Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.
Identifieur interne : 000081 ( Main/Corpus ); précédent : 000080; suivant : 000082Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.
Auteurs : Rujipas Sirijatuphat ; Yupin Suputtamongkol ; Nasikarn Angkasekwinai ; Navin Horthongkham ; Methee Chayakulkeeree ; Pinyo Rattanaumpawan ; Pornpan Koomanachai ; Susan Assanasen ; Yong Rongrungruang ; Nitipatana Chierakul ; Ranistha Ratanarat ; Anupop Jitmuang ; Walaiporn Wangchinda ; Wannee KantakamalakulSource :
- BMC infectious diseases [ 1471-2334 ] ; 2021.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Amides (therapeutic use), Antiviral Agents (therapeutic use), COVID-19 (drug therapy), COVID-19 (epidemiology), Chloroquine (therapeutic use), Darunavir (therapeutic use), Disease Progression (MeSH), Drug Combinations (MeSH), Female (MeSH), Hospitals (MeSH), Hospitals, University (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Lopinavir (therapeutic use), Male (MeSH), Middle Aged (MeSH), Pyrazines (therapeutic use), Referral and Consultation (MeSH), Retrospective Studies (MeSH), Ritonavir (therapeutic use), Thailand (epidemiology), Treatment Outcome (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Amides, Antiviral Agents, Chloroquine, Darunavir, Hydroxychloroquine, Lopinavir, Pyrazines, Ritonavir.
- geographic , epidemiology : Thailand.
- drug therapy : COVID-19.
- epidemiology : COVID-19.
- Adult, Aged, Aged, 80 and over, Disease Progression, Drug Combinations, Female, Hospitals, Hospitals, University, Humans, Male, Middle Aged, Referral and Consultation, Retrospective Studies, Treatment Outcome, Young Adult.
Abstract
BACKGROUND
The epidemiology and outcomes of COVID-19 patients in Thailand are scarce.
METHODS
This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020.
RESULTS
The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive.
CONCLUSIONS
The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.
DOI: 10.1186/s12879-021-06081-z
PubMed: 33902480
PubMed Central: PMC8072093
Links to Exploration step
pubmed:33902480Le document en format XML
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Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Ratanarat, Ranistha" sort="Ratanarat, Ranistha" uniqKey="Ratanarat R" first="Ranistha" last="Ratanarat">Ranistha Ratanarat</name><affiliation><nlm:affiliation>Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Jitmuang, Anupop" sort="Jitmuang, Anupop" uniqKey="Jitmuang A" first="Anupop" last="Jitmuang">Anupop Jitmuang</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Wangchinda, Walaiporn" sort="Wangchinda, Walaiporn" uniqKey="Wangchinda W" first="Walaiporn" last="Wangchinda">Walaiporn Wangchinda</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Kantakamalakul, Wannee" sort="Kantakamalakul, Wannee" uniqKey="Kantakamalakul W" first="Wannee" last="Kantakamalakul">Wannee Kantakamalakul</name><affiliation><nlm:affiliation>Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33902480</idno><idno type="pmid">33902480</idno><idno type="doi">10.1186/s12879-021-06081-z</idno><idno type="pmc">PMC8072093</idno><idno type="wicri:Area/Main/Corpus">000081</idno><idno type="wicri:explorRef" wicri:stream="Main" 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Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Angkasekwinai, Nasikarn" sort="Angkasekwinai, Nasikarn" uniqKey="Angkasekwinai N" first="Nasikarn" last="Angkasekwinai">Nasikarn Angkasekwinai</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. nasikarn@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Horthongkham, Navin" sort="Horthongkham, Navin" uniqKey="Horthongkham N" first="Navin" last="Horthongkham">Navin Horthongkham</name><affiliation><nlm:affiliation>Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Chayakulkeeree, Methee" sort="Chayakulkeeree, Methee" uniqKey="Chayakulkeeree M" first="Methee" last="Chayakulkeeree">Methee Chayakulkeeree</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Rattanaumpawan, Pinyo" sort="Rattanaumpawan, Pinyo" uniqKey="Rattanaumpawan P" first="Pinyo" last="Rattanaumpawan">Pinyo Rattanaumpawan</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Koomanachai, Pornpan" sort="Koomanachai, Pornpan" uniqKey="Koomanachai P" first="Pornpan" last="Koomanachai">Pornpan Koomanachai</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Assanasen, Susan" sort="Assanasen, Susan" uniqKey="Assanasen S" first="Susan" last="Assanasen">Susan Assanasen</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Rongrungruang, Yong" sort="Rongrungruang, Yong" uniqKey="Rongrungruang Y" first="Yong" last="Rongrungruang">Yong Rongrungruang</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Chierakul, Nitipatana" sort="Chierakul, Nitipatana" uniqKey="Chierakul N" first="Nitipatana" last="Chierakul">Nitipatana Chierakul</name><affiliation><nlm:affiliation>Division of Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Ratanarat, Ranistha" sort="Ratanarat, Ranistha" uniqKey="Ratanarat R" first="Ranistha" last="Ratanarat">Ranistha Ratanarat</name><affiliation><nlm:affiliation>Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Jitmuang, Anupop" sort="Jitmuang, Anupop" uniqKey="Jitmuang A" first="Anupop" last="Jitmuang">Anupop Jitmuang</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Wangchinda, Walaiporn" sort="Wangchinda, Walaiporn" uniqKey="Wangchinda W" first="Walaiporn" last="Wangchinda">Walaiporn Wangchinda</name><affiliation><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Kantakamalakul, Wannee" sort="Kantakamalakul, Wannee" uniqKey="Kantakamalakul W" first="Wannee" last="Kantakamalakul">Wannee Kantakamalakul</name><affiliation><nlm:affiliation>Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMC infectious diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Amides (therapeutic use)</term><term>Antiviral Agents (therapeutic use)</term><term>COVID-19 (drug therapy)</term><term>COVID-19 (epidemiology)</term><term>Chloroquine (therapeutic use)</term><term>Darunavir (therapeutic use)</term><term>Disease Progression (MeSH)</term><term>Drug Combinations (MeSH)</term><term>Female (MeSH)</term><term>Hospitals (MeSH)</term><term>Hospitals, University (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (therapeutic use)</term><term>Lopinavir (therapeutic use)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pyrazines (therapeutic use)</term><term>Referral and Consultation (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Ritonavir (therapeutic use)</term><term>Thailand (epidemiology)</term><term>Treatment Outcome (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amides</term><term>Antiviral Agents</term><term>Chloroquine</term><term>Darunavir</term><term>Hydroxychloroquine</term><term>Lopinavir</term><term>Pyrazines</term><term>Ritonavir</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Thailand</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Drug Combinations</term><term>Female</term><term>Hospitals</term><term>Hospitals, University</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Referral and Consultation</term><term>Retrospective Studies</term><term>Treatment Outcome</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The epidemiology and outcomes of COVID-19 patients in Thailand are scarce.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">33902480</PMID><DateCompleted><Year>2021</Year><Month>04</Month><Day>28</Day></DateCompleted><DateRevised><Year>2021</Year><Month>04</Month><Day>30</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2334</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>Apr</Month><Day>26</Day></PubDate></JournalIssue><Title>BMC infectious diseases</Title><ISOAbbreviation>BMC Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.</ArticleTitle><Pagination><MedlinePgn>382</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12879-021-06081-z</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The epidemiology and outcomes of COVID-19 patients in Thailand are scarce.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sirijatuphat</LastName><ForeName>Rujipas</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suputtamongkol</LastName><ForeName>Yupin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Angkasekwinai</LastName><ForeName>Nasikarn</ForeName><Initials>N</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5723-4877</Identifier><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. nasikarn@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horthongkham</LastName><ForeName>Navin</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chayakulkeeree</LastName><ForeName>Methee</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rattanaumpawan</LastName><ForeName>Pinyo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koomanachai</LastName><ForeName>Pornpan</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assanasen</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rongrungruang</LastName><ForeName>Yong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chierakul</LastName><ForeName>Nitipatana</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ratanarat</LastName><ForeName>Ranistha</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jitmuang</LastName><ForeName>Anupop</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wangchinda</LastName><ForeName>Walaiporn</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kantakamalakul</LastName><ForeName>Wannee</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>04</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Infect Dis</MedlineTA><NlmUniqueID>100968551</NlmUniqueID><ISSNLinking>1471-2334</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000577">Amides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011719">Pyrazines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C558899">lopinavir-ritonavir drug 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