Pharmacological strategies for COVID-19 - A review of the most promising repurposed antiviral drugs.
Identifieur interne : 000633 ( Main/Corpus ); précédent : 000632; suivant : 000634Pharmacological strategies for COVID-19 - A review of the most promising repurposed antiviral drugs.
Auteurs : Deepti Chopra ; Jaspreet K. Boparai ; Bharti Bhandari ; Anurag Srivastava ; Rakesh GuptaSource :
- Infectious disorders drug targets [ 2212-3989 ] ; 2020.
Abstract
A novel coronavirus, SARS-CoV-2 (2019-nCoV) emerged in December 2019 as an immediate global challenge. Comprehensive efforts at present time are focused simultaneously on containing spread of this virus and extenuating the ill effects. There is an immediate need for drugs that can help before a vaccine can be developed. Researchers are endeavoring to find antiviral therapies specific to the virus. As the condition is an emerging, rapidly evolving situation and development of new drugs is a long process, and is unfeasible to face the immediate global challenge. Strategy to reposition the previously used drugs can prove to be effective to combat this difficult to treat situation. Several drugs such as Hydroxychloroquine, Umifenovir, Remdesivir, Lopinavir/Ritonavir, interferon, Darunavir, Favipiravir, Nitazoxanide etc. are currently undergoing clinical studies to test the safety and efficacy of the drug against this pandemic. The present review gives a snapshot look of the current clinical experience with repurposed antiviral drugs.
DOI: 10.2174/1871526520666201218151841
PubMed: 33342420
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India.</nlm:affiliation></affiliation></author><author><name sortKey="Bhandari, Bharti" sort="Bhandari, Bharti" uniqKey="Bhandari B" first="Bharti" last="Bhandari">Bharti Bhandari</name><affiliation><nlm:affiliation>Department of Physiology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. India.</nlm:affiliation></affiliation></author><author><name sortKey="Srivastava, Anurag" sort="Srivastava, Anurag" uniqKey="Srivastava A" first="Anurag" last="Srivastava">Anurag Srivastava</name><affiliation><nlm:affiliation>Department of Community Medicine, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. India.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Rakesh" sort="Gupta, Rakesh" uniqKey="Gupta R" first="Rakesh" last="Gupta">Rakesh Gupta</name><affiliation><nlm:affiliation>Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. 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India.</nlm:affiliation></affiliation></author><author><name sortKey="Boparai, Jaspreet K" sort="Boparai, Jaspreet K" uniqKey="Boparai J" first="Jaspreet K" last="Boparai">Jaspreet K. Boparai</name><affiliation><nlm:affiliation>Department of Pharmacology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. India.</nlm:affiliation></affiliation></author><author><name sortKey="Bhandari, Bharti" sort="Bhandari, Bharti" uniqKey="Bhandari B" first="Bharti" last="Bhandari">Bharti Bhandari</name><affiliation><nlm:affiliation>Department of Physiology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. India.</nlm:affiliation></affiliation></author><author><name sortKey="Srivastava, Anurag" sort="Srivastava, Anurag" uniqKey="Srivastava A" first="Anurag" last="Srivastava">Anurag Srivastava</name><affiliation><nlm:affiliation>Department of Community Medicine, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. India.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Rakesh" sort="Gupta, Rakesh" uniqKey="Gupta R" first="Rakesh" last="Gupta">Rakesh Gupta</name><affiliation><nlm:affiliation>Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. India.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Infectious disorders drug targets</title><idno type="eISSN">2212-3989</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel coronavirus, SARS-CoV-2 (2019-nCoV) emerged in December 2019 as an immediate global challenge. Comprehensive efforts at present time are focused simultaneously on containing spread of this virus and extenuating the ill effects. There is an immediate need for drugs that can help before a vaccine can be developed. Researchers are endeavoring to find antiviral therapies specific to the virus. As the condition is an emerging, rapidly evolving situation and development of new drugs is a long process, and is unfeasible to face the immediate global challenge. Strategy to reposition the previously used drugs can prove to be effective to combat this difficult to treat situation. Several drugs such as Hydroxychloroquine, Umifenovir, Remdesivir, Lopinavir/Ritonavir, interferon, Darunavir, Favipiravir, Nitazoxanide etc. are currently undergoing clinical studies to test the safety and efficacy of the drug against this pandemic. The present review gives a snapshot look of the current clinical experience with repurposed antiviral drugs.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33342420</PMID><DateRevised><Year>2020</Year><Month>12</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2212-3989</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Dec</Month><Day>18</Day></PubDate></JournalIssue><Title>Infectious disorders drug targets</Title><ISOAbbreviation>Infect Disord Drug Targets</ISOAbbreviation></Journal><ArticleTitle>Pharmacological strategies for COVID-19 - A review of the most promising repurposed antiviral drugs.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.2174/1871526520666201218151841</ELocationID><Abstract><AbstractText>A novel coronavirus, SARS-CoV-2 (2019-nCoV) emerged in December 2019 as an immediate global challenge. Comprehensive efforts at present time are focused simultaneously on containing spread of this virus and extenuating the ill effects. There is an immediate need for drugs that can help before a vaccine can be developed. Researchers are endeavoring to find antiviral therapies specific to the virus. As the condition is an emerging, rapidly evolving situation and development of new drugs is a long process, and is unfeasible to face the immediate global challenge. Strategy to reposition the previously used drugs can prove to be effective to combat this difficult to treat situation. Several drugs such as Hydroxychloroquine, Umifenovir, Remdesivir, Lopinavir/Ritonavir, interferon, Darunavir, Favipiravir, Nitazoxanide etc. are currently undergoing clinical studies to test the safety and efficacy of the drug against this pandemic. The present review gives a snapshot look of the current clinical experience with repurposed antiviral drugs.</AbstractText><CopyrightInformation>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chopra</LastName><ForeName>Deepti</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boparai</LastName><ForeName>Jaspreet K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh. 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