Effect of hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, an update with an intention-to-treat analysis and clinical outcomes.
Identifieur interne : 000531 ( Main/Corpus ); précédent : 000530; suivant : 000532Effect of hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, an update with an intention-to-treat analysis and clinical outcomes.
Auteurs : Philippe Gautret ; Van Thuan Hoang ; Jean-Christophe Lagier ; Didier RaoultSource :
- International journal of antimicrobial agents [ 1872-7913 ] ; 2021.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Anti-Bacterial Agents (therapeutic use), Antimalarials (therapeutic use), Antiviral Agents (therapeutic use), Azithromycin (therapeutic use), COVID-19 (drug therapy), COVID-19 (mortality), COVID-19 (virology), COVID-19 Testing (methods), Drug Combinations (MeSH), Drug Repositioning (MeSH), Drug Synergism (MeSH), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Hydroxychloroquine (therapeutic use), Male (MeSH), Middle Aged (MeSH), Nasopharynx (virology), RNA, Viral (genetics), Reverse Transcriptase Polymerase Chain Reaction (MeSH), SARS-CoV-2 (drug effects), SARS-CoV-2 (genetics), SARS-CoV-2 (pathogenicity), Survival Analysis (MeSH), Treatment Outcome (MeSH), Viral Load (drug effects).
- MESH :
- chemical , genetics : RNA, Viral.
- chemical , therapeutic use : Anti-Bacterial Agents, Antimalarials, Antiviral Agents, Azithromycin, Hydroxychloroquine.
- drug effects : SARS-CoV-2, Viral Load.
- drug therapy : COVID-19.
- genetics : SARS-CoV-2.
- methods : COVID-19 Testing.
- mortality : COVID-19.
- pathogenicity : SARS-CoV-2.
- statistics & numerical data : Hospitalization.
- virology : COVID-19, Nasopharynx.
- Aged, Aged, 80 and over, Drug Combinations, Drug Repositioning, Drug Synergism, Female, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Survival Analysis, Treatment Outcome.
DOI: 10.1016/j.ijantimicag.2020.106239
PubMed: 33408029
PubMed Central: PMC7779264
Links to Exploration step
pubmed:33408029Le document en format XML
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<author><name sortKey="Gautret, Philippe" sort="Gautret, Philippe" uniqKey="Gautret P" first="Philippe" last="Gautret">Philippe Gautret</name>
<affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation>
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<author><name sortKey="Hoang, Van Thuan" sort="Hoang, Van Thuan" uniqKey="Hoang V" first="Van Thuan" last="Hoang">Van Thuan Hoang</name>
<affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam.</nlm:affiliation>
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<author><name sortKey="Lagier, Jean Christophe" sort="Lagier, Jean Christophe" uniqKey="Lagier J" first="Jean-Christophe" last="Lagier">Jean-Christophe Lagier</name>
<affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation>
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<term>Antiviral Agents (therapeutic use)</term>
<term>Azithromycin (therapeutic use)</term>
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<term>COVID-19 (mortality)</term>
<term>COVID-19 (virology)</term>
<term>COVID-19 Testing (methods)</term>
<term>Drug Combinations (MeSH)</term>
<term>Drug Repositioning (MeSH)</term>
<term>Drug Synergism (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Nasopharynx (virology)</term>
<term>RNA, Viral (genetics)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term>
<term>SARS-CoV-2 (drug effects)</term>
<term>SARS-CoV-2 (genetics)</term>
<term>SARS-CoV-2 (pathogenicity)</term>
<term>Survival Analysis (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Viral Load (drug effects)</term>
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<term>Nasopharynx</term>
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<Title>International journal of antimicrobial agents</Title>
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<CoiStatement>Declaration of Competing Interest The authors declare no competing interests.</CoiStatement>
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