CovidChloroV1, Main, Corpus, bibRecord, 000096

Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases.

Identifieur interne : 000096 ( Main/Corpus ); précédent : 000095; suivant : 000097

Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases.

Auteurs : Khanh Pham ; Heidi Torres ; Michael J. Satlin ; Parag Goyal ; Roy M. Gulick

Source :

Rheumatology advances in practice [ 2514-1775 ] ; 2021.

RBID : pubmed:33875975

Abstract

Objective

To compare baseline characteristics, clinical presentations and outcomes of patients with rheumatic conditions requiring hospitalization for coronavirus disease 2019 (COVID-19) who received chronic HCQ with those who did not receive chronic HCQ.

Methods

We identified all patients with a rheumatologic disease who were admitted with COVID-19 to two hospitals in New York City between 3 March 3 and 30 April 2020. Patients who received chronic HCQ prior to admission were matched 1:2 (±10 years of age) with patients who did not receive chronic HCQ. We compared demographics, comorbidities, HCQ dosages, concurrent medications, presentations and outcomes between the groups.

Results

There were 14 patients receiving HCQ and 28 matched control subjects. The median age of cases was 63 years [interquartile range (IQR) 43-73) and 60 years (IQR 41-75) for controls. Control subjects had a higher prevalence of pulmonary diseases (42.8%), diabetes (35.7%) and obesity (35.7%) than their case counterparts (28.6%, 14.3% and 7.1%, respectively). A higher proportion of cases than control subjects (50%

Conclusion

HCQ therapy in individuals with rheumatic conditions was not associated with less severe presentations of COVID-19 among hospitalized patients compared with individuals with rheumatic conditions not receiving HCQ.

DOI: 10.1093/rap/rkab014
PubMed: 33875975
PubMed Central: PMC7989153

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pubmed:33875975

Le document en format XML

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<author><name sortKey="Pham, Khanh" sort="Pham, Khanh" uniqKey="Pham K" first="Khanh" last="Pham">Khanh Pham</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Torres, Heidi" sort="Torres, Heidi" uniqKey="Torres H" first="Heidi" last="Torres">Heidi Torres</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Satlin, Michael J" sort="Satlin, Michael J" uniqKey="Satlin M" first="Michael J" last="Satlin">Michael J. Satlin</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goyal, Parag" sort="Goyal, Parag" uniqKey="Goyal P" first="Parag" last="Goyal">Parag Goyal</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gulick, Roy M" sort="Gulick, Roy M" uniqKey="Gulick R" first="Roy M" last="Gulick">Roy M. Gulick</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases.</title>
<author><name sortKey="Pham, Khanh" sort="Pham, Khanh" uniqKey="Pham K" first="Khanh" last="Pham">Khanh Pham</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
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<author><name sortKey="Torres, Heidi" sort="Torres, Heidi" uniqKey="Torres H" first="Heidi" last="Torres">Heidi Torres</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
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<author><name sortKey="Satlin, Michael J" sort="Satlin, Michael J" uniqKey="Satlin M" first="Michael J" last="Satlin">Michael J. Satlin</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation>
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<author><name sortKey="Goyal, Parag" sort="Goyal, Parag" uniqKey="Goyal P" first="Parag" last="Goyal">Parag Goyal</name>
<affiliation><nlm:affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation>
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<author><name sortKey="Gulick, Roy M" sort="Gulick, Roy M" uniqKey="Gulick R" first="Roy M" last="Gulick">Roy M. Gulick</name>
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<series><title level="j">Rheumatology advances in practice</title>
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<front><div type="abstract" xml:lang="en"><p><b>Objective</b>
</p>
<p>To compare baseline characteristics, clinical presentations and outcomes of patients with rheumatic conditions requiring hospitalization for coronavirus disease 2019 (COVID-19) who received chronic HCQ with those who did not receive chronic HCQ.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Methods</b>
</p>
<p>We identified all patients with a rheumatologic disease who were admitted with COVID-19 to two hospitals in New York City between 3 March 3 and 30 April 2020. Patients who received chronic HCQ prior to admission were matched 1:2 (±10 years of age) with patients who did not receive chronic HCQ. We compared demographics, comorbidities, HCQ dosages, concurrent medications, presentations and outcomes between the groups.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>There were 14 patients receiving HCQ and 28 matched control subjects. The median age of cases was 63 years [interquartile range (IQR) 43-73) and 60 years (IQR 41-75) for controls. Control subjects had a higher prevalence of pulmonary diseases (42.8%), diabetes (35.7%) and obesity (35.7%) than their case counterparts (28.6%, 14.3% and 7.1%, respectively). A higher proportion of cases than control subjects (50% </p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusion</b>
</p>
<p>HCQ therapy in individuals with rheumatic conditions was not associated with less severe presentations of COVID-19 among hospitalized patients compared with individuals with rheumatic conditions not receiving HCQ.</p>
</div>
</front>
</TEI>
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<DateRevised><Year>2021</Year>
<Month>04</Month>
<Day>28</Day>
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<Issue>1</Issue>
<PubDate><Year>2021</Year>
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<Title>Rheumatology advances in practice</Title>
<ISOAbbreviation>Rheumatol Adv Pract</ISOAbbreviation>
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<ArticleTitle>Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.1093/rap/rkab014</ELocationID>
<Abstract><AbstractText Label="Objective" NlmCategory="UNASSIGNED">To compare baseline characteristics, clinical presentations and outcomes of patients with rheumatic conditions requiring hospitalization for coronavirus disease 2019 (COVID-19) who received chronic HCQ with those who did not receive chronic HCQ.</AbstractText>
<AbstractText Label="Methods" NlmCategory="UNASSIGNED">We identified all patients with a rheumatologic disease who were admitted with COVID-19 to two hospitals in New York City between 3 March 3 and 30 April 2020. Patients who received chronic HCQ prior to admission were matched 1:2 (±10 years of age) with patients who did not receive chronic HCQ. We compared demographics, comorbidities, HCQ dosages, concurrent medications, presentations and outcomes between the groups.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">There were 14 patients receiving HCQ and 28 matched control subjects. The median age of cases was 63 years [interquartile range (IQR) 43-73) and 60 years (IQR 41-75) for controls. Control subjects had a higher prevalence of pulmonary diseases (42.8%), diabetes (35.7%) and obesity (35.7%) than their case counterparts (28.6%, 14.3% and 7.1%, respectively). A higher proportion of cases than control subjects (50% <i>vs</i>
 25%) reported the use of prednisone for their rheumatic conditions prior to admission. Despite these differences in baseline characteristics, univariate logistic regression revealed no statistically significant differences in the need for mechanical ventilation [OR 1.5 (95% CI 0.34, 6.38)] or in-hospital mortality [OR 0.77 (95% CI 0.13, 4.56)].</AbstractText>
<AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">HCQ therapy in individuals with rheumatic conditions was not associated with less severe presentations of COVID-19 among hospitalized patients compared with individuals with rheumatic conditions not receiving HCQ.</AbstractText>
<CopyrightInformation>© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.</CopyrightInformation>
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<ForeName>Khanh</ForeName>
<Initials>K</Initials>
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<AffiliationInfo><Affiliation>NewYork-Presbyterian Hospital, Weill Cornell Medical Center.</Affiliation>
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<Author ValidYN="Y"><LastName>Torres</LastName>
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<Author ValidYN="Y"><LastName>Goyal</LastName>
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<Author ValidYN="Y"><LastName>Gulick</LastName>
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Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases.

Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases.

Source :

Abstract

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