Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?
Identifieur interne : 000728 ( Main/Corpus ); précédent : 000727; suivant : 000729Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?
Auteurs : Mohammad Obeidat ; Alexandra L. Isaacson ; Stephanie J. Chen ; Marina Ivanovic ; Danniele HolandaSource :
- Ultrastructural pathology [ 1521-0758 ] ; 2020.
English descriptors
- KwdEn :
- Acute Kidney Injury (chemically induced), Acute Kidney Injury (metabolism), Acute Kidney Injury (pathology), Aged (MeSH), Antiviral Agents (adverse effects), Autopsy (MeSH), COVID-19 (drug therapy), Fatal Outcome (MeSH), Humans (MeSH), Hydroxychloroquine (adverse effects), Kidney Tubules (drug effects), Kidney Tubules (metabolism), Kidney Tubules (ultrastructure), Male (MeSH), Organelles (drug effects), Organelles (metabolism), Organelles (ultrastructure), Phospholipids (metabolism).
- MESH :
- chemical , adverse effects : Antiviral Agents, Hydroxychloroquine.
- chemically induced : Acute Kidney Injury.
- drug effects : Kidney Tubules, Organelles.
- drug therapy : COVID-19.
- metabolism : Acute Kidney Injury, Kidney Tubules, Organelles, Phospholipids.
- pathology : Acute Kidney Injury.
- ultrastructure : Kidney Tubules, Organelles.
- Aged, Autopsy, Fatal Outcome, Humans, Male.
Abstract
COVID-19 (from SARS-CoV-2) is the cause of an ongoing pandemic, with an increasing number of cases and significant mortality worldwide. Clinical trials and extensive studies are being conducted on a large scale for a better understanding of the pathophysiology of this disease and its effect on different organs. Several experimental treatment protocols have been introduced, in which hydroxychloroquine (HCQ) was one of the first drugs used. While patients can develop many side effects of HCQ, studies have documented a rare association of long-term HCQ treatment with zebra-like bodies in the ultrastructural examination of kidney biopsies, a finding typically seen in Fabry's disease, as well as in association with chronic HCQ use, among other drugs. We present a similar finding in the postmortem examination of a male in his early seventies with COVID-19 infection, who received five days of HCQ treatment before stopping the medication due to cardiac and renal toxicity.
DOI: 10.1080/01913123.2020.1850966
PubMed: 33274661
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?</title><author><name sortKey="Obeidat, Mohammad" sort="Obeidat, Mohammad" uniqKey="Obeidat M" first="Mohammad" last="Obeidat">Mohammad Obeidat</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Isaacson, Alexandra L" sort="Isaacson, Alexandra L" uniqKey="Isaacson A" first="Alexandra L" last="Isaacson">Alexandra L. Isaacson</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Stephanie J" sort="Chen, Stephanie J" uniqKey="Chen S" first="Stephanie J" last="Chen">Stephanie J. Chen</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ivanovic, Marina" sort="Ivanovic, Marina" uniqKey="Ivanovic M" first="Marina" last="Ivanovic">Marina Ivanovic</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holanda, Danniele" sort="Holanda, Danniele" uniqKey="Holanda D" first="Danniele" last="Holanda">Danniele Holanda</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33274661</idno><idno type="pmid">33274661</idno><idno type="doi">10.1080/01913123.2020.1850966</idno><idno type="wicri:Area/Main/Corpus">000728</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000728</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?</title><author><name sortKey="Obeidat, Mohammad" sort="Obeidat, Mohammad" uniqKey="Obeidat M" first="Mohammad" last="Obeidat">Mohammad Obeidat</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Isaacson, Alexandra L" sort="Isaacson, Alexandra L" uniqKey="Isaacson A" first="Alexandra L" last="Isaacson">Alexandra L. Isaacson</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Stephanie J" sort="Chen, Stephanie J" uniqKey="Chen S" first="Stephanie J" last="Chen">Stephanie J. Chen</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ivanovic, Marina" sort="Ivanovic, Marina" uniqKey="Ivanovic M" first="Marina" last="Ivanovic">Marina Ivanovic</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holanda, Danniele" sort="Holanda, Danniele" uniqKey="Holanda D" first="Danniele" last="Holanda">Danniele Holanda</name><affiliation><nlm:affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Ultrastructural pathology</title><idno type="eISSN">1521-0758</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (chemically induced)</term><term>Acute Kidney Injury (metabolism)</term><term>Acute Kidney Injury (pathology)</term><term>Aged (MeSH)</term><term>Antiviral Agents (adverse effects)</term><term>Autopsy (MeSH)</term><term>COVID-19 (drug therapy)</term><term>Fatal Outcome (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (adverse effects)</term><term>Kidney Tubules (drug effects)</term><term>Kidney Tubules (metabolism)</term><term>Kidney Tubules (ultrastructure)</term><term>Male (MeSH)</term><term>Organelles (drug effects)</term><term>Organelles (metabolism)</term><term>Organelles (ultrastructure)</term><term>Phospholipids (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiviral Agents</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Acute Kidney Injury</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Kidney Tubules</term><term>Organelles</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acute Kidney Injury</term><term>Kidney Tubules</term><term>Organelles</term><term>Phospholipids</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Acute Kidney Injury</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Kidney Tubules</term><term>Organelles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Autopsy</term><term>Fatal Outcome</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">COVID-19 (from SARS-CoV-2) is the cause of an ongoing pandemic, with an increasing number of cases and significant mortality worldwide. Clinical trials and extensive studies are being conducted on a large scale for a better understanding of the pathophysiology of this disease and its effect on different organs. Several experimental treatment protocols have been introduced, in which hydroxychloroquine (HCQ) was one of the first drugs used. While patients can develop many side effects of HCQ, studies have documented a rare association of long-term HCQ treatment with zebra-like bodies in the ultrastructural examination of kidney biopsies, a finding typically seen in Fabry's disease, as well as in association with chronic HCQ use, among other drugs. We present a similar finding in the postmortem examination of a male in his early seventies with COVID-19 infection, who received five days of HCQ treatment before stopping the medication due to cardiac and renal toxicity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33274661</PMID><DateCompleted><Year>2021</Year><Month>01</Month><Day>27</Day></DateCompleted><DateRevised><Year>2021</Year><Month>03</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-0758</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>4-6</Issue><PubDate><Year>2020</Year><Month>Nov</Month><Day>20</Day></PubDate></JournalIssue><Title>Ultrastructural pathology</Title><ISOAbbreviation>Ultrastruct Pathol</ISOAbbreviation></Journal><ArticleTitle>Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?</ArticleTitle><Pagination><MedlinePgn>519-523</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/01913123.2020.1850966</ELocationID><Abstract><AbstractText>COVID-19 (from SARS-CoV-2) is the cause of an ongoing pandemic, with an increasing number of cases and significant mortality worldwide. Clinical trials and extensive studies are being conducted on a large scale for a better understanding of the pathophysiology of this disease and its effect on different organs. Several experimental treatment protocols have been introduced, in which hydroxychloroquine (HCQ) was one of the first drugs used. While patients can develop many side effects of HCQ, studies have documented a rare association of long-term HCQ treatment with zebra-like bodies in the ultrastructural examination of kidney biopsies, a finding typically seen in Fabry's disease, as well as in association with chronic HCQ use, among other drugs. We present a similar finding in the postmortem examination of a male in his early seventies with COVID-19 infection, who received five days of HCQ treatment before stopping the medication due to cardiac and renal toxicity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Obeidat</LastName><ForeName>Mohammad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isaacson</LastName><ForeName>Alexandra L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Stephanie J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ivanovic</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holanda</LastName><ForeName>Danniele</ForeName><Initials>D</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-6872-2673</Identifier><AffiliationInfo><Affiliation>Department of Pathology, University of Iowa Hospitals and Clinics , Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>12</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ultrastruct Pathol</MedlineTA><NlmUniqueID>8002867</NlmUniqueID><ISSNLinking>0191-3123</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010743">Phospholipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ultrastruct Pathol. 2021 Jan 2;45(1):78</RefSource><PMID Version="1">33377412</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D058186" MajorTopicYN="N">Acute Kidney Injury</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001344" MajorTopicYN="N">Autopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007684" MajorTopicYN="N">Kidney Tubules</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015388" MajorTopicYN="N">Organelles</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010743" MajorTopicYN="N">Phospholipids</DescriptorName><QualifierName 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