COVID-19 in lung transplant recipients: A single center case series from New York City.
Identifieur interne : 000D03 ( Main/Corpus ); précédent : 000D02; suivant : 000D04COVID-19 in lung transplant recipients: A single center case series from New York City.
Auteurs : Meghan Aversa ; Luke Benvenuto ; Michaela Anderson ; Lori Shah ; Hilary Robbins ; Marcus Pereira ; Jenna Scheffert ; Maggie Carroll ; Jamie Hum ; Margaret Nolan ; Genevieve Reilly ; Philippe Lemaitre ; Bryan P. Stanifer ; Frank D'Ovidio ; Joshua Sonett ; Selim ArcasoySource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Antibodies, Monoclonal, Humanized (therapeutic use), Antiviral Agents (therapeutic use), COVID-19 (drug therapy), COVID-19 (epidemiology), Female (MeSH), Graft Rejection (epidemiology), Graft Rejection (prevention & control), Humans (MeSH), Immunosuppression (methods), Incidence (MeSH), Lung Transplantation (MeSH), Male (MeSH), Middle Aged (MeSH), New York City (epidemiology), Pandemics (MeSH), Retrospective Studies (MeSH), SARS-CoV-2 (MeSH), Survival Rate (trends), Transplant Recipients (MeSH).
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antiviral Agents.
- geographic , epidemiology : New York City.
- drug therapy : COVID-19.
- epidemiology : COVID-19, Graft Rejection.
- methods : Immunosuppression.
- prevention & control : Graft Rejection.
- trends : Survival Rate.
- Adult, Aged, Female, Humans, Incidence, Lung Transplantation, Male, Middle Aged, Pandemics, Retrospective Studies, SARS-CoV-2, Transplant Recipients.
Abstract
There are limited data describing COVID-19 in lung transplant recipients. We performed a single center, retrospective case series study of lung transplant patients followed by the Columbia Lung Transplant program who tested positive for SARS-CoV-2 between March 19 and May 19, 2020. Thirty-two lung transplant patients developed mild (16%), moderate (44%), or severe (41%) COVID-19. The median age of patients was 65 years, and the median time from lung transplant was 5.6 years. Symptoms included cough (66%), dyspnea (50%), fever (47%), and gastrointestinal upset (44%). Patients received hydroxychloroquine (84%), azithromycin (75%), augmented steroids (44%), tocilizumab (19%), and remdesivir (9%). Eleven patients (34%) died at a median time of 14 days from admission. Complications during admission included: acute kidney injury (63%), transaminitis (31%), shock (31%), acute respiratory distress syndrome (25%), neurological events (25%), arrhythmias (22%), and venous thromboembolism (9%). Compared to patients with moderate COVID-19, patients with severe COVID-19 had higher peak white blood cell counts (15.8 vs 7 × 103 /uL, P = .019), C-reactive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004) levels, and lower nadir lymphocyte counts (0.09 vs. 0.4 × 103 /uL, P = .006). COVID-19 is associated with severe illness and a high mortality rate in lung transplant recipients.
DOI: 10.1111/ajt.16241
PubMed: 32881315
PubMed Central: PMC7436464
Links to Exploration step
pubmed:32881315Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19 in lung transplant recipients: A single center case series from New York City.</title><author><name sortKey="Aversa, Meghan" sort="Aversa, Meghan" uniqKey="Aversa M" first="Meghan" last="Aversa">Meghan Aversa</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benvenuto, Luke" sort="Benvenuto, Luke" uniqKey="Benvenuto L" first="Luke" last="Benvenuto">Luke Benvenuto</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Michaela" sort="Anderson, Michaela" uniqKey="Anderson M" first="Michaela" last="Anderson">Michaela Anderson</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shah, Lori" sort="Shah, Lori" uniqKey="Shah L" first="Lori" last="Shah">Lori Shah</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Robbins, Hilary" sort="Robbins, Hilary" uniqKey="Robbins H" first="Hilary" last="Robbins">Hilary Robbins</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pereira, Marcus" sort="Pereira, Marcus" uniqKey="Pereira M" first="Marcus" last="Pereira">Marcus Pereira</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Scheffert, Jenna" sort="Scheffert, Jenna" uniqKey="Scheffert J" first="Jenna" last="Scheffert">Jenna Scheffert</name><affiliation><nlm:affiliation>Department of Pharmacy, New York-Presbyterian Hospital, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carroll, Maggie" sort="Carroll, Maggie" uniqKey="Carroll M" first="Maggie" last="Carroll">Maggie Carroll</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hum, Jamie" sort="Hum, Jamie" uniqKey="Hum J" first="Jamie" last="Hum">Jamie Hum</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nolan, Margaret" sort="Nolan, Margaret" uniqKey="Nolan M" first="Margaret" last="Nolan">Margaret Nolan</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Reilly, Genevieve" sort="Reilly, Genevieve" uniqKey="Reilly G" first="Genevieve" last="Reilly">Genevieve Reilly</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lemaitre, Philippe" sort="Lemaitre, Philippe" uniqKey="Lemaitre P" first="Philippe" last="Lemaitre">Philippe Lemaitre</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stanifer, Bryan P" sort="Stanifer, Bryan P" uniqKey="Stanifer B" first="Bryan P" last="Stanifer">Bryan P. Stanifer</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="D Ovidio, Frank" sort="D Ovidio, Frank" uniqKey="D Ovidio F" first="Frank" last="D'Ovidio">Frank D'Ovidio</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sonett, Joshua" sort="Sonett, Joshua" uniqKey="Sonett J" first="Joshua" last="Sonett">Joshua Sonett</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arcasoy, Selim" sort="Arcasoy, Selim" uniqKey="Arcasoy S" first="Selim" last="Arcasoy">Selim Arcasoy</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32881315</idno><idno type="pmid">32881315</idno><idno type="doi">10.1111/ajt.16241</idno><idno type="pmc">PMC7436464</idno><idno type="wicri:Area/Main/Corpus">000D03</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000D03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 in lung transplant recipients: A single center case series from New York City.</title><author><name sortKey="Aversa, Meghan" sort="Aversa, Meghan" uniqKey="Aversa M" first="Meghan" last="Aversa">Meghan Aversa</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benvenuto, Luke" sort="Benvenuto, Luke" uniqKey="Benvenuto L" first="Luke" last="Benvenuto">Luke Benvenuto</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Michaela" sort="Anderson, Michaela" uniqKey="Anderson M" first="Michaela" last="Anderson">Michaela Anderson</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shah, Lori" sort="Shah, Lori" uniqKey="Shah L" first="Lori" last="Shah">Lori Shah</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Robbins, Hilary" sort="Robbins, Hilary" uniqKey="Robbins H" first="Hilary" last="Robbins">Hilary Robbins</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pereira, Marcus" sort="Pereira, Marcus" uniqKey="Pereira M" first="Marcus" last="Pereira">Marcus Pereira</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Scheffert, Jenna" sort="Scheffert, Jenna" uniqKey="Scheffert J" first="Jenna" last="Scheffert">Jenna Scheffert</name><affiliation><nlm:affiliation>Department of Pharmacy, New York-Presbyterian Hospital, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carroll, Maggie" sort="Carroll, Maggie" uniqKey="Carroll M" first="Maggie" last="Carroll">Maggie Carroll</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hum, Jamie" sort="Hum, Jamie" uniqKey="Hum J" first="Jamie" last="Hum">Jamie Hum</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nolan, Margaret" sort="Nolan, Margaret" uniqKey="Nolan M" first="Margaret" last="Nolan">Margaret Nolan</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Reilly, Genevieve" sort="Reilly, Genevieve" uniqKey="Reilly G" first="Genevieve" last="Reilly">Genevieve Reilly</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lemaitre, Philippe" sort="Lemaitre, Philippe" uniqKey="Lemaitre P" first="Philippe" last="Lemaitre">Philippe Lemaitre</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stanifer, Bryan P" sort="Stanifer, Bryan P" uniqKey="Stanifer B" first="Bryan P" last="Stanifer">Bryan P. Stanifer</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="D Ovidio, Frank" sort="D Ovidio, Frank" uniqKey="D Ovidio F" first="Frank" last="D'Ovidio">Frank D'Ovidio</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sonett, Joshua" sort="Sonett, Joshua" uniqKey="Sonett J" first="Joshua" last="Sonett">Joshua Sonett</name><affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arcasoy, Selim" sort="Arcasoy, Selim" uniqKey="Arcasoy S" first="Selim" last="Arcasoy">Selim Arcasoy</name><affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Antiviral Agents (therapeutic use)</term><term>COVID-19 (drug therapy)</term><term>COVID-19 (epidemiology)</term><term>Female (MeSH)</term><term>Graft Rejection (epidemiology)</term><term>Graft Rejection (prevention & control)</term><term>Humans (MeSH)</term><term>Immunosuppression (methods)</term><term>Incidence (MeSH)</term><term>Lung Transplantation (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>New York City (epidemiology)</term><term>Pandemics (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Survival Rate (trends)</term><term>Transplant Recipients (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>New York City</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunosuppression</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Lung Transplantation</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>SARS-CoV-2</term><term>Transplant Recipients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are limited data describing COVID-19 in lung transplant recipients. We performed a single center, retrospective case series study of lung transplant patients followed by the Columbia Lung Transplant program who tested positive for SARS-CoV-2 between March 19 and May 19, 2020. Thirty-two lung transplant patients developed mild (16%), moderate (44%), or severe (41%) COVID-19. The median age of patients was 65 years, and the median time from lung transplant was 5.6 years. Symptoms included cough (66%), dyspnea (50%), fever (47%), and gastrointestinal upset (44%). Patients received hydroxychloroquine (84%), azithromycin (75%), augmented steroids (44%), tocilizumab (19%), and remdesivir (9%). Eleven patients (34%) died at a median time of 14 days from admission. Complications during admission included: acute kidney injury (63%), transaminitis (31%), shock (31%), acute respiratory distress syndrome (25%), neurological events (25%), arrhythmias (22%), and venous thromboembolism (9%). Compared to patients with moderate COVID-19, patients with severe COVID-19 had higher peak white blood cell counts (15.8 vs 7 × 10<sup>3</sup> /uL, P = .019), C-reactive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004) levels, and lower nadir lymphocyte counts (0.09 vs. 0.4 × 10<sup>3</sup> /uL, P = .006). COVID-19 is associated with severe illness and a high mortality rate in lung transplant recipients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32881315</PMID><DateCompleted><Year>2020</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>11</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>COVID-19 in lung transplant recipients: A single center case series from New York City.</ArticleTitle><Pagination><MedlinePgn>3072-3080</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.16241</ELocationID><Abstract><AbstractText>There are limited data describing COVID-19 in lung transplant recipients. We performed a single center, retrospective case series study of lung transplant patients followed by the Columbia Lung Transplant program who tested positive for SARS-CoV-2 between March 19 and May 19, 2020. Thirty-two lung transplant patients developed mild (16%), moderate (44%), or severe (41%) COVID-19. The median age of patients was 65 years, and the median time from lung transplant was 5.6 years. Symptoms included cough (66%), dyspnea (50%), fever (47%), and gastrointestinal upset (44%). Patients received hydroxychloroquine (84%), azithromycin (75%), augmented steroids (44%), tocilizumab (19%), and remdesivir (9%). Eleven patients (34%) died at a median time of 14 days from admission. Complications during admission included: acute kidney injury (63%), transaminitis (31%), shock (31%), acute respiratory distress syndrome (25%), neurological events (25%), arrhythmias (22%), and venous thromboembolism (9%). Compared to patients with moderate COVID-19, patients with severe COVID-19 had higher peak white blood cell counts (15.8 vs 7 × 10<sup>3</sup> /uL, P = .019), C-reactive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004) levels, and lower nadir lymphocyte counts (0.09 vs. 0.4 × 10<sup>3</sup> /uL, P = .006). COVID-19 is associated with severe illness and a high mortality rate in lung transplant recipients.</AbstractText><CopyrightInformation>© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aversa</LastName><ForeName>Meghan</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-7361-0024</Identifier><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benvenuto</LastName><ForeName>Luke</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0001-8005-8074</Identifier><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Michaela</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-9274-7643</Identifier><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>Lori</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robbins</LastName><ForeName>Hilary</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pereira</LastName><ForeName>Marcus</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-9214-9122</Identifier><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scheffert</LastName><ForeName>Jenna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, New York-Presbyterian Hospital, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carroll</LastName><ForeName>Maggie</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0003-2477-6818</Identifier><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hum</LastName><ForeName>Jamie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nolan</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reilly</LastName><ForeName>Genevieve</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemaitre</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanifer</LastName><ForeName>Bryan P</ForeName><Initials>BP</Initials><AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Ovidio</LastName><ForeName>Frank</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0003-1678-2345</Identifier><AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sonett</LastName><ForeName>Joshua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arcasoy</LastName><ForeName>Selim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>From the Columbia University Lung Transplant Program</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>I031V2H011</RegistryNumber><NameOfSubstance UI="C502936">tocilizumab</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061067" MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic 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