Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.
Identifieur interne : 000C35 ( Main/Corpus ); précédent : 000C34; suivant : 000C36Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.
Auteurs : Yu Kang ; Hui Wang ; Hong Chen ; Bo Wang ; Yingying Yang ; Xuan Zhao ; Qihui Ran ; Jiafu WeiSource :
- International heart journal [ 1349-3299 ] ; 2020.
English descriptors
- KwdEn :
- Aged, 80 and over (MeSH), Betacoronavirus (MeSH), Bradycardia (chemically induced), COVID-19 (MeSH), Coronavirus Infections (drug therapy), Female (MeSH), Humans (MeSH), Hydroxychloroquine (adverse effects), Long QT Syndrome (chemically induced), Pandemics (MeSH), Pneumonia, Viral (drug therapy), SARS-CoV-2 (MeSH).
- MESH :
- chemical , adverse effects : Hydroxychloroquine.
- chemically induced : Bradycardia, Long QT Syndrome.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Aged, 80 and over, Betacoronavirus, COVID-19, Female, Humans, Pandemics, SARS-CoV-2.
Abstract
An 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases.
DOI: 10.1536/ihj.20-271
PubMed: 32921678
Links to Exploration step
pubmed:32921678Le document en format XML
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last="Wang">Bo Wang</name><affiliation><nlm:affiliation>Department of Intensive Care Unit, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Yingying" sort="Yang, Yingying" uniqKey="Yang Y" first="Yingying" last="Yang">Yingying Yang</name><affiliation><nlm:affiliation>Department of Nephrology, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Xuan" sort="Zhao, Xuan" uniqKey="Zhao X" first="Xuan" last="Zhao">Xuan Zhao</name><affiliation><nlm:affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</nlm:affiliation></affiliation></author><author><name sortKey="Ran, Qihui" sort="Ran, Qihui" uniqKey="Ran Q" first="Qihui" last="Ran">Qihui Ran</name><affiliation><nlm:affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Jiafu" sort="Wei, Jiafu" uniqKey="Wei J" first="Jiafu" last="Wei">Jiafu Wei</name><affiliation><nlm:affiliation>Department of Cardiology, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32921678</idno><idno type="pmid">32921678</idno><idno type="doi">10.1536/ihj.20-271</idno><idno type="wicri:Area/Main/Corpus">000C35</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.</title><author><name sortKey="Kang, Yu" sort="Kang, Yu" uniqKey="Kang Y" first="Yu" last="Kang">Yu Kang</name><affiliation><nlm:affiliation>Department of Cardiology, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hui" sort="Wang, Hui" uniqKey="Wang H" first="Hui" last="Wang">Hui Wang</name><affiliation><nlm:affiliation>Department of Cardiology, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation><nlm:affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Bo" sort="Wang, Bo" uniqKey="Wang B" first="Bo" last="Wang">Bo Wang</name><affiliation><nlm:affiliation>Department of Intensive Care Unit, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Yingying" sort="Yang, Yingying" uniqKey="Yang Y" first="Yingying" last="Yang">Yingying Yang</name><affiliation><nlm:affiliation>Department of Nephrology, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Xuan" sort="Zhao, Xuan" uniqKey="Zhao X" first="Xuan" last="Zhao">Xuan Zhao</name><affiliation><nlm:affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</nlm:affiliation></affiliation></author><author><name sortKey="Ran, Qihui" sort="Ran, Qihui" uniqKey="Ran Q" first="Qihui" last="Ran">Qihui Ran</name><affiliation><nlm:affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Jiafu" sort="Wei, Jiafu" uniqKey="Wei J" first="Jiafu" last="Wei">Jiafu Wei</name><affiliation><nlm:affiliation>Department of Cardiology, West China Hospital, Sichuan University.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International heart journal</title><idno type="eISSN">1349-3299</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Bradycardia (chemically induced)</term><term>COVID-19 (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (adverse effects)</term><term>Long QT Syndrome (chemically induced)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>SARS-CoV-2 (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Bradycardia</term><term>Long QT Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>COVID-19</term><term>Female</term><term>Humans</term><term>Pandemics</term><term>SARS-CoV-2</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32921678</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1349-3299</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>29</Day></PubDate></JournalIssue><Title>International heart journal</Title><ISOAbbreviation>Int Heart J</ISOAbbreviation></Journal><ArticleTitle>Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.</ArticleTitle><Pagination><MedlinePgn>1056-1058</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1536/ihj.20-271</ELocationID><Abstract><AbstractText>An 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Cardiology, West China Hospital, Sichuan University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Cardiology, West China Hospital, Sichuan University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Unit, West China Hospital, Sichuan University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Yingying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Nephrology, West China Hospital, Sichuan University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Xuan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ran</LastName><ForeName>Qihui</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Unit, The Public Health Clinical Center of Chengdu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Jiafu</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiology, West China Hospital, Sichuan University.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Int Heart J</MedlineTA><NlmUniqueID>101244240</NlmUniqueID><ISSNLinking>1349-2365</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Int Heart J. 2020;61(5):863-864</RefSource><PMID Version="1">32999194</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001919" MajorTopicYN="N">Bradycardia</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008133" MajorTopicYN="N">Long QT Syndrome</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" 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