Myotonic dystrophy type 1 as a major risk factor for severe COVID-19?
Identifieur interne : 000A41 ( Main/Corpus ); précédent : 000A40; suivant : 000A42Myotonic dystrophy type 1 as a major risk factor for severe COVID-19?
Auteurs : Sebastiaan Dhont ; Rutger Callens ; Dieter Stevens ; Fre Bauters ; Jan L. De Bleecker ; Eric Derom ; Eva Van BraeckelSource :
- Acta neurologica Belgica [ 2240-2993 ] ; 2020.
Abstract
The coronavirus disease 2019 (COVID-19) pandemic is challenging health care systems worldwide. People with myotonic dystrophy type 1 (DM1) represent a high-risk population during infectious disease outbreaks, little is known about the potential impact of COVID-19 on patients with DM1. We studied the clinical course of COVID-19 in three hospitalized patients with myotonic dystrophy type 1 or Steinert's disease, between April 1, 2020-April 30-2020. All three had advanced Steinert's disease receiving non-invasive nocturnal home ventilatory support. Two of them lived in a residential care centre. Two patients had a limited respiratory capacity, whereas one patient had a rather preserved functional capacity but more comorbidities. Two out of three patients were obese, none of them had diabetes mellitus. Two patients received hydroxychloroquine. Despite maximal supportive care with oxygen therapy, antibiotics, intensive respiratory physiotherapy and non-invasive positive pressure ventilation, all three patients eventually died due to COVID-19. Our case series of three patients with DM1 admitted for COVID-19 confirms that they are at high risk for severe disease and poor outcome. Clinical trials are needed to define best practices and determinants of outcomes in this unique population.
DOI: 10.1007/s13760-020-01514-z
PubMed: 33052531
PubMed Central: PMC7556549
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Myotonic dystrophy type 1 as a major risk factor for severe COVID-19?</title><author><name sortKey="Dhont, Sebastiaan" sort="Dhont, Sebastiaan" uniqKey="Dhont S" first="Sebastiaan" last="Dhont">Sebastiaan Dhont</name><affiliation><nlm:affiliation>Department of Internal Medicine and Paediatrics, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. sebastiaan.dhont@ugent.be.</nlm:affiliation></affiliation></author><author><name sortKey="Callens, Rutger" sort="Callens, Rutger" uniqKey="Callens R" first="Rutger" last="Callens">Rutger Callens</name><affiliation><nlm:affiliation>Department of Internal Medicine and Paediatrics, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Stevens, Dieter" sort="Stevens, Dieter" uniqKey="Stevens D" first="Dieter" last="Stevens">Dieter Stevens</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Bauters, Fre" sort="Bauters, Fre" uniqKey="Bauters F" first="Fre" last="Bauters">Fre Bauters</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="De Bleecker, Jan L" sort="De Bleecker, Jan L" uniqKey="De Bleecker J" first="Jan L" last="De Bleecker">Jan L. De Bleecker</name><affiliation><nlm:affiliation>Neuromuscular Reference Centre, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Derom, Eric" sort="Derom, Eric" uniqKey="Derom E" first="Eric" last="Derom">Eric Derom</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Van Braeckel, Eva" sort="Van Braeckel, Eva" uniqKey="Van Braeckel E" first="Eva" last="Van Braeckel">Eva Van Braeckel</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33052531</idno><idno type="pmid">33052531</idno><idno type="doi">10.1007/s13760-020-01514-z</idno><idno type="pmc">PMC7556549</idno><idno type="wicri:Area/Main/Corpus">000A41</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Myotonic dystrophy type 1 as a major risk factor for severe COVID-19?</title><author><name sortKey="Dhont, Sebastiaan" sort="Dhont, Sebastiaan" uniqKey="Dhont S" first="Sebastiaan" last="Dhont">Sebastiaan Dhont</name><affiliation><nlm:affiliation>Department of Internal Medicine and Paediatrics, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. sebastiaan.dhont@ugent.be.</nlm:affiliation></affiliation></author><author><name sortKey="Callens, Rutger" sort="Callens, Rutger" uniqKey="Callens R" first="Rutger" last="Callens">Rutger Callens</name><affiliation><nlm:affiliation>Department of Internal Medicine and Paediatrics, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Stevens, Dieter" sort="Stevens, Dieter" uniqKey="Stevens D" first="Dieter" last="Stevens">Dieter Stevens</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Bauters, Fre" sort="Bauters, Fre" uniqKey="Bauters F" first="Fre" last="Bauters">Fre Bauters</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="De Bleecker, Jan L" sort="De Bleecker, Jan L" uniqKey="De Bleecker J" first="Jan L" last="De Bleecker">Jan L. De Bleecker</name><affiliation><nlm:affiliation>Neuromuscular Reference Centre, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Derom, Eric" sort="Derom, Eric" uniqKey="Derom E" first="Eric" last="Derom">Eric Derom</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Van Braeckel, Eva" sort="Van Braeckel, Eva" uniqKey="Van Braeckel E" first="Eva" last="Van Braeckel">Eva Van Braeckel</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Acta neurologica Belgica</title><idno type="eISSN">2240-2993</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The coronavirus disease 2019 (COVID-19) pandemic is challenging health care systems worldwide. People with myotonic dystrophy type 1 (DM1) represent a high-risk population during infectious disease outbreaks, little is known about the potential impact of COVID-19 on patients with DM1. We studied the clinical course of COVID-19 in three hospitalized patients with myotonic dystrophy type 1 or Steinert's disease, between April 1, 2020-April 30-2020. All three had advanced Steinert's disease receiving non-invasive nocturnal home ventilatory support. Two of them lived in a residential care centre. Two patients had a limited respiratory capacity, whereas one patient had a rather preserved functional capacity but more comorbidities. Two out of three patients were obese, none of them had diabetes mellitus. Two patients received hydroxychloroquine. Despite maximal supportive care with oxygen therapy, antibiotics, intensive respiratory physiotherapy and non-invasive positive pressure ventilation, all three patients eventually died due to COVID-19. Our case series of three patients with DM1 admitted for COVID-19 confirms that they are at high risk for severe disease and poor outcome. Clinical trials are needed to define best practices and determinants of outcomes in this unique population.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33052531</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2240-2993</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Oct</Month><Day>14</Day></PubDate></JournalIssue><Title>Acta neurologica Belgica</Title><ISOAbbreviation>Acta Neurol Belg</ISOAbbreviation></Journal><ArticleTitle>Myotonic dystrophy type 1 as a major risk factor for severe COVID-19?</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s13760-020-01514-z</ELocationID><Abstract><AbstractText>The coronavirus disease 2019 (COVID-19) pandemic is challenging health care systems worldwide. People with myotonic dystrophy type 1 (DM1) represent a high-risk population during infectious disease outbreaks, little is known about the potential impact of COVID-19 on patients with DM1. We studied the clinical course of COVID-19 in three hospitalized patients with myotonic dystrophy type 1 or Steinert's disease, between April 1, 2020-April 30-2020. All three had advanced Steinert's disease receiving non-invasive nocturnal home ventilatory support. Two of them lived in a residential care centre. Two patients had a limited respiratory capacity, whereas one patient had a rather preserved functional capacity but more comorbidities. Two out of three patients were obese, none of them had diabetes mellitus. Two patients received hydroxychloroquine. Despite maximal supportive care with oxygen therapy, antibiotics, intensive respiratory physiotherapy and non-invasive positive pressure ventilation, all three patients eventually died due to COVID-19. Our case series of three patients with DM1 admitted for COVID-19 confirms that they are at high risk for severe disease and poor outcome. Clinical trials are needed to define best practices and determinants of outcomes in this unique population.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dhont</LastName><ForeName>Sebastiaan</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5615-3191</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine and Paediatrics, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. sebastiaan.dhont@ugent.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Callens</LastName><ForeName>Rutger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Paediatrics, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stevens</LastName><ForeName>Dieter</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauters</LastName><ForeName>Fre</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Bleecker</LastName><ForeName>Jan L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Neuromuscular Reference Centre, Ghent University Hospital, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Derom</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Braeckel</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Acta Neurol Belg</MedlineTA><NlmUniqueID>0247035</NlmUniqueID><ISSNLinking>0300-9009</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Myotonic dystrophy</Keyword><Keyword MajorTopicYN="N">Neuromuscular disorders</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Steinert’s disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>07</Day></PubMedPubDate><PubMedPubDate 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