Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2.
Identifieur interne : 000F88 ( Main/Corpus ); précédent : 000F87; suivant : 000F89Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2.
Auteurs : Arif Jamal Siddiqui ; Sadaf Jahan ; Syed Amir Ashraf ; Mousa Alreshidi ; Mohammad Saquib Ashraf ; Mitesh Patel ; Mejdi Snoussi ; Ritu Singh ; Mohd AdnanSource :
- Journal of biomolecular structure & dynamics [ 1538-0254 ] ; 2020.
Abstract
The spread of new coronavirus infection starting December 2019 as novel SARS-CoV-2, identified as the causing agent of COVID-19, has affected all over the world and been declared as pandemic. Approximately, more than 8,807,398 confirmed cases of COVID-19 infection and 464,483 deaths have been reported globally till the end of 21 June 2020. Until now, there is no specific drug therapy or vaccine available for the treatment of COVID-19. However, some potential antimalarial drugs like hydroxychloroquine and azithromycin, antifilarial drug ivermectin and antiviral drugs have been tested by many research groups worldwide for their possible effect against the COVID-19. Hydroxychloroquine and ivermectin have been identified to act by creating the acidic condition in cells and inhibiting the importin (IMPα/β1) mediated viral import. There is a possibility that some other antimalarial drugs/antibiotics in combination with immunomodulators may help in combatting this pandemic disease. Therefore, this review focuses on the current use of various drugs as single agents (hydroxychloroquine, ivermectin, azithromycin, favipiravir, remdesivir, umifenovir, teicoplanin, nitazoxanide, doxycycline, and dexamethasone) or in combinations with immunomodulators additionally. Furthermore, possible mode of action, efficacy and current stage of clinical trials of various drug combinations against COVID-19 disease has also been discussed in detail. Communicated by Ramaswamy H. Sarma.
DOI: 10.1080/07391102.2020.1802345
PubMed: 32752944
PubMed Central: PMC7484586
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Siddiqui</name><affiliation><nlm:affiliation>Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Jahan, Sadaf" sort="Jahan, Sadaf" uniqKey="Jahan S" first="Sadaf" last="Jahan">Sadaf Jahan</name><affiliation><nlm:affiliation>Department of Medical Laboratory, College of Applied Medical Sciences, Majmaah University, Al Majma'ah, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ashraf, Syed Amir" sort="Ashraf, Syed Amir" uniqKey="Ashraf S" first="Syed Amir" last="Ashraf">Syed Amir Ashraf</name><affiliation><nlm:affiliation>Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Alreshidi, Mousa" sort="Alreshidi, Mousa" uniqKey="Alreshidi M" first="Mousa" last="Alreshidi">Mousa Alreshidi</name><affiliation><nlm:affiliation>Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ashraf, Mohammad Saquib" sort="Ashraf, Mohammad Saquib" uniqKey="Ashraf M" first="Mohammad Saquib" last="Ashraf">Mohammad Saquib Ashraf</name><affiliation><nlm:affiliation>Department of Clinical Laboratory Sciences, College of Applied Medical Science, Shaqra University, Al Dawadimi, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Mitesh" sort="Patel, Mitesh" uniqKey="Patel M" first="Mitesh" last="Patel">Mitesh Patel</name><affiliation><nlm:affiliation>Bapalal Vaidya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, Surat, Gujarat, India.</nlm:affiliation></affiliation></author><author><name sortKey="Snoussi, Mejdi" sort="Snoussi, Mejdi" uniqKey="Snoussi M" first="Mejdi" last="Snoussi">Mejdi Snoussi</name><affiliation><nlm:affiliation>Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Laboratory of Genetics, Biodiversity and Valorization of Bio-resources, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Singh, Ritu" sort="Singh, Ritu" uniqKey="Singh R" first="Ritu" last="Singh">Ritu Singh</name><affiliation><nlm:affiliation>Department of Environmental Sciences, School of Earth Sciences, Central University of Rajasthan, Ajmer, India.</nlm:affiliation></affiliation></author><author><name sortKey="Adnan, Mohd" sort="Adnan, Mohd" uniqKey="Adnan M" first="Mohd" last="Adnan">Mohd Adnan</name><affiliation><nlm:affiliation>Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of biomolecular structure & dynamics</title><idno type="eISSN">1538-0254</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The spread of new coronavirus infection starting December 2019 as novel SARS-CoV-2, identified as the causing agent of COVID-19, has affected all over the world and been declared as pandemic. Approximately, more than 8,807,398 confirmed cases of COVID-19 infection and 464,483 deaths have been reported globally till the end of 21 June 2020. Until now, there is no specific drug therapy or vaccine available for the treatment of COVID-19. However, some potential antimalarial drugs like hydroxychloroquine and azithromycin, antifilarial drug ivermectin and antiviral drugs have been tested by many research groups worldwide for their possible effect against the COVID-19. Hydroxychloroquine and ivermectin have been identified to act by creating the acidic condition in cells and inhibiting the importin (IMPα/β1) mediated viral import. There is a possibility that some other antimalarial drugs/antibiotics in combination with immunomodulators may help in combatting this pandemic disease. Therefore, this review focuses on the current use of various drugs as single agents (hydroxychloroquine, ivermectin, azithromycin, favipiravir, remdesivir, umifenovir, teicoplanin, nitazoxanide, doxycycline, and dexamethasone) or in combinations with immunomodulators additionally. Furthermore, possible mode of action, efficacy and current stage of clinical trials of various drug combinations against COVID-19 disease has also been discussed in detail. Communicated by Ramaswamy H. Sarma.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32752944</PMID><DateRevised><Year>2021</Year><Month>05</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-0254</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>05</Day></PubDate></JournalIssue><Title>Journal of biomolecular structure & dynamics</Title><ISOAbbreviation>J Biomol Struct Dyn</ISOAbbreviation></Journal><ArticleTitle>Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2.</ArticleTitle><Pagination><MedlinePgn>1-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/07391102.2020.1802345</ELocationID><Abstract><AbstractText>The spread of new coronavirus infection starting December 2019 as novel SARS-CoV-2, identified as the causing agent of COVID-19, has affected all over the world and been declared as pandemic. Approximately, more than 8,807,398 confirmed cases of COVID-19 infection and 464,483 deaths have been reported globally till the end of 21 June 2020. Until now, there is no specific drug therapy or vaccine available for the treatment of COVID-19. However, some potential antimalarial drugs like hydroxychloroquine and azithromycin, antifilarial drug ivermectin and antiviral drugs have been tested by many research groups worldwide for their possible effect against the COVID-19. Hydroxychloroquine and ivermectin have been identified to act by creating the acidic condition in cells and inhibiting the importin (IMPα/β1) mediated viral import. There is a possibility that some other antimalarial drugs/antibiotics in combination with immunomodulators may help in combatting this pandemic disease. Therefore, this review focuses on the current use of various drugs as single agents (hydroxychloroquine, ivermectin, azithromycin, favipiravir, remdesivir, umifenovir, teicoplanin, nitazoxanide, doxycycline, and dexamethasone) or in combinations with immunomodulators additionally. Furthermore, possible mode of action, efficacy and current stage of clinical trials of various drug combinations against COVID-19 disease has also been discussed in detail. Communicated by Ramaswamy H. Sarma.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Siddiqui</LastName><ForeName>Arif Jamal</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6236-0920</Identifier><AffiliationInfo><Affiliation>Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahan</LastName><ForeName>Sadaf</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Laboratory, College of Applied Medical Sciences, Majmaah University, Al Majma'ah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ashraf</LastName><ForeName>Syed Amir</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alreshidi</LastName><ForeName>Mousa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ashraf</LastName><ForeName>Mohammad Saquib</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory Sciences, College of Applied Medical Science, Shaqra University, Al Dawadimi, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Mitesh</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9283-2124</Identifier><AffiliationInfo><Affiliation>Bapalal Vaidya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, Surat, Gujarat, India.</Affiliation></AffiliationInfo></Author><Author 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