Comparison of clinical and laboratory features and treatment options of 237 Comparison of clinical and laboratory features and treatment options of 237 symptomatic and asymptomatic children infected with SARS-CoV-2 in the early phase of the COVID-19 pandemic in Turkey.
Identifieur interne : 000754 ( Main/Corpus ); précédent : 000753; suivant : 000755Comparison of clinical and laboratory features and treatment options of 237 Comparison of clinical and laboratory features and treatment options of 237 symptomatic and asymptomatic children infected with SARS-CoV-2 in the early phase of the COVID-19 pandemic in Turkey.
Auteurs : Ahmet Soysal ; Erdem Gönüllü ; Hüseyin Arslan ; Bü Ra Sultan Kibar ; Serdar Pop ; Gözde Nur Yurtta ; Hacer Demirbacak ; Füsun Ünal ; Sedat Öktem ; Serkan At C ; Arife Derda Yücel En ; Nalan Karabay R ; Metin Karaböcüo LuSource :
- Japanese journal of infectious diseases [ 1884-2836 ] ; 2020.
Abstract
Since the first report of COVID-19 in December 2019, little is known about therapeutic usage of hydroxychloroquine in pediatric patients with COVID-19. We retrospectively retrieved data for SARS-CoV-2 PCR positive pediatric patients from 20 hospitals in 8 different cities in Turkey. We obtained patients' epidemiological, clinical, laboratory features and drugs used for treatment of COVID-19. 237 nasopharyngeal swab SARS-CoV-2 PCR positive children were included into the study from March 26 to June 20, 2020. The mean age of asymptomatic children (118±62 months) was found to be higher than that of symptomatic children (89±69 months). Symptomatic children had a significantly lower mean lymphocyte count and higher mean CRP, D-dimer value, procalcitonin and LDH than asymptomatic children in univariate analysis. Out of 156 children, 78 (50%) children received Hydroxychloroquine-containing regimen, 15 of them were treated with hydroxychloroquine + azithromycin + oseltamivir, 44 were treated with hydroxychloroquine + azithromycin and 21 were only treated with hydroxychloroquine. Among the 156 patients who received medical treatment, 90 (58%) patients had pre and/or post-treatment ECG performed upon them. However, none of them either reported ECG abnormalities or a need for discontinuation of hydroxychloroquine because of adverse drug reaction.
DOI: 10.7883/yoken.JJID.2020.781
PubMed: 33250495
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sortKey="Arslan, Huseyin" sort="Arslan, Huseyin" uniqKey="Arslan H" first="Hüseyin" last="Arslan">Hüseyin Arslan</name><affiliation><nlm:affiliation>Department of Pediatrics, Medipol University, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Kibar, Bu Ra Sultan" sort="Kibar, Bu Ra Sultan" uniqKey="Kibar B" first="Bü Ra Sultan" last="Kibar">Bü Ra Sultan Kibar</name><affiliation><nlm:affiliation>Yalova State Hospital, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Pop, Serdar" sort="Pop, Serdar" uniqKey="Pop S" first="Serdar" last="Pop">Serdar Pop</name><affiliation><nlm:affiliation>Erbaa State Hospital, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Yurtta, Gozde Nur" sort="Yurtta, Gozde Nur" uniqKey="Yurtta G" first="Gözde Nur" last="Yurtta">Gözde Nur Yurtta</name><affiliation><nlm:affiliation>Tokat State Hospital, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Demirbacak, Hacer" sort="Demirbacak, Hacer" uniqKey="Demirbacak H" first="Hacer" last="Demirbacak">Hacer Demirbacak</name><affiliation><nlm:affiliation>Yalova State Hospital, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Unal, Fusun" sort="Unal, Fusun" uniqKey="Unal F" first="Füsun" last="Ünal">Füsun Ünal</name><affiliation><nlm:affiliation>Department of Pediatrics, Medipol University, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Oktem, Sedat" sort="Oktem, Sedat" uniqKey="Oktem S" first="Sedat" last="Öktem">Sedat Öktem</name><affiliation><nlm:affiliation>Department of Pediatrics, Medipol University, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="At C, Serkan" sort="At C, Serkan" uniqKey="At C S" first="Serkan" last="At C">Serkan At C</name><affiliation><nlm:affiliation>Division of Pediatric Infectious Diseases, Okan University Hospital, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey=" En, Arife Derda Yucel" sort=" En, Arife Derda Yucel" uniqKey=" En A" first="Arife Derda Yücel" last=" En">Arife Derda Yücel En</name><affiliation><nlm:affiliation>Yalova State Hospital, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Karabay R, Nalan" sort="Karabay R, Nalan" uniqKey="Karabay R N" first="Nalan" last="Karabay R">Nalan Karabay R</name><affiliation><nlm:affiliation>Department of Pediatrics, Medipol University, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Karabocuo Lu, Metin" sort="Karabocuo Lu, Metin" uniqKey="Karabocuo Lu M" first="Metin" last="Karaböcüo Lu">Metin Karaböcüo Lu</name><affiliation><nlm:affiliation>Division of Pediatric Infectious Diseases, Memorial Ataşehir Hospital, Turkey.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Japanese journal of infectious diseases</title><idno type="eISSN">1884-2836</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since the first report of COVID-19 in December 2019, little is known about therapeutic usage of hydroxychloroquine in pediatric patients with COVID-19. We retrospectively retrieved data for SARS-CoV-2 PCR positive pediatric patients from 20 hospitals in 8 different cities in Turkey. We obtained patients' epidemiological, clinical, laboratory features and drugs used for treatment of COVID-19. 237 nasopharyngeal swab SARS-CoV-2 PCR positive children were included into the study from March 26 to June 20, 2020. The mean age of asymptomatic children (118±62 months) was found to be higher than that of symptomatic children (89±69 months). Symptomatic children had a significantly lower mean lymphocyte count and higher mean CRP, D-dimer value, procalcitonin and LDH than asymptomatic children in univariate analysis. Out of 156 children, 78 (50%) children received Hydroxychloroquine-containing regimen, 15 of them were treated with hydroxychloroquine + azithromycin + oseltamivir, 44 were treated with hydroxychloroquine + azithromycin and 21 were only treated with hydroxychloroquine. Among the 156 patients who received medical treatment, 90 (58%) patients had pre and/or post-treatment ECG performed upon them. However, none of them either reported ECG abnormalities or a need for discontinuation of hydroxychloroquine because of adverse drug reaction.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33250495</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1884-2836</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Nov</Month><Day>30</Day></PubDate></JournalIssue><Title>Japanese journal of infectious diseases</Title><ISOAbbreviation>Jpn J Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Comparison of clinical and laboratory features and treatment options of 237 Comparison of clinical and laboratory features and treatment options of 237 symptomatic and asymptomatic children infected with SARS-CoV-2 in the early phase of the COVID-19 pandemic in Turkey.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.7883/yoken.JJID.2020.781</ELocationID><Abstract><AbstractText>Since the first report of COVID-19 in December 2019, little is known about therapeutic usage of hydroxychloroquine in pediatric patients with COVID-19. We retrospectively retrieved data for SARS-CoV-2 PCR positive pediatric patients from 20 hospitals in 8 different cities in Turkey. We obtained patients' epidemiological, clinical, laboratory features and drugs used for treatment of COVID-19. 237 nasopharyngeal swab SARS-CoV-2 PCR positive children were included into the study from March 26 to June 20, 2020. The mean age of asymptomatic children (118±62 months) was found to be higher than that of symptomatic children (89±69 months). Symptomatic children had a significantly lower mean lymphocyte count and higher mean CRP, D-dimer value, procalcitonin and LDH than asymptomatic children in univariate analysis. Out of 156 children, 78 (50%) children received Hydroxychloroquine-containing regimen, 15 of them were treated with hydroxychloroquine + azithromycin + oseltamivir, 44 were treated with hydroxychloroquine + azithromycin and 21 were only treated with hydroxychloroquine. Among the 156 patients who received medical treatment, 90 (58%) patients had pre and/or post-treatment ECG performed upon them. However, none of them either reported ECG abnormalities or a need for discontinuation of hydroxychloroquine because of adverse drug reaction.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Soysal</LastName><ForeName>Ahmet</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Pediatric Infectious Diseases, Memorial Ataşehir Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gönüllü</LastName><ForeName>Erdem</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Pediatric Infectious Diseases, Memorial Ataşehir Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arslan</LastName><ForeName>Hüseyin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Medipol University, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kibar</LastName><ForeName>Büşra Sultan</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Yalova State Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pop</LastName><ForeName>Serdar</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Erbaa State Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yurttaş</LastName><ForeName>Gözde Nur</ForeName><Initials>GN</Initials><AffiliationInfo><Affiliation>Tokat State Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demirbacak</LastName><ForeName>Hacer</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Yalova State Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ünal</LastName><ForeName>Füsun</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Medipol University, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Öktem</LastName><ForeName>Sedat</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Medipol University, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atıcı</LastName><ForeName>Serkan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Pediatric Infectious Diseases, Okan University Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Şen</LastName><ForeName>Arife Derda Yücel</ForeName><Initials>ADY</Initials><AffiliationInfo><Affiliation>Yalova State Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karabayır</LastName><ForeName>Nalan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Medipol University, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karaböcüoğlu</LastName><ForeName>Metin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Pediatric Infectious Diseases, Memorial Ataşehir Hospital, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>PEDCOVID19 study group.</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Jpn J Infect Dis</MedlineTA><NlmUniqueID>100893704</NlmUniqueID><ISSNLinking>1344-6304</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Turkey </Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>30</Day><Hour>5</Hour><Minute>51</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>12</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33250495</ArticleId><ArticleId IdType="doi">10.7883/yoken.JJID.2020.781</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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