Underlying heart diseases and acute COVID-19 outcomes.
Identifieur interne : 000627 ( Main/Corpus ); précédent : 000626; suivant : 000628Underlying heart diseases and acute COVID-19 outcomes.
Auteurs : Iván J. Nú Ez-Gil ; Antonio Fernández-Ortiz ; Charbel Maroud Eid ; Jia Huang ; Rodolfo Romero ; Victor Manuel Becerra-Mu Oz ; Aitor Uribarri ; Gisela Feltes ; Daniela Trabatoni ; Inmaculada Fernandez-Rozas ; Maria C. Viana-Llamas ; Martino Pepe ; Enrico Cerrato ; Maurizio Bertaina ; Thamar Capel Astrua ; Emilio Alfonso ; Alex F. Castro-Mejía ; Sergio Raposeiras-Roubin ; Fabrizio D'Ascenzo ; Carolina Espejo Paeres ; Jaime Signes-Costa ; Alfredo Bardaji ; Cristina Fernandez-Pérez ; Francisco Marin ; Oscar Fabregat-Andres ; Ibrahim Akin ; Vicente Estrada ; Carlos MacayaSource :
- Cardiology journal [ 1898-018X ] ; 2021.
English descriptors
- KwdEn :
- MESH :
- epidemiology : COVID-19, Heart Diseases.
- Aged, Comorbidity, Female, Global Health, Humans, Male, Middle Aged, Pandemics, Prognosis, Registries, Retrospective Studies, Risk Factors, SARS-CoV-2.
Abstract
BACKGROUND
The presence of any underlying heart condition could influence outcomes during the coronavirus disease 2019 (COVID-19).
METHODS
The registry HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19, NCT04334291) is an international ambispective study, enrolling COVID-19 patients discharged from hospital, dead or alive.
RESULTS
HOPE enrolled 2798 patients from 35 centers in 7 countries. Median age was 67 years (IQR: 53.0-78.0), and most were male (59.5%). A relevant heart disease was present in 682 (24%) cases. These were older, more frequently male, with higher overall burden of cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, smoking habit, obesity) and other comorbidities such renal failure, lung, cerebrovascular disease and oncologic antecedents (p < 0.01, for all). The heart cohort received more corticoids (28.9% vs. 20.4%, p < 0.001), antibiotics, but less hydroxychloroquine, antivirals or tocilizumab. Considering the epidemiologic profile, a previous heart condition was independently related with shortterm mortality in the Cox multivariate analysis (1.62; 95% CI 1.29-2.03; p < 0.001). Moreover, heart patients needed more respiratory, circulatory support, and presented more in-hospital events, such heart failure, renal failure, respiratory insufficiency, sepsis, systemic infammatory response syndrome and clinically relevant bleedings (all, p < 0.001), and mortality (39.7% vs. 15.5%; p < 0.001).
CONCLUSIONS
An underlying heart disease is an adverse prognostic factor for patients suffering COVID-19. Its presence could be related with different clinical drug management and would benefit from maintaining treatment with angiotensin converting enzyme inhibitors or angiotensin receptor blockers during in-hospital stay.
DOI: 10.5603/CJ.a2020.0183
PubMed: 33346365
PubMed Central: PMC8078951
Links to Exploration step
pubmed:33346365Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Underlying heart diseases and acute COVID-19 outcomes.</title><author><name sortKey="Nu Ez Gil, Ivan J" sort="Nu Ez Gil, Ivan J" uniqKey="Nu Ez Gil I" first="Iván J" last="Nú Ez-Gil">Iván J. Nú Ez-Gil</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain. ibnsky@yahoo.es.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ortiz, Antonio" sort="Fernandez Ortiz, Antonio" uniqKey="Fernandez Ortiz A" first="Antonio" last="Fernández-Ortiz">Antonio Fernández-Ortiz</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maroud Eid, Charbel" sort="Maroud Eid, Charbel" uniqKey="Maroud Eid C" first="Charbel" last="Maroud Eid">Charbel Maroud Eid</name><affiliation><nlm:affiliation>H La Paz, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jia" sort="Huang, Jia" uniqKey="Huang J" first="Jia" last="Huang">Jia Huang</name><affiliation><nlm:affiliation>The Second People's Hospital of Shenzhen, Shenzhen, China.</nlm:affiliation></affiliation></author><author><name sortKey="Romero, Rodolfo" sort="Romero, Rodolfo" uniqKey="Romero R" first="Rodolfo" last="Romero">Rodolfo Romero</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becerra Mu Oz, Victor Manuel" sort="Becerra Mu Oz, Victor Manuel" uniqKey="Becerra Mu Oz V" first="Victor Manuel" last="Becerra-Mu Oz">Victor Manuel Becerra-Mu Oz</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Uribarri, Aitor" sort="Uribarri, Aitor" uniqKey="Uribarri A" first="Aitor" last="Uribarri">Aitor Uribarri</name><affiliation><nlm:affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Feltes, Gisela" sort="Feltes, Gisela" uniqKey="Feltes G" first="Gisela" last="Feltes">Gisela Feltes</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América.</nlm:affiliation></affiliation></author><author><name sortKey="Trabatoni, Daniela" sort="Trabatoni, Daniela" uniqKey="Trabatoni D" first="Daniela" last="Trabatoni">Daniela Trabatoni</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rozas, Inmaculada" sort="Fernandez Rozas, Inmaculada" uniqKey="Fernandez Rozas I" first="Inmaculada" last="Fernandez-Rozas">Inmaculada Fernandez-Rozas</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Viana Llamas, Maria C" sort="Viana Llamas, Maria C" uniqKey="Viana Llamas M" first="Maria C" last="Viana-Llamas">Maria C. Viana-Llamas</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pepe, Martino" sort="Pepe, Martino" uniqKey="Pepe M" first="Martino" last="Pepe">Martino Pepe</name><affiliation><nlm:affiliation>Azienda ospedaliero-universitaria consorziale policlinico di Bari.</nlm:affiliation></affiliation></author><author><name sortKey="Cerrato, Enrico" sort="Cerrato, Enrico" uniqKey="Cerrato E" first="Enrico" last="Cerrato">Enrico Cerrato</name><affiliation><nlm:affiliation>San Luigi Gonzaga University Hospital, Rivoli, Turin. Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bertaina, Maurizio" sort="Bertaina, Maurizio" uniqKey="Bertaina M" first="Maurizio" last="Bertaina">Maurizio Bertaina</name><affiliation><nlm:affiliation>Martini Hospital,via Tofane, Turin. Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Capel Astrua, Thamar" sort="Capel Astrua, Thamar" uniqKey="Capel Astrua T" first="Thamar" last="Capel Astrua">Thamar Capel Astrua</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alfonso, Emilio" sort="Alfonso, Emilio" uniqKey="Alfonso E" first="Emilio" last="Alfonso">Emilio Alfonso</name><affiliation><nlm:affiliation>Instituto de Cardiología y Cirugía Cardiovascular, Havana, Cuba.</nlm:affiliation></affiliation></author><author><name sortKey="Castro Mejia, Alex F" sort="Castro Mejia, Alex F" uniqKey="Castro Mejia A" first="Alex F" last="Castro-Mejía">Alex F. Castro-Mejía</name><affiliation><nlm:affiliation>Hospital General del norte de Guayaquil IESS Los Ceibos.</nlm:affiliation></affiliation></author><author><name sortKey="Raposeiras Roubin, Sergio" sort="Raposeiras Roubin, Sergio" uniqKey="Raposeiras Roubin S" first="Sergio" last="Raposeiras-Roubin">Sergio Raposeiras-Roubin</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo. Spain.</nlm:affiliation></affiliation></author><author><name sortKey="D Ascenzo, Fabrizio" sort="D Ascenzo, Fabrizio" uniqKey="D Ascenzo F" first="Fabrizio" last="D'Ascenzo">Fabrizio D'Ascenzo</name><affiliation><nlm:affiliation>San Giovanni Battista.</nlm:affiliation></affiliation></author><author><name sortKey="Espejo Paeres, Carolina" sort="Espejo Paeres, Carolina" uniqKey="Espejo Paeres C" first="Carolina" last="Espejo Paeres">Carolina Espejo Paeres</name><affiliation><nlm:affiliation>H Principe Asturias, Alcalá de Henares, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Signes Costa, Jaime" sort="Signes Costa, Jaime" uniqKey="Signes Costa J" first="Jaime" last="Signes-Costa">Jaime Signes-Costa</name><affiliation><nlm:affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bardaji, Alfredo" sort="Bardaji, Alfredo" uniqKey="Bardaji A" first="Alfredo" last="Bardaji">Alfredo Bardaji</name><affiliation><nlm:affiliation>University Hospital Joan XXIII. Tarragona. Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Perez, Cristina" sort="Fernandez Perez, Cristina" uniqKey="Fernandez Perez C" first="Cristina" last="Fernandez-Pérez">Cristina Fernandez-Pérez</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marin, Francisco" sort="Marin, Francisco" uniqKey="Marin F" first="Francisco" last="Marin">Francisco Marin</name><affiliation><nlm:affiliation>Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat Andres, Oscar" sort="Fabregat Andres, Oscar" uniqKey="Fabregat Andres O" first="Oscar" last="Fabregat-Andres">Oscar Fabregat-Andres</name><affiliation><nlm:affiliation>Hospital IMED, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Akin, Ibrahim" sort="Akin, Ibrahim" uniqKey="Akin I" first="Ibrahim" last="Akin">Ibrahim Akin</name><affiliation><nlm:affiliation>First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany, DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Estrada, Vicente" sort="Estrada, Vicente" uniqKey="Estrada V" first="Vicente" last="Estrada">Vicente Estrada</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33346365</idno><idno type="pmid">33346365</idno><idno type="doi">10.5603/CJ.a2020.0183</idno><idno type="pmc">PMC8078951</idno><idno type="wicri:Area/Main/Corpus">000627</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000627</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Underlying heart diseases and acute COVID-19 outcomes.</title><author><name sortKey="Nu Ez Gil, Ivan J" sort="Nu Ez Gil, Ivan J" uniqKey="Nu Ez Gil I" first="Iván J" last="Nú Ez-Gil">Iván J. Nú Ez-Gil</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain. ibnsky@yahoo.es.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Ortiz, Antonio" sort="Fernandez Ortiz, Antonio" uniqKey="Fernandez Ortiz A" first="Antonio" last="Fernández-Ortiz">Antonio Fernández-Ortiz</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maroud Eid, Charbel" sort="Maroud Eid, Charbel" uniqKey="Maroud Eid C" first="Charbel" last="Maroud Eid">Charbel Maroud Eid</name><affiliation><nlm:affiliation>H La Paz, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jia" sort="Huang, Jia" uniqKey="Huang J" first="Jia" last="Huang">Jia Huang</name><affiliation><nlm:affiliation>The Second People's Hospital of Shenzhen, Shenzhen, China.</nlm:affiliation></affiliation></author><author><name sortKey="Romero, Rodolfo" sort="Romero, Rodolfo" uniqKey="Romero R" first="Rodolfo" last="Romero">Rodolfo Romero</name><affiliation><nlm:affiliation>Hospital Universitario Getafe, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becerra Mu Oz, Victor Manuel" sort="Becerra Mu Oz, Victor Manuel" uniqKey="Becerra Mu Oz V" first="Victor Manuel" last="Becerra-Mu Oz">Victor Manuel Becerra-Mu Oz</name><affiliation><nlm:affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Uribarri, Aitor" sort="Uribarri, Aitor" uniqKey="Uribarri A" first="Aitor" last="Uribarri">Aitor Uribarri</name><affiliation><nlm:affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Feltes, Gisela" sort="Feltes, Gisela" uniqKey="Feltes G" first="Gisela" last="Feltes">Gisela Feltes</name><affiliation><nlm:affiliation>Hospital Nuestra Señora de América.</nlm:affiliation></affiliation></author><author><name sortKey="Trabatoni, Daniela" sort="Trabatoni, Daniela" uniqKey="Trabatoni D" first="Daniela" last="Trabatoni">Daniela Trabatoni</name><affiliation><nlm:affiliation>Centro Cardiologico Monzino, IRCCS, Milano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rozas, Inmaculada" sort="Fernandez Rozas, Inmaculada" uniqKey="Fernandez Rozas I" first="Inmaculada" last="Fernandez-Rozas">Inmaculada Fernandez-Rozas</name><affiliation><nlm:affiliation>Hospital Severo Ochoa, Leganés, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Viana Llamas, Maria C" sort="Viana Llamas, Maria C" uniqKey="Viana Llamas M" first="Maria C" last="Viana-Llamas">Maria C. Viana-Llamas</name><affiliation><nlm:affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Pepe, Martino" sort="Pepe, Martino" uniqKey="Pepe M" first="Martino" last="Pepe">Martino Pepe</name><affiliation><nlm:affiliation>Azienda ospedaliero-universitaria consorziale policlinico di Bari.</nlm:affiliation></affiliation></author><author><name sortKey="Cerrato, Enrico" sort="Cerrato, Enrico" uniqKey="Cerrato E" first="Enrico" last="Cerrato">Enrico Cerrato</name><affiliation><nlm:affiliation>San Luigi Gonzaga University Hospital, Rivoli, Turin. Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bertaina, Maurizio" sort="Bertaina, Maurizio" uniqKey="Bertaina M" first="Maurizio" last="Bertaina">Maurizio Bertaina</name><affiliation><nlm:affiliation>Martini Hospital,via Tofane, Turin. Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Capel Astrua, Thamar" sort="Capel Astrua, Thamar" uniqKey="Capel Astrua T" first="Thamar" last="Capel Astrua">Thamar Capel Astrua</name><affiliation><nlm:affiliation>Hospital Virgen del Mar, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alfonso, Emilio" sort="Alfonso, Emilio" uniqKey="Alfonso E" first="Emilio" last="Alfonso">Emilio Alfonso</name><affiliation><nlm:affiliation>Instituto de Cardiología y Cirugía Cardiovascular, Havana, Cuba.</nlm:affiliation></affiliation></author><author><name sortKey="Castro Mejia, Alex F" sort="Castro Mejia, Alex F" uniqKey="Castro Mejia A" first="Alex F" last="Castro-Mejía">Alex F. Castro-Mejía</name><affiliation><nlm:affiliation>Hospital General del norte de Guayaquil IESS Los Ceibos.</nlm:affiliation></affiliation></author><author><name sortKey="Raposeiras Roubin, Sergio" sort="Raposeiras Roubin, Sergio" uniqKey="Raposeiras Roubin S" first="Sergio" last="Raposeiras-Roubin">Sergio Raposeiras-Roubin</name><affiliation><nlm:affiliation>University Hospital Álvaro Cunqueiro, Vigo. Spain.</nlm:affiliation></affiliation></author><author><name sortKey="D Ascenzo, Fabrizio" sort="D Ascenzo, Fabrizio" uniqKey="D Ascenzo F" first="Fabrizio" last="D'Ascenzo">Fabrizio D'Ascenzo</name><affiliation><nlm:affiliation>San Giovanni Battista.</nlm:affiliation></affiliation></author><author><name sortKey="Espejo Paeres, Carolina" sort="Espejo Paeres, Carolina" uniqKey="Espejo Paeres C" first="Carolina" last="Espejo Paeres">Carolina Espejo Paeres</name><affiliation><nlm:affiliation>H Principe Asturias, Alcalá de Henares, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Signes Costa, Jaime" sort="Signes Costa, Jaime" uniqKey="Signes Costa J" first="Jaime" last="Signes-Costa">Jaime Signes-Costa</name><affiliation><nlm:affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bardaji, Alfredo" sort="Bardaji, Alfredo" uniqKey="Bardaji A" first="Alfredo" last="Bardaji">Alfredo Bardaji</name><affiliation><nlm:affiliation>University Hospital Joan XXIII. Tarragona. Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Perez, Cristina" sort="Fernandez Perez, Cristina" uniqKey="Fernandez Perez C" first="Cristina" last="Fernandez-Pérez">Cristina Fernandez-Pérez</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marin, Francisco" sort="Marin, Francisco" uniqKey="Marin F" first="Francisco" last="Marin">Francisco Marin</name><affiliation><nlm:affiliation>Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Fabregat Andres, Oscar" sort="Fabregat Andres, Oscar" uniqKey="Fabregat Andres O" first="Oscar" last="Fabregat-Andres">Oscar Fabregat-Andres</name><affiliation><nlm:affiliation>Hospital IMED, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Akin, Ibrahim" sort="Akin, Ibrahim" uniqKey="Akin I" first="Ibrahim" last="Akin">Ibrahim Akin</name><affiliation><nlm:affiliation>First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany, DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Estrada, Vicente" sort="Estrada, Vicente" uniqKey="Estrada V" first="Vicente" last="Estrada">Vicente Estrada</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Macaya, Carlos" sort="Macaya, Carlos" uniqKey="Macaya C" first="Carlos" last="Macaya">Carlos Macaya</name><affiliation><nlm:affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cardiology journal</title><idno type="eISSN">1898-018X</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>COVID-19 (epidemiology)</term><term>Comorbidity (MeSH)</term><term>Female (MeSH)</term><term>Global Health (MeSH)</term><term>Heart Diseases (epidemiology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Prognosis (MeSH)</term><term>Registries (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>SARS-CoV-2 (MeSH)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term><term>Heart Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Comorbidity</term><term>Female</term><term>Global Health</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prognosis</term><term>Registries</term><term>Retrospective Studies</term><term>Risk Factors</term><term>SARS-CoV-2</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The presence of any underlying heart condition could influence outcomes during the coronavirus disease 2019 (COVID-19).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The registry HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19, NCT04334291) is an international ambispective study, enrolling COVID-19 patients discharged from hospital, dead or alive.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>HOPE enrolled 2798 patients from 35 centers in 7 countries. Median age was 67 years (IQR: 53.0-78.0), and most were male (59.5%). A relevant heart disease was present in 682 (24%) cases. These were older, more frequently male, with higher overall burden of cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, smoking habit, obesity) and other comorbidities such renal failure, lung, cerebrovascular disease and oncologic antecedents (p < 0.01, for all). The heart cohort received more corticoids (28.9% vs. 20.4%, p < 0.001), antibiotics, but less hydroxychloroquine, antivirals or tocilizumab. Considering the epidemiologic profile, a previous heart condition was independently related with shortterm mortality in the Cox multivariate analysis (1.62; 95% CI 1.29-2.03; p < 0.001). Moreover, heart patients needed more respiratory, circulatory support, and presented more in-hospital events, such heart failure, renal failure, respiratory insufficiency, sepsis, systemic infammatory response syndrome and clinically relevant bleedings (all, p < 0.001), and mortality (39.7% vs. 15.5%; p < 0.001).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>An underlying heart disease is an adverse prognostic factor for patients suffering COVID-19. Its presence could be related with different clinical drug management and would benefit from maintaining treatment with angiotensin converting enzyme inhibitors or angiotensin receptor blockers during in-hospital stay.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33346365</PMID><DateCompleted><Year>2021</Year><Month>05</Month><Day>06</Day></DateCompleted><DateRevised><Year>2021</Year><Month>05</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1898-018X</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>2</Issue><PubDate><Year>2021</Year></PubDate></JournalIssue><Title>Cardiology journal</Title><ISOAbbreviation>Cardiol J</ISOAbbreviation></Journal><ArticleTitle>Underlying heart diseases and acute COVID-19 outcomes.</ArticleTitle><Pagination><MedlinePgn>202-214</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5603/CJ.a2020.0183</ELocationID><Abstract><AbstractText Label="BACKGROUND">The presence of any underlying heart condition could influence outcomes during the coronavirus disease 2019 (COVID-19).</AbstractText><AbstractText Label="METHODS">The registry HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19, NCT04334291) is an international ambispective study, enrolling COVID-19 patients discharged from hospital, dead or alive.</AbstractText><AbstractText Label="RESULTS">HOPE enrolled 2798 patients from 35 centers in 7 countries. Median age was 67 years (IQR: 53.0-78.0), and most were male (59.5%). A relevant heart disease was present in 682 (24%) cases. These were older, more frequently male, with higher overall burden of cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, smoking habit, obesity) and other comorbidities such renal failure, lung, cerebrovascular disease and oncologic antecedents (p < 0.01, for all). The heart cohort received more corticoids (28.9% vs. 20.4%, p < 0.001), antibiotics, but less hydroxychloroquine, antivirals or tocilizumab. Considering the epidemiologic profile, a previous heart condition was independently related with shortterm mortality in the Cox multivariate analysis (1.62; 95% CI 1.29-2.03; p < 0.001). Moreover, heart patients needed more respiratory, circulatory support, and presented more in-hospital events, such heart failure, renal failure, respiratory insufficiency, sepsis, systemic infammatory response syndrome and clinically relevant bleedings (all, p < 0.001), and mortality (39.7% vs. 15.5%; p < 0.001).</AbstractText><AbstractText Label="CONCLUSIONS">An underlying heart disease is an adverse prognostic factor for patients suffering COVID-19. Its presence could be related with different clinical drug management and would benefit from maintaining treatment with angiotensin converting enzyme inhibitors or angiotensin receptor blockers during in-hospital stay.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Núñez-Gil</LastName><ForeName>Iván J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain. ibnsky@yahoo.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Ortiz</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maroud Eid</LastName><ForeName>Charbel</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>H La Paz, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Second People's Hospital of Shenzhen, Shenzhen, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>Rodolfo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hospital Universitario Getafe, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becerra-Muñoz</LastName><ForeName>Victor Manuel</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uribarri</LastName><ForeName>Aitor</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario de Valladolid, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feltes</LastName><ForeName>Gisela</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Hospital Nuestra Señora de América.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trabatoni</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centro Cardiologico Monzino, IRCCS, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez-Rozas</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Hospital Severo Ochoa, Leganés, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viana-Llamas</LastName><ForeName>Maria C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Hospital Universitario Guadalajara, Guadalajara, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pepe</LastName><ForeName>Martino</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Azienda ospedaliero-universitaria consorziale policlinico di Bari.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerrato</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>San Luigi Gonzaga University Hospital, Rivoli, Turin. Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertaina</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Martini Hospital,via Tofane, Turin. Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capel Astrua</LastName><ForeName>Thamar</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Hospital Virgen del Mar, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alfonso</LastName><ForeName>Emilio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Instituto de Cardiología y Cirugía Cardiovascular, Havana, Cuba.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castro-Mejía</LastName><ForeName>Alex F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Hospital General del norte de Guayaquil IESS Los Ceibos.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raposeiras-Roubin</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Hospital Álvaro Cunqueiro, Vigo. Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Ascenzo</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>San Giovanni Battista.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Espejo Paeres</LastName><ForeName>Carolina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>H Principe Asturias, Alcalá de Henares, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Signes-Costa</LastName><ForeName>Jaime</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bardaji</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University Hospital Joan XXIII. Tarragona. Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez-Pérez</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marin</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fabregat-Andres</LastName><ForeName>Oscar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Hospital IMED, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akin</LastName><ForeName>Ibrahim</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>First Department of Medicine, Medical Faculty Mannheim, University Heidelberg, Mannheim, 68167, Germany, DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Estrada</LastName><ForeName>Vicente</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macaya</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Prof Martin Lagos, sn, 28040 Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>12</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Poland</Country><MedlineTA>Cardiol J</MedlineTA><NlmUniqueID>101392712</NlmUniqueID><ISSNLinking>1898-018X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014943" MajorTopicYN="N">Global Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006331" MajorTopicYN="N">Heart Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="Y">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword 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