Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.
Identifieur interne : 000224 ( Main/Corpus ); précédent : 000223; suivant : 000225Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.
Auteurs : Jia Liu ; Ruiyuan Cao ; Mingyue Xu ; Xi Wang ; Huanyu Zhang ; Hengrui Hu ; Yufeng Li ; Zhihong Hu ; Wu Zhong ; Manli WangSource :
- Cell discovery [ 2056-5968 ] ; 2020.
DOI: 10.1038/s41421-020-0156-0
PubMed: 33731711
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.</title><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Ruiyuan" sort="Cao, Ruiyuan" uniqKey="Cao R" first="Ruiyuan" last="Cao">Ruiyuan Cao</name><affiliation><nlm:affiliation>National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Mingyue" sort="Xu, Mingyue" uniqKey="Xu M" first="Mingyue" last="Xu">Mingyue Xu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xi" sort="Wang, Xi" uniqKey="Wang X" first="Xi" last="Wang">Xi Wang</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Huanyu" sort="Zhang, Huanyu" uniqKey="Zhang H" first="Huanyu" last="Zhang">Huanyu Zhang</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hengrui" sort="Hu, Hengrui" uniqKey="Hu H" first="Hengrui" last="Hu">Hengrui Hu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yufeng" sort="Li, Yufeng" uniqKey="Li Y" first="Yufeng" last="Li">Yufeng Li</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhihong" sort="Hu, Zhihong" uniqKey="Hu Z" first="Zhihong" last="Hu">Zhihong Hu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. huzh@wh.iov.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Wu" sort="Zhong, Wu" uniqKey="Zhong W" first="Wu" last="Zhong">Wu Zhong</name><affiliation><nlm:affiliation>National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China. zhongwu@bmi.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Manli" sort="Wang, Manli" uniqKey="Wang M" first="Manli" last="Wang">Manli Wang</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. wangml@wh.iov.cn.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33731711</idno><idno type="pmid">33731711</idno><idno type="doi">10.1038/s41421-020-0156-0</idno><idno type="wicri:Area/Main/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.</title><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Ruiyuan" sort="Cao, Ruiyuan" uniqKey="Cao R" first="Ruiyuan" last="Cao">Ruiyuan Cao</name><affiliation><nlm:affiliation>National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Mingyue" sort="Xu, Mingyue" uniqKey="Xu M" first="Mingyue" last="Xu">Mingyue Xu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xi" sort="Wang, Xi" uniqKey="Wang X" first="Xi" last="Wang">Xi Wang</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Huanyu" sort="Zhang, Huanyu" uniqKey="Zhang H" first="Huanyu" last="Zhang">Huanyu Zhang</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hengrui" sort="Hu, Hengrui" uniqKey="Hu H" first="Hengrui" last="Hu">Hengrui Hu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yufeng" sort="Li, Yufeng" uniqKey="Li Y" first="Yufeng" last="Li">Yufeng Li</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhihong" sort="Hu, Zhihong" uniqKey="Hu Z" first="Zhihong" last="Hu">Zhihong Hu</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. huzh@wh.iov.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Wu" sort="Zhong, Wu" uniqKey="Zhong W" first="Wu" last="Zhong">Wu Zhong</name><affiliation><nlm:affiliation>National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China. zhongwu@bmi.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Manli" sort="Wang, Manli" uniqKey="Wang M" first="Manli" last="Wang">Manli Wang</name><affiliation><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. wangml@wh.iov.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell discovery</title><idno type="ISSN">2056-5968</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33731711</PMID><DateRevised><Year>2021</Year><Month>03</Month><Day>19</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2056-5968</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Mar</Month><Day>18</Day></PubDate></JournalIssue><Title>Cell discovery</Title><ISOAbbreviation>Cell Discov</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.</ArticleTitle><Pagination><MedlinePgn>16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41421-020-0156-0</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Liu</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Cao</LastName><ForeName>Ruiyuan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Xu</LastName><ForeName>Mingyue</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xi</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Virology, Wuhan Institute of 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China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yufeng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of the Chinese Academy of Sciences, 100049, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Zhihong</ForeName><Initials>Z</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1560-0928</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. huzh@wh.iov.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Wu</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China. zhongwu@bmi.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Manli</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. wangml@wh.iov.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cell Discov</MedlineTA><NlmUniqueID>101661034</NlmUniqueID><ISSNLinking>2056-5968</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>19</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33731711</ArticleId><ArticleId IdType="doi">10.1038/s41421-020-0156-0</ArticleId><ArticleId IdType="pii">10.1038/s41421-020-0156-0</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Wang, M. et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30, 269–271 (2020).</Citation><ArticleIdList><ArticleId IdType="doi">10.1038/s41422-020-0282-0</ArticleId></ArticleIdList></Reference><Reference><Citation>Holshue, M. L. et al. First case of 2019 novel coronavirus in the United States. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2001191 (2020).</Citation><ArticleIdList><ArticleId IdType="doi">10.1056/NEJMoa2001191</ArticleId><ArticleId IdType="pubmed">32004427</ArticleId></ArticleIdList></Reference><Reference><Citation>Weniger, H. Review of side effects and toxicity of chloroquine. Bull. World Health 79, 906 (1979).</Citation></Reference><Reference><Citation>McChesney, E. W. Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate. Am. J. Med. 75, 11–18 (1983).</Citation><ArticleIdList><ArticleId IdType="doi">10.1016/0002-9343(83)91265-2</ArticleId></ArticleIdList></Reference><Reference><Citation>Mauthe, M. et al. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy 14, 1435–1455 (2018).</Citation><ArticleIdList><ArticleId IdType="doi">10.1080/15548627.2018.1474314</ArticleId></ArticleIdList></Reference><Reference><Citation>Savarino, A. et al. New insights into the antiviral effects of chloroquine. Lancet Infect. Dis. 6, 67–69 (2006).</Citation><ArticleIdList><ArticleId IdType="doi">10.1016/S1473-3099(06)70361-9</ArticleId></ArticleIdList></Reference><Reference><Citation>Mingo, R. M. et al. Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step. J. Virol. 89, 2931–2943 (2015).</Citation><ArticleIdList><ArticleId IdType="doi">10.1128/JVI.03398-14</ArticleId></ArticleIdList></Reference><Reference><Citation>Zheng, N., Zhang, X. & Rosania, G. R. Effect of phospholipidosis on the cellular pharmacokinetics of chloroquine. J. Pharmacol. Exp. Ther. 336, 661–671 (2011).</Citation><ArticleIdList><ArticleId IdType="doi">10.1124/jpet.110.175679</ArticleId></ArticleIdList></Reference><Reference><Citation>Ohkuma, S. & Poole, B. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Natl Acad. Sci. USA 75, 3327–3331 (1978).</Citation><ArticleIdList><ArticleId IdType="doi">10.1073/pnas.75.7.3327</ArticleId></ArticleIdList></Reference><Reference><Citation>Popert, A. J. Choloroquine: a review. Rheumatology 15, 235–238 (1976).</Citation><ArticleIdList><ArticleId IdType="doi">10.1093/rheumatology/15.3.235</ArticleId></ArticleIdList></Reference><Reference><Citation>Laaksonen, A. L., Koskiahde, V. & Juva, K. Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine. Scand. J. rheumatol. 3, 103–108 (1974).</Citation><ArticleIdList><ArticleId IdType="doi">10.3109/03009747409115809</ArticleId></ArticleIdList></Reference><Reference><Citation>Huang, C. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395, 497–506 (2020).</Citation><ArticleIdList><ArticleId IdType="doi">10.1016/S0140-6736(20)30183-5</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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