SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy?
Identifieur interne : 000586 ( Main/Corpus ); précédent : 000585; suivant : 000587SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy?
Auteurs : Maddalena Giglia ; Giacomo Beci ; Elena Rosselli Del Turco ; Viola Guardigni ; Alberto Amedeo ; Giulia Cucchetto ; Gabriella Verucchi ; Marco Cipolli ; Leonardo Calza ; Pierluigi VialeSource :
- Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace [ 1122-0643 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Antibodies, Monoclonal, Humanized (administration & dosage), Antiviral Agents (administration & dosage), COVID-19 (complications), COVID-19 (diagnosis), COVID-19 (drug therapy), COVID-19 (physiopathology), Cystic Fibrosis (complications), Cystic Fibrosis (immunology), Cystic Fibrosis (physiopathology), Drug Combinations (MeSH), Humans (MeSH), Hydroxychloroquine (administration & dosage), Lopinavir (administration & dosage), Lung (diagnostic imaging), Lung (physiopathology), Male (MeSH), Oxygen Inhalation Therapy (methods), Pneumonia, Viral (diagnosis), Pneumonia, Viral (drug therapy), Pneumonia, Viral (etiology), Receptors, Interleukin-6 (antagonists & inhibitors), Respiratory Function Tests (methods), Respiratory Tract Infections (drug therapy), Respiratory Tract Infections (etiology), Respiratory Tract Infections (microbiology), Ritonavir (administration & dosage), SARS-CoV-2 (isolation & purification), Tomography, X-Ray Computed (methods), Treatment Outcome (MeSH).
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Antiviral Agents, Hydroxychloroquine, Lopinavir, Ritonavir.
- chemical , antagonists & inhibitors : Receptors, Interleukin-6.
- complications : COVID-19, Cystic Fibrosis.
- diagnosis : COVID-19, Pneumonia, Viral.
- diagnostic imaging : Lung.
- drug therapy : COVID-19, Pneumonia, Viral, Respiratory Tract Infections.
- etiology : Pneumonia, Viral, Respiratory Tract Infections.
- immunology : Cystic Fibrosis.
- isolation & purification : SARS-CoV-2.
- methods : Oxygen Inhalation Therapy, Respiratory Function Tests, Tomography, X-Ray Computed.
- microbiology : Respiratory Tract Infections.
- physiopathology : COVID-19, Cystic Fibrosis, Lung.
- Adult, Drug Combinations, Humans, Male, Treatment Outcome.
Abstract
We report the case of a man affected by cystic fibrosis who developed a severe SARS-CoV-2 related pneumonia in March 2020. In addition to lopinavir/ritonavir and hydroxychloroquine, he was treated with two doses of tocilizumab, displaying a significant clinical improvement. This is the first case described in the literature of an adult patient affected by cystic fibrosis who received tocilizumab for COVID-19, with documented total recovery, also assessed by a spirometry.
DOI: 10.4081/monaldi.2020.1579
PubMed: 33372741
Links to Exploration step
pubmed:33372741Le document en format XML
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Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. leonardo.calza@unibo.it.</nlm:affiliation></affiliation></author><author><name sortKey="Viale, Pierluigi" sort="Viale, Pierluigi" uniqKey="Viale P" first="Pierluigi" last="Viale">Pierluigi Viale</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. 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Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. maddalena.giglia@studio.unibo.it.</nlm:affiliation></affiliation></author><author><name sortKey="Beci, Giacomo" sort="Beci, Giacomo" uniqKey="Beci G" first="Giacomo" last="Beci">Giacomo Beci</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. giacomo.beci@studio.unibo.it.</nlm:affiliation></affiliation></author><author><name sortKey="Rosselli Del Turco, Elena" sort="Rosselli Del Turco, Elena" uniqKey="Rosselli Del Turco E" first="Elena" last="Rosselli Del Turco">Elena Rosselli Del Turco</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. erossellidelturco@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Guardigni, Viola" sort="Guardigni, Viola" uniqKey="Guardigni V" first="Viola" last="Guardigni">Viola Guardigni</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. viola.guardigni2@unibo.it.</nlm:affiliation></affiliation></author><author><name sortKey="Amedeo, Alberto" sort="Amedeo, Alberto" uniqKey="Amedeo A" first="Alberto" last="Amedeo">Alberto Amedeo</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. alberto.amedeo@studio.unibo.it.</nlm:affiliation></affiliation></author><author><name sortKey="Cucchetto, Giulia" sort="Cucchetto, Giulia" uniqKey="Cucchetto G" first="Giulia" last="Cucchetto">Giulia Cucchetto</name><affiliation><nlm:affiliation>Cystic Fibrosis Regional Centre, AOUI Verona. giulia.cucchetto@aovr.veneto.it.</nlm:affiliation></affiliation></author><author><name sortKey="Verucchi, Gabriella" sort="Verucchi, Gabriella" uniqKey="Verucchi G" first="Gabriella" last="Verucchi">Gabriella Verucchi</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. gabriella.verucchi@unibo.it.</nlm:affiliation></affiliation></author><author><name sortKey="Cipolli, Marco" sort="Cipolli, Marco" uniqKey="Cipolli M" first="Marco" last="Cipolli">Marco Cipolli</name><affiliation><nlm:affiliation>Cystic Fibrosis Regional Centre, AOUI Verona. marco.cipolli@aovr.veneto.it.</nlm:affiliation></affiliation></author><author><name sortKey="Calza, Leonardo" sort="Calza, Leonardo" uniqKey="Calza L" first="Leonardo" last="Calza">Leonardo Calza</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. leonardo.calza@unibo.it.</nlm:affiliation></affiliation></author><author><name sortKey="Viale, Pierluigi" sort="Viale, Pierluigi" uniqKey="Viale P" first="Pierluigi" last="Viale">Pierluigi Viale</name><affiliation><nlm:affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. pierluigi.viale@unibo.it.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace</title><idno type="ISSN">1122-0643</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Antibodies, Monoclonal, Humanized (administration & dosage)</term><term>Antiviral Agents (administration & dosage)</term><term>COVID-19 (complications)</term><term>COVID-19 (diagnosis)</term><term>COVID-19 (drug therapy)</term><term>COVID-19 (physiopathology)</term><term>Cystic Fibrosis (complications)</term><term>Cystic Fibrosis (immunology)</term><term>Cystic Fibrosis (physiopathology)</term><term>Drug Combinations (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (administration & dosage)</term><term>Lopinavir (administration & dosage)</term><term>Lung (diagnostic imaging)</term><term>Lung (physiopathology)</term><term>Male (MeSH)</term><term>Oxygen Inhalation Therapy (methods)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (etiology)</term><term>Receptors, Interleukin-6 (antagonists & inhibitors)</term><term>Respiratory Function Tests (methods)</term><term>Respiratory Tract Infections (drug therapy)</term><term>Respiratory Tract Infections (etiology)</term><term>Respiratory Tract Infections (microbiology)</term><term>Ritonavir (administration & dosage)</term><term>SARS-CoV-2 (isolation & purification)</term><term>Tomography, X-Ray Computed (methods)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antiviral Agents</term><term>Hydroxychloroquine</term><term>Lopinavir</term><term>Ritonavir</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptors, Interleukin-6</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>COVID-19</term><term>Cystic Fibrosis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>COVID-19</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term><term>Pneumonia, Viral</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pneumonia, Viral</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cystic Fibrosis</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Oxygen Inhalation Therapy</term><term>Respiratory Function Tests</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>COVID-19</term><term>Cystic Fibrosis</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Drug Combinations</term><term>Humans</term><term>Male</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the case of a man affected by cystic fibrosis who developed a severe SARS-CoV-2 related pneumonia in March 2020. In addition to lopinavir/ritonavir and hydroxychloroquine, he was treated with two doses of tocilizumab, displaying a significant clinical improvement. This is the first case described in the literature of an adult patient affected by cystic fibrosis who received tocilizumab for COVID-19, with documented total recovery, also assessed by a spirometry.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33372741</PMID><DateCompleted><Year>2021</Year><Month>01</Month><Day>04</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>04</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">1122-0643</ISSN><JournalIssue CitedMedium="Internet"><Volume>90</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Dec</Month><Day>23</Day></PubDate></JournalIssue><Title>Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace</Title><ISOAbbreviation>Monaldi Arch Chest Dis</ISOAbbreviation></Journal><ArticleTitle>SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy?</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.4081/monaldi.2020.1579</ELocationID><Abstract><AbstractText>We report the case of a man affected by cystic fibrosis who developed a severe SARS-CoV-2 related pneumonia in March 2020. In addition to lopinavir/ritonavir and hydroxychloroquine, he was treated with two doses of tocilizumab, displaying a significant clinical improvement. This is the first case described in the literature of an adult patient affected by cystic fibrosis who received tocilizumab for COVID-19, with documented total recovery, also assessed by a spirometry.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Giglia</LastName><ForeName>Maddalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. maddalena.giglia@studio.unibo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beci</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. giacomo.beci@studio.unibo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosselli Del Turco</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. erossellidelturco@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guardigni</LastName><ForeName>Viola</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. viola.guardigni2@unibo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amedeo</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. alberto.amedeo@studio.unibo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cucchetto</LastName><ForeName>Giulia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Cystic Fibrosis Regional Centre, AOUI Verona. giulia.cucchetto@aovr.veneto.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verucchi</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. gabriella.verucchi@unibo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cipolli</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cystic Fibrosis Regional Centre, AOUI Verona. marco.cipolli@aovr.veneto.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calza</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. leonardo.calza@unibo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viale</LastName><ForeName>Pierluigi</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, "Alma Mater Studiorum" University of Bologna. pierluigi.viale@unibo.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>12</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Monaldi Arch Chest Dis</MedlineTA><NlmUniqueID>9307314</NlmUniqueID><ISSNLinking>1122-0643</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug 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UI="D061067" MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="Y">COVID-19</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003550" MajorTopicYN="Y">Cystic Fibrosis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061466" MajorTopicYN="N">Lopinavir</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010102" MajorTopicYN="N">Oxygen Inhalation Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019947" MajorTopicYN="N">Receptors, Interleukin-6</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012129" MajorTopicYN="N">Respiratory Function Tests</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012141" 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Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>12</Month><Day>29</Day><Hour>8</Hour><Minute>38</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33372741</ArticleId><ArticleId IdType="doi">10.4081/monaldi.2020.1579</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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