CovidChloroV1, Main, Corpus, bibRecord, 000F22

Weather the Cytokine Storm: A Report of Successful Management of a Colon Cancer Survivor and a Critically Ill Patient with COVID-19.

Identifieur interne : 000F22 ( Main/Corpus ); précédent : 000F21; suivant : 000F23

Weather the Cytokine Storm: A Report of Successful Management of a Colon Cancer Survivor and a Critically Ill Patient with COVID-19.

Auteurs : Mansoor Khalid ; Tarek Dernaika ; Lirin Jacob ; Pavan Annamaraju ; Achuta K. Guddati

Source :

Case reports in oncology [ 1662-6575 ]

RBID : pubmed:32774271

Abstract

Patients with novel corona virus infection (COVID-19) can develop acute respiratory failure secondary to acute respiratory distress syndrome. Cytokine storm is suggested as one of underlying mechanisms for the rapid clinical decline. Immunocompromised patients and cancer patients are at particular risk for poor outcomes due to COVID-19 infection. This case report describes the presentation and clinical course of a cancer survivor who became critically ill and required mechanical ventilation. The patient was treated with hydroxychloroquine, azithromycin, and ceftriaxone; however, he remained febrile, hypoxemic, continued to require full mechanical ventilator support and his chest X-ray showed increased bilateral infiltrates. The patient was treated with tocilizumab, after which he improved and was successfully extubated. This report illustrates a possible role of tocilizumab in management of cytokine storm in critically ill patients with COVID-19 infection.

DOI: 10.1159/000509507
PubMed: 32774271
PubMed Central: PMC7360508

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pubmed:32774271

Le document en format XML

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<author><name sortKey="Khalid, Mansoor" sort="Khalid, Mansoor" uniqKey="Khalid M" first="Mansoor" last="Khalid">Mansoor Khalid</name>
<affiliation><nlm:affiliation>Mercy Hospital, Oklahoma City, Oklahoma, USA.</nlm:affiliation>
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</author>
<author><name sortKey="Dernaika, Tarek" sort="Dernaika, Tarek" uniqKey="Dernaika T" first="Tarek" last="Dernaika">Tarek Dernaika</name>
<affiliation><nlm:affiliation>Mercy Hospital, Oklahoma City, Oklahoma, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jacob, Lirin" sort="Jacob, Lirin" uniqKey="Jacob L" first="Lirin" last="Jacob">Lirin Jacob</name>
<affiliation><nlm:affiliation>Mercy Hospital, Oklahoma City, Oklahoma, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Annamaraju, Pavan" sort="Annamaraju, Pavan" uniqKey="Annamaraju P" first="Pavan" last="Annamaraju">Pavan Annamaraju</name>
<affiliation><nlm:affiliation>Johnston Memorial Hospital, Ballad Health System, Abingdon, Virginia, USA.</nlm:affiliation>
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<author><name sortKey="Guddati, Achuta K" sort="Guddati, Achuta K" uniqKey="Guddati A" first="Achuta K" last="Guddati">Achuta K. Guddati</name>
<affiliation><nlm:affiliation>Division of Hematology/Oncology, Augusta University, Augusta, Georgia, USA.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Weather the Cytokine Storm: A Report of Successful Management of a Colon Cancer Survivor and a Critically Ill Patient with COVID-19.</title>
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<front><div type="abstract" xml:lang="en">Patients with novel corona virus infection (COVID-19) can develop acute respiratory failure secondary to acute respiratory distress syndrome. Cytokine storm is suggested as one of underlying mechanisms for the rapid clinical decline. Immunocompromised patients and cancer patients are at particular risk for poor outcomes due to COVID-19 infection. This case report describes the presentation and clinical course of a cancer survivor who became critically ill and required mechanical ventilation. The patient was treated with hydroxychloroquine, azithromycin, and ceftriaxone; however, he remained febrile, hypoxemic, continued to require full mechanical ventilator support and his chest X-ray showed increased bilateral infiltrates. The patient was treated with tocilizumab, after which he improved and was successfully extubated. This report illustrates a possible role of tocilizumab in management of cytokine storm in critically ill patients with COVID-19 infection.</div>
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<Day>28</Day>
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<Title>Case reports in oncology</Title>
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<ArticleTitle>Weather the Cytokine Storm: A Report of Successful Management of a Colon Cancer Survivor and a Critically Ill Patient with COVID-19.</ArticleTitle>
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<Abstract><AbstractText>Patients with novel corona virus infection (COVID-19) can develop acute respiratory failure secondary to acute respiratory distress syndrome. Cytokine storm is suggested as one of underlying mechanisms for the rapid clinical decline. Immunocompromised patients and cancer patients are at particular risk for poor outcomes due to COVID-19 infection. This case report describes the presentation and clinical course of a cancer survivor who became critically ill and required mechanical ventilation. The patient was treated with hydroxychloroquine, azithromycin, and ceftriaxone; however, he remained febrile, hypoxemic, continued to require full mechanical ventilator support and his chest X-ray showed increased bilateral infiltrates. The patient was treated with tocilizumab, after which he improved and was successfully extubated. This report illustrates a possible role of tocilizumab in management of cytokine storm in critically ill patients with COVID-19 infection.</AbstractText>
<CopyrightInformation>Copyright © 2020 by S. Karger AG, Basel.</CopyrightInformation>
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<CoiStatement>No conflicts of interest exist for all the authors.</CoiStatement>
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Weather the Cytokine Storm: A Report of Successful Management of a Colon Cancer Survivor and a Critically Ill Patient with COVID-19.

Weather the Cytokine Storm: A Report of Successful Management of a Colon Cancer Survivor and a Critically Ill Patient with COVID-19.

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