CovidChloroV1, Main, Corpus, bibRecord, 000E94

Hydroxychloroquine and Coronavirus Disease 2019: A Systematic Review of a Scientific Failure.

Identifieur interne : 000E94 ( Main/Corpus ); précédent : 000E93; suivant : 000E95

Hydroxychloroquine and Coronavirus Disease 2019: A Systematic Review of a Scientific Failure.

Auteurs : Stav Rakedzon ; Yara Khoury ; Gilad Rozenberg ; Ami Neuberger

Source :

Rambam Maimonides medical journal [ 2076-9172 ] ; 2020.

RBID : pubmed:32792041

Abstract

INTRODUCTION

Hydroxychloroquine (HCQ) emerged early in the course of the coronavirus disease 2019 (COVID-19) pandemic as a possible drug with potential therapeutic and prophylactic benefits. It was quickly adopted in China, Europe, and the USA. We systematically reviewed the existing clinical evidence of HCQ use for the prevention and treatment of COVID-19.

METHODS

We screened for clinical studies describing HCQ administration to treat or prevent COVID-19 in PubMed. We included randomized controlled trials (RCTs), non-randomized comparative cohorts, and case series studies that had all undergone peer review.

RESULTS

A total of 623 studies were screened; 17 studies evaluating HCQ treatment were included. A total of 13 were observational studies, and 4 were RCTs. In terms of effect on mortality rates, observational studies provided conflicting results. As a whole, RCTs, including one large British RCT that has not yet been published, showed no significant effect of HCQ on mortality rates, clinical cure, and virologic response. The use of HCQ as a post-exposure prophylactic agent was found to be ineffective in one RCT.

CONCLUSION

There is no evidence supporting HCQ for prophylaxis or treatment of COVID-19. Many observational trials were methodologically flawed. Scientific efforts have been disappointingly fragmented, and well-conducted trials have only recently been completed, more than 7 months and 600,000 deaths into the pandemic.

DOI: 10.5041/RMMJ.10416
PubMed: 32792041
PubMed Central: PMC7426548

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pubmed:32792041

Le document en format XML

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<author><name sortKey="Rakedzon, Stav" sort="Rakedzon, Stav" uniqKey="Rakedzon S" first="Stav" last="Rakedzon">Stav Rakedzon</name>
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<author><name sortKey="Khoury, Yara" sort="Khoury, Yara" uniqKey="Khoury Y" first="Yara" last="Khoury">Yara Khoury</name>
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<author><name sortKey="Rozenberg, Gilad" sort="Rozenberg, Gilad" uniqKey="Rozenberg G" first="Gilad" last="Rozenberg">Gilad Rozenberg</name>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
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<p>Hydroxychloroquine (HCQ) emerged early in the course of the coronavirus disease 2019 (COVID-19) pandemic as a possible drug with potential therapeutic and prophylactic benefits. It was quickly adopted in China, Europe, and the USA. We systematically reviewed the existing clinical evidence of HCQ use for the prevention and treatment of COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We screened for clinical studies describing HCQ administration to treat or prevent COVID-19 in PubMed. We included randomized controlled trials (RCTs), non-randomized comparative cohorts, and case series studies that had all undergone peer review.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>A total of 623 studies were screened; 17 studies evaluating HCQ treatment were included. A total of 13 were observational studies, and 4 were RCTs. In terms of effect on mortality rates, observational studies provided conflicting results. As a whole, RCTs, including one large British RCT that has not yet been published, showed no significant effect of HCQ on mortality rates, clinical cure, and virologic response. The use of HCQ as a post-exposure prophylactic agent was found to be ineffective in one RCT.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>There is no evidence supporting HCQ for prophylaxis or treatment of COVID-19. Many observational trials were methodologically flawed. Scientific efforts have been disappointingly fragmented, and well-conducted trials have only recently been completed, more than 7 months and 600,000 deaths into the pandemic.</p>
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<ReferenceList><Reference><Citation>Med (N Y). 2020 Jun 5;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32838355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 May 14;369:m1849</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32409561</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Heart Rhythm. 2020 Sep;17(9):1425-1433</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32407884</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32391667</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Discov. 2020 Mar 18;6:16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32194981</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect. 2020 Aug;81(2):266-275</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32473235</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Jun 23;323(24):2493-2502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32392282</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 May 22;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32450107</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Drug Investig. 2018 Aug;38(8):653-671</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29737455</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2411-2418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32379955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2003 Dec;84(Pt 12):3291-3303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14645910</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2020 Sep 1;5(9):1036-1041</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32936252</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2020 Jun;26(6):808-809</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32488217</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Korean J Intern Med. 2020 Jun 16;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32536150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 May;55(5):105938</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32171740</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Infect Dis. 2020 Aug;97:396-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32623082</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 May;55(5):105960</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32251731</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Intensive Care Med. 2020 Sep;46(9):1772-1773</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32514594</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Assoc Physicians India. 2020 Jun;68(6):13-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32610873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Travel Med Infect Dis. 2020 Mar - Apr;34:101663</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32289548</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Aug 6;383(6):517-525</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32492293</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Swiss Med Wkly. 2020 Apr 29;150:w20262</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32347963</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Travel Med Infect Dis. 2020 Jul - Aug;36:101791</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32593867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 May 14;369:m1844</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32409486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Travel Med Infect Dis. 2020 May - Jun;35:101738</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32387409</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Mal Infect. 2020 Jun;50(4):384</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32240719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):223-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15076236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Daru. 2020 Dec;28(2):507-516</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32562159</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Jun 13;395(10240):1820</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32511943</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jun 18;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32556143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Nov 19;383(21):2041-2052</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32706953</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci China Life Sci. 2020 Oct;63(10):1515-1521</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32418114</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

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Hydroxychloroquine and Coronavirus Disease 2019: A Systematic Review of a Scientific Failure.

Hydroxychloroquine and Coronavirus Disease 2019: A Systematic Review of a Scientific Failure.

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Abstract

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