COVID-19 in lung transplant recipients: A single center case series from New York City.
Identifieur interne : 000D03 ( Main/Corpus ); précédent : 000D02; suivant : 000D04COVID-19 in lung transplant recipients: A single center case series from New York City.
Auteurs : Meghan Aversa ; Luke Benvenuto ; Michaela Anderson ; Lori Shah ; Hilary Robbins ; Marcus Pereira ; Jenna Scheffert ; Maggie Carroll ; Jamie Hum ; Margaret Nolan ; Genevieve Reilly ; Philippe Lemaitre ; Bryan P. Stanifer ; Frank D'Ovidio ; Joshua Sonett ; Selim ArcasoySource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Antibodies, Monoclonal, Humanized (therapeutic use), Antiviral Agents (therapeutic use), COVID-19 (drug therapy), COVID-19 (epidemiology), Female (MeSH), Graft Rejection (epidemiology), Graft Rejection (prevention & control), Humans (MeSH), Immunosuppression (methods), Incidence (MeSH), Lung Transplantation (MeSH), Male (MeSH), Middle Aged (MeSH), New York City (epidemiology), Pandemics (MeSH), Retrospective Studies (MeSH), SARS-CoV-2 (MeSH), Survival Rate (trends), Transplant Recipients (MeSH).
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antiviral Agents.
- geographic , epidemiology : New York City.
- drug therapy : COVID-19.
- epidemiology : COVID-19, Graft Rejection.
- methods : Immunosuppression.
- prevention & control : Graft Rejection.
- trends : Survival Rate.
- Adult, Aged, Female, Humans, Incidence, Lung Transplantation, Male, Middle Aged, Pandemics, Retrospective Studies, SARS-CoV-2, Transplant Recipients.
Abstract
There are limited data describing COVID-19 in lung transplant recipients. We performed a single center, retrospective case series study of lung transplant patients followed by the Columbia Lung Transplant program who tested positive for SARS-CoV-2 between March 19 and May 19, 2020. Thirty-two lung transplant patients developed mild (16%), moderate (44%), or severe (41%) COVID-19. The median age of patients was 65 years, and the median time from lung transplant was 5.6 years. Symptoms included cough (66%), dyspnea (50%), fever (47%), and gastrointestinal upset (44%). Patients received hydroxychloroquine (84%), azithromycin (75%), augmented steroids (44%), tocilizumab (19%), and remdesivir (9%). Eleven patients (34%) died at a median time of 14 days from admission. Complications during admission included: acute kidney injury (63%), transaminitis (31%), shock (31%), acute respiratory distress syndrome (25%), neurological events (25%), arrhythmias (22%), and venous thromboembolism (9%). Compared to patients with moderate COVID-19, patients with severe COVID-19 had higher peak white blood cell counts (15.8 vs 7 × 103 /uL, P = .019), C-reactive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004) levels, and lower nadir lymphocyte counts (0.09 vs. 0.4 × 103 /uL, P = .006). COVID-19 is associated with severe illness and a high mortality rate in lung transplant recipients.
DOI: 10.1111/ajt.16241
PubMed: 32881315
PubMed Central: PMC7436464
Links to Exploration step
pubmed:32881315Le document en format XML
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<author><name sortKey="Anderson, Michaela" sort="Anderson, Michaela" uniqKey="Anderson M" first="Michaela" last="Anderson">Michaela Anderson</name>
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<author><name sortKey="Pereira, Marcus" sort="Pereira, Marcus" uniqKey="Pereira M" first="Marcus" last="Pereira">Marcus Pereira</name>
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<author><name sortKey="Scheffert, Jenna" sort="Scheffert, Jenna" uniqKey="Scheffert J" first="Jenna" last="Scheffert">Jenna Scheffert</name>
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<author><name sortKey="Nolan, Margaret" sort="Nolan, Margaret" uniqKey="Nolan M" first="Margaret" last="Nolan">Margaret Nolan</name>
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<author><name sortKey="Reilly, Genevieve" sort="Reilly, Genevieve" uniqKey="Reilly G" first="Genevieve" last="Reilly">Genevieve Reilly</name>
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<author><name sortKey="Lemaitre, Philippe" sort="Lemaitre, Philippe" uniqKey="Lemaitre P" first="Philippe" last="Lemaitre">Philippe Lemaitre</name>
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<author><name sortKey="Stanifer, Bryan P" sort="Stanifer, Bryan P" uniqKey="Stanifer B" first="Bryan P" last="Stanifer">Bryan P. Stanifer</name>
<affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="D Ovidio, Frank" sort="D Ovidio, Frank" uniqKey="D Ovidio F" first="Frank" last="D'Ovidio">Frank D'Ovidio</name>
<affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sonett, Joshua" sort="Sonett, Joshua" uniqKey="Sonett J" first="Joshua" last="Sonett">Joshua Sonett</name>
<affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Arcasoy, Selim" sort="Arcasoy, Selim" uniqKey="Arcasoy S" first="Selim" last="Arcasoy">Selim Arcasoy</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 in lung transplant recipients: A single center case series from New York City.</title>
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<author><name sortKey="Benvenuto, Luke" sort="Benvenuto, Luke" uniqKey="Benvenuto L" first="Luke" last="Benvenuto">Luke Benvenuto</name>
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</affiliation>
</author>
<author><name sortKey="Anderson, Michaela" sort="Anderson, Michaela" uniqKey="Anderson M" first="Michaela" last="Anderson">Michaela Anderson</name>
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</affiliation>
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<author><name sortKey="Robbins, Hilary" sort="Robbins, Hilary" uniqKey="Robbins H" first="Hilary" last="Robbins">Hilary Robbins</name>
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<author><name sortKey="Pereira, Marcus" sort="Pereira, Marcus" uniqKey="Pereira M" first="Marcus" last="Pereira">Marcus Pereira</name>
<affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scheffert, Jenna" sort="Scheffert, Jenna" uniqKey="Scheffert J" first="Jenna" last="Scheffert">Jenna Scheffert</name>
<affiliation><nlm:affiliation>Department of Pharmacy, New York-Presbyterian Hospital, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Carroll, Maggie" sort="Carroll, Maggie" uniqKey="Carroll M" first="Maggie" last="Carroll">Maggie Carroll</name>
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</affiliation>
</author>
<author><name sortKey="Hum, Jamie" sort="Hum, Jamie" uniqKey="Hum J" first="Jamie" last="Hum">Jamie Hum</name>
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</affiliation>
</author>
<author><name sortKey="Nolan, Margaret" sort="Nolan, Margaret" uniqKey="Nolan M" first="Margaret" last="Nolan">Margaret Nolan</name>
<affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reilly, Genevieve" sort="Reilly, Genevieve" uniqKey="Reilly G" first="Genevieve" last="Reilly">Genevieve Reilly</name>
<affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lemaitre, Philippe" sort="Lemaitre, Philippe" uniqKey="Lemaitre P" first="Philippe" last="Lemaitre">Philippe Lemaitre</name>
<affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stanifer, Bryan P" sort="Stanifer, Bryan P" uniqKey="Stanifer B" first="Bryan P" last="Stanifer">Bryan P. Stanifer</name>
<affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="D Ovidio, Frank" sort="D Ovidio, Frank" uniqKey="D Ovidio F" first="Frank" last="D'Ovidio">Frank D'Ovidio</name>
<affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sonett, Joshua" sort="Sonett, Joshua" uniqKey="Sonett J" first="Joshua" last="Sonett">Joshua Sonett</name>
<affiliation><nlm:affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Arcasoy, Selim" sort="Arcasoy, Selim" uniqKey="Arcasoy S" first="Selim" last="Arcasoy">Selim Arcasoy</name>
<affiliation><nlm:affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
</affiliation>
</author>
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<series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title>
<idno type="eISSN">1600-6143</idno>
<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>COVID-19 (drug therapy)</term>
<term>COVID-19 (epidemiology)</term>
<term>Female (MeSH)</term>
<term>Graft Rejection (epidemiology)</term>
<term>Graft Rejection (prevention & control)</term>
<term>Humans (MeSH)</term>
<term>Immunosuppression (methods)</term>
<term>Incidence (MeSH)</term>
<term>Lung Transplantation (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>New York City (epidemiology)</term>
<term>Pandemics (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Survival Rate (trends)</term>
<term>Transplant Recipients (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>New York City</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term>
<term>Graft Rejection</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunosuppression</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term>
</keywords>
<keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Lung Transplantation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>SARS-CoV-2</term>
<term>Transplant Recipients</term>
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<front><div type="abstract" xml:lang="en">There are limited data describing COVID-19 in lung transplant recipients. We performed a single center, retrospective case series study of lung transplant patients followed by the Columbia Lung Transplant program who tested positive for SARS-CoV-2 between March 19 and May 19, 2020. Thirty-two lung transplant patients developed mild (16%), moderate (44%), or severe (41%) COVID-19. The median age of patients was 65 years, and the median time from lung transplant was 5.6 years. Symptoms included cough (66%), dyspnea (50%), fever (47%), and gastrointestinal upset (44%). Patients received hydroxychloroquine (84%), azithromycin (75%), augmented steroids (44%), tocilizumab (19%), and remdesivir (9%). Eleven patients (34%) died at a median time of 14 days from admission. Complications during admission included: acute kidney injury (63%), transaminitis (31%), shock (31%), acute respiratory distress syndrome (25%), neurological events (25%), arrhythmias (22%), and venous thromboembolism (9%). Compared to patients with moderate COVID-19, patients with severe COVID-19 had higher peak white blood cell counts (15.8 vs 7 × 10<sup>3</sup>
/uL, P = .019), C-reactive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004) levels, and lower nadir lymphocyte counts (0.09 vs. 0.4 × 10<sup>3</sup>
/uL, P = .006). COVID-19 is associated with severe illness and a high mortality rate in lung transplant recipients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32881315</PMID>
<DateCompleted><Year>2020</Year>
<Month>12</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>23</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>20</Volume>
<Issue>11</Issue>
<PubDate><Year>2020</Year>
<Month>11</Month>
</PubDate>
</JournalIssue>
<Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title>
<ISOAbbreviation>Am J Transplant</ISOAbbreviation>
</Journal>
<ArticleTitle>COVID-19 in lung transplant recipients: A single center case series from New York City.</ArticleTitle>
<Pagination><MedlinePgn>3072-3080</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.16241</ELocationID>
<Abstract><AbstractText>There are limited data describing COVID-19 in lung transplant recipients. We performed a single center, retrospective case series study of lung transplant patients followed by the Columbia Lung Transplant program who tested positive for SARS-CoV-2 between March 19 and May 19, 2020. Thirty-two lung transplant patients developed mild (16%), moderate (44%), or severe (41%) COVID-19. The median age of patients was 65 years, and the median time from lung transplant was 5.6 years. Symptoms included cough (66%), dyspnea (50%), fever (47%), and gastrointestinal upset (44%). Patients received hydroxychloroquine (84%), azithromycin (75%), augmented steroids (44%), tocilizumab (19%), and remdesivir (9%). Eleven patients (34%) died at a median time of 14 days from admission. Complications during admission included: acute kidney injury (63%), transaminitis (31%), shock (31%), acute respiratory distress syndrome (25%), neurological events (25%), arrhythmias (22%), and venous thromboembolism (9%). Compared to patients with moderate COVID-19, patients with severe COVID-19 had higher peak white blood cell counts (15.8 vs 7 × 10<sup>3</sup>
/uL, P = .019), C-reactive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004) levels, and lower nadir lymphocyte counts (0.09 vs. 0.4 × 10<sup>3</sup>
/uL, P = .006). COVID-19 is associated with severe illness and a high mortality rate in lung transplant recipients.</AbstractText>
<CopyrightInformation>© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aversa</LastName>
<ForeName>Meghan</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0002-7361-0024</Identifier>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Benvenuto</LastName>
<ForeName>Luke</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0001-8005-8074</Identifier>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>Michaela</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0001-9274-7643</Identifier>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shah</LastName>
<ForeName>Lori</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robbins</LastName>
<ForeName>Hilary</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pereira</LastName>
<ForeName>Marcus</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0002-9214-9122</Identifier>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scheffert</LastName>
<ForeName>Jenna</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, New York-Presbyterian Hospital, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carroll</LastName>
<ForeName>Maggie</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0003-2477-6818</Identifier>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hum</LastName>
<ForeName>Jamie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nolan</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reilly</LastName>
<ForeName>Genevieve</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lemaitre</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stanifer</LastName>
<ForeName>Bryan P</ForeName>
<Initials>BP</Initials>
<AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>D'Ovidio</LastName>
<ForeName>Frank</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">0000-0003-1678-2345</Identifier>
<AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sonett</LastName>
<ForeName>Joshua</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Division of Thoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arcasoy</LastName>
<ForeName>Selim</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, New York, New York, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>From the Columbia University Lung Transplant Program</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>05</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Transplant</MedlineTA>
<NlmUniqueID>100968638</NlmUniqueID>
<ISSNLinking>1600-6135</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>I031V2H011</RegistryNumber>
<NameOfSubstance UI="C502936">tocilizumab</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061067" MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006084" MajorTopicYN="N">Graft Rejection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016040" MajorTopicYN="Y">Lung Transplantation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009519" MajorTopicYN="N" Type="Geographic">New York City</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="Y">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D066027" MajorTopicYN="Y">Transplant Recipients</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>06</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>07</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>12</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32881315</ArticleId>
<ArticleId IdType="doi">10.1111/ajt.16241</ArticleId>
<ArticleId IdType="pmc">PMC7436464</ArticleId>
</ArticleIdList>
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