CovidChloroV1, Main, Corpus, bibRecord, 000A44

Why PB28 Could Be a Covid 2019 Game Changer?

Identifieur interne : 000A44 ( Main/Corpus ); précédent : 000A43; suivant : 000A45

Why PB28 Could Be a Covid 2019 Game Changer?

Auteurs : Nicola Antonio Colabufo ; Marcello Leopoldo ; Savina Ferorelli ; Carmen Abate ; Marialessandra Contino ; Maria Grazia Perrone ; Mauro Niso ; Roberto Perrone ; Francesco Berardi

Source :

ACS medicinal chemistry letters [ 1948-5875 ] ; 2020.

RBID : pubmed:33052254

Abstract

PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past decade in our research group. A possible mechanism to explain its surprising anti-COVID-19 activity is suggested..

DOI: 10.1021/acsmedchemlett.0c00271
PubMed: 33052254
PubMed Central: PMC7437449

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pubmed:33052254

Le document en format XML

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<author><name sortKey="Colabufo, Nicola Antonio" sort="Colabufo, Nicola Antonio" uniqKey="Colabufo N" first="Nicola Antonio" last="Colabufo">Nicola Antonio Colabufo</name>
<affiliation><nlm:affiliation>Dipartimento Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4, 70125 Bari, Italy.</nlm:affiliation>
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<author><name sortKey="Leopoldo, Marcello" sort="Leopoldo, Marcello" uniqKey="Leopoldo M" first="Marcello" last="Leopoldo">Marcello Leopoldo</name>
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<author><name sortKey="Ferorelli, Savina" sort="Ferorelli, Savina" uniqKey="Ferorelli S" first="Savina" last="Ferorelli">Savina Ferorelli</name>
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<author><name sortKey="Contino, Marialessandra" sort="Contino, Marialessandra" uniqKey="Contino M" first="Marialessandra" last="Contino">Marialessandra Contino</name>
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<author><name sortKey="Perrone, Maria Grazia" sort="Perrone, Maria Grazia" uniqKey="Perrone M" first="Maria Grazia" last="Perrone">Maria Grazia Perrone</name>
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<author><name sortKey="Niso, Mauro" sort="Niso, Mauro" uniqKey="Niso M" first="Mauro" last="Niso">Mauro Niso</name>
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<author><name sortKey="Perrone, Roberto" sort="Perrone, Roberto" uniqKey="Perrone R" first="Roberto" last="Perrone">Roberto Perrone</name>
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<author><name sortKey="Berardi, Francesco" sort="Berardi, Francesco" uniqKey="Berardi F" first="Francesco" last="Berardi">Francesco Berardi</name>
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<author><name sortKey="Ferorelli, Savina" sort="Ferorelli, Savina" uniqKey="Ferorelli S" first="Savina" last="Ferorelli">Savina Ferorelli</name>
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<author><name sortKey="Abate, Carmen" sort="Abate, Carmen" uniqKey="Abate C" first="Carmen" last="Abate">Carmen Abate</name>
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<author><name sortKey="Perrone, Maria Grazia" sort="Perrone, Maria Grazia" uniqKey="Perrone M" first="Maria Grazia" last="Perrone">Maria Grazia Perrone</name>
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<author><name sortKey="Niso, Mauro" sort="Niso, Mauro" uniqKey="Niso M" first="Mauro" last="Niso">Mauro Niso</name>
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<front><div type="abstract" xml:lang="en">PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without interaction with cardiac proteins. PB28 has been designed, developed, and biologically evaluated in the past decade in our research group. A possible mechanism to explain its surprising anti-COVID-19 activity is suggested..</div>
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<ReferenceList><Reference><Citation>Mol Cancer Ther. 2006 Jul;5(7):1807-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16891467</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2014 Apr 24;57(8):3314-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24697311</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 1996 Jan 5;39(1):176-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8568804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Discov Today. 2020 Jul;25(7):1121-1123</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32371138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cleve Clin J Med. 2020 Sep 2;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32371558</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect. 2020 Jul;81(1):e24-e27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32283146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 1995 Mar 17;38(6):942-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7699710</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):106-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15322732</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2006 Jul 13;49(14):4153-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16821775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 1994 Jan 7;37(1):99-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8289207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ChemMedChem. 2010 Feb 1;5(2):268-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20077462</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2011 Aug 25;54(16):5858-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21744858</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem Lett. 2008 Mar 15;18(6):2183-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18178434</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2004 Apr 22;47(9):2308-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15084129</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Cancer. 2017 Jan 13;17(1):51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28086830</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2009 Dec 10;52(23):7817-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19842660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Rev Med Pharmacol Sci. 2020 Apr;24(8):4539-4547</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32373993</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drugs Context. 2020 Apr 28;9:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32373183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2011 Nov;7(11):1335-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21799305</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2014 Aug;10(8):1426-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24991833</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Jul;583(7816):459-468</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32353859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Calcium. 2006 Jul;40(1):23-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16687172</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Why PB28 Could Be a Covid 2019 Game Changer?

Why PB28 Could Be a Covid 2019 Game Changer?

Source :

Abstract

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