A Systematic Review of Treatment and Outcomes of Pregnant Women With COVID-19-A Call for Clinical Trials.
Identifieur interne : 000C21 ( Main/Corpus ); précédent : 000C20; suivant : 000C22A Systematic Review of Treatment and Outcomes of Pregnant Women With COVID-19-A Call for Clinical Trials.
Auteurs : Katelyn A. Pastick ; Melanie R. Nicol ; Elizabeth Smyth ; Rebecca Zash ; David R. Boulware ; Radha Rajasingham ; Emily G. McdonaldSource :
- Open forum infectious diseases [ 2328-8957 ] ; 2020.
Abstract
Background
Data pertaining to COVID-19 in pregnancy are limited; to better inform clinicians, we collated data from COVID-19 cases during pregnancy and summarized clinical trials enrolling this population.
Methods
We performed a systematic literature review of PubMed/MEDLINE to identify cases of COVID-19 in pregnancy or the postpartum period and associated outcomes. We then evaluated the proportion of COVID-19 clinical trials (from ClinicalTrials.gov) excluding pregnant or breastfeeding persons (both through June 29, 2020).
Results
We identified 11 308 published cases of COVID-19 during pregnancy. Of those reporting disease severity, 21% (416/1999) were severe/critical. Maternal and neonatal survival were reassuring (98% [10 437/10 597] and 99% [1155/1163], respectively). Neonatal disease was rare, with only 41 possible cases of infection reported in the literature. Of 2351 ongoing COVID-19 therapeutic clinical trials, 1282 were enrolling persons of reproductive age and 65% (829/1282) excluded pregnant persons. Pregnancy was an exclusion criterion for 69% (75/109) of chloroquine/hydroxychloroquine, 80% (28/35) of lopinavir/ritonavir, and 48% (44/91) of convalescent plasma studies. We identified 48 actively recruiting or completed drug trials reporting inclusion of this population.
Conclusions
There are limited published reports of COVID-19 in pregnancy despite more than 14 million cases worldwide. To date, clinical outcomes appear reassuring, but data related to important long-term outcomes are missing or not yet reported. The large number of clinical trials excluding pregnant persons, despite interventions with safety data in pregnancy, is concerning. In addition to observational cohort studies, pregnancy-specific adaptive clinical trials could be designed to identify safe and effective treatments.
DOI: 10.1093/ofid/ofaa350
PubMed: 32929403
PubMed Central: PMC7454907
Links to Exploration step
pubmed:32929403Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Systematic Review of Treatment and Outcomes of Pregnant Women With COVID-19-A Call for Clinical Trials.</title><author><name sortKey="Pastick, Katelyn A" sort="Pastick, Katelyn A" uniqKey="Pastick K" first="Katelyn A" last="Pastick">Katelyn A. Pastick</name><affiliation><nlm:affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nicol, Melanie R" sort="Nicol, Melanie R" uniqKey="Nicol M" first="Melanie R" last="Nicol">Melanie R. Nicol</name><affiliation><nlm:affiliation>Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Elizabeth" sort="Smyth, Elizabeth" uniqKey="Smyth E" first="Elizabeth" last="Smyth">Elizabeth Smyth</name><affiliation><nlm:affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zash, Rebecca" sort="Zash, Rebecca" uniqKey="Zash R" first="Rebecca" last="Zash">Rebecca Zash</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R" last="Boulware">David R. Boulware</name><affiliation><nlm:affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rajasingham, Radha" sort="Rajasingham, Radha" uniqKey="Rajasingham R" first="Radha" last="Rajasingham">Radha Rajasingham</name><affiliation><nlm:affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcdonald, Emily G" sort="Mcdonald, Emily G" uniqKey="Mcdonald E" first="Emily G" last="Mcdonald">Emily G. Mcdonald</name><affiliation><nlm:affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32929403</idno><idno type="pmid">32929403</idno><idno type="doi">10.1093/ofid/ofaa350</idno><idno type="pmc">PMC7454907</idno><idno type="wicri:Area/Main/Corpus">000C21</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Systematic Review of Treatment and Outcomes of Pregnant Women With COVID-19-A Call for Clinical Trials.</title><author><name sortKey="Pastick, Katelyn A" sort="Pastick, Katelyn A" uniqKey="Pastick K" first="Katelyn A" last="Pastick">Katelyn A. Pastick</name><affiliation><nlm:affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nicol, Melanie R" sort="Nicol, Melanie R" uniqKey="Nicol M" first="Melanie R" last="Nicol">Melanie R. Nicol</name><affiliation><nlm:affiliation>Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Elizabeth" sort="Smyth, Elizabeth" uniqKey="Smyth E" first="Elizabeth" last="Smyth">Elizabeth Smyth</name><affiliation><nlm:affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zash, Rebecca" sort="Zash, Rebecca" uniqKey="Zash R" first="Rebecca" last="Zash">Rebecca Zash</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R" last="Boulware">David R. Boulware</name><affiliation><nlm:affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rajasingham, Radha" sort="Rajasingham, Radha" uniqKey="Rajasingham R" first="Radha" last="Rajasingham">Radha Rajasingham</name><affiliation><nlm:affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcdonald, Emily G" sort="Mcdonald, Emily G" uniqKey="Mcdonald E" first="Emily G" last="Mcdonald">Emily G. Mcdonald</name><affiliation><nlm:affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Open forum infectious diseases</title><idno type="ISSN">2328-8957</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Data pertaining to COVID-19 in pregnancy are limited; to better inform clinicians, we collated data from COVID-19 cases during pregnancy and summarized clinical trials enrolling this population.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>We performed a systematic literature review of PubMed/MEDLINE to identify cases of COVID-19 in pregnancy or the postpartum period and associated outcomes. We then evaluated the proportion of COVID-19 clinical trials (from ClinicalTrials.gov) excluding pregnant or breastfeeding persons (both through June 29, 2020).</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>We identified 11 308 published cases of COVID-19 during pregnancy. Of those reporting disease severity, 21% (416/1999) were severe/critical. Maternal and neonatal survival were reassuring (98% [10 437/10 597] and 99% [1155/1163], respectively). Neonatal disease was rare, with only 41 possible cases of infection reported in the literature. Of 2351 ongoing COVID-19 therapeutic clinical trials, 1282 were enrolling persons of reproductive age and 65% (829/1282) excluded pregnant persons. Pregnancy was an exclusion criterion for 69% (75/109) of chloroquine/hydroxychloroquine, 80% (28/35) of lopinavir/ritonavir, and 48% (44/91) of convalescent plasma studies. We identified 48 actively recruiting or completed drug trials reporting inclusion of this population.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>There are limited published reports of COVID-19 in pregnancy despite more than 14 million cases worldwide. To date, clinical outcomes appear reassuring, but data related to important long-term outcomes are missing or not yet reported. The large number of clinical trials excluding pregnant persons, despite interventions with safety data in pregnancy, is concerning. In addition to observational cohort studies, pregnancy-specific adaptive clinical trials could be designed to identify safe and effective treatments.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32929403</PMID><DateRevised><Year>2021</Year><Month>04</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2328-8957</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Open forum infectious diseases</Title><ISOAbbreviation>Open Forum Infect Dis</ISOAbbreviation></Journal><ArticleTitle>A Systematic Review of Treatment and Outcomes of Pregnant Women With COVID-19-A Call for Clinical Trials.</ArticleTitle><Pagination><MedlinePgn>ofaa350</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ofid/ofaa350</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Data pertaining to COVID-19 in pregnancy are limited; to better inform clinicians, we collated data from COVID-19 cases during pregnancy and summarized clinical trials enrolling this population.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">We performed a systematic literature review of PubMed/MEDLINE to identify cases of COVID-19 in pregnancy or the postpartum period and associated outcomes. We then evaluated the proportion of COVID-19 clinical trials (from ClinicalTrials.gov) excluding pregnant or breastfeeding persons (both through June 29, 2020).</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">We identified 11 308 published cases of COVID-19 during pregnancy. Of those reporting disease severity, 21% (416/1999) were severe/critical. Maternal and neonatal survival were reassuring (98% [10 437/10 597] and 99% [1155/1163], respectively). Neonatal disease was rare, with only 41 possible cases of infection reported in the literature. Of 2351 ongoing COVID-19 therapeutic clinical trials, 1282 were enrolling persons of reproductive age and 65% (829/1282) excluded pregnant persons. Pregnancy was an exclusion criterion for 69% (75/109) of chloroquine/hydroxychloroquine, 80% (28/35) of lopinavir/ritonavir, and 48% (44/91) of convalescent plasma studies. We identified 48 actively recruiting or completed drug trials reporting inclusion of this population.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">There are limited published reports of COVID-19 in pregnancy despite more than 14 million cases worldwide. To date, clinical outcomes appear reassuring, but data related to important long-term outcomes are missing or not yet reported. The large number of clinical trials excluding pregnant persons, despite interventions with safety data in pregnancy, is concerning. In addition to observational cohort studies, pregnancy-specific adaptive clinical trials could be designed to identify safe and effective treatments.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pastick</LastName><ForeName>Katelyn A</ForeName><Initials>KA</Initials><Identifier Source="ORCID">0000-0002-1306-1713</Identifier><AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicol</LastName><ForeName>Melanie R</ForeName><Initials>MR</Initials><Identifier Source="ORCID">0000-0001-5513-5509</Identifier><AffiliationInfo><Affiliation>Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smyth</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zash</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0001-5707-421X</Identifier><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boulware</LastName><ForeName>David R</ForeName><Initials>DR</Initials><Identifier Source="ORCID">0000-0002-4715-0060</Identifier><AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajasingham</LastName><ForeName>Radha</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0001-5531-0231</Identifier><AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McDonald</LastName><ForeName>Emily G</ForeName><Initials>EG</Initials><Identifier Source="ORCID">0000-0003-0783-0624</Identifier><AffiliationInfo><Affiliation>Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K08 AI134262</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 AI138851</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Open Forum Infect Dis</MedlineTA><NlmUniqueID>101637045</NlmUniqueID><ISSNLinking>2328-8957</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">breastfeeding</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword><Keyword MajorTopicYN="N">pregnancy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>15</Day><Hour>5</Hour><Minute>48</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32929403</ArticleId><ArticleId IdType="doi">10.1093/ofid/ofaa350</ArticleId><ArticleId IdType="pii">ofaa350</ArticleId><ArticleId IdType="pmc">PMC7454907</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):853-857</Citation><ArticleIdList><ArticleId IdType="pubmed">32161941</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 12;323(18):1846-1848</Citation><ArticleIdList><ArticleId IdType="pubmed">32215581</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2020 Apr 03;69(13):382-386</Citation><ArticleIdList><ArticleId IdType="pubmed">32240123</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Obstet Gynecol. 2015 Dec;213(6):810-5</Citation><ArticleIdList><ArticleId IdType="pubmed">26008178</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2008 Jan;14(1):95-100</Citation><ArticleIdList><ArticleId IdType="pubmed">18258087</ArticleId></ArticleIdList></Reference><Reference><Citation>AIDS Rev. 2013 Jan-Mar;15(1):38-48</Citation><ArticleIdList><ArticleId IdType="pubmed">23449228</ArticleId></ArticleIdList></Reference><Reference><Citation>Case Rep Womens Health. 2020 May 16;27:e00220</Citation><ArticleIdList><ArticleId IdType="pubmed">32426242</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Obstet Gynecol Reprod Biol. 2020 Jun;249:98-99</Citation><ArticleIdList><ArticleId IdType="pubmed">32327266</ArticleId></ArticleIdList></Reference><Reference><Citation>Arthritis Rheumatol. 2020 Apr;72(4):529-556</Citation><ArticleIdList><ArticleId IdType="pubmed">32090480</ArticleId></ArticleIdList></Reference><Reference><Citation>J Reprod Immunol. 2020 Jun;139:103122</Citation><ArticleIdList><ArticleId IdType="pubmed">32244166</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Infect. 2020 Jun;26(6):788-790</Citation><ArticleIdList><ArticleId IdType="pubmed">32278081</ArticleId></ArticleIdList></Reference><Reference><Citation>Medicina (Kaunas). 2020 Jun 22;56(6):</Citation><ArticleIdList><ArticleId IdType="pubmed">32580461</ArticleId></ArticleIdList></Reference><Reference><Citation>AJP Rep. 2020 Apr;10(2):e179-e182</Citation><ArticleIdList><ArticleId IdType="pubmed">32566368</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation><ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gynecol Obstet Hum Reprod. 2020 Sep;49(7):101826</Citation><ArticleIdList><ArticleId IdType="pubmed">32505805</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Obstet Gynecol MFM. 2020 Aug;2(3):100135</Citation><ArticleIdList><ArticleId IdType="pubmed">32391520</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2020 May;20(5):559-564</Citation><ArticleIdList><ArticleId IdType="pubmed">32220284</ArticleId></ArticleIdList></Reference><Reference><Citation>Viruses. 2020 Feb 10;12(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">32050635</ArticleId></ArticleIdList></Reference><Reference><Citation>BJOG. 2020 Aug;127(9):1116-1121</Citation><ArticleIdList><ArticleId IdType="pubmed">32339382</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2020 Oct 20;173(8):623-631</Citation><ArticleIdList><ArticleId IdType="pubmed">32673060</ArticleId></ArticleIdList></Reference><Reference><Citation>Obstet Gynecol. 2019 Apr;133(4):e287-e295</Citation><ArticleIdList><ArticleId IdType="pubmed">30913201</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2020 Jun 8;369:m2107</Citation><ArticleIdList><ArticleId IdType="pubmed">32513659</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Aug 6;383(6):517-525</Citation><ArticleIdList><ArticleId IdType="pubmed">32492293</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2020 Sep 1;130(9):4947-4953</Citation><ArticleIdList><ArticleId IdType="pubmed">32573498</ArticleId></ArticleIdList></Reference><Reference><Citation>BJOG. 2003 Jul;110(7):641-2</Citation><ArticleIdList><ArticleId IdType="pubmed">12842052</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):879-881</Citation><ArticleIdList><ArticleId IdType="pubmed">32296817</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Med. 2020 Apr;14(2):193-198</Citation><ArticleIdList><ArticleId IdType="pubmed">32285380</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Perinatol. 2020 Jun;37(8):861-865</Citation><ArticleIdList><ArticleId IdType="pubmed">32305046</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 12;323(18):1848-1849</Citation><ArticleIdList><ArticleId IdType="pubmed">32215589</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Obstet Gynecol MFM. 2020 Aug;2(3):100145</Citation><ArticleIdList><ArticleId IdType="pubmed">32427221</ArticleId></ArticleIdList></Reference><Reference><Citation>CMAJ. 2020 Jun 15;192(24):E647-E650</Citation><ArticleIdList><ArticleId IdType="pubmed">32409520</ArticleId></ArticleIdList></Reference><Reference><Citation>BJOG. 2020 Aug;127(9):1109-1115</Citation><ArticleIdList><ArticleId IdType="pubmed">32369656</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Obstet Gynecol Reprod Biol. 2020 Aug;251:272-274</Citation><ArticleIdList><ArticleId IdType="pubmed">32402627</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Perinatol. 2020 Jun;37(8):869-872</Citation><ArticleIdList><ArticleId IdType="pubmed">32359227</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Clin Pathol. 2020 Jun 8;154(1):23-32</Citation><ArticleIdList><ArticleId IdType="pubmed">32441303</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Pediatr. 2014 Feb 11;2:9</Citation><ArticleIdList><ArticleId IdType="pubmed">24575394</ArticleId></ArticleIdList></Reference><Reference><Citation>Case Rep Womens Health. 2020 May 16;27:e00221</Citation><ArticleIdList><ArticleId IdType="pubmed">32426243</ArticleId></ArticleIdList></Reference><Reference><Citation>Obstet Gynecol. 2020 Aug;136(2):252-258</Citation><ArticleIdList><ArticleId IdType="pubmed">32433453</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Obstet Gynecol MFM. 2020 Aug;2(3):100133</Citation><ArticleIdList><ArticleId IdType="pubmed">32391518</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000C21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:32929403
|texte= A Systematic Review of Treatment and Outcomes of Pregnant Women With COVID-19-A Call for Clinical Trials.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32929403" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |