Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.
Identifieur interne : 000943 ( Main/Corpus ); précédent : 000942; suivant : 000944Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.
Auteurs : Saurabh Gupta ; Vishal Singh ; Pritish Kumar Varadwaj ; Navajeet Chakravartty ; A V S Krishna Mohan Katta ; Sivarama Prasad Lekkala ; George Thomas ; Srinivasan Narasimhan ; Arjula R. Reddy ; V B Reddy LachagariSource :
- Journal of biomolecular structure & dynamics [ 1538-0254 ] ; 2020.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for the current global pandemic that has caused a death toll of >1.12 million worldwide and number continues to climb in several countries. Currently, there are neither specific antiviral drugs nor vaccines for the treatment and prevention of COVID-19. We screened in silico, a group of natural spice and herbal secondary metabolites (SMs) for their inhibition efficacy against multiple target proteins of SARS-CoV-2 as well as the human angiotensin-converting enzyme 2 protein. Docking and simulation results indicated that epicatechin, embelin, hesperidin, cafestol, murrayanine and murrayaquinone-A have higher inhibition efficacy over at least one of the known antiviral drugs such as Hydroxychloroquine, Remdesivir and Ribavirin. Combination of these potentially effective SMs from their respective plant sources was analysed, and its absorption and acute oral toxicity were examined in Wistar rats and classified as category 5 as per the Globally Harmonized System. The identified SMs may be useful in the development of preventive nutraceuticals, food supplements and antiviral drugs. Communicated by Ramaswamy H. Sarma.
DOI: 10.1080/07391102.2020.1837679
PubMed: 33107812
PubMed Central: PMC7605658
Links to Exploration step
pubmed:33107812Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.</title>
<author><name sortKey="Gupta, Saurabh" sort="Gupta, Saurabh" uniqKey="Gupta S" first="Saurabh" last="Gupta">Saurabh Gupta</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Singh, Vishal" sort="Singh, Vishal" uniqKey="Singh V" first="Vishal" last="Singh">Vishal Singh</name>
<affiliation><nlm:affiliation>Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Varadwaj, Pritish Kumar" sort="Varadwaj, Pritish Kumar" uniqKey="Varadwaj P" first="Pritish Kumar" last="Varadwaj">Pritish Kumar Varadwaj</name>
<affiliation><nlm:affiliation>Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chakravartty, Navajeet" sort="Chakravartty, Navajeet" uniqKey="Chakravartty N" first="Navajeet" last="Chakravartty">Navajeet Chakravartty</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Katta, A V S Krishna Mohan" sort="Katta, A V S Krishna Mohan" uniqKey="Katta A" first="A V S Krishna Mohan" last="Katta">A V S Krishna Mohan Katta</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lekkala, Sivarama Prasad" sort="Lekkala, Sivarama Prasad" uniqKey="Lekkala S" first="Sivarama Prasad" last="Lekkala">Sivarama Prasad Lekkala</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Thomas, George" sort="Thomas, George" uniqKey="Thomas G" first="George" last="Thomas">George Thomas</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Kakkanad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Narasimhan, Srinivasan" sort="Narasimhan, Srinivasan" uniqKey="Narasimhan S" first="Srinivasan" last="Narasimhan">Srinivasan Narasimhan</name>
<affiliation><nlm:affiliation>Asthagiri Herbal Research Foundation, Chennai, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reddy, Arjula R" sort="Reddy, Arjula R" uniqKey="Reddy A" first="Arjula R" last="Reddy">Arjula R. Reddy</name>
<affiliation><nlm:affiliation>Department of Plant Sciences, University of Hyderabad, Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reddy Lachagari, V B" sort="Reddy Lachagari, V B" uniqKey="Reddy Lachagari V" first="V B" last="Reddy Lachagari">V B Reddy Lachagari</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:33107812</idno>
<idno type="pmid">33107812</idno>
<idno type="doi">10.1080/07391102.2020.1837679</idno>
<idno type="pmc">PMC7605658</idno>
<idno type="wicri:Area/Main/Corpus">000943</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000943</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.</title>
<author><name sortKey="Gupta, Saurabh" sort="Gupta, Saurabh" uniqKey="Gupta S" first="Saurabh" last="Gupta">Saurabh Gupta</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Singh, Vishal" sort="Singh, Vishal" uniqKey="Singh V" first="Vishal" last="Singh">Vishal Singh</name>
<affiliation><nlm:affiliation>Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Varadwaj, Pritish Kumar" sort="Varadwaj, Pritish Kumar" uniqKey="Varadwaj P" first="Pritish Kumar" last="Varadwaj">Pritish Kumar Varadwaj</name>
<affiliation><nlm:affiliation>Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chakravartty, Navajeet" sort="Chakravartty, Navajeet" uniqKey="Chakravartty N" first="Navajeet" last="Chakravartty">Navajeet Chakravartty</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Katta, A V S Krishna Mohan" sort="Katta, A V S Krishna Mohan" uniqKey="Katta A" first="A V S Krishna Mohan" last="Katta">A V S Krishna Mohan Katta</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lekkala, Sivarama Prasad" sort="Lekkala, Sivarama Prasad" uniqKey="Lekkala S" first="Sivarama Prasad" last="Lekkala">Sivarama Prasad Lekkala</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Thomas, George" sort="Thomas, George" uniqKey="Thomas G" first="George" last="Thomas">George Thomas</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Kakkanad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Narasimhan, Srinivasan" sort="Narasimhan, Srinivasan" uniqKey="Narasimhan S" first="Srinivasan" last="Narasimhan">Srinivasan Narasimhan</name>
<affiliation><nlm:affiliation>Asthagiri Herbal Research Foundation, Chennai, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reddy, Arjula R" sort="Reddy, Arjula R" uniqKey="Reddy A" first="Arjula R" last="Reddy">Arjula R. Reddy</name>
<affiliation><nlm:affiliation>Department of Plant Sciences, University of Hyderabad, Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reddy Lachagari, V B" sort="Reddy Lachagari, V B" uniqKey="Reddy Lachagari V" first="V B" last="Reddy Lachagari">V B Reddy Lachagari</name>
<affiliation><nlm:affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of biomolecular structure & dynamics</title>
<idno type="eISSN">1538-0254</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for the current global pandemic that has caused a death toll of >1.12 million worldwide and number continues to climb in several countries. Currently, there are neither specific antiviral drugs nor vaccines for the treatment and prevention of COVID-19. We screened <i>in silico</i>
, a group of natural spice and herbal secondary metabolites (SMs) for their inhibition efficacy against multiple target proteins of SARS-CoV-2 as well as the human angiotensin-converting enzyme 2 protein. Docking and simulation results indicated that epicatechin, embelin, hesperidin, cafestol, murrayanine and murrayaquinone-A have higher inhibition efficacy over at least one of the known antiviral drugs such as Hydroxychloroquine, Remdesivir and Ribavirin. Combination of these potentially effective SMs from their respective plant sources was analysed, and its absorption and acute oral toxicity were examined in Wistar rats and classified as category 5 as per the Globally Harmonized System. The identified SMs may be useful in the development of preventive nutraceuticals, food supplements and antiviral drugs. Communicated by Ramaswamy H. Sarma.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33107812</PMID>
<DateRevised><Year>2021</Year>
<Month>05</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-0254</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year>
<Month>Oct</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Journal of biomolecular structure & dynamics</Title>
<ISOAbbreviation>J Biomol Struct Dyn</ISOAbbreviation>
</Journal>
<ArticleTitle>Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins.</ArticleTitle>
<Pagination><MedlinePgn>1-20</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/07391102.2020.1837679</ELocationID>
<Abstract><AbstractText>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for the current global pandemic that has caused a death toll of >1.12 million worldwide and number continues to climb in several countries. Currently, there are neither specific antiviral drugs nor vaccines for the treatment and prevention of COVID-19. We screened <i>in silico</i>
, a group of natural spice and herbal secondary metabolites (SMs) for their inhibition efficacy against multiple target proteins of SARS-CoV-2 as well as the human angiotensin-converting enzyme 2 protein. Docking and simulation results indicated that epicatechin, embelin, hesperidin, cafestol, murrayanine and murrayaquinone-A have higher inhibition efficacy over at least one of the known antiviral drugs such as Hydroxychloroquine, Remdesivir and Ribavirin. Combination of these potentially effective SMs from their respective plant sources was analysed, and its absorption and acute oral toxicity were examined in Wistar rats and classified as category 5 as per the Globally Harmonized System. The identified SMs may be useful in the development of preventive nutraceuticals, food supplements and antiviral drugs. Communicated by Ramaswamy H. Sarma.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gupta</LastName>
<ForeName>Saurabh</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-1327-7389</Identifier>
<AffiliationInfo><Affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Singh</LastName>
<ForeName>Vishal</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Varadwaj</LastName>
<ForeName>Pritish Kumar</ForeName>
<Initials>PK</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-5706-2411</Identifier>
<AffiliationInfo><Affiliation>Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chakravartty</LastName>
<ForeName>Navajeet</ForeName>
<Initials>N</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-0663-0113</Identifier>
<AffiliationInfo><Affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Katta</LastName>
<ForeName>A V S Krishna Mohan</ForeName>
<Initials>AVSKM</Initials>
<AffiliationInfo><Affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lekkala</LastName>
<ForeName>Sivarama Prasad</ForeName>
<Initials>SP</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-4973-0659</Identifier>
<AffiliationInfo><Affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-1914-5923</Identifier>
<AffiliationInfo><Affiliation>AgriGenome Labs Pvt. Ltd., Kakkanad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Narasimhan</LastName>
<ForeName>Srinivasan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Asthagiri Herbal Research Foundation, Chennai, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reddy</LastName>
<ForeName>Arjula R</ForeName>
<Initials>AR</Initials>
<AffiliationInfo><Affiliation>Department of Plant Sciences, University of Hyderabad, Hyderabad, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reddy Lachagari</LastName>
<ForeName>V B</ForeName>
<Initials>VB</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-4708-7866</Identifier>
<AffiliationInfo><Affiliation>AgriGenome Labs Pvt. Ltd., Hyderabad, India.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>10</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Biomol Struct Dyn</MedlineTA>
<NlmUniqueID>8404176</NlmUniqueID>
<ISSNLinking>0739-1102</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anupama</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">docking and simulation</Keyword>
<Keyword MajorTopicYN="N">epicatechin</Keyword>
<Keyword MajorTopicYN="N">hesperidin</Keyword>
<Keyword MajorTopicYN="N">murrayanine</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>10</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>12</Hour>
<Minute>11</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">33107812</ArticleId>
<ArticleId IdType="doi">10.1080/07391102.2020.1837679</ArticleId>
<ArticleId IdType="pmc">PMC7605658</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nucleic Acids Res. 2012 Feb;40(4):1737-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22039154</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2017 Jun 26;13(6):e1006474</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28651017</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2003 Jan 29;51(3):571-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12537425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2020 Mar 27;11(1):1620</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32221306</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2015 Aug 27;10(8):e0136630</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26313938</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9436-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26159422</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2018 Dec 10;8(1):17823</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30531867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Protein Sci. 2020 Jul;29(7):1596-1605</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32304108</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2020 Jun 19;368(6497):1331-1335</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32321856</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Mar;579(7798):270-273</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32015507</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Pharm Sin B. 2020 May;10(5):766-788</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32292689</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2003 Apr 1;34(7):840-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12654472</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2020 Sep;92(9):1542-1548</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32181901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2020 Jun;20(6):350</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32286537</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Apr 30;382(18):1708-1720</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32109013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E162-E171</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29279395</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Adv Res. 2020 Mar 16;24:91-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32257431</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2020 Apr 16;181(2):281-292.e6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32155444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virol J. 2019 May 27;16(1):69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31133031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Pharm Sin B. 2020 Jul;10(7):1228-1238</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32363136</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Nov 28;503(7477):535-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24172901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2012 Dec;86(24):13598-608</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23035226</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Comput Struct Biotechnol J. 2020;18:2573-2582</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32983400</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2019 Sep 13;294(37):13606-13618</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31350335</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomed Res Int. 2020 May 30;2020:4389089</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32596311</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biomol Struct Dyn. 2015;33(11):2421-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25967133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Integr Med Res. 2020 Jun;9(2):100407</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32289016</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect. 2020 Jul;81(1):e24-e27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32283146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2020 Mar 17;94(7):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31996437</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Discov. 2020 May 2;6(1):28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33934117</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2017 Oct;510:165-174</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28738245</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 2004 Feb;12(2):341-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14962394</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Apr 29;8(4):e62416</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23658627</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2019 Jul 9;47(12):6538-6550</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31131400</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 Jun 13;300(5626):1763-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12746549</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cells. 2020 May 20;9(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32443810</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2020 Jun;92(6):584-588</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32083328</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2020 May 15;368(6492):779-782</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32277040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Apr;81(7):3151-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17202208</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oxid Med Cell Longev. 2015;2015:181260</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26180580</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Jul 31;9(7):e99782</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25080241</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes Metab Syndr. 2020 Jul - Aug;14(4):407-412</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32335367</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Evid Based Complement Alternat Med. 2019 Apr 2;2019:2676307</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31061668</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2011 May;7(5):e1002059</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21637813</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1824-1836</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32282022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Med Chem. 2008;15(10):997-1005</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18393857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2018 Aug 13;14(8):e1007236</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30102747</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2005 Dec;11(12):1860-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16485471</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1843-1844</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32159775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>iScience. 2020 Jul 24;23(7):101258</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32592996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Mar;579(7798):265-269</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32015508</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000943 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000943 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= CovidChloroV1 |flux= Main |étape= Corpus |type= RBID |clé= pubmed:33107812 |texte= Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:33107812" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a CovidChloroV1
![]() | This area was generated with Dilib version V0.6.38. | ![]() |