CovidChloroV1, Main, Corpus, bibRecord, 000479

Kidney Transplantation and COVID-19: Two Case Reports.

Identifieur interne : 000479 ( Main/Corpus ); précédent : 000478; suivant : 000480

Kidney Transplantation and COVID-19: Two Case Reports.

Auteurs : Sabri Tekin ; Hatice Özdo An ; Mustafa Kemal Demir ; Hagar Soultan ; Sadia Zafar

Source :

Transplantation proceedings [ 1873-2623 ] ; 2020.

RBID : pubmed:33451758

Abstract

Immunocompromised populations are at great risk of the current 2020 global emergency of coronavirus disease 2019 (COVID-19), and treatment of kidney transplant recipients with COVID-19 is currently not declared. Hence, the purpose of the study is to set a clear treatment regimen. We report here a therapeutic course of 2 patients who underwent transplant surgery in March 2020 and got infected soon after. Since the transplant, these 2 patients have received triple maintenance immunosuppressive therapy with oral tacrolimus, mycophenolate mofetil (MMF), and prednisone, and they have been regularly followed up at our hospital. The tacrolimus trough level was between 10 and 12 ng/mL. After the diagnosis of COVID-19, MMF was stopped and the tacrolimus dose was reduced so that blood level was between 4 and 6 ng/mL. The first patient was a 30-year-old man who, despite being treated with hydroxychloroquine, favipiravir, oseltamivir, and azithromycin therapy, died because of the presence of other comorbidities. The second case was a 58-year-old man who fully recovered from COVID-19 pneumonia with treatment with methylprednisolone, MMF, azithromycin, favipiravir, hydroxychloroquine, and reduction in immunosuppression dosage. This reflects the importance of using glucocorticoids in the treatment of COVID-19 along with other medications and the decreased mortality rate associated with their use.

DOI: 10.1016/j.transproceed.2020.10.051
PubMed: 33451758
PubMed Central: PMC7833881

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pubmed:33451758

Le document en format XML

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<affiliation><nlm:affiliation>Department of Organ Transplantation, Faculty of Medicine, Bahcesehir University, İstanbul, Turkey. Electronic address: tekinsabri@hotmail.com.</nlm:affiliation>
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<author><name sortKey="Ozdo An, Hatice" sort="Ozdo An, Hatice" uniqKey="Ozdo An H" first="Hatice" last="Özdo An">Hatice Özdo An</name>
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<author><name sortKey="Demir, Mustafa Kemal" sort="Demir, Mustafa Kemal" uniqKey="Demir M" first="Mustafa Kemal" last="Demir">Mustafa Kemal Demir</name>
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<front><div type="abstract" xml:lang="en">Immunocompromised populations are at great risk of the current 2020 global emergency of coronavirus disease 2019 (COVID-19), and treatment of kidney transplant recipients with COVID-19 is currently not declared. Hence, the purpose of the study is to set a clear treatment regimen. We report here a therapeutic course of 2 patients who underwent transplant surgery in March 2020 and got infected soon after. Since the transplant, these 2 patients have received triple maintenance immunosuppressive therapy with oral tacrolimus, mycophenolate mofetil (MMF), and prednisone, and they have been regularly followed up at our hospital. The tacrolimus trough level was between 10 and 12 ng/mL. After the diagnosis of COVID-19, MMF was stopped and the tacrolimus dose was reduced so that blood level was between 4 and 6 ng/mL. The first patient was a 30-year-old man who, despite being treated with hydroxychloroquine, favipiravir, oseltamivir, and azithromycin therapy, died because of the presence of other comorbidities. The second case was a 58-year-old man who fully recovered from COVID-19 pneumonia with treatment with methylprednisolone, MMF, azithromycin, favipiravir, hydroxychloroquine, and reduction in immunosuppression dosage. This reflects the importance of using glucocorticoids in the treatment of COVID-19 along with other medications and the decreased mortality rate associated with their use.</div>
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Kidney Transplantation and COVID-19: Two Case Reports.

Kidney Transplantation and COVID-19: Two Case Reports.

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