Health Care Workers' Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study.
Identifieur interne : 000367 ( Main/Corpus ); précédent : 000366; suivant : 000368Health Care Workers' Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study.
Auteurs : Alberto M. Borobia ; Irene García-García ; Lucía Díaz-García ; Amelia Rodríguez-Mariblanca ; Lucía Martínez De Soto ; Jaime Monserrat Villatoro ; Enrique Seco Meseguer ; Juan J. González ; Jesús Frías Iniesta ; Elena Ramírez García ; Jose Ram N Arribas ; Antonio J. Carcas-SansuánSource :
- Journal of medical Internet research [ 1438-8871 ] ; 2021.
English descriptors
- KwdEn :
- Adult (MeSH), Attitude of Health Personnel (MeSH), COVID-19 (drug therapy), COVID-19 (epidemiology), COVID-19 (psychology), Female (MeSH), Health Personnel (psychology), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Randomized Controlled Trials as Topic (methods), Randomized Controlled Trials as Topic (psychology), SARS-CoV-2 (isolation & purification), Surveys and Questionnaires (MeSH).
- MESH :
- drug therapy : COVID-19.
- epidemiology : COVID-19.
- isolation & purification : SARS-CoV-2.
- methods : Randomized Controlled Trials as Topic.
- psychology : COVID-19, Health Personnel, Randomized Controlled Trials as Topic.
- Adult, Attitude of Health Personnel, Female, Humans, Male, Middle Aged, Pandemics, Surveys and Questionnaires.
Abstract
BACKGROUND
In April 2020, two independent clinical trials to assess SARS-CoV-2 prophylaxis strategies among health care workers were initiated at our hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs combination therapy vs placebo).
OBJECTIVE
This study aimed to evaluate the reasons why health care workers chose to participate in the MeCOVID and EPICOS trials, as well as why they chose one over the other.
METHODS
Both trials were offered to health care workers through an internal news bulletin. After an initial screening visit, all subjects were asked to respond to a web-based survey.
RESULTS
In the first month, 206 health care workers were screened and 160 were randomized. The survey participation was high at 73.3%. Health care workers cited "to contribute to scientific knowledge" (n=80, 53.0%), followed by "to avoid SARS-CoV-2 infection" (n=33, 21.9%) and "the interest to be tested for SARS-CoV-2" (n=28, 18.5%), as their primary reasons to participate in the trials. We observed significant differences in the expected personal benefits across physicians and nurses (P=.01). The vast majority of volunteers (n=202, 98.0%) selected the MeCOVID trial, their primary reason being their concern regarding adverse reactions to treatments in the EPICOS trial (n=102, 69.4%).
CONCLUSIONS
Health care workers' reasons to participate in prophylaxis trials in an acute pandemic context appear to be driven largely by their desire to contribute to science and to gain health benefits. Safety outweighed efficacy when choosing between the two clinical trials.
DOI: 10.2196/23441
PubMed: 33556032
PubMed Central: PMC7909307
Links to Exploration step
pubmed:33556032Le document en format XML
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Borobia</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Garcia, Irene" sort="Garcia Garcia, Irene" uniqKey="Garcia Garcia I" first="Irene" last="García-García">Irene García-García</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Diaz Garcia, Lucia" sort="Diaz Garcia, Lucia" uniqKey="Diaz Garcia L" first="Lucía" last="Díaz-García">Lucía Díaz-García</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Mariblanca, Amelia" sort="Rodriguez Mariblanca, Amelia" uniqKey="Rodriguez Mariblanca A" first="Amelia" last="Rodríguez-Mariblanca">Amelia Rodríguez-Mariblanca</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martinez De Soto, Lucia" sort="Martinez De Soto, Lucia" uniqKey="Martinez De Soto L" first="Lucía" last="Martínez De Soto">Lucía Martínez De Soto</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Monserrat Villatoro, Jaime" sort="Monserrat Villatoro, Jaime" uniqKey="Monserrat Villatoro J" first="Jaime" last="Monserrat Villatoro">Jaime Monserrat Villatoro</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Seco Meseguer, Enrique" sort="Seco Meseguer, Enrique" uniqKey="Seco Meseguer E" first="Enrique" last="Seco Meseguer">Enrique Seco Meseguer</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez, Juan J" sort="Gonzalez, Juan J" uniqKey="Gonzalez J" first="Juan J" last="González">Juan J. 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Carcas-Sansuán</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33556032</idno><idno type="pmid">33556032</idno><idno type="doi">10.2196/23441</idno><idno type="pmc">PMC7909307</idno><idno type="wicri:Area/Main/Corpus">000367</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000367</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Health Care Workers' Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study.</title><author><name sortKey="Borobia, Alberto M" sort="Borobia, Alberto M" uniqKey="Borobia A" first="Alberto M" last="Borobia">Alberto M. Borobia</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Garcia, Irene" sort="Garcia Garcia, Irene" uniqKey="Garcia Garcia I" first="Irene" last="García-García">Irene García-García</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Diaz Garcia, Lucia" sort="Diaz Garcia, Lucia" uniqKey="Diaz Garcia L" first="Lucía" last="Díaz-García">Lucía Díaz-García</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Mariblanca, Amelia" sort="Rodriguez Mariblanca, Amelia" uniqKey="Rodriguez Mariblanca A" first="Amelia" last="Rodríguez-Mariblanca">Amelia Rodríguez-Mariblanca</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martinez De Soto, Lucia" sort="Martinez De Soto, Lucia" uniqKey="Martinez De Soto L" first="Lucía" last="Martínez De Soto">Lucía Martínez De Soto</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Monserrat Villatoro, Jaime" sort="Monserrat Villatoro, Jaime" uniqKey="Monserrat Villatoro J" first="Jaime" last="Monserrat Villatoro">Jaime Monserrat Villatoro</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Seco Meseguer, Enrique" sort="Seco Meseguer, Enrique" uniqKey="Seco Meseguer E" first="Enrique" last="Seco Meseguer">Enrique Seco Meseguer</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez, Juan J" sort="Gonzalez, Juan J" uniqKey="Gonzalez J" first="Juan J" last="González">Juan J. González</name><affiliation><nlm:affiliation>Internal Medicine Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Frias Iniesta, Jesus" sort="Frias Iniesta, Jesus" uniqKey="Frias Iniesta J" first="Jesús" last="Frías Iniesta">Jesús Frías Iniesta</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ramirez Garcia, Elena" sort="Ramirez Garcia, Elena" uniqKey="Ramirez Garcia E" first="Elena" last="Ramírez García">Elena Ramírez García</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Arribas, Jose Ram N" sort="Arribas, Jose Ram N" uniqKey="Arribas J" first="Jose Ram N" last="Arribas">Jose Ram N Arribas</name><affiliation><nlm:affiliation>Internal Medicine Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Carcas Sansuan, Antonio J" sort="Carcas Sansuan, Antonio J" uniqKey="Carcas Sansuan A" first="Antonio J" last="Carcas-Sansuán">Antonio J. Carcas-Sansuán</name><affiliation><nlm:affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of medical Internet research</title><idno type="eISSN">1438-8871</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Attitude of Health Personnel (MeSH)</term><term>COVID-19 (drug therapy)</term><term>COVID-19 (epidemiology)</term><term>COVID-19 (psychology)</term><term>Female (MeSH)</term><term>Health Personnel (psychology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Randomized Controlled Trials as Topic (methods)</term><term>Randomized Controlled Trials as Topic (psychology)</term><term>SARS-CoV-2 (isolation & purification)</term><term>Surveys and Questionnaires (MeSH)</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>COVID-19</term><term>Health Personnel</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Attitude of Health Personnel</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>In April 2020, two independent clinical trials to assess SARS-CoV-2 prophylaxis strategies among health care workers were initiated at our hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs combination therapy vs placebo).</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>This study aimed to evaluate the reasons why health care workers chose to participate in the MeCOVID and EPICOS trials, as well as why they chose one over the other.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Both trials were offered to health care workers through an internal news bulletin. After an initial screening visit, all subjects were asked to respond to a web-based survey.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In the first month, 206 health care workers were screened and 160 were randomized. The survey participation was high at 73.3%. Health care workers cited "to contribute to scientific knowledge" (n=80, 53.0%), followed by "to avoid SARS-CoV-2 infection" (n=33, 21.9%) and "the interest to be tested for SARS-CoV-2" (n=28, 18.5%), as their primary reasons to participate in the trials. We observed significant differences in the expected personal benefits across physicians and nurses (P=.01). The vast majority of volunteers (n=202, 98.0%) selected the MeCOVID trial, their primary reason being their concern regarding adverse reactions to treatments in the EPICOS trial (n=102, 69.4%).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Health care workers' reasons to participate in prophylaxis trials in an acute pandemic context appear to be driven largely by their desire to contribute to science and to gain health benefits. Safety outweighed efficacy when choosing between the two clinical trials.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">33556032</PMID><DateCompleted><Year>2021</Year><Month>03</Month><Day>18</Day></DateCompleted><DateRevised><Year>2021</Year><Month>03</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1438-8871</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>2</Issue><PubDate><Year>2021</Year><Month>02</Month><Day>25</Day></PubDate></JournalIssue><Title>Journal of medical Internet research</Title><ISOAbbreviation>J Med Internet Res</ISOAbbreviation></Journal><ArticleTitle>Health Care Workers' Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study.</ArticleTitle><Pagination><MedlinePgn>e23441</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2196/23441</ELocationID><Abstract><AbstractText Label="BACKGROUND">In April 2020, two independent clinical trials to assess SARS-CoV-2 prophylaxis strategies among health care workers were initiated at our hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs combination therapy vs placebo).</AbstractText><AbstractText Label="OBJECTIVE">This study aimed to evaluate the reasons why health care workers chose to participate in the MeCOVID and EPICOS trials, as well as why they chose one over the other.</AbstractText><AbstractText Label="METHODS">Both trials were offered to health care workers through an internal news bulletin. After an initial screening visit, all subjects were asked to respond to a web-based survey.</AbstractText><AbstractText Label="RESULTS">In the first month, 206 health care workers were screened and 160 were randomized. The survey participation was high at 73.3%. Health care workers cited "to contribute to scientific knowledge" (n=80, 53.0%), followed by "to avoid SARS-CoV-2 infection" (n=33, 21.9%) and "the interest to be tested for SARS-CoV-2" (n=28, 18.5%), as their primary reasons to participate in the trials. We observed significant differences in the expected personal benefits across physicians and nurses (P=.01). The vast majority of volunteers (n=202, 98.0%) selected the MeCOVID trial, their primary reason being their concern regarding adverse reactions to treatments in the EPICOS trial (n=102, 69.4%).</AbstractText><AbstractText Label="CONCLUSIONS">Health care workers' reasons to participate in prophylaxis trials in an acute pandemic context appear to be driven largely by their desire to contribute to science and to gain health benefits. Safety outweighed efficacy when choosing between the two clinical trials.</AbstractText><CopyrightInformation>©Alberto M Borobia, Irene García-García, Lucía Díaz-García, Amelia Rodríguez-Mariblanca, Lucía Martínez de Soto, Jaime Monserrat Villatoro, Enrique Seco Meseguer, Juan J González, Jesús Frías Iniesta, Elena Ramírez García, Jose Ramón Arribas, Antonio J Carcas-Sansuán. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 25.02.2021.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Borobia</LastName><ForeName>Alberto M</ForeName><Initials>AM</Initials><Identifier Source="ORCID">0000-0002-8584-3263</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>García-García</LastName><ForeName>Irene</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0002-4831-9374</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díaz-García</LastName><ForeName>Lucía</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0002-5371-9735</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Mariblanca</LastName><ForeName>Amelia</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0001-7095-9944</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez de Soto</LastName><ForeName>Lucía</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0002-2941-0922</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monserrat Villatoro</LastName><ForeName>Jaime</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-9100-3324</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seco Meseguer</LastName><ForeName>Enrique</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0002-4488-2661</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González</LastName><ForeName>Juan J</ForeName><Initials>JJ</Initials><Identifier Source="ORCID">0000-0002-3652-002X</Identifier><AffiliationInfo><Affiliation>Internal Medicine Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frías Iniesta</LastName><ForeName>Jesús</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0001-9538-9677</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramírez García</LastName><ForeName>Elena</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0002-4052-8876</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arribas</LastName><ForeName>Jose Ramón</ForeName><Initials>JR</Initials><Identifier Source="ORCID">0000-0002-7410-9450</Identifier><AffiliationInfo><Affiliation>Internal Medicine Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carcas-Sansuán</LastName><ForeName>Antonio J</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">0000-0003-1823-4174</Identifier><AffiliationInfo><Affiliation>Clinical Pharmacology Department, La Paz University Hospital (IdiPAZ), School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>02</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>J Med Internet Res</MedlineTA><NlmUniqueID>100959882</NlmUniqueID><ISSNLinking>1438-8871</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001291" MajorTopicYN="Y">Attitude of Health Personnel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006282" MajorTopicYN="N">Health Personnel</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">clinical trials</Keyword><Keyword MajorTopicYN="Y">health care worker</Keyword><Keyword MajorTopicYN="Y">motivation</Keyword><Keyword MajorTopicYN="Y">personnel</Keyword><Keyword MajorTopicYN="Y">pre-exposure</Keyword><Keyword MajorTopicYN="Y">professional practice</Keyword><Keyword MajorTopicYN="Y">prophylaxis</Keyword><Keyword MajorTopicYN="Y">volunteers, web-based survey</Keyword><Keyword MajorTopicYN="Y">workplace safety</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>02</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>2</Month><Day>8</Day><Hour>17</Hour><Minute>10</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33556032</ArticleId><ArticleId IdType="pii">v23i2e23441</ArticleId><ArticleId IdType="doi">10.2196/23441</ArticleId><ArticleId IdType="pmc">PMC7909307</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>PLoS One. 2018 Jul 25;13(7):e0200560</Citation><ArticleIdList><ArticleId 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