A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic.
Identifieur interne : 000354 ( Main/Corpus ); précédent : 000353; suivant : 000355A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic.
Auteurs : Tofael Ahmed Sumon ; Md Ashraf Hussain ; Md Tawheed Hasan ; Mahmudul Hasan ; Won Je Jang ; Eleus Hussain Bhuiya ; Abdullah Al Mamun Chowdhury ; S M Sharifuzzaman ; Christopher Lyon Brown ; Hyun-Ju Kwon ; Eun-Woo LeeSource :
- Frontiers in molecular biosciences [ 2296-889X ] ; 2020.
Abstract
A new strain of coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic was first detected in the city of Wuhan in Hubei province, China in late December 2019. To date, more than 1 million deaths and nearly 57 million confirmed cases have been recorded across 220 countries due to COVID-19, which is the greatest threat to global public health in our time. Although SARS-CoV-2 is genetically similar to other coronaviruses, i.e., SARS and Middle East respiratory syndrome coronavirus (MERS-CoV), no confirmed therapeutics are yet available against COVID-19, and governments, scientists, and pharmaceutical companies worldwide are working together in search for effective drugs and vaccines. Repurposing of relevant therapies, developing vaccines, and using bioinformatics to identify potential drug targets are strongly in focus to combat COVID-19. This review deals with the pathogenesis of COVID-19 and its clinical symptoms in humans including the most recent updates on candidate drugs and vaccines. Potential drugs (remdesivir, hydroxychloroquine, azithromycin, dexamethasone) and vaccines [mRNA-1273; measles, mumps and rubella (MMR), bacille Calmette-Guérin (BCG)] in human clinical trials are discussed with their composition, dosage, mode of action, and possible release dates according to the trial register of US National Library of Medicines (clinicaltrials.gov), European Union (clinicaltrialsregister.eu), and Chinese Clinical Trial Registry (chictr.org.cn) website. Moreover, recent reports on in silico approaches like molecular docking, molecular dynamics simulations, network-based identification, and homology modeling are included, toward repurposing strategies for the use of already approved drugs against newly emerged pathogens. Limitations of effectiveness, side effects, and safety issues of each approach are also highlighted. This review should be useful for the researchers working to find out an effective strategy for defeating SARS-CoV-2.
DOI: 10.3389/fmolb.2020.585899
PubMed: 33569389
PubMed Central: PMC7868442
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Tawheed" last="Hasan">Md Tawheed Hasan</name><affiliation><nlm:affiliation>Department of Aquaculture, Sylhet Agricultural University, Sylhet, Bangladesh.</nlm:affiliation></affiliation></author><author><name sortKey="Hasan, Mahmudul" sort="Hasan, Mahmudul" uniqKey="Hasan M" first="Mahmudul" last="Hasan">Mahmudul Hasan</name><affiliation><nlm:affiliation>Department of Pharmaceuticals and Industrial Biotechnology, Sylhet Agricultural University, Sylhet, Bangladesh.</nlm:affiliation></affiliation></author><author><name sortKey="Jang, Won Je" sort="Jang, Won Je" uniqKey="Jang W" first="Won Je" last="Jang">Won Je Jang</name><affiliation><nlm:affiliation>Department of Biotechnology, Pukyong National University, Busan, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Bhuiya, Eleus Hussain" sort="Bhuiya, Eleus Hussain" uniqKey="Bhuiya E" first="Eleus Hussain" last="Bhuiya">Eleus Hussain Bhuiya</name><affiliation><nlm:affiliation>Division of Analytical Development, Globe Biotech Limited, Dhaka, Bangladesh.</nlm:affiliation></affiliation></author><author><name sortKey="Chowdhury, Abdullah Al Mamun" sort="Chowdhury, Abdullah Al Mamun" uniqKey="Chowdhury A" first="Abdullah Al Mamun" last="Chowdhury">Abdullah Al Mamun Chowdhury</name><affiliation><nlm:affiliation>Department of Surgery, Rangamati General Hospital, Rangamati, Bangladesh.</nlm:affiliation></affiliation></author><author><name sortKey="Sharifuzzaman, S M" sort="Sharifuzzaman, S M" uniqKey="Sharifuzzaman S" first="S M" last="Sharifuzzaman">S M Sharifuzzaman</name><affiliation><nlm:affiliation>Institute of Marine Sciences, University of Chittagong, Chittagong, Bangladesh.</nlm:affiliation></affiliation></author><author><name sortKey="Brown, Christopher Lyon" sort="Brown, Christopher Lyon" uniqKey="Brown C" first="Christopher Lyon" last="Brown">Christopher Lyon Brown</name><affiliation><nlm:affiliation>World Fisheries University Pilot Programme, Pukyong National University, Busan, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kwon, Hyun Ju" sort="Kwon, Hyun Ju" uniqKey="Kwon H" first="Hyun-Ju" last="Kwon">Hyun-Ju Kwon</name><affiliation><nlm:affiliation>Biopharmaceutical Engineering Major, Division of Applied Bioengineering, Dong-Eui University, Busan, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Eun Woo" sort="Lee, Eun Woo" uniqKey="Lee E" first="Eun-Woo" last="Lee">Eun-Woo Lee</name><affiliation><nlm:affiliation>Biopharmaceutical Engineering Major, Division of Applied Bioengineering, Dong-Eui University, Busan, South Korea.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Frontiers in molecular biosciences</title><idno type="ISSN">2296-889X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new strain of coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic was first detected in the city of Wuhan in Hubei province, China in late December 2019. To date, more than 1 million deaths and nearly 57 million confirmed cases have been recorded across 220 countries due to COVID-19, which is the greatest threat to global public health in our time. Although SARS-CoV-2 is genetically similar to other coronaviruses, i.e., SARS and Middle East respiratory syndrome coronavirus (MERS<i>-</i>CoV), no confirmed therapeutics are yet available against COVID-19, and governments, scientists, and pharmaceutical companies worldwide are working together in search for effective drugs and vaccines. Repurposing of relevant therapies, developing vaccines, and using bioinformatics to identify potential drug targets are strongly in focus to combat COVID-19. This review deals with the pathogenesis of COVID-19 and its clinical symptoms in humans including the most recent updates on candidate drugs and vaccines. Potential drugs (remdesivir, hydroxychloroquine, azithromycin, dexamethasone) and vaccines [mRNA-1273; measles, mumps and rubella (MMR), bacille Calmette-Guérin (BCG)] in human clinical trials are discussed with their composition, dosage, mode of action, and possible release dates according to the trial register of US National Library of Medicines (clinicaltrials.gov), European Union (clinicaltrialsregister.eu), and Chinese Clinical Trial Registry (chictr.org.cn) website. Moreover, recent reports on <i>in silico</i> approaches like molecular docking, molecular dynamics simulations, network-based identification, and homology modeling are included, toward repurposing strategies for the use of already approved drugs against newly emerged pathogens. Limitations of effectiveness, side effects, and safety issues of each approach are also highlighted. This review should be useful for the researchers working to find out an effective strategy for defeating SARS-CoV-2.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33569389</PMID><DateRevised><Year>2021</Year><Month>02</Month><Day>12</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2296-889X</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in molecular biosciences</Title><ISOAbbreviation>Front Mol Biosci</ISOAbbreviation></Journal><ArticleTitle>A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic.</ArticleTitle><Pagination><MedlinePgn>585899</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fmolb.2020.585899</ELocationID><Abstract><AbstractText>A new strain of coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic was first detected in the city of Wuhan in Hubei province, China in late December 2019. To date, more than 1 million deaths and nearly 57 million confirmed cases have been recorded across 220 countries due to COVID-19, which is the greatest threat to global public health in our time. Although SARS-CoV-2 is genetically similar to other coronaviruses, i.e., SARS and Middle East respiratory syndrome coronavirus (MERS<i>-</i>CoV), no confirmed therapeutics are yet available against COVID-19, and governments, scientists, and pharmaceutical companies worldwide are working together in search for effective drugs and vaccines. Repurposing of relevant therapies, developing vaccines, and using bioinformatics to identify potential drug targets are strongly in focus to combat COVID-19. This review deals with the pathogenesis of COVID-19 and its clinical symptoms in humans including the most recent updates on candidate drugs and vaccines. Potential drugs (remdesivir, hydroxychloroquine, azithromycin, dexamethasone) and vaccines [mRNA-1273; measles, mumps and rubella (MMR), bacille Calmette-Guérin (BCG)] in human clinical trials are discussed with their composition, dosage, mode of action, and possible release dates according to the trial register of US National Library of Medicines (clinicaltrials.gov), European Union (clinicaltrialsregister.eu), and Chinese Clinical Trial Registry (chictr.org.cn) website. Moreover, recent reports on <i>in silico</i> approaches like molecular docking, molecular dynamics simulations, network-based identification, and homology modeling are included, toward repurposing strategies for the use of already approved drugs against newly emerged pathogens. Limitations of effectiveness, side effects, and safety issues of each approach are also highlighted. This review should be useful for the researchers working to find out an effective strategy for defeating SARS-CoV-2.</AbstractText><CopyrightInformation>Copyright © 2021 Sumon, Hussain, Hasan, Hasan, Jang, Bhuiya, Chowdhury, Sharifuzzaman, Brown, Kwon and Lee.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sumon</LastName><ForeName>Tofael Ahmed</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Department of Fish Health Management, Sylhet Agricultural University, Sylhet, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hussain</LastName><ForeName>Md Ashraf</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Fisheries Technology and Quality Control, Sylhet Agricultural University, Sylhet, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hasan</LastName><ForeName>Md Tawheed</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Aquaculture, Sylhet Agricultural University, Sylhet, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hasan</LastName><ForeName>Mahmudul</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pharmaceuticals and Industrial Biotechnology, Sylhet Agricultural University, Sylhet, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jang</LastName><ForeName>Won Je</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, Pukyong National University, Busan, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhuiya</LastName><ForeName>Eleus Hussain</ForeName><Initials>EH</Initials><AffiliationInfo><Affiliation>Division of Analytical Development, Globe Biotech Limited, Dhaka, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chowdhury</LastName><ForeName>Abdullah Al Mamun</ForeName><Initials>AAM</Initials><AffiliationInfo><Affiliation>Department of Surgery, Rangamati General Hospital, Rangamati, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharifuzzaman</LastName><ForeName>S M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Institute of Marine Sciences, University of Chittagong, Chittagong, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>Christopher Lyon</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>World Fisheries University Pilot Programme, Pukyong National University, Busan, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Hyun-Ju</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Biopharmaceutical Engineering Major, Division of Applied Bioengineering, Dong-Eui University, Busan, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Eun-Woo</ForeName><Initials>EW</Initials><AffiliationInfo><Affiliation>Biopharmaceutical Engineering Major, Division of Applied Bioengineering, Dong-Eui University, Busan, South Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>01</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Mol Biosci</MedlineTA><NlmUniqueID>101653173</NlmUniqueID><ISSNLinking>2296-889X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">drugs</Keyword><Keyword MajorTopicYN="N">in silico approaches</Keyword><Keyword MajorTopicYN="N">vaccines</Keyword></KeywordList><CoiStatement>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>12</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>2</Month><Day>11</Day><Hour>5</Hour><Minute>55</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>2</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>12</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33569389</ArticleId><ArticleId IdType="doi">10.3389/fmolb.2020.585899</ArticleId><ArticleId IdType="pmc">PMC7868442</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Clin Infect Dis. 2018 May 2;66(10):1501-1503</Citation><ArticleIdList><ArticleId IdType="pubmed">29315362</ArticleId></ArticleIdList></Reference><Reference><Citation>Virusdisease. 2020 May 2;:1-6</Citation><ArticleIdList><ArticleId IdType="pubmed">32363219</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 12;323(18):1824-1836</Citation><ArticleIdList><ArticleId IdType="pubmed">32282022</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 Jul 17;:1-17</Citation><ArticleIdList><ArticleId IdType="pubmed">32677533</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Nov 19;71(16):2027-2034</Citation><ArticleIdList><ArticleId IdType="pubmed">32221519</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2020 Mar 13;367(6483):1260-1263</Citation><ArticleIdList><ArticleId IdType="pubmed">32075877</ArticleId></ArticleIdList></Reference><Reference><Citation>Viruses. 2020 May 10;12(5):</Citation><ArticleIdList><ArticleId IdType="pubmed">32397688</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15657466</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2020 Jun;178:104786</Citation><ArticleIdList><ArticleId IdType="pubmed">32251767</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 May 14;:1-14</Citation><ArticleIdList><ArticleId IdType="pubmed">32362217</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 30;395(10238):1695-1704</Citation><ArticleIdList><ArticleId IdType="pubmed">32401715</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Apr;8(4):420-422</Citation><ArticleIdList><ArticleId IdType="pubmed">32085846</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Discov Ther. 2020;14(1):58-60</Citation><ArticleIdList><ArticleId IdType="pubmed">32147628</ArticleId></ArticleIdList></Reference><Reference><Citation>Mil Med Res. 2020 Mar 13;7(1):11</Citation><ArticleIdList><ArticleId IdType="pubmed">32169119</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Microbes Infect. 2020 Dec;9(1):221-236</Citation><ArticleIdList><ArticleId IdType="pubmed">31987001</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Aug 15;396(10249):467-478</Citation><ArticleIdList><ArticleId IdType="pubmed">32702298</ArticleId></ArticleIdList></Reference><Reference><Citation>J Chem Inf Model. 2007 May-Jun;47(3):1258-62</Citation><ArticleIdList><ArticleId IdType="pubmed">17447753</ArticleId></ArticleIdList></Reference><Reference><Citation>Life Sci. 2020 Jul 1;252:117652</Citation><ArticleIdList><ArticleId IdType="pubmed">32278693</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2016 Feb 23;315(8):801-10</Citation><ArticleIdList><ArticleId IdType="pubmed">26903338</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation><ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Biochem Anal. 2003;44:509-23</Citation><ArticleIdList><ArticleId IdType="pubmed">12647402</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Mar 17;323(11):1061-1069</Citation><ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation><ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Res Pract. 2020 Mar-Apr;10(2):54-64</Citation><ArticleIdList><ArticleId IdType="pubmed">32363221</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 May 13;:1-12</Citation><ArticleIdList><ArticleId IdType="pubmed">32345124</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Nov 12;383(20):1920-1931</Citation><ArticleIdList><ArticleId IdType="pubmed">32663912</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Dis Poverty. 2020 Sep 16;9(1):132</Citation><ArticleIdList><ArticleId IdType="pubmed">32938504</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioanalysis. 2018 Feb;10(3):163-180</Citation><ArticleIdList><ArticleId IdType="pubmed">29333863</ArticleId></ArticleIdList></Reference><Reference><Citation>Asian Pac J Allergy Immunol. 2020 Mar;38(1):10-18</Citation><ArticleIdList><ArticleId IdType="pubmed">32134278</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Apr 30;382(18):1708-1720</Citation><ArticleIdList><ArticleId IdType="pubmed">32109013</ArticleId></ArticleIdList></Reference><Reference><Citation>ACS Cent Sci. 2020 Mar 25;6(3):315-331</Citation><ArticleIdList><ArticleId IdType="pubmed">32226821</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2006 Sep;3(9):e343</Citation><ArticleIdList><ArticleId IdType="pubmed">16968120</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2020 May 21;64(6):</Citation><ArticleIdList><ArticleId IdType="pubmed">32205349</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Discov Today. 2002 Jun 1;7(11):S83-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12047885</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Dev Res. 2020 Jul 6;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32632960</ArticleId></ArticleIdList></Reference><Reference><Citation>Engineering (Beijing). 2020 Oct;6(10):1192-1198</Citation><ArticleIdList><ArticleId IdType="pubmed">32346491</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharmacol Rep. 2020 May 11;:1-15</Citation><ArticleIdList><ArticleId IdType="pubmed">32395418</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pharm Anal. 2020 Apr;10(2):102-108</Citation><ArticleIdList><ArticleId IdType="pubmed">32282863</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2014 May;105:17-21</Citation><ArticleIdList><ArticleId IdType="pubmed">24583123</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacotherapy. 2020 Jun;40(6):592-598</Citation><ArticleIdList><ArticleId IdType="pubmed">32281114</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Aug 6;383(6):517-525</Citation><ArticleIdList><ArticleId IdType="pubmed">32492293</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 Apr 26;:1-13</Citation><ArticleIdList><ArticleId IdType="pubmed">32306862</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Inform. 2021 Jan;40(1):e2000115</Citation><ArticleIdList><ArticleId IdType="pubmed">32722864</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Med Sci. 2020 Apr 25;16(3):490-496</Citation><ArticleIdList><ArticleId IdType="pubmed">32399094</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 May 6;:1-10</Citation><ArticleIdList><ArticleId IdType="pubmed">32306822</ArticleId></ArticleIdList></Reference><Reference><Citation>Chemphyschem. 2020 Jul 17;21(14):1486-1514</Citation><ArticleIdList><ArticleId IdType="pubmed">32452115</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Genet Evol. 2020 Sep;83:104327</Citation><ArticleIdList><ArticleId IdType="pubmed">32320825</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 Jul 22;:1-11</Citation><ArticleIdList><ArticleId IdType="pubmed">32698689</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 May 2;:1-16</Citation><ArticleIdList><ArticleId IdType="pubmed">32295479</ArticleId></ArticleIdList></Reference><Reference><Citation>F1000Res. 2020 Feb 21;9:129</Citation><ArticleIdList><ArticleId IdType="pubmed">32194944</ArticleId></ArticleIdList></Reference><Reference><Citation>J Proteome Res. 2020 Nov 6;19(11):4567-4575</Citation><ArticleIdList><ArticleId IdType="pubmed">32786890</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2007 Oct;30(4):297-308</Citation><ArticleIdList><ArticleId IdType="pubmed">17629679</ArticleId></ArticleIdList></Reference><Reference><Citation>Pathogens. 2020 Mar 04;9(3):</Citation><ArticleIdList><ArticleId IdType="pubmed">32143502</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2020 May - Jun;35:101646</Citation><ArticleIdList><ArticleId IdType="pubmed">32294562</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Drug Discov. 2020 May;19(5):305-306</Citation><ArticleIdList><ArticleId IdType="pubmed">32273591</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Mar 5;382(10):929-936</Citation><ArticleIdList><ArticleId IdType="pubmed">32004427</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Recognit. 2011 Mar-Apr;24(2):149-64</Citation><ArticleIdList><ArticleId IdType="pubmed">21360606</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 May 6;:1-9</Citation><ArticleIdList><ArticleId IdType="pubmed">32338164</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2008 Apr;133(1):13-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17374415</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Respir J. 2020 Apr 16;55(4):</Citation><ArticleIdList><ArticleId IdType="pubmed">32269085</ArticleId></ArticleIdList></Reference><Reference><Citation>Microbes Infect. 2020 Mar;22(2):74-79</Citation><ArticleIdList><ArticleId IdType="pubmed">32017984</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Pharmacol. 2017 May 23;8:298</Citation><ArticleIdList><ArticleId IdType="pubmed">28588497</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Trop Med Rep. 2020 Mar 3;:1-4</Citation><ArticleIdList><ArticleId IdType="pubmed">32219057</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Discov. 2020 Mar 16;6:14</Citation><ArticleIdList><ArticleId IdType="pubmed">32194980</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Nov;78(22):12672-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15507655</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2020 Jun 2;172(11):754-755</Citation><ArticleIdList><ArticleId IdType="pubmed">32232419</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Inf Med. 2008;47(4):283-95</Citation><ArticleIdList><ArticleId IdType="pubmed">18690362</ArticleId></ArticleIdList></Reference><Reference><Citation>Molecules. 2020 Aug 23;25(17):</Citation><ArticleIdList><ArticleId IdType="pubmed">32842509</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pharm Anal. 2020 Aug;10(4):313-319</Citation><ArticleIdList><ArticleId IdType="pubmed">32296570</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Cell Biol. 2020 May 18;12(4):322-325</Citation><ArticleIdList><ArticleId IdType="pubmed">32236562</ArticleId></ArticleIdList></Reference><Reference><Citation>F1000Res. 2015 May 01;4:104</Citation><ArticleIdList><ArticleId IdType="pubmed">26167272</ArticleId></ArticleIdList></Reference><Reference><Citation>Biophys Rev. 2014 Mar;6(1):75-87</Citation><ArticleIdList><ArticleId IdType="pubmed">28509958</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2019 Dec 12;381(24):2293-2303</Citation><ArticleIdList><ArticleId IdType="pubmed">31774950</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Coll Emerg Physicians Open. 2020 Apr 19;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32838367</ArticleId></ArticleIdList></Reference><Reference><Citation>EXCLI J. 2020 Mar 17;19:400-409</Citation><ArticleIdList><ArticleId IdType="pubmed">32210741</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2020 May - Jun;35:101738</Citation><ArticleIdList><ArticleId IdType="pubmed">32387409</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharmacol. 2020 Sep 15;883:173348</Citation><ArticleIdList><ArticleId IdType="pubmed">32634438</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Clin Microbiol Antimicrob. 2020 Sep 2;19(1):40</Citation><ArticleIdList><ArticleId IdType="pubmed">32878641</ArticleId></ArticleIdList></Reference><Reference><Citation>Turk J Biol. 2020 Jun 21;44(3):228-241</Citation><ArticleIdList><ArticleId IdType="pubmed">32595359</ArticleId></ArticleIdList></Reference><Reference><Citation>J Integr Med. 2020 Mar;18(2):152-158</Citation><ArticleIdList><ArticleId IdType="pubmed">32113846</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 Apr;580(7805):576-577</Citation><ArticleIdList><ArticleId IdType="pubmed">32346146</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009 Nov 17;4(11):e7870</Citation><ArticleIdList><ArticleId IdType="pubmed">19924243</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Biotechnol. 2020 May;38(5):523-532</Citation><ArticleIdList><ArticleId IdType="pubmed">32203293</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2011 Jan;85(2):873-82</Citation><ArticleIdList><ArticleId IdType="pubmed">21068237</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2020 May 29;368(6494):1012-1015</Citation><ArticleIdList><ArticleId IdType="pubmed">32303590</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Chem. 2021 Jan;106:104490</Citation><ArticleIdList><ArticleId IdType="pubmed">33261845</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 May 18;:1-9</Citation><ArticleIdList><ArticleId IdType="pubmed">32266867</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 Apr 15;:1-11</Citation><ArticleIdList><ArticleId IdType="pubmed">32238078</ArticleId></ArticleIdList></Reference><Reference><Citation>Rev Panam Salud Publica. 2020 Mar 20;44:e40</Citation><ArticleIdList><ArticleId IdType="pubmed">32256547</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2020 Jun;80(6):607-613</Citation><ArticleIdList><ArticleId IdType="pubmed">32283152</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975</Citation><ArticleIdList><ArticleId IdType="pubmed">32350134</ArticleId></ArticleIdList></Reference><Reference><Citation>Mem Inst Oswaldo Cruz. 2020;115:e200179</Citation><ArticleIdList><ArticleId IdType="pubmed">32490889</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation><ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId></ArticleIdList></Reference><Reference><Citation>New Microbes New Infect. 2020 Apr 20;35:100682</Citation><ArticleIdList><ArticleId IdType="pubmed">32313660</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(4):e35421</Citation><ArticleIdList><ArticleId IdType="pubmed">22536382</ArticleId></ArticleIdList></Reference><Reference><Citation>Viruses. 2020 Mar 27;12(4):</Citation><ArticleIdList><ArticleId IdType="pubmed">32230900</ArticleId></ArticleIdList></Reference><Reference><Citation>Comput Biol Med. 2020 Apr;119:103670</Citation><ArticleIdList><ArticleId IdType="pubmed">32209231</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Virol. 2020 Oct;92(10):2087-2095</Citation><ArticleIdList><ArticleId IdType="pubmed">32374457</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Vaccin Immunother. 2020 Jun 2;16(6):1232-1238</Citation><ArticleIdList><ArticleId IdType="pubmed">32186952</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2020 Jul 28;11:1784</Citation><ArticleIdList><ArticleId IdType="pubmed">32849643</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2020 May;80(5):554-562</Citation><ArticleIdList><ArticleId IdType="pubmed">32169481</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Pharmacol. 2007 Sep;152(1):21-37</Citation><ArticleIdList><ArticleId IdType="pubmed">17549046</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Nov 5;383(19):1813-1826</Citation><ArticleIdList><ArticleId IdType="pubmed">32445440</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Feb 15;395(10223):507-513</Citation><ArticleIdList><ArticleId IdType="pubmed">32007143</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Clin Microbiol Antimicrob. 2020 May 30;19(1):23</Citation><ArticleIdList><ArticleId IdType="pubmed">32473642</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Jun 11;382(24):2327-2336</Citation><ArticleIdList><ArticleId IdType="pubmed">32275812</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2020 Apr 16;181(2):271-280.e8</Citation><ArticleIdList><ArticleId IdType="pubmed">32142651</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Microbes Infect. 2020 Dec;9(1):386-389</Citation><ArticleIdList><ArticleId IdType="pubmed">32065057</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Discov Today. 2014 Apr;19(4):433-40</Citation><ArticleIdList><ArticleId IdType="pubmed">24183925</ArticleId></ArticleIdList></Reference><Reference><Citation>Rev Med Virol. 2020 Sep;30(5):e2123</Citation><ArticleIdList><ArticleId IdType="pubmed">32648313</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Infect Dis. 2020 Jul;96:500-502</Citation><ArticleIdList><ArticleId IdType="pubmed">32470602</ArticleId></ArticleIdList></Reference><Reference><Citation>J Microbiol Immunol Infect. 2020 Mar 31;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32265180</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Public Health. 2020 Sep;13(9):1210-1223</Citation><ArticleIdList><ArticleId IdType="pubmed">32561274</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2006 Feb;6(2):67-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16439323</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2020 May 20;:1-19</Citation><ArticleIdList><ArticleId IdType="pubmed">32396769</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation><ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2020 Apr 14;52(4):583-589</Citation><ArticleIdList><ArticleId IdType="pubmed">32259480</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2020 Apr 3;368(6486):14-16</Citation><ArticleIdList><ArticleId IdType="pubmed">32241928</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterology. 2020 May;158(6):1831-1833.e3</Citation><ArticleIdList><ArticleId IdType="pubmed">32142773</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 Mar;579(7798):265-269</Citation><ArticleIdList><ArticleId IdType="pubmed">32015508</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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