Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.
Identifieur interne : 000F73 ( Main/Corpus ); précédent : 000F72; suivant : 000F74Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.
Auteurs : Kyung Soo Hong ; Jong Geol Jang ; Jian Hur ; Jong Ho Lee ; Hong Nam Kim ; Wonhwa Lee ; June Hong AhnSource :
- Infection & chemotherapy [ 2093-2340 ] ; 2020.
Abstract
There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, P = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.
DOI: 10.3947/ic.2020.52.3.396
PubMed: 32757497
PubMed Central: PMC7533217
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.</title><author><name sortKey="Hong, Kyung Soo" sort="Hong, Kyung Soo" uniqKey="Hong K" first="Kyung Soo" last="Hong">Kyung Soo Hong</name><affiliation><nlm:affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jang, Jong Geol" sort="Jang, Jong Geol" uniqKey="Jang J" first="Jong Geol" last="Jang">Jong Geol Jang</name><affiliation><nlm:affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Hur, Jian" sort="Hur, Jian" uniqKey="Hur J" first="Jian" last="Hur">Jian Hur</name><affiliation><nlm:affiliation>Division of Infection, Department of Internal Medicine, College of Medicine, Yeungnam University, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jong Ho" sort="Lee, Jong Ho" uniqKey="Lee J" first="Jong Ho" last="Lee">Jong Ho Lee</name><affiliation><nlm:affiliation>Department of Laboratory Medicine, College of Medicine, Yeungnam University, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hong Nam" sort="Kim, Hong Nam" uniqKey="Kim H" first="Hong Nam" last="Kim">Hong Nam Kim</name><affiliation><nlm:affiliation>Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea. hongnam.kim@kist.re.kr.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Wonhwa" sort="Lee, Wonhwa" uniqKey="Lee W" first="Wonhwa" last="Lee">Wonhwa Lee</name><affiliation><nlm:affiliation>Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. bywonhwalee@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, June Hong" sort="Ahn, June Hong" uniqKey="Ahn J" first="June Hong" last="Ahn">June Hong Ahn</name><affiliation><nlm:affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea. fireajh@gmail.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32757497</idno><idno type="pmid">32757497</idno><idno type="doi">10.3947/ic.2020.52.3.396</idno><idno type="pmc">PMC7533217</idno><idno type="wicri:Area/Main/Corpus">000F73</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000F73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.</title><author><name sortKey="Hong, Kyung Soo" sort="Hong, Kyung Soo" uniqKey="Hong K" first="Kyung Soo" last="Hong">Kyung Soo Hong</name><affiliation><nlm:affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jang, Jong Geol" sort="Jang, Jong Geol" uniqKey="Jang J" first="Jong Geol" last="Jang">Jong Geol Jang</name><affiliation><nlm:affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Hur, Jian" sort="Hur, Jian" uniqKey="Hur J" first="Jian" last="Hur">Jian Hur</name><affiliation><nlm:affiliation>Division of Infection, Department of Internal Medicine, College of Medicine, Yeungnam University, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jong Ho" sort="Lee, Jong Ho" uniqKey="Lee J" first="Jong Ho" last="Lee">Jong Ho Lee</name><affiliation><nlm:affiliation>Department of Laboratory Medicine, College of Medicine, Yeungnam University, Yeungnam University Medical Center, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hong Nam" sort="Kim, Hong Nam" uniqKey="Kim H" first="Hong Nam" last="Kim">Hong Nam Kim</name><affiliation><nlm:affiliation>Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea. hongnam.kim@kist.re.kr.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Wonhwa" sort="Lee, Wonhwa" uniqKey="Lee W" first="Wonhwa" last="Lee">Wonhwa Lee</name><affiliation><nlm:affiliation>Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. bywonhwalee@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, June Hong" sort="Ahn, June Hong" uniqKey="Ahn J" first="June Hong" last="Ahn">June Hong Ahn</name><affiliation><nlm:affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea. fireajh@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Infection & chemotherapy</title><idno type="ISSN">2093-2340</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, <i>P</i> = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32757497</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2093-2340</ISSN><JournalIssue CitedMedium="Print"><Volume>52</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Infection & chemotherapy</Title><ISOAbbreviation>Infect Chemother</ISOAbbreviation></Journal><ArticleTitle>Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication.</ArticleTitle><Pagination><MedlinePgn>396-402</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3947/ic.2020.52.3.396</ELocationID><Abstract><AbstractText>There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study, administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, <i>P</i> = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible.</AbstractText><CopyrightInformation>Copyright © 2020 by The Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, and The Korean Society for AIDS.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Kyung Soo</ForeName><Initials>KS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2931-6861</Identifier><AffiliationInfo><Affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jang</LastName><ForeName>Jong Geol</ForeName><Initials>JG</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8040-5363</Identifier><AffiliationInfo><Affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hur</LastName><ForeName>Jian</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-3219-8368</Identifier><AffiliationInfo><Affiliation>Division of Infection, Department of Internal Medicine, College of Medicine, Yeungnam University, Yeungnam University Medical Center, Daegu, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jong Ho</ForeName><Initials>JH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6837-838X</Identifier><AffiliationInfo><Affiliation>Department of Laboratory Medicine, College of Medicine, Yeungnam University, Yeungnam University Medical Center, Daegu, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Kim</LastName><ForeName>Hong Nam</ForeName><Initials>HN</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0329-0029</Identifier><AffiliationInfo><Affiliation>Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea. hongnam.kim@kist.re.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Lee</LastName><ForeName>Wonhwa</ForeName><Initials>W</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4336-5221</Identifier><AffiliationInfo><Affiliation>Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. bywonhwalee@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ahn</LastName><ForeName>June Hong</ForeName><Initials>JH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7104-8325</Identifier><AffiliationInfo><Affiliation>Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, Korea. fireajh@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>2018R1A2A3075013</GrantID><Acronym>NRF</Acronym><Agency>National Research Foundation of Korea</Agency><Country>Korea</Country></Grant><Grant><GrantID>NRF-2016M3C7A1913845</GrantID><Acronym>NRF</Acronym><Agency>National Research Foundation of Korea</Agency><Country>Korea</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>Infect Chemother</MedlineTA><NlmUniqueID>101531537</NlmUniqueID><ISSNLinking>1598-8112</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronavirus disease 2019</Keyword><Keyword MajorTopicYN="N">Early</Keyword><Keyword MajorTopicYN="N">Eradication</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword></KeywordList><CoiStatement>No conflicts of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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