COVID-19 in a patient with advanced Merkel cell carcinoma receiving immunotherapy.
Identifieur interne : 000C63 ( Main/Corpus ); précédent : 000C62; suivant : 000C64COVID-19 in a patient with advanced Merkel cell carcinoma receiving immunotherapy.
Auteurs : Cesar Martins Da Costa ; Zenaide Silva De Souza ; Alessandra Corte Real Salgues ; Guilherme Harada ; Pedro Paulo Marino Rodrigues Ayres ; Daniela Bulh Es Vieira Nunes ; Artur Katz ; Rodrigo Ramella MunhozSource :
- Immunotherapy [ 1750-7448 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Antibodies, Monoclonal, Humanized (therapeutic use), Antineoplastic Agents, Immunological (therapeutic use), Betacoronavirus (MeSH), COVID-19 (MeSH), Carcinoma, Merkel Cell (complications), Carcinoma, Merkel Cell (pathology), Carcinoma, Merkel Cell (therapy), Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (pathology), Coronavirus Infections (therapy), Humans (MeSH), Immunotherapy (adverse effects), Lung (diagnostic imaging), Lung (pathology), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (pathology), Pneumonia, Viral (therapy), Programmed Cell Death 1 Receptor (antagonists & inhibitors), SARS-CoV-2 (MeSH), Skin Neoplasms (complications), Skin Neoplasms (pathology), Skin Neoplasms (therapy), Tomography, X-Ray Computed (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Programmed Cell Death 1 Receptor.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Immunological.
- adverse effects : Immunotherapy.
- complications : Carcinoma, Merkel Cell, Coronavirus Infections, Pneumonia, Viral, Skin Neoplasms.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- diagnostic imaging : Lung.
- pathology : Carcinoma, Merkel Cell, Coronavirus Infections, Lung, Pneumonia, Viral, Skin Neoplasms.
- therapy : Carcinoma, Merkel Cell, Coronavirus Infections, Pneumonia, Viral, Skin Neoplasms.
- Aged, Betacoronavirus, COVID-19, Humans, Male, Pandemics, SARS-CoV-2, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
Background: Little is known about the 2019 novel coronavirus disease (COVID-19) course and outcomes in patients receiving immunotherapy. Here we describe a metastatic Merkel cell carcinoma patient with a severe acute respiratory syndrome coronavirus 2 infection while receiving pembrolizumab. Case presentation: A 66-year-old man, with a metastatic Merkel cell carcinoma receiving pembrolizumab, presented with fever. Chest computed tomography (CT) showed pulmonary ground-glass opacities, suggesting viral or immuno-related etiology. On day 7, the patient was hospitalized due to dyspnea and worsening of the radiological findings. Real time polymerase chain reaction (RT-PCR) testing confirmed COVID-19. The patient developed acute respiratory distress syndrome and acute kidney injury. Hydroxychloroquine was administered for 5 days, but discontinued after supraventricular extrasystoles. Clinical improvement allowed the patient's discharge after 81 days of hospitalization. Conclusion: A careful evaluation of oncologic patients receiving immunotherapy during the COVID-19 pandemic is of utmost importance.
DOI: 10.2217/imt-2020-0193
PubMed: 32900245
PubMed Central: PMC7480322
Links to Exploration step
pubmed:32900245Le document en format XML
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<term>Antineoplastic Agents, Immunological (therapeutic use)</term>
<term>Betacoronavirus (MeSH)</term>
<term>COVID-19 (MeSH)</term>
<term>Carcinoma, Merkel Cell (complications)</term>
<term>Carcinoma, Merkel Cell (pathology)</term>
<term>Carcinoma, Merkel Cell (therapy)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (pathology)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Humans (MeSH)</term>
<term>Immunotherapy (adverse effects)</term>
<term>Lung (diagnostic imaging)</term>
<term>Lung (pathology)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (pathology)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Programmed Cell Death 1 Receptor (antagonists & inhibitors)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Skin Neoplasms (complications)</term>
<term>Skin Neoplasms (pathology)</term>
<term>Skin Neoplasms (therapy)</term>
<term>Tomography, X-Ray Computed (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Skin Neoplasms</term>
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<term>Pneumonia, Viral</term>
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<term>Coronavirus Infections</term>
<term>Lung</term>
<term>Pneumonia, Viral</term>
<term>Skin Neoplasms</term>
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<term>Pneumonia, Viral</term>
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<term>COVID-19</term>
<term>Humans</term>
<term>Male</term>
<term>Pandemics</term>
<term>SARS-CoV-2</term>
<term>Tomography, X-Ray Computed</term>
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<front><div type="abstract" xml:lang="en"><b>Background:</b>
Little is known about the 2019 novel coronavirus disease (COVID-19) course and outcomes in patients receiving immunotherapy. Here we describe a metastatic Merkel cell carcinoma patient with a severe acute respiratory syndrome coronavirus 2 infection while receiving pembrolizumab. <b>Case presentation:</b>
A 66-year-old man, with a metastatic Merkel cell carcinoma receiving pembrolizumab, presented with fever. Chest computed tomography (CT) showed pulmonary ground-glass opacities, suggesting viral or immuno-related etiology. On day 7, the patient was hospitalized due to dyspnea and worsening of the radiological findings. Real time polymerase chain reaction (RT-PCR) testing confirmed COVID-19. The patient developed acute respiratory distress syndrome and acute kidney injury. Hydroxychloroquine was administered for 5 days, but discontinued after supraventricular extrasystoles. Clinical improvement allowed the patient's discharge after 81 days of hospitalization. <b>Conclusion:</b>
A careful evaluation of oncologic patients receiving immunotherapy during the COVID-19 pandemic is of utmost importance.</div>
</front>
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<Abstract><AbstractText><b>Background:</b>
Little is known about the 2019 novel coronavirus disease (COVID-19) course and outcomes in patients receiving immunotherapy. Here we describe a metastatic Merkel cell carcinoma patient with a severe acute respiratory syndrome coronavirus 2 infection while receiving pembrolizumab. <b>Case presentation:</b>
A 66-year-old man, with a metastatic Merkel cell carcinoma receiving pembrolizumab, presented with fever. Chest computed tomography (CT) showed pulmonary ground-glass opacities, suggesting viral or immuno-related etiology. On day 7, the patient was hospitalized due to dyspnea and worsening of the radiological findings. Real time polymerase chain reaction (RT-PCR) testing confirmed COVID-19. The patient developed acute respiratory distress syndrome and acute kidney injury. Hydroxychloroquine was administered for 5 days, but discontinued after supraventricular extrasystoles. Clinical improvement allowed the patient's discharge after 81 days of hospitalization. <b>Conclusion:</b>
A careful evaluation of oncologic patients receiving immunotherapy during the COVID-19 pandemic is of utmost importance.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>da Costa</LastName>
<ForeName>Cesar Martins</ForeName>
<Initials>CM</Initials>
<Identifier Source="ORCID">0000-0003-1753-6840</Identifier>
<AffiliationInfo><Affiliation>Oncology Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.</Affiliation>
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<Author ValidYN="Y"><LastName>de Souza</LastName>
<ForeName>Zenaide Silva</ForeName>
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<Author ValidYN="Y"><LastName>Real Salgues</LastName>
<ForeName>Alessandra Corte</ForeName>
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<Author ValidYN="Y"><LastName>Harada</LastName>
<ForeName>Guilherme</ForeName>
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<Author ValidYN="Y"><LastName>Marino Rodrigues Ayres</LastName>
<ForeName>Pedro Paulo</ForeName>
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<Author ValidYN="Y"><LastName>Vieira Nunes</LastName>
<ForeName>Daniela Bulhões</ForeName>
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<Author ValidYN="Y"><LastName>Katz</LastName>
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<Author ValidYN="Y"><LastName>Munhoz</LastName>
<ForeName>Rodrigo Ramella</ForeName>
<Initials>RR</Initials>
<Identifier Source="ORCID">0000-0001-8898-2798</Identifier>
<AffiliationInfo><Affiliation>Oncology Center, Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.</Affiliation>
</AffiliationInfo>
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