under discussion whether patients under immunosuppressive therapy also have a higher risk of suffering a severe course of the COVID-19 disease. In principle though, there is currently no data available for a general reduction or pause of immunosuppression in patients with autoimmune diseases because of the SARS-CoV-2 pandemic. However, since there is currently neither an effective therapy nor corresponding vaccination protection, the indication for a prolonged immunosuppressive therapy should be made with special care. In particular, immunotherapeutic agents that produce long-term effects (e.g., rituximab) should be used with special caution. In contrast, immunomodulating substances that do not suppress antiviral immunity (e.g. systemic immunoglobulins, doxycycline), or that have intrinsic effects on SARS-CoV-2 (calcineurin inhibitors, chloroquine, hydroxychloroquine) may be useful alternatives.</AbstractText>
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