Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.
Identifieur interne : 000F73 ( Main/Corpus ); précédent : 000F72; suivant : 000F74Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.
Auteurs : Kyung Soo Hong ; Jong Geol Jang ; Jian Hur ; Jong Ho Lee ; Hong Nam Kim ; Wonhwa Lee ; June Hong AhnSource :
- Infection & chemotherapy [ 2093-2340 ] ; 2020.
Abstract
There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, P = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.
DOI: 10.3947/ic.2020.52.3.396
PubMed: 32757497
PubMed Central: PMC7533217
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pubmed:32757497Le document en format XML
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<author><name sortKey="Kim, Hong Nam" sort="Kim, Hong Nam" uniqKey="Kim H" first="Hong Nam" last="Kim">Hong Nam Kim</name>
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<author><name sortKey="Lee, Wonhwa" sort="Lee, Wonhwa" uniqKey="Lee W" first="Wonhwa" last="Lee">Wonhwa Lee</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.</title>
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<front><div type="abstract" xml:lang="en">There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, <i>P</i>
= 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.</div>
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<Abstract><AbstractText>There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, <i>P</i>
= 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.</AbstractText>
<CopyrightInformation>Copyright © 2020 by The Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, and The Korean Society for AIDS.</CopyrightInformation>
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