Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study.
Identifieur interne : 000B51 ( Main/Corpus ); précédent : 000B50; suivant : 000B52Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study.
Auteurs : Piercarlo Sarzi-Puttini ; Daniela Marotto ; Roberto Caporali ; Carlo Maurizio Montecucco ; Ennio Giulio Favalli ; Franco Franceschini ; Michela Fredi ; Silvia Balduzzi ; Chiara Bazzani ; Sara Bongiovanni ; Valeria Giorgi ; Alberto Batticciotto ; Antonella Cappelli ; Patrizia Balzarini ; Lorenzo Dagna ; Silvia Sartorelli ; Viviana Ravagnani ; Silvia Tamanini ; Sonia Farah ; Paola Faggioli ; Laura Castelnovo ; Alfredo Maria Lurati ; Massimo Galli ; Fausto SalaffiSource :
- Journal of autoimmunity [ 1095-9157 ] ; 2021.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Antirheumatic Agents (therapeutic use), COVID-19 (epidemiology), COVID-19 (immunology), Female (MeSH), Humans (MeSH), Immunocompromised Host (MeSH), Italy (epidemiology), Male (MeSH), Middle Aged (MeSH), Prevalence (MeSH), Retrospective Studies (MeSH), Rheumatic Diseases (drug therapy), SARS-CoV-2 (MeSH).
- MESH :
- chemical , therapeutic use : Antirheumatic Agents.
- geographic , epidemiology : Italy.
- drug therapy : Rheumatic Diseases.
- epidemiology : COVID-19.
- immunology : COVID-19.
- Adult, Aged, Female, Humans, Immunocompromised Host, Male, Middle Aged, Prevalence, Retrospective Studies, SARS-CoV-2.
Abstract
OBJECTIVE
The COVID-19 pandemic has raised questions about the management of systemic immunosuppressive treatments for rheumatic conditions. It is well known that rheumatic patients are at risk of developing infections because of their immunocompromised state. Moreover, drugs such as hydroxychloroquine or tocilizumab that are widely used to treat rheumatic diseases are now being used to treat COVID-19. The aim of this multicentre retrospective study of rheumatic patients in the Italian regions of Lombardy and Marche was to determine whether patients receiving biological or small molecules treatment are more susceptible to the development of COVID-19 than the general population.
METHODS
The local registry data of 10,260 rheumatic patients being treated with bDMARDs or small molecules were evaluated from 15 March to 23 April 2020. The final analysis was based on the registry data relating to 7.204, telephone contacts and/or outpatient visits.
RESULTS
Forty-seven of the 7.204 patients were diagnosed with COVID-19, seven of whom died; the patients who had symptoms resembling those of COVID-19 but had negative swabs were considered negative for the disease. The overall infection rate was 0.65, and the crude case fatality risk (CFR) in the patients with COVID-19 was 14.9%. There was no difference in the mortality rate among the patients receiving the different individual biological drugs or small molecules.
CONCLUSIONS
Our findings suggest that the susceptibility of rheumatic patients to COVID-19 is the same as that of the general population, but confirm that age, disease duration, and the number of co-morbidities are associated with an increased risk of a severe form of the disease. It seems that immunosuppressants drugs do not effectively represent a risk factor for COVID- 19.
DOI: 10.1016/j.jaut.2020.102545
PubMed: 32972804
PubMed Central: PMC7506330
Links to Exploration step
pubmed:32972804Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study.</title><author><name sortKey="Sarzi Puttini, Piercarlo" sort="Sarzi Puttini, Piercarlo" uniqKey="Sarzi Puttini P" first="Piercarlo" last="Sarzi-Puttini">Piercarlo Sarzi-Puttini</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: piercarlo.sarziputtini@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Marotto, Daniela" sort="Marotto, Daniela" uniqKey="Marotto D" first="Daniela" last="Marotto">Daniela Marotto</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: daniela.marotto@tiscali.it.</nlm:affiliation></affiliation></author><author><name sortKey="Caporali, Roberto" sort="Caporali, Roberto" uniqKey="Caporali R" first="Roberto" last="Caporali">Roberto Caporali</name><affiliation><nlm:affiliation>Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy. Electronic address: roberto.caporali@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Montecucco, Carlo Maurizio" sort="Montecucco, Carlo Maurizio" uniqKey="Montecucco C" first="Carlo Maurizio" last="Montecucco">Carlo Maurizio Montecucco</name><affiliation><nlm:affiliation>Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: c.montecucco@smatteo.pv.it.</nlm:affiliation></affiliation></author><author><name sortKey="Favalli, Ennio Giulio" sort="Favalli, Ennio Giulio" uniqKey="Favalli E" first="Ennio Giulio" last="Favalli">Ennio Giulio Favalli</name><affiliation><nlm:affiliation>Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy. Electronic address: ennio.favalli@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Franceschini, Franco" sort="Franceschini, Franco" uniqKey="Franceschini F" first="Franco" last="Franceschini">Franco Franceschini</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: franco.franceschini@unibs.it.</nlm:affiliation></affiliation></author><author><name sortKey="Fredi, Michela" sort="Fredi, Michela" uniqKey="Fredi M" first="Michela" last="Fredi">Michela Fredi</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: fredi.micaela@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Balduzzi, Silvia" sort="Balduzzi, Silvia" uniqKey="Balduzzi S" first="Silvia" last="Balduzzi">Silvia Balduzzi</name><affiliation><nlm:affiliation>Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: silvia.balduzzi@hotmail.it.</nlm:affiliation></affiliation></author><author><name sortKey="Bazzani, Chiara" sort="Bazzani, Chiara" uniqKey="Bazzani C" first="Chiara" last="Bazzani">Chiara Bazzani</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: bazzani.reumatologia@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Bongiovanni, Sara" sort="Bongiovanni, Sara" uniqKey="Bongiovanni S" first="Sara" last="Bongiovanni">Sara Bongiovanni</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: sara.bongiovanni@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Giorgi, Valeria" sort="Giorgi, Valeria" uniqKey="Giorgi V" first="Valeria" last="Giorgi">Valeria Giorgi</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: vale.gio@fastwebnet.it.</nlm:affiliation></affiliation></author><author><name sortKey="Batticciotto, Alberto" sort="Batticciotto, Alberto" uniqKey="Batticciotto A" first="Alberto" last="Batticciotto">Alberto Batticciotto</name><affiliation><nlm:affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: battic@tiscali.it.</nlm:affiliation></affiliation></author><author><name sortKey="Cappelli, Antonella" sort="Cappelli, Antonella" uniqKey="Cappelli A" first="Antonella" last="Cappelli">Antonella Cappelli</name><affiliation><nlm:affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: antonella.cappelli@asst-settelaghi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Balzarini, Patrizia" sort="Balzarini, Patrizia" uniqKey="Balzarini P" first="Patrizia" last="Balzarini">Patrizia Balzarini</name><affiliation><nlm:affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: patrizia.balzarini@asst-settelaghi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Dagna, Lorenzo" sort="Dagna, Lorenzo" uniqKey="Dagna L" first="Lorenzo" last="Dagna">Lorenzo Dagna</name><affiliation><nlm:affiliation>Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address: dagna.lorenzo@unisr.it.</nlm:affiliation></affiliation></author><author><name sortKey="Sartorelli, Silvia" sort="Sartorelli, Silvia" uniqKey="Sartorelli S" first="Silvia" last="Sartorelli">Silvia Sartorelli</name><affiliation><nlm:affiliation>Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address: sartorelli.silvia@hsr.it.</nlm:affiliation></affiliation></author><author><name sortKey="Ravagnani, Viviana" sort="Ravagnani, Viviana" uniqKey="Ravagnani V" first="Viviana" last="Ravagnani">Viviana Ravagnani</name><affiliation><nlm:affiliation>SSD Allergologia e Immunologia Clinica, ASST Mantova, Italy. Electronic address: viviana.ravagnani@asst-mantova.it.</nlm:affiliation></affiliation></author><author><name sortKey="Tamanini, Silvia" sort="Tamanini, Silvia" uniqKey="Tamanini S" first="Silvia" last="Tamanini">Silvia Tamanini</name><affiliation><nlm:affiliation>SSD Allergologia e Immunologia Clinica, ASST Mantova, Italy. Electronic address: silvia.tamanini@asst-mantova.it.</nlm:affiliation></affiliation></author><author><name sortKey="Farah, Sonia" sort="Farah, Sonia" uniqKey="Farah S" first="Sonia" last="Farah">Sonia Farah</name><affiliation><nlm:affiliation>Rheumatological Clinic, Ospedale "Carlo Urbani", Università Politecnica delle Marche, Jesi, Ancona, Italy. Electronic address: sonia.farah91@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Faggioli, Paola" sort="Faggioli, Paola" uniqKey="Faggioli P" first="Paola" last="Faggioli">Paola Faggioli</name><affiliation><nlm:affiliation>Department of Internal Medicine ASST Ovest Milanese, Legnano, Italy; Rheumatology Department ASST Ovest Milanese, Magenta, Italy. Electronic address: faggioli.paola@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Castelnovo, Laura" sort="Castelnovo, Laura" uniqKey="Castelnovo L" first="Laura" last="Castelnovo">Laura Castelnovo</name><affiliation><nlm:affiliation>Department of Internal Medicine ASST Ovest Milanese, Legnano, Italy. Electronic address: laura.castelnuovo@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Lurati, Alfredo Maria" sort="Lurati, Alfredo Maria" uniqKey="Lurati A" first="Alfredo Maria" last="Lurati">Alfredo Maria Lurati</name><affiliation><nlm:affiliation>Rheumatology Department ASST Ovest Milanese, Magenta, Italy. Electronic address: alfredomarialurati@asst-ovestmi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Galli, Massimo" sort="Galli, Massimo" uniqKey="Galli M" first="Massimo" last="Galli">Massimo Galli</name><affiliation><nlm:affiliation>Department of Clinical and Biomedical Sciences "Luigi Sacco", University of Milano, Milano, Italy; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milano, Italy. Electronic address: massimo.galli@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Salaffi, Fausto" sort="Salaffi, Fausto" uniqKey="Salaffi F" first="Fausto" last="Salaffi">Fausto Salaffi</name><affiliation><nlm:affiliation>Rheumatological Clinic, Ospedale "Carlo Urbani", Università Politecnica delle Marche, Jesi, Ancona, Italy. Electronic address: fausto.salaffi@gmail.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:32972804</idno><idno type="pmid">32972804</idno><idno type="doi">10.1016/j.jaut.2020.102545</idno><idno type="pmc">PMC7506330</idno><idno type="wicri:Area/Main/Corpus">000B51</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study.</title><author><name sortKey="Sarzi Puttini, Piercarlo" sort="Sarzi Puttini, Piercarlo" uniqKey="Sarzi Puttini P" first="Piercarlo" last="Sarzi-Puttini">Piercarlo Sarzi-Puttini</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: piercarlo.sarziputtini@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Marotto, Daniela" sort="Marotto, Daniela" uniqKey="Marotto D" first="Daniela" last="Marotto">Daniela Marotto</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: daniela.marotto@tiscali.it.</nlm:affiliation></affiliation></author><author><name sortKey="Caporali, Roberto" sort="Caporali, Roberto" uniqKey="Caporali R" first="Roberto" last="Caporali">Roberto Caporali</name><affiliation><nlm:affiliation>Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy. Electronic address: roberto.caporali@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Montecucco, Carlo Maurizio" sort="Montecucco, Carlo Maurizio" uniqKey="Montecucco C" first="Carlo Maurizio" last="Montecucco">Carlo Maurizio Montecucco</name><affiliation><nlm:affiliation>Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: c.montecucco@smatteo.pv.it.</nlm:affiliation></affiliation></author><author><name sortKey="Favalli, Ennio Giulio" sort="Favalli, Ennio Giulio" uniqKey="Favalli E" first="Ennio Giulio" last="Favalli">Ennio Giulio Favalli</name><affiliation><nlm:affiliation>Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy. Electronic address: ennio.favalli@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Franceschini, Franco" sort="Franceschini, Franco" uniqKey="Franceschini F" first="Franco" last="Franceschini">Franco Franceschini</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: franco.franceschini@unibs.it.</nlm:affiliation></affiliation></author><author><name sortKey="Fredi, Michela" sort="Fredi, Michela" uniqKey="Fredi M" first="Michela" last="Fredi">Michela Fredi</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: fredi.micaela@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Balduzzi, Silvia" sort="Balduzzi, Silvia" uniqKey="Balduzzi S" first="Silvia" last="Balduzzi">Silvia Balduzzi</name><affiliation><nlm:affiliation>Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: silvia.balduzzi@hotmail.it.</nlm:affiliation></affiliation></author><author><name sortKey="Bazzani, Chiara" sort="Bazzani, Chiara" uniqKey="Bazzani C" first="Chiara" last="Bazzani">Chiara Bazzani</name><affiliation><nlm:affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: bazzani.reumatologia@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Bongiovanni, Sara" sort="Bongiovanni, Sara" uniqKey="Bongiovanni S" first="Sara" last="Bongiovanni">Sara Bongiovanni</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: sara.bongiovanni@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Giorgi, Valeria" sort="Giorgi, Valeria" uniqKey="Giorgi V" first="Valeria" last="Giorgi">Valeria Giorgi</name><affiliation><nlm:affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: vale.gio@fastwebnet.it.</nlm:affiliation></affiliation></author><author><name sortKey="Batticciotto, Alberto" sort="Batticciotto, Alberto" uniqKey="Batticciotto A" first="Alberto" last="Batticciotto">Alberto Batticciotto</name><affiliation><nlm:affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: battic@tiscali.it.</nlm:affiliation></affiliation></author><author><name sortKey="Cappelli, Antonella" sort="Cappelli, Antonella" uniqKey="Cappelli A" first="Antonella" last="Cappelli">Antonella Cappelli</name><affiliation><nlm:affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: antonella.cappelli@asst-settelaghi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Balzarini, Patrizia" sort="Balzarini, Patrizia" uniqKey="Balzarini P" first="Patrizia" last="Balzarini">Patrizia Balzarini</name><affiliation><nlm:affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: patrizia.balzarini@asst-settelaghi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Dagna, Lorenzo" sort="Dagna, Lorenzo" uniqKey="Dagna L" first="Lorenzo" last="Dagna">Lorenzo Dagna</name><affiliation><nlm:affiliation>Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address: dagna.lorenzo@unisr.it.</nlm:affiliation></affiliation></author><author><name sortKey="Sartorelli, Silvia" sort="Sartorelli, Silvia" uniqKey="Sartorelli S" first="Silvia" last="Sartorelli">Silvia Sartorelli</name><affiliation><nlm:affiliation>Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address: sartorelli.silvia@hsr.it.</nlm:affiliation></affiliation></author><author><name sortKey="Ravagnani, Viviana" sort="Ravagnani, Viviana" uniqKey="Ravagnani V" first="Viviana" last="Ravagnani">Viviana Ravagnani</name><affiliation><nlm:affiliation>SSD Allergologia e Immunologia Clinica, ASST Mantova, Italy. Electronic address: viviana.ravagnani@asst-mantova.it.</nlm:affiliation></affiliation></author><author><name sortKey="Tamanini, Silvia" sort="Tamanini, Silvia" uniqKey="Tamanini S" first="Silvia" last="Tamanini">Silvia Tamanini</name><affiliation><nlm:affiliation>SSD Allergologia e Immunologia Clinica, ASST Mantova, Italy. Electronic address: silvia.tamanini@asst-mantova.it.</nlm:affiliation></affiliation></author><author><name sortKey="Farah, Sonia" sort="Farah, Sonia" uniqKey="Farah S" first="Sonia" last="Farah">Sonia Farah</name><affiliation><nlm:affiliation>Rheumatological Clinic, Ospedale "Carlo Urbani", Università Politecnica delle Marche, Jesi, Ancona, Italy. Electronic address: sonia.farah91@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Faggioli, Paola" sort="Faggioli, Paola" uniqKey="Faggioli P" first="Paola" last="Faggioli">Paola Faggioli</name><affiliation><nlm:affiliation>Department of Internal Medicine ASST Ovest Milanese, Legnano, Italy; Rheumatology Department ASST Ovest Milanese, Magenta, Italy. Electronic address: faggioli.paola@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Castelnovo, Laura" sort="Castelnovo, Laura" uniqKey="Castelnovo L" first="Laura" last="Castelnovo">Laura Castelnovo</name><affiliation><nlm:affiliation>Department of Internal Medicine ASST Ovest Milanese, Legnano, Italy. Electronic address: laura.castelnuovo@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Lurati, Alfredo Maria" sort="Lurati, Alfredo Maria" uniqKey="Lurati A" first="Alfredo Maria" last="Lurati">Alfredo Maria Lurati</name><affiliation><nlm:affiliation>Rheumatology Department ASST Ovest Milanese, Magenta, Italy. Electronic address: alfredomarialurati@asst-ovestmi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Galli, Massimo" sort="Galli, Massimo" uniqKey="Galli M" first="Massimo" last="Galli">Massimo Galli</name><affiliation><nlm:affiliation>Department of Clinical and Biomedical Sciences "Luigi Sacco", University of Milano, Milano, Italy; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milano, Italy. Electronic address: massimo.galli@unimi.it.</nlm:affiliation></affiliation></author><author><name sortKey="Salaffi, Fausto" sort="Salaffi, Fausto" uniqKey="Salaffi F" first="Fausto" last="Salaffi">Fausto Salaffi</name><affiliation><nlm:affiliation>Rheumatological Clinic, Ospedale "Carlo Urbani", Università Politecnica delle Marche, Jesi, Ancona, Italy. Electronic address: fausto.salaffi@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of autoimmunity</title><idno type="eISSN">1095-9157</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Antirheumatic Agents (therapeutic use)</term><term>COVID-19 (epidemiology)</term><term>COVID-19 (immunology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunocompromised Host (MeSH)</term><term>Italy (epidemiology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Prevalence (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Rheumatic Diseases (drug therapy)</term><term>SARS-CoV-2 (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Rheumatic Diseases</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Immunocompromised Host</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Retrospective Studies</term><term>SARS-CoV-2</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>The COVID-19 pandemic has raised questions about the management of systemic immunosuppressive treatments for rheumatic conditions. It is well known that rheumatic patients are at risk of developing infections because of their immunocompromised state. Moreover, drugs such as hydroxychloroquine or tocilizumab that are widely used to treat rheumatic diseases are now being used to treat COVID-19. The aim of this multicentre retrospective study of rheumatic patients in the Italian regions of Lombardy and Marche was to determine whether patients receiving biological or small molecules treatment are more susceptible to the development of COVID-19 than the general population.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The local registry data of 10,260 rheumatic patients being treated with bDMARDs or small molecules were evaluated from 15 March to 23 April 2020. The final analysis was based on the registry data relating to 7.204, telephone contacts and/or outpatient visits.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Forty-seven of the 7.204 patients were diagnosed with COVID-19, seven of whom died; the patients who had symptoms resembling those of COVID-19 but had negative swabs were considered negative for the disease. The overall infection rate was 0.65, and the crude case fatality risk (CFR) in the patients with COVID-19 was 14.9%. There was no difference in the mortality rate among the patients receiving the different individual biological drugs or small molecules.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our findings suggest that the susceptibility of rheumatic patients to COVID-19 is the same as that of the general population, but confirm that age, disease duration, and the number of co-morbidities are associated with an increased risk of a severe form of the disease. It seems that immunosuppressants drugs do not effectively represent a risk factor for COVID- 19.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32972804</PMID><DateCompleted><Year>2021</Year><Month>01</Month><Day>07</Day></DateCompleted><DateRevised><Year>2021</Year><Month>02</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9157</ISSN><JournalIssue CitedMedium="Internet"><Volume>116</Volume><PubDate><Year>2021</Year><Month>01</Month></PubDate></JournalIssue><Title>Journal of autoimmunity</Title><ISOAbbreviation>J Autoimmun</ISOAbbreviation></Journal><ArticleTitle>Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study.</ArticleTitle><Pagination><MedlinePgn>102545</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0896-8411(20)30171-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaut.2020.102545</ELocationID><Abstract><AbstractText Label="OBJECTIVE">The COVID-19 pandemic has raised questions about the management of systemic immunosuppressive treatments for rheumatic conditions. It is well known that rheumatic patients are at risk of developing infections because of their immunocompromised state. Moreover, drugs such as hydroxychloroquine or tocilizumab that are widely used to treat rheumatic diseases are now being used to treat COVID-19. The aim of this multicentre retrospective study of rheumatic patients in the Italian regions of Lombardy and Marche was to determine whether patients receiving biological or small molecules treatment are more susceptible to the development of COVID-19 than the general population.</AbstractText><AbstractText Label="METHODS">The local registry data of 10,260 rheumatic patients being treated with bDMARDs or small molecules were evaluated from 15 March to 23 April 2020. The final analysis was based on the registry data relating to 7.204, telephone contacts and/or outpatient visits.</AbstractText><AbstractText Label="RESULTS">Forty-seven of the 7.204 patients were diagnosed with COVID-19, seven of whom died; the patients who had symptoms resembling those of COVID-19 but had negative swabs were considered negative for the disease. The overall infection rate was 0.65, and the crude case fatality risk (CFR) in the patients with COVID-19 was 14.9%. There was no difference in the mortality rate among the patients receiving the different individual biological drugs or small molecules.</AbstractText><AbstractText Label="CONCLUSIONS">Our findings suggest that the susceptibility of rheumatic patients to COVID-19 is the same as that of the general population, but confirm that age, disease duration, and the number of co-morbidities are associated with an increased risk of a severe form of the disease. It seems that immunosuppressants drugs do not effectively represent a risk factor for COVID- 19.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sarzi-Puttini</LastName><ForeName>Piercarlo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: piercarlo.sarziputtini@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marotto</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: daniela.marotto@tiscali.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caporali</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy. Electronic address: roberto.caporali@unimi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montecucco</LastName><ForeName>Carlo Maurizio</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: c.montecucco@smatteo.pv.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Favalli</LastName><ForeName>Ennio Giulio</ForeName><Initials>EG</Initials><AffiliationInfo><Affiliation>Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy. Electronic address: ennio.favalli@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franceschini</LastName><ForeName>Franco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: franco.franceschini@unibs.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fredi</LastName><ForeName>Michela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: fredi.micaela@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balduzzi</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: silvia.balduzzi@hotmail.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bazzani</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: bazzani.reumatologia@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bongiovanni</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: sara.bongiovanni@unimi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giorgi</LastName><ForeName>Valeria</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy. Electronic address: vale.gio@fastwebnet.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Batticciotto</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: battic@tiscali.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cappelli</LastName><ForeName>Antonella</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: antonella.cappelli@asst-settelaghi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balzarini</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy. Electronic address: patrizia.balzarini@asst-settelaghi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dagna</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address: dagna.lorenzo@unisr.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sartorelli</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address: sartorelli.silvia@hsr.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ravagnani</LastName><ForeName>Viviana</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>SSD Allergologia e Immunologia Clinica, ASST Mantova, Italy. Electronic address: viviana.ravagnani@asst-mantova.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamanini</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>SSD Allergologia e Immunologia Clinica, ASST Mantova, Italy. Electronic address: silvia.tamanini@asst-mantova.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farah</LastName><ForeName>Sonia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Rheumatological Clinic, Ospedale "Carlo Urbani", Università Politecnica delle Marche, Jesi, Ancona, Italy. Electronic address: sonia.farah91@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faggioli</LastName><ForeName>Paola</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine ASST Ovest Milanese, Legnano, Italy; Rheumatology Department ASST Ovest Milanese, Magenta, Italy. Electronic address: faggioli.paola@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castelnovo</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine ASST Ovest Milanese, Legnano, Italy. Electronic address: laura.castelnuovo@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lurati</LastName><ForeName>Alfredo Maria</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Rheumatology Department ASST Ovest Milanese, Magenta, Italy. Electronic address: alfredomarialurati@asst-ovestmi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galli</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical and Biomedical Sciences "Luigi Sacco", University of Milano, Milano, Italy; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milano, Italy. Electronic address: massimo.galli@unimi.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salaffi</LastName><ForeName>Fausto</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Rheumatological Clinic, Ospedale "Carlo Urbani", Università Politecnica delle Marche, Jesi, Ancona, Italy. Electronic address: fausto.salaffi@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Autoimmun</MedlineTA><NlmUniqueID>8812164</NlmUniqueID><ISSNLinking>0896-8411</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018501" MajorTopicYN="N">Antirheumatic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016867" MajorTopicYN="Y">Immunocompromised Host</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012216" MajorTopicYN="N">Rheumatic Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Biologics</Keyword><Keyword MajorTopicYN="Y">COVID 19</Keyword><Keyword MajorTopicYN="Y">Dmards</Keyword><Keyword MajorTopicYN="Y">Infections</Keyword><Keyword MajorTopicYN="Y">Registries</Keyword><Keyword MajorTopicYN="Y">Rheumatic disease</Keyword><Keyword MajorTopicYN="Y">Small molecules</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>25</Day><Hour>5</Hour><Minute>40</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32972804</ArticleId><ArticleId IdType="pii">S0896-8411(20)30171-2</ArticleId><ArticleId IdType="doi">10.1016/j.jaut.2020.102545</ArticleId><ArticleId IdType="pmc">PMC7506330</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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