A retrospective comparison of drugs against COVID-19.
Identifieur interne : 000651 ( Main/Corpus ); précédent : 000650; suivant : 000652A retrospective comparison of drugs against COVID-19.
Auteurs : Jiahong Tan ; Yuan Yuan ; Cheng Xu ; Chunyan Song ; Dan Liu ; Ding Ma ; Qinglei GaoSource :
- Virus research [ 1872-7492 ] ; 2021.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antibodies, Viral (blood), COVID-19 (diagnosis), COVID-19 (drug therapy), COVID-19 (pathology), Drug Combinations (MeSH), Female (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Immunoglobulin G (blood), Immunoglobulin M (blood), Indoles (therapeutic use), Length of Stay (MeSH), Lopinavir (therapeutic use), Male (MeSH), Middle Aged (MeSH), Oseltamivir (therapeutic use), Retrospective Studies (MeSH), Ritonavir (therapeutic use), SARS-CoV-2 (immunology), SARS-CoV-2 (isolation & purification), Young Adult (MeSH).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- chemical , therapeutic use : Adrenal Cortex Hormones, Hydroxychloroquine, Indoles, Lopinavir, Oseltamivir, Ritonavir.
- diagnosis : COVID-19.
- drug therapy : COVID-19.
- immunology : SARS-CoV-2.
- isolation & purification : SARS-CoV-2.
- pathology : COVID-19.
- Adult, Aged, Aged, 80 and over, Drug Combinations, Female, Humans, Length of Stay, Male, Middle Aged, Retrospective Studies, Young Adult.
Abstract
Coronavirus disease 19 (COVID-19) has posed serious threats to the general population. To relieve the crisis, a comparison of drug effects against COVID-19 is instructive. Between January 27, 2020 and March 21, 2020, a total of 333 patients treated with arbidol, corticosteroids, hydroxychloroquine, lopinavir/ritonavir, or oseltamivir monotherapy, having definite outcomes and serological antibody detection results, were retrospectively analyzed. The hydroxychloroquine group had a significantly reduced duration of hospital stay than the arbidol and corticosteroids groups. The oseltamivir group had a significantly shorter length of hospital stay than the arbidol, corticosteroids, and lopinavir/ritonavir groups. The hydroxychloroquine group had a significantly higher IgM titer than the other four groups and exhibited significantly higher IgG levels than the arbidol, lopinavir/ritonavir, and oseltamivir groups. Our findings indicated that hydroxychloroquine might have the potential for efficient COVID-19 management, while oseltamivir should be prudently considered in combination therapy.
DOI: 10.1016/j.virusres.2020.198262
PubMed: 33333102
PubMed Central: PMC7833729
Links to Exploration step
pubmed:33333102Le document en format XML
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<term>Aged, 80 and over (MeSH)</term>
<term>Antibodies, Viral (blood)</term>
<term>COVID-19 (diagnosis)</term>
<term>COVID-19 (drug therapy)</term>
<term>COVID-19 (pathology)</term>
<term>Drug Combinations (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Immunoglobulin G (blood)</term>
<term>Immunoglobulin M (blood)</term>
<term>Indoles (therapeutic use)</term>
<term>Length of Stay (MeSH)</term>
<term>Lopinavir (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Ritonavir (therapeutic use)</term>
<term>SARS-CoV-2 (immunology)</term>
<term>SARS-CoV-2 (isolation & purification)</term>
<term>Young Adult (MeSH)</term>
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<front><div type="abstract" xml:lang="en">Coronavirus disease 19 (COVID-19) has posed serious threats to the general population. To relieve the crisis, a comparison of drug effects against COVID-19 is instructive. Between January 27, 2020 and March 21, 2020, a total of 333 patients treated with arbidol, corticosteroids, hydroxychloroquine, lopinavir/ritonavir, or oseltamivir monotherapy, having definite outcomes and serological antibody detection results, were retrospectively analyzed. The hydroxychloroquine group had a significantly reduced duration of hospital stay than the arbidol and corticosteroids groups. The oseltamivir group had a significantly shorter length of hospital stay than the arbidol, corticosteroids, and lopinavir/ritonavir groups. The hydroxychloroquine group had a significantly higher IgM titer than the other four groups and exhibited significantly higher IgG levels than the arbidol, lopinavir/ritonavir, and oseltamivir groups. Our findings indicated that hydroxychloroquine might have the potential for efficient COVID-19 management, while oseltamivir should be prudently considered in combination therapy.</div>
</front>
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<Abstract><AbstractText>Coronavirus disease 19 (COVID-19) has posed serious threats to the general population. To relieve the crisis, a comparison of drug effects against COVID-19 is instructive. Between January 27, 2020 and March 21, 2020, a total of 333 patients treated with arbidol, corticosteroids, hydroxychloroquine, lopinavir/ritonavir, or oseltamivir monotherapy, having definite outcomes and serological antibody detection results, were retrospectively analyzed. The hydroxychloroquine group had a significantly reduced duration of hospital stay than the arbidol and corticosteroids groups. The oseltamivir group had a significantly shorter length of hospital stay than the arbidol, corticosteroids, and lopinavir/ritonavir groups. The hydroxychloroquine group had a significantly higher IgM titer than the other four groups and exhibited significantly higher IgG levels than the arbidol, lopinavir/ritonavir, and oseltamivir groups. Our findings indicated that hydroxychloroquine might have the potential for efficient COVID-19 management, while oseltamivir should be prudently considered in combination therapy.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Jiahong</ForeName>
<Initials>J</Initials>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China. Electronic address: qingleigao@hotmail.com.</Affiliation>
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