Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry.
Identifieur interne : 000865 ( Main/Corpus ); précédent : 000864; suivant : 000866Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry.
Auteurs : Iván J. Nú Ez-Gil ; Cristina Fernández-Pérez ; Vicente Estrada ; Víctor M. Becerra-Mu Oz ; Ibrahim El-Battrawy ; Aitor Uribarri ; Inmaculada Fernández-Rozas ; Gisela Feltes ; María C. Viana-Llamas ; Daniela Trabattoni ; Javier L Pez-País ; Martino Pepe ; Rodolfo Romero ; Alex F. Castro-Mejía ; Enrico Cerrato ; Thamar Capel Astrua ; Fabrizio D'Ascenzo ; Oscar Fabregat-Andres ; José Moreu ; Federico Guerra ; Jaime Signes-Costa ; Francisco Marín ; Danilo Buosenso ; Alfredo Bardají ; Sergio Raposeiras-Roubín ; Javier Elola ; Ángel Molino ; Juan J. G Mez-Doblas ; Mohammad Abumayyaleh ; Álvaro Aparisi ; María Molina ; Asunci N Guerri ; Ram N Arroyo-Espliguero ; Emilio Assanelli ; Massimo Mapelli ; José M. García-Acu A ; Gaetano Brindicci ; Edoardo Manzone ; María E. Ortega-Armas ; Matteo Bianco ; Chinh Pham Trung ; María José Nú Ez ; Carmen Castellanos-Lluch ; Elisa García-Vázquez ; Noemí Cabello-Clotet ; Karim Jamhour-Chelh ; María J. Tellez ; Antonio Fernández-Ortiz ; Carlos MacayaSource :
- Internal and emergency medicine [ 1970-9366 ] ; 2020.
Abstract
Recently the coronavirus disease (COVID-19) outbreak has been declared a pandemic. Despite its aggressive extension and significant morbidity and mortality, risk factors are poorly characterized outside China. We designed a registry, HOPE COVID-19 (NCT04334291), assessing data of 1021 patients discharged (dead or alive) after COVID-19, from 23 hospitals in 4 countries, between 8 February and 1 April. The primary end-point was all-cause mortality aiming to produce a mortality risk score calculator. The median age was 68 years (IQR 52-79), and 59.5% were male. Most frequent comorbidities were hypertension (46.8%) and dyslipidemia (35.8%). A relevant heart or lung disease were depicted in 20%. And renal, neurological, or oncological disease, respectively, were detected in nearly 10%. Most common symptoms were fever, cough, and dyspnea at admission. 311 patients died and 710 were discharged alive. In the death-multivariate analysis, raised as most relevant: age, hypertension, obesity, renal insufficiency, any immunosuppressive disease, 02 saturation < 92% and an elevated C reactive protein (AUC = 0.87; Hosmer-Lemeshow test, p > 0.999; bootstrap-optimist: 0.0018). We provide a simple clinical score to estimate probability of death, dividing patients in four grades (I-IV) of increasing probability. Hydroxychloroquine (79.2%) and antivirals (67.6%) were the specific drugs most commonly used. After a propensity score adjustment, the results suggested a slight improvement in mortality rates (adjusted-ORhydroxychloroquine 0.88; 95% CI 0.81-0.91, p = 0.005; adjusted-ORantiviral 0.94; 95% CI 0.87-1.01; p = 0.115). COVID-19 produces important mortality, mostly in patients with comorbidities with respiratory symptoms. Hydroxychloroquine could be associated with survival benefit, but this data need to be confirmed with further trials. Trial Registration: NCT04334291/EUPAS34399.
DOI: 10.1007/s11739-020-02543-5
PubMed: 33165755
PubMed Central: PMC7649104
Links to Exploration step
pubmed:33165755Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry.</title><author><name sortKey="Nu Ez Gil, Ivan J" sort="Nu Ez Gil, Ivan J" uniqKey="Nu Ez Gil I" first="Iván J" last="Nú Ez-Gil">Iván J. Nú Ez-Gil</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain. ibnsky@yahoo.es.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Perez, Cristina" sort="Fernandez Perez, Cristina" uniqKey="Fernandez Perez C" first="Cristina" last="Fernández-Pérez">Cristina Fernández-Pérez</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Estrada, Vicente" sort="Estrada, Vicente" uniqKey="Estrada V" first="Vicente" last="Estrada">Vicente Estrada</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becerra Mu Oz, Victor M" sort="Becerra Mu Oz, Victor M" uniqKey="Becerra Mu Oz V" first="Víctor M" last="Becerra-Mu Oz">Víctor M. Becerra-Mu Oz</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="El Battrawy, Ibrahim" sort="El Battrawy, Ibrahim" uniqKey="El Battrawy I" first="Ibrahim" last="El-Battrawy">Ibrahim El-Battrawy</name><affiliation><nlm:affiliation>University Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Uribarri, Aitor" sort="Uribarri, Aitor" uniqKey="Uribarri A" first="Aitor" last="Uribarri">Aitor Uribarri</name><affiliation><nlm:affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rozas, Inmaculada" sort="Fernandez Rozas, Inmaculada" uniqKey="Fernandez Rozas I" first="Inmaculada" last="Fernández-Rozas">Inmaculada Fernández-Rozas</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Feltes, Gisela" sort="Feltes, Gisela" uniqKey="Feltes G" first="Gisela" last="Feltes">Gisela Feltes</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Viana Llamas, Maria C" sort="Viana Llamas, Maria C" uniqKey="Viana Llamas M" first="María C" last="Viana-Llamas">María C. Viana-Llamas</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Trabattoni, Daniela" sort="Trabattoni, Daniela" uniqKey="Trabattoni D" first="Daniela" last="Trabattoni">Daniela Trabattoni</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Pais, Javier" sort="L Pez Pais, Javier" uniqKey="L Pez Pais J" first="Javier" last="L Pez-País">Javier L Pez-País</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pepe, Martino" sort="Pepe, Martino" uniqKey="Pepe M" first="Martino" last="Pepe">Martino Pepe</name><affiliation><nlm:affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Romero, Rodolfo" sort="Romero, Rodolfo" uniqKey="Romero R" first="Rodolfo" last="Romero">Rodolfo Romero</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Castro Mejia, Alex F" sort="Castro Mejia, Alex F" uniqKey="Castro Mejia A" first="Alex F" last="Castro-Mejía">Alex F. Castro-Mejía</name><affiliation><nlm:affiliation>Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</nlm:affiliation></affiliation></author><author><name sortKey="Cerrato, Enrico" sort="Cerrato, Enrico" uniqKey="Cerrato E" first="Enrico" last="Cerrato">Enrico Cerrato</name><affiliation><nlm:affiliation>Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Rivoli Infermi Hospital, Rivoli, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Astrua, Thamar Capel" sort="Astrua, Thamar Capel" uniqKey="Astrua T" first="Thamar Capel" last="Astrua">Thamar Capel Astrua</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="D Ascenzo, Fabrizio" sort="D Ascenzo, Fabrizio" uniqKey="D Ascenzo F" first="Fabrizio" last="D'Ascenzo">Fabrizio D'Ascenzo</name><affiliation><nlm:affiliation>San Giovanni Battista, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat Andres, Oscar" sort="Fabregat Andres, Oscar" uniqKey="Fabregat Andres O" first="Oscar" last="Fabregat-Andres">Oscar Fabregat-Andres</name><affiliation><nlm:affiliation>Hospital IMED, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Moreu, Jose" sort="Moreu, Jose" uniqKey="Moreu J" first="José" last="Moreu">José Moreu</name><affiliation><nlm:affiliation>Complejo hospitalario de Toledo, Toledo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Guerra, Federico" sort="Guerra, Federico" uniqKey="Guerra F" first="Federico" last="Guerra">Federico Guerra</name><affiliation><nlm:affiliation>Cardiology and Arrhythmology Clinic, Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Signes Costa, Jaime" sort="Signes Costa, Jaime" uniqKey="Signes Costa J" first="Jaime" last="Signes-Costa">Jaime Signes-Costa</name><affiliation><nlm:affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marin, Francisco" sort="Marin, Francisco" uniqKey="Marin F" first="Francisco" last="Marín">Francisco Marín</name><affiliation><nlm:affiliation>Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Buosenso, Danilo" sort="Buosenso, Danilo" uniqKey="Buosenso D" first="Danilo" last="Buosenso">Danilo Buosenso</name><affiliation><nlm:affiliation>Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bardaji, Alfredo" sort="Bardaji, Alfredo" uniqKey="Bardaji A" first="Alfredo" last="Bardají">Alfredo Bardají</name><affiliation><nlm:affiliation>University Hospital Joan XXIII, Tarragona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Raposeiras Roubin, Sergio" sort="Raposeiras Roubin, Sergio" uniqKey="Raposeiras Roubin S" first="Sergio" last="Raposeiras-Roubín">Sergio Raposeiras-Roubín</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elola, Javier" sort="Elola, Javier" uniqKey="Elola J" first="Javier" last="Elola">Javier Elola</name><affiliation><nlm:affiliation>Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Molino, Angel" sort="Molino, Angel" uniqKey="Molino A" first="Ángel" last="Molino">Ángel Molino</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="G Mez Doblas, Juan J" sort="G Mez Doblas, Juan J" uniqKey="G Mez Doblas J" first="Juan J" last="G Mez-Doblas">Juan J. G Mez-Doblas</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Abumayyaleh, Mohammad" sort="Abumayyaleh, Mohammad" uniqKey="Abumayyaleh M" first="Mohammad" last="Abumayyaleh">Mohammad Abumayyaleh</name><affiliation><nlm:affiliation>University Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aparisi, Alvaro" sort="Aparisi, Alvaro" uniqKey="Aparisi A" first="Álvaro" last="Aparisi">Álvaro Aparisi</name><affiliation><nlm:affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Guerri, Asunci N" sort="Guerri, Asunci N" uniqKey="Guerri A" first="Asunci N" last="Guerri">Asunci N Guerri</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Arroyo Espliguero, Ram N" sort="Arroyo Espliguero, Ram N" uniqKey="Arroyo Espliguero R" first="Ram N" last="Arroyo-Espliguero">Ram N Arroyo-Espliguero</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Assanelli, Emilio" sort="Assanelli, Emilio" uniqKey="Assanelli E" first="Emilio" last="Assanelli">Emilio Assanelli</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Mapelli, Massimo" sort="Mapelli, Massimo" uniqKey="Mapelli M" first="Massimo" last="Mapelli">Massimo Mapelli</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Acu A, Jose M" sort="Garcia Acu A, Jose M" uniqKey="Garcia Acu A J" first="José M" last="García-Acu A">José M. García-Acu A</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Brindicci, Gaetano" sort="Brindicci, Gaetano" uniqKey="Brindicci G" first="Gaetano" last="Brindicci">Gaetano Brindicci</name><affiliation><nlm:affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Manzone, Edoardo" sort="Manzone, Edoardo" uniqKey="Manzone E" first="Edoardo" last="Manzone">Edoardo Manzone</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ortega Armas, Maria E" sort="Ortega Armas, Maria E" uniqKey="Ortega Armas M" first="María E" last="Ortega-Armas">María E. Ortega-Armas</name><affiliation><nlm:affiliation>Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</nlm:affiliation></affiliation></author><author><name sortKey="Bianco, Matteo" sort="Bianco, Matteo" uniqKey="Bianco M" first="Matteo" last="Bianco">Matteo Bianco</name><affiliation><nlm:affiliation>Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Trung, Chinh Pham" sort="Trung, Chinh Pham" uniqKey="Trung C" first="Chinh Pham" last="Trung">Chinh Pham Trung</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Nu Ez, Maria Jose" sort="Nu Ez, Maria Jose" uniqKey="Nu Ez M" first="María José" last="Nú Ez">María José Nú Ez</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Castellanos Lluch, Carmen" sort="Castellanos Lluch, Carmen" uniqKey="Castellanos Lluch C" first="Carmen" last="Castellanos-Lluch">Carmen Castellanos-Lluch</name><affiliation><nlm:affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Vazquez, Elisa" sort="Garcia Vazquez, Elisa" uniqKey="Garcia Vazquez E" first="Elisa" last="García-Vázquez">Elisa García-Vázquez</name><affiliation><nlm:affiliation>Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cabello Clotet, Noemi" sort="Cabello Clotet, Noemi" uniqKey="Cabello Clotet N" first="Noemí" last="Cabello-Clotet">Noemí Cabello-Clotet</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Jamhour Chelh, Karim" sort="Jamhour Chelh, Karim" uniqKey="Jamhour Chelh K" first="Karim" last="Jamhour-Chelh">Karim Jamhour-Chelh</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tellez, Maria J" sort="Tellez, Maria J" uniqKey="Tellez M" first="María J" last="Tellez">María J. Tellez</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ortiz, Antonio" sort="Fernandez Ortiz, Antonio" uniqKey="Fernandez Ortiz A" first="Antonio" last="Fernández-Ortiz">Antonio Fernández-Ortiz</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33165755</idno><idno type="pmid">33165755</idno><idno type="doi">10.1007/s11739-020-02543-5</idno><idno type="pmc">PMC7649104</idno><idno type="wicri:Area/Main/Corpus">000865</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000865</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry.</title><author><name sortKey="Nu Ez Gil, Ivan J" sort="Nu Ez Gil, Ivan J" uniqKey="Nu Ez Gil I" first="Iván J" last="Nú Ez-Gil">Iván J. Nú Ez-Gil</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain. ibnsky@yahoo.es.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Perez, Cristina" sort="Fernandez Perez, Cristina" uniqKey="Fernandez Perez C" first="Cristina" last="Fernández-Pérez">Cristina Fernández-Pérez</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Estrada, Vicente" sort="Estrada, Vicente" uniqKey="Estrada V" first="Vicente" last="Estrada">Vicente Estrada</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becerra Mu Oz, Victor M" sort="Becerra Mu Oz, Victor M" uniqKey="Becerra Mu Oz V" first="Víctor M" last="Becerra-Mu Oz">Víctor M. Becerra-Mu Oz</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="El Battrawy, Ibrahim" sort="El Battrawy, Ibrahim" uniqKey="El Battrawy I" first="Ibrahim" last="El-Battrawy">Ibrahim El-Battrawy</name><affiliation><nlm:affiliation>University Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Uribarri, Aitor" sort="Uribarri, Aitor" uniqKey="Uribarri A" first="Aitor" last="Uribarri">Aitor Uribarri</name><affiliation><nlm:affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rozas, Inmaculada" sort="Fernandez Rozas, Inmaculada" uniqKey="Fernandez Rozas I" first="Inmaculada" last="Fernández-Rozas">Inmaculada Fernández-Rozas</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Feltes, Gisela" sort="Feltes, Gisela" uniqKey="Feltes G" first="Gisela" last="Feltes">Gisela Feltes</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Viana Llamas, Maria C" sort="Viana Llamas, Maria C" uniqKey="Viana Llamas M" first="María C" last="Viana-Llamas">María C. Viana-Llamas</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Trabattoni, Daniela" sort="Trabattoni, Daniela" uniqKey="Trabattoni D" first="Daniela" last="Trabattoni">Daniela Trabattoni</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Pais, Javier" sort="L Pez Pais, Javier" uniqKey="L Pez Pais J" first="Javier" last="L Pez-País">Javier L Pez-País</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pepe, Martino" sort="Pepe, Martino" uniqKey="Pepe M" first="Martino" last="Pepe">Martino Pepe</name><affiliation><nlm:affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Romero, Rodolfo" sort="Romero, Rodolfo" uniqKey="Romero R" first="Rodolfo" last="Romero">Rodolfo Romero</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Castro Mejia, Alex F" sort="Castro Mejia, Alex F" uniqKey="Castro Mejia A" first="Alex F" last="Castro-Mejía">Alex F. Castro-Mejía</name><affiliation><nlm:affiliation>Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</nlm:affiliation></affiliation></author><author><name sortKey="Cerrato, Enrico" sort="Cerrato, Enrico" uniqKey="Cerrato E" first="Enrico" last="Cerrato">Enrico Cerrato</name><affiliation><nlm:affiliation>Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Rivoli Infermi Hospital, Rivoli, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Astrua, Thamar Capel" sort="Astrua, Thamar Capel" uniqKey="Astrua T" first="Thamar Capel" last="Astrua">Thamar Capel Astrua</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="D Ascenzo, Fabrizio" sort="D Ascenzo, Fabrizio" uniqKey="D Ascenzo F" first="Fabrizio" last="D'Ascenzo">Fabrizio D'Ascenzo</name><affiliation><nlm:affiliation>San Giovanni Battista, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat Andres, Oscar" sort="Fabregat Andres, Oscar" uniqKey="Fabregat Andres O" first="Oscar" last="Fabregat-Andres">Oscar Fabregat-Andres</name><affiliation><nlm:affiliation>Hospital IMED, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Moreu, Jose" sort="Moreu, Jose" uniqKey="Moreu J" first="José" last="Moreu">José Moreu</name><affiliation><nlm:affiliation>Complejo hospitalario de Toledo, Toledo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Guerra, Federico" sort="Guerra, Federico" uniqKey="Guerra F" first="Federico" last="Guerra">Federico Guerra</name><affiliation><nlm:affiliation>Cardiology and Arrhythmology Clinic, Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Signes Costa, Jaime" sort="Signes Costa, Jaime" uniqKey="Signes Costa J" first="Jaime" last="Signes-Costa">Jaime Signes-Costa</name><affiliation><nlm:affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marin, Francisco" sort="Marin, Francisco" uniqKey="Marin F" first="Francisco" last="Marín">Francisco Marín</name><affiliation><nlm:affiliation>Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Buosenso, Danilo" sort="Buosenso, Danilo" uniqKey="Buosenso D" first="Danilo" last="Buosenso">Danilo Buosenso</name><affiliation><nlm:affiliation>Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bardaji, Alfredo" sort="Bardaji, Alfredo" uniqKey="Bardaji A" first="Alfredo" last="Bardají">Alfredo Bardají</name><affiliation><nlm:affiliation>University Hospital Joan XXIII, Tarragona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Raposeiras Roubin, Sergio" sort="Raposeiras Roubin, Sergio" uniqKey="Raposeiras Roubin S" first="Sergio" last="Raposeiras-Roubín">Sergio Raposeiras-Roubín</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elola, Javier" sort="Elola, Javier" uniqKey="Elola J" first="Javier" last="Elola">Javier Elola</name><affiliation><nlm:affiliation>Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Molino, Angel" sort="Molino, Angel" uniqKey="Molino A" first="Ángel" last="Molino">Ángel Molino</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="G Mez Doblas, Juan J" sort="G Mez Doblas, Juan J" uniqKey="G Mez Doblas J" first="Juan J" last="G Mez-Doblas">Juan J. G Mez-Doblas</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Abumayyaleh, Mohammad" sort="Abumayyaleh, Mohammad" uniqKey="Abumayyaleh M" first="Mohammad" last="Abumayyaleh">Mohammad Abumayyaleh</name><affiliation><nlm:affiliation>University Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aparisi, Alvaro" sort="Aparisi, Alvaro" uniqKey="Aparisi A" first="Álvaro" last="Aparisi">Álvaro Aparisi</name><affiliation><nlm:affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Guerri, Asunci N" sort="Guerri, Asunci N" uniqKey="Guerri A" first="Asunci N" last="Guerri">Asunci N Guerri</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Arroyo Espliguero, Ram N" sort="Arroyo Espliguero, Ram N" uniqKey="Arroyo Espliguero R" first="Ram N" last="Arroyo-Espliguero">Ram N Arroyo-Espliguero</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Assanelli, Emilio" sort="Assanelli, Emilio" uniqKey="Assanelli E" first="Emilio" last="Assanelli">Emilio Assanelli</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Mapelli, Massimo" sort="Mapelli, Massimo" uniqKey="Mapelli M" first="Massimo" last="Mapelli">Massimo Mapelli</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Acu A, Jose M" sort="Garcia Acu A, Jose M" uniqKey="Garcia Acu A J" first="José M" last="García-Acu A">José M. García-Acu A</name><affiliation><nlm:affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Brindicci, Gaetano" sort="Brindicci, Gaetano" uniqKey="Brindicci G" first="Gaetano" last="Brindicci">Gaetano Brindicci</name><affiliation><nlm:affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Manzone, Edoardo" sort="Manzone, Edoardo" uniqKey="Manzone E" first="Edoardo" last="Manzone">Edoardo Manzone</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ortega Armas, Maria E" sort="Ortega Armas, Maria E" uniqKey="Ortega Armas M" first="María E" last="Ortega-Armas">María E. Ortega-Armas</name><affiliation><nlm:affiliation>Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</nlm:affiliation></affiliation></author><author><name sortKey="Bianco, Matteo" sort="Bianco, Matteo" uniqKey="Bianco M" first="Matteo" last="Bianco">Matteo Bianco</name><affiliation><nlm:affiliation>Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Trung, Chinh Pham" sort="Trung, Chinh Pham" uniqKey="Trung C" first="Chinh Pham" last="Trung">Chinh Pham Trung</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Nu Ez, Maria Jose" sort="Nu Ez, Maria Jose" uniqKey="Nu Ez M" first="María José" last="Nú Ez">María José Nú Ez</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Castellanos Lluch, Carmen" sort="Castellanos Lluch, Carmen" uniqKey="Castellanos Lluch C" first="Carmen" last="Castellanos-Lluch">Carmen Castellanos-Lluch</name><affiliation><nlm:affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Vazquez, Elisa" sort="Garcia Vazquez, Elisa" uniqKey="Garcia Vazquez E" first="Elisa" last="García-Vázquez">Elisa García-Vázquez</name><affiliation><nlm:affiliation>Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cabello Clotet, Noemi" sort="Cabello Clotet, Noemi" uniqKey="Cabello Clotet N" first="Noemí" last="Cabello-Clotet">Noemí Cabello-Clotet</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Jamhour Chelh, Karim" sort="Jamhour Chelh, Karim" uniqKey="Jamhour Chelh K" first="Karim" last="Jamhour-Chelh">Karim Jamhour-Chelh</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tellez, Maria J" sort="Tellez, Maria J" uniqKey="Tellez M" first="María J" last="Tellez">María J. Tellez</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ortiz, Antonio" sort="Fernandez Ortiz, Antonio" uniqKey="Fernandez Ortiz A" first="Antonio" last="Fernández-Ortiz">Antonio Fernández-Ortiz</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation><nlm:affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Internal and emergency medicine</title><idno type="eISSN">1970-9366</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently the coronavirus disease (COVID-19) outbreak has been declared a pandemic. Despite its aggressive extension and significant morbidity and mortality, risk factors are poorly characterized outside China. We designed a registry, HOPE COVID-19 (NCT04334291), assessing data of 1021 patients discharged (dead or alive) after COVID-19, from 23 hospitals in 4 countries, between 8 February and 1 April. The primary end-point was all-cause mortality aiming to produce a mortality risk score calculator. The median age was 68 years (IQR 52-79), and 59.5% were male. Most frequent comorbidities were hypertension (46.8%) and dyslipidemia (35.8%). A relevant heart or lung disease were depicted in 20%. And renal, neurological, or oncological disease, respectively, were detected in nearly 10%. Most common symptoms were fever, cough, and dyspnea at admission. 311 patients died and 710 were discharged alive. In the death-multivariate analysis, raised as most relevant: age, hypertension, obesity, renal insufficiency, any immunosuppressive disease, 02 saturation < 92% and an elevated C reactive protein (AUC = 0.87; Hosmer-Lemeshow test, p > 0.999; bootstrap-optimist: 0.0018). We provide a simple clinical score to estimate probability of death, dividing patients in four grades (I-IV) of increasing probability. Hydroxychloroquine (79.2%) and antivirals (67.6%) were the specific drugs most commonly used. After a propensity score adjustment, the results suggested a slight improvement in mortality rates (adjusted-OR<sub>hydroxychloroquine</sub> 0.88; 95% CI 0.81-0.91, p = 0.005; adjusted-OR<sub>antiviral</sub> 0.94; 95% CI 0.87-1.01; p = 0.115). COVID-19 produces important mortality, mostly in patients with comorbidities with respiratory symptoms. Hydroxychloroquine could be associated with survival benefit, but this data need to be confirmed with further trials. Trial Registration: NCT04334291/EUPAS34399.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33165755</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1970-9366</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Nov</Month><Day>09</Day></PubDate></JournalIssue><Title>Internal and emergency medicine</Title><ISOAbbreviation>Intern Emerg Med</ISOAbbreviation></Journal><ArticleTitle>Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11739-020-02543-5</ELocationID><Abstract><AbstractText>Recently the coronavirus disease (COVID-19) outbreak has been declared a pandemic. Despite its aggressive extension and significant morbidity and mortality, risk factors are poorly characterized outside China. We designed a registry, HOPE COVID-19 (NCT04334291), assessing data of 1021 patients discharged (dead or alive) after COVID-19, from 23 hospitals in 4 countries, between 8 February and 1 April. The primary end-point was all-cause mortality aiming to produce a mortality risk score calculator. The median age was 68 years (IQR 52-79), and 59.5% were male. Most frequent comorbidities were hypertension (46.8%) and dyslipidemia (35.8%). A relevant heart or lung disease were depicted in 20%. And renal, neurological, or oncological disease, respectively, were detected in nearly 10%. Most common symptoms were fever, cough, and dyspnea at admission. 311 patients died and 710 were discharged alive. In the death-multivariate analysis, raised as most relevant: age, hypertension, obesity, renal insufficiency, any immunosuppressive disease, 02 saturation < 92% and an elevated C reactive protein (AUC = 0.87; Hosmer-Lemeshow test, p > 0.999; bootstrap-optimist: 0.0018). We provide a simple clinical score to estimate probability of death, dividing patients in four grades (I-IV) of increasing probability. Hydroxychloroquine (79.2%) and antivirals (67.6%) were the specific drugs most commonly used. After a propensity score adjustment, the results suggested a slight improvement in mortality rates (adjusted-OR<sub>hydroxychloroquine</sub> 0.88; 95% CI 0.81-0.91, p = 0.005; adjusted-OR<sub>antiviral</sub> 0.94; 95% CI 0.87-1.01; p = 0.115). COVID-19 produces important mortality, mostly in patients with comorbidities with respiratory symptoms. Hydroxychloroquine could be associated with survival benefit, but this data need to be confirmed with further trials. Trial Registration: NCT04334291/EUPAS34399.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Núñez-Gil</LastName><ForeName>Iván J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain. ibnsky@yahoo.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Pérez</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Estrada</LastName><ForeName>Vicente</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becerra-Muñoz</LastName><ForeName>Víctor M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Battrawy</LastName><ForeName>Ibrahim</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>University Mannheim, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uribarri</LastName><ForeName>Aitor</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Rozas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Hospital Severo Ochoa, Leganés, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feltes</LastName><ForeName>Gisela</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viana-Llamas</LastName><ForeName>María C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trabattoni</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-País</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pepe</LastName><ForeName>Martino</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>Rodolfo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hospital Universitario Getafe, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castro-Mejía</LastName><ForeName>Alex F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerrato</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Rivoli Infermi Hospital, Rivoli, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Astrua</LastName><ForeName>Thamar Capel</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Hospital Virgen del Mar, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Ascenzo</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>San Giovanni Battista, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fabregat-Andres</LastName><ForeName>Oscar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Hospital IMED, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreu</LastName><ForeName>José</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Complejo hospitalario de Toledo, Toledo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerra</LastName><ForeName>Federico</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Cardiology and Arrhythmology Clinic, Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Signes-Costa</LastName><ForeName>Jaime</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marín</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buosenso</LastName><ForeName>Danilo</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bardají</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University Hospital Joan XXIII, Tarragona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raposeiras-Roubín</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elola</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fundación Instituto para la Mejora de la Asistencia Sanitaria (IMAS), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molino</LastName><ForeName>Ángel</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Doblas</LastName><ForeName>Juan J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de La Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abumayyaleh</LastName><ForeName>Mohammad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University Mannheim, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aparisi</LastName><ForeName>Álvaro</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molina</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital Severo Ochoa, Leganés, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerri</LastName><ForeName>Asunción</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Nuestra Señora de América, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arroyo-Espliguero</LastName><ForeName>Ramón</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assanelli</LastName><ForeName>Emilio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mapelli</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centro Cardiologico Monzino, IRCCS, Milan, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Acuña</LastName><ForeName>José M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brindicci</LastName><ForeName>Gaetano</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Azienda Ospedaliero-Universitaria Consorziale Policlinico Di Bari, Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manzone</LastName><ForeName>Edoardo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Hospital Universitario Getafe, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ortega-Armas</LastName><ForeName>María E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Hospital General del Norte de Guayaquil IESS Los Ceibos, Guayaquil, Ecuador.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bianco</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cardiology Division, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trung</LastName><ForeName>Chinh Pham</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Hospital Virgen del Mar, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Núñez</LastName><ForeName>María José</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castellanos-Lluch</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Vázquez</LastName><ForeName>Elisa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Hospital Clinico Universitario Virgen de la Arreixaca, Murcia, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IMIB-Arreixaca, Universidad de Murcia, Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cabello-Clotet</LastName><ForeName>Noemí</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamhour-Chelh</LastName><ForeName>Karim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University Hospital Álvaro Cunqueiro, Vigo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tellez</LastName><ForeName>María J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Ortiz</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macaya</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Prof Martin Lagos St., 28040, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>HOPE COVID-19 Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT04334291</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Intern Emerg Med</MedlineTA><NlmUniqueID>101263418</NlmUniqueID><ISSNLinking>1828-0447</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Mortality</Keyword><Keyword MajorTopicYN="N">Prognosis</Keyword><Keyword MajorTopicYN="N">Registry</Keyword><Keyword MajorTopicYN="N">Score</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>9</Day><Hour>14</Hour><Minute>27</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33165755</ArticleId><ArticleId IdType="doi">10.1007/s11739-020-02543-5</ArticleId><ArticleId IdType="pii">10.1007/s11739-020-02543-5</ArticleId><ArticleId IdType="pmc">PMC7649104</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>JAMA. 2020 Apr 7;323(13):1239-1242</Citation><ArticleIdList><ArticleId IdType="pubmed">32091533</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation><ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId></ArticleIdList></Reference><Reference><Citation>Zhonghua Bing Li Xue Za Zhi. 2020 May 8;49(5):411-417</Citation><ArticleIdList><ArticleId IdType="pubmed">32172546</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation><ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Apr 30;382(18):1708-1720</Citation><ArticleIdList><ArticleId IdType="pubmed">32109013</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation><ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Nephrol. 2011 Oct 18;7(12):718-29</Citation><ArticleIdList><ArticleId IdType="pubmed">22009248</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2010 Feb 05;6(2):e1000756</Citation><ArticleIdList><ArticleId IdType="pubmed">20140198</ArticleId></ArticleIdList></Reference><Reference><Citation>Kidney Int. 2020 May;97(5):829-838</Citation><ArticleIdList><ArticleId IdType="pubmed">32247631</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2009 Nov 4;302(17):1896-902</Citation><ArticleIdList><ArticleId IdType="pubmed">19887665</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Clin Invest. 2009 Jul;39(7):618-25</Citation><ArticleIdList><ArticleId IdType="pubmed">19453650</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2020 May;20(5):533-534</Citation><ArticleIdList><ArticleId IdType="pubmed">32087114</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Cardiol. 2020 Jul 1;5(7):802-810</Citation><ArticleIdList><ArticleId IdType="pubmed">32211816</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 12;323(18):1775-1776</Citation><ArticleIdList><ArticleId IdType="pubmed">32203977</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation><ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId></ArticleIdList></Reference><Reference><Citation>Circulation. 2015 Jan 13;131(2):211-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25561516</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Infect Dis. 2020 May;94:91-95</Citation><ArticleIdList><ArticleId IdType="pubmed">32173574</ArticleId></ArticleIdList></Reference><Reference><Citation>J Crit Care. 2020 Jun;57:279-283</Citation><ArticleIdList><ArticleId IdType="pubmed">32173110</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 28;395(10229):1033-1034</Citation><ArticleIdList><ArticleId IdType="pubmed">32192578</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Med. 2014 Apr 10;12:61</Citation><ArticleIdList><ArticleId IdType="pubmed">24722122</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Apr 4;395(10230):1111</Citation><ArticleIdList><ArticleId IdType="pubmed">32220278</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Res Cardiol. 2020 May;109(5):531-538</Citation><ArticleIdList><ArticleId IdType="pubmed">32161990</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Acad Emerg Med. 2020 Mar 24;8(1):e35</Citation><ArticleIdList><ArticleId IdType="pubmed">32232218</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 21;395(10228):e52</Citation><ArticleIdList><ArticleId IdType="pubmed">32171074</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2016 Apr 2;387(10026):1377-1396</Citation><ArticleIdList><ArticleId IdType="pubmed">27115820</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000865 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000865 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:33165755
|texte= Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:33165755" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |