Medication safety in a pandemic: A multicentre point prevalence study of QTc monitoring of hydroxychloroquine for COVID-19.
Identifieur interne : 000043 ( Main/Corpus ); précédent : 000042; suivant : 000044Medication safety in a pandemic: A multicentre point prevalence study of QTc monitoring of hydroxychloroquine for COVID-19.
Auteurs : Steven M. Smoke ; Henry Leach ; Nicole Leonida ; Karan Raja ; Monica Shah ; Vishal Patel ; Gargi Patel ; Nicole M. Daniel ; Jessica Gerges ; Akshar PatelSource :
- Journal of clinical pharmacy and therapeutics [ 1365-2710 ] ; 2021.
Abstract
WHAT IS KNOWN AND OBJECTIVE
A pandemic can strain all aspects of the healthcare system, including the ability to monitor the safety of medication use. Reviewing the adequacy of medication safety practices during the COVID-19 pandemic is critical to informing responses to future pandemics. The purpose of this study was to evaluate medication safety practices at a height of both COVID-19 cases and hydroxychloroquine use.
METHODS
This was a multicentre observational point prevalence study. Adult inpatients receiving hydroxychloroquine for COVID-19 between March 22 and 28, 2020 were included. The primary outcome was the percentage of patients receiving appropriate QTc monitoring. Secondary outcomes included QTc prolongation, early discontinuation of hydroxychloroquine and ventricular arrhythmias.
RESULTS AND DISCUSSION
A total of 59% (167/284) of patients treated with hydroxychloroquine received appropriate QTc monitoring. QTc prolongation occurred in 25%. Hydroxychloroquine was prematurely discontinued in 1.4% of patients, all due to QTc prolongation. Ventricular arrhythmia occurred in 1.1%.
WHAT IS NEW AND CONCLUSION
Medication safety practices were suboptimal with regard to hydroxychloroquine monitoring at the height of the COVID-19 pandemic. Preparation for future pandemics should devote considerable attention to medication safety.
DOI: 10.1111/jcpt.13429
PubMed: 33959987
Links to Exploration step
pubmed:33959987Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Medication safety in a pandemic: A multicentre point prevalence study of QTc monitoring of hydroxychloroquine for COVID-19.</title>
<author><name sortKey="Smoke, Steven M" sort="Smoke, Steven M" uniqKey="Smoke S" first="Steven M" last="Smoke">Steven M. Smoke</name>
<affiliation><nlm:affiliation>Pharmacy Department, Saint Barnabas Medical Center, Livingston, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leach, Henry" sort="Leach, Henry" uniqKey="Leach H" first="Henry" last="Leach">Henry Leach</name>
<affiliation><nlm:affiliation>Pharmacy Department, Barnabas Health Behavioral Health Center, Toms River, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leonida, Nicole" sort="Leonida, Nicole" uniqKey="Leonida N" first="Nicole" last="Leonida">Nicole Leonida</name>
<affiliation><nlm:affiliation>Pharmacy Department, Jersey City Medical Center, Jersey City, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Raja, Karan" sort="Raja, Karan" uniqKey="Raja K" first="Karan" last="Raja">Karan Raja</name>
<affiliation><nlm:affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shah, Monica" sort="Shah, Monica" uniqKey="Shah M" first="Monica" last="Shah">Monica Shah</name>
<affiliation><nlm:affiliation>Pharmacy Department, Monmouth Medical Center, Long Branch, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Patel, Vishal" sort="Patel, Vishal" uniqKey="Patel V" first="Vishal" last="Patel">Vishal Patel</name>
<affiliation><nlm:affiliation>Idaho College of Osteopathic Medicine, Meridian, ID, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Patel, Gargi" sort="Patel, Gargi" uniqKey="Patel G" first="Gargi" last="Patel">Gargi Patel</name>
<affiliation><nlm:affiliation>Pharmacy Department, Community Medical Center, Toms River, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Daniel, Nicole M" sort="Daniel, Nicole M" uniqKey="Daniel N" first="Nicole M" last="Daniel">Nicole M. Daniel</name>
<affiliation><nlm:affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gerges, Jessica" sort="Gerges, Jessica" uniqKey="Gerges J" first="Jessica" last="Gerges">Jessica Gerges</name>
<affiliation><nlm:affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Patel, Akshar" sort="Patel, Akshar" uniqKey="Patel A" first="Akshar" last="Patel">Akshar Patel</name>
<affiliation><nlm:affiliation>Pharmacy Department, Saint Barnabas Medical Center, Livingston, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2021">2021</date>
<idno type="RBID">pubmed:33959987</idno>
<idno type="pmid">33959987</idno>
<idno type="doi">10.1111/jcpt.13429</idno>
<idno type="wicri:Area/Main/Corpus">000043</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000043</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Medication safety in a pandemic: A multicentre point prevalence study of QTc monitoring of hydroxychloroquine for COVID-19.</title>
<author><name sortKey="Smoke, Steven M" sort="Smoke, Steven M" uniqKey="Smoke S" first="Steven M" last="Smoke">Steven M. Smoke</name>
<affiliation><nlm:affiliation>Pharmacy Department, Saint Barnabas Medical Center, Livingston, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leach, Henry" sort="Leach, Henry" uniqKey="Leach H" first="Henry" last="Leach">Henry Leach</name>
<affiliation><nlm:affiliation>Pharmacy Department, Barnabas Health Behavioral Health Center, Toms River, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leonida, Nicole" sort="Leonida, Nicole" uniqKey="Leonida N" first="Nicole" last="Leonida">Nicole Leonida</name>
<affiliation><nlm:affiliation>Pharmacy Department, Jersey City Medical Center, Jersey City, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Raja, Karan" sort="Raja, Karan" uniqKey="Raja K" first="Karan" last="Raja">Karan Raja</name>
<affiliation><nlm:affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shah, Monica" sort="Shah, Monica" uniqKey="Shah M" first="Monica" last="Shah">Monica Shah</name>
<affiliation><nlm:affiliation>Pharmacy Department, Monmouth Medical Center, Long Branch, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Patel, Vishal" sort="Patel, Vishal" uniqKey="Patel V" first="Vishal" last="Patel">Vishal Patel</name>
<affiliation><nlm:affiliation>Idaho College of Osteopathic Medicine, Meridian, ID, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Patel, Gargi" sort="Patel, Gargi" uniqKey="Patel G" first="Gargi" last="Patel">Gargi Patel</name>
<affiliation><nlm:affiliation>Pharmacy Department, Community Medical Center, Toms River, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Daniel, Nicole M" sort="Daniel, Nicole M" uniqKey="Daniel N" first="Nicole M" last="Daniel">Nicole M. Daniel</name>
<affiliation><nlm:affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gerges, Jessica" sort="Gerges, Jessica" uniqKey="Gerges J" first="Jessica" last="Gerges">Jessica Gerges</name>
<affiliation><nlm:affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Patel, Akshar" sort="Patel, Akshar" uniqKey="Patel A" first="Akshar" last="Patel">Akshar Patel</name>
<affiliation><nlm:affiliation>Pharmacy Department, Saint Barnabas Medical Center, Livingston, NJ, USA.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of clinical pharmacy and therapeutics</title>
<idno type="eISSN">1365-2710</idno>
<imprint><date when="2021" type="published">2021</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>WHAT IS KNOWN AND OBJECTIVE</b>
</p>
<p>A pandemic can strain all aspects of the healthcare system, including the ability to monitor the safety of medication use. Reviewing the adequacy of medication safety practices during the COVID-19 pandemic is critical to informing responses to future pandemics. The purpose of this study was to evaluate medication safety practices at a height of both COVID-19 cases and hydroxychloroquine use.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>This was a multicentre observational point prevalence study. Adult inpatients receiving hydroxychloroquine for COVID-19 between March 22 and 28, 2020 were included. The primary outcome was the percentage of patients receiving appropriate QTc monitoring. Secondary outcomes included QTc prolongation, early discontinuation of hydroxychloroquine and ventricular arrhythmias.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS AND DISCUSSION</b>
</p>
<p>A total of 59% (167/284) of patients treated with hydroxychloroquine received appropriate QTc monitoring. QTc prolongation occurred in 25%. Hydroxychloroquine was prematurely discontinued in 1.4% of patients, all due to QTc prolongation. Ventricular arrhythmia occurred in 1.1%.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>WHAT IS NEW AND CONCLUSION</b>
</p>
<p>Medication safety practices were suboptimal with regard to hydroxychloroquine monitoring at the height of the COVID-19 pandemic. Preparation for future pandemics should devote considerable attention to medication safety.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33959987</PMID>
<DateRevised><Year>2021</Year>
<Month>05</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2710</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year>
<Month>May</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>Journal of clinical pharmacy and therapeutics</Title>
<ISOAbbreviation>J Clin Pharm Ther</ISOAbbreviation>
</Journal>
<ArticleTitle>Medication safety in a pandemic: A multicentre point prevalence study of QTc monitoring of hydroxychloroquine for COVID-19.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/jcpt.13429</ELocationID>
<Abstract><AbstractText Label="WHAT IS KNOWN AND OBJECTIVE" NlmCategory="OBJECTIVE">A pandemic can strain all aspects of the healthcare system, including the ability to monitor the safety of medication use. Reviewing the adequacy of medication safety practices during the COVID-19 pandemic is critical to informing responses to future pandemics. The purpose of this study was to evaluate medication safety practices at a height of both COVID-19 cases and hydroxychloroquine use.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This was a multicentre observational point prevalence study. Adult inpatients receiving hydroxychloroquine for COVID-19 between March 22 and 28, 2020 were included. The primary outcome was the percentage of patients receiving appropriate QTc monitoring. Secondary outcomes included QTc prolongation, early discontinuation of hydroxychloroquine and ventricular arrhythmias.</AbstractText>
<AbstractText Label="RESULTS AND DISCUSSION" NlmCategory="CONCLUSIONS">A total of 59% (167/284) of patients treated with hydroxychloroquine received appropriate QTc monitoring. QTc prolongation occurred in 25%. Hydroxychloroquine was prematurely discontinued in 1.4% of patients, all due to QTc prolongation. Ventricular arrhythmia occurred in 1.1%.</AbstractText>
<AbstractText Label="WHAT IS NEW AND CONCLUSION" NlmCategory="CONCLUSIONS">Medication safety practices were suboptimal with regard to hydroxychloroquine monitoring at the height of the COVID-19 pandemic. Preparation for future pandemics should devote considerable attention to medication safety.</AbstractText>
<CopyrightInformation>© 2021 John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Smoke</LastName>
<ForeName>Steven M</ForeName>
<Initials>SM</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-4847-3432</Identifier>
<AffiliationInfo><Affiliation>Pharmacy Department, Saint Barnabas Medical Center, Livingston, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leach</LastName>
<ForeName>Henry</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-1142-9868</Identifier>
<AffiliationInfo><Affiliation>Pharmacy Department, Barnabas Health Behavioral Health Center, Toms River, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leonida</LastName>
<ForeName>Nicole</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Pharmacy Department, Jersey City Medical Center, Jersey City, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Raja</LastName>
<ForeName>Karan</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shah</LastName>
<ForeName>Monica</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Pharmacy Department, Monmouth Medical Center, Long Branch, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Patel</LastName>
<ForeName>Vishal</ForeName>
<Initials>V</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-0886-5063</Identifier>
<AffiliationInfo><Affiliation>Idaho College of Osteopathic Medicine, Meridian, ID, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Patel</LastName>
<ForeName>Gargi</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Pharmacy Department, Community Medical Center, Toms River, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daniel</LastName>
<ForeName>Nicole M</ForeName>
<Initials>NM</Initials>
<AffiliationInfo><Affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gerges</LastName>
<ForeName>Jessica</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Pharmacy Department, Clara Maass Medical Center, Belleville, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Patel</LastName>
<ForeName>Akshar</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Pharmacy Department, Saint Barnabas Medical Center, Livingston, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2021</Year>
<Month>05</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Clin Pharm Ther</MedlineTA>
<NlmUniqueID>8704308</NlmUniqueID>
<ISSNLinking>0269-4727</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Covid-19</Keyword>
<Keyword MajorTopicYN="N">drug monitoring</Keyword>
<Keyword MajorTopicYN="N">hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="N">medication safety</Keyword>
<Keyword MajorTopicYN="N">pandemic</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2021</Year>
<Month>02</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2021</Year>
<Month>04</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2021</Year>
<Month>5</Month>
<Day>7</Day>
<Hour>7</Hour>
<Minute>30</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2021</Year>
<Month>5</Month>
<Day>8</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2021</Year>
<Month>5</Month>
<Day>8</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">33959987</ArticleId>
<ArticleId IdType="doi">10.1111/jcpt.13429</ArticleId>
</ArticleIdList>
<ReferenceList><Title>REFERENCES</Title>
<Reference><Citation>World Health Organization. Coronavirus Disease (Covid-19) Dashboard. https://covid19.who.int/. Date: February 6, 2021. Date accessed: February6, 2021.</Citation>
</Reference>
<Reference><Citation>Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30(3):269-271.</Citation>
</Reference>
<Reference><Citation>Gautret P, Lagier J-C, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;56(1):105949.</Citation>
</Reference>
<Reference><Citation>Statement of the International Society of Antimicrobial Chemotherapy (ISAC) posted on its website. 2020. https://www.isac.world/news-and-publications/official-isac-statement.</Citation>
</Reference>
<Reference><Citation>Kim AHJ, Sparks JA, Liew JW, et al. A rush to judgment? Rapid reporting and dissemination of results and its consequences regarding the use of hydroxychloroquine for COVID-19. Ann Intern Med. 2020;172(12):819-821.10.7326/M20-1223.</Citation>
</Reference>
<Reference><Citation>Vaduganathan M, van Meijgaard J, Mehra MR, et al. Prescription fill patterns for commonly used drugs during the COVID-19 pandemic in the United States. JAMA. 2020;323(24):2524-2526.10.1001/jama.2020.9184.</Citation>
</Reference>
<Reference><Citation>RECOVERY Collaborative Group, Horby P, Mafham M, et al. Effect of hydroxychloroquine in hospitalized patients with Covid-19. N Engl J Med. 2020;383(21):2030-2040.</Citation>
</Reference>
<Reference><Citation>Skipper CP, Pastick KA, Engen NW, et al. Hydroxychloroquine in nonhospitalized adults with early COVID-19: A randomized trial. Ann Intern Med. 2020;173(8):623-631. doi: 10.7326/M20-4207. Epub 2020 Jul 16. PMID: 32673060; PMCID: PMC7384270.</Citation>
</Reference>
<Reference><Citation>Cavalcanti AB, Zampieri FG, Rosa RG, et al. Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19. N Engl J Med. 2020;383(21):2041-2052.</Citation>
</Reference>
<Reference><Citation>Wang G, Lu CJ, Trafford AW, et al. Mechanistic insights into ventricular arrhythmogenesis of hydroxychloroquine and azithromycin for the treatment of COVID-19. bioRxiv. 2020. org/10.1101/2020.05.21.108605.</Citation>
</Reference>
<Reference><Citation>Sandau KE, Funk M, Auerbach A, et al. Update to practice standards for electrocardiographic monitoring in hospital settings: a scientific statement from the American Heart Association. Circulation. 2017;136(19):e273-e344. doi: 10.1161/CIR.0000000000000527. Epub 2017 Oct 3. PMID: 28974521.</Citation>
</Reference>
<Reference><Citation>Tisdale JE, Jaynes HA, Kingery JR, et al. Development and validation of a risk score to predict QT interval prolongation in hospitalized patients. Circ Cardiovasc Qual Outcomes. 2013;6(4):479-487.</Citation>
</Reference>
<Reference><Citation>CredibleMeds website. http://www.crediblemeds.org. Accessed November 8, 2020.</Citation>
</Reference>
<Reference><Citation>The Use of the WHO-UMC System for Standardized Case Causality Assessment. The Uppsala Monitoring Centre. Available at: https://www.who.int/medicines/areas/quality safety/safety efficacy/WHOcausality assessment.pdf. Accessed November 11, 2020.</Citation>
</Reference>
<Reference><Citation>Mercuro NJ, Yen CF, Shim DJ, et al. Risk of qt interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019(COVID-19). JAMA Cardiol. 2020;5(9):1036-1041.</Citation>
</Reference>
<Reference><Citation>Ramireddy A, Chugh H, Reinier K, et al. Experience with hydroxychloroquine and azithromycin in the coronavirus disease 2019 pandemic: implications for qt interval monitoring. J Am Heart Assoc. 2020;9(12):e017144.</Citation>
</Reference>
<Reference><Citation>Saleh M, Gabriels J, Chang D, et al. Effect of chloroquine, hydroxychloroquine, and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection. Circ Arrhythm Electrophysiol. 2020;13(6):e008662. doi: 10.1161/CIRCEP.120.008662. Epub 2020 Apr 29. PMID: 32347743; PMCID: PMC7299095.</Citation>
</Reference>
<Reference><Citation>Daniel NM, Walsh K, Leach H, Stummer L. Implementation of a QTc-interval monitoring protocol by pharmacists to decrease cardiac risk in at-risk patients in an acute care inpatient psychiatric facility. Ment Health Clin. 2019;9(2):82-87.</Citation>
</Reference>
<Reference><Citation>Hutchins LM, Temple JD, Hilmas E. Impact of pharmacist intervention on electrocardiogram monitoring of pediatric patients on multiple QTc interval-prolonging medications. J Pediatr Pharmacol Ther. 2017;22(6):399-405. doi: 10.5863/1551-6776-22.6.399. PMID: 29290739; PMCID: PMC5736251.</Citation>
</Reference>
<Reference><Citation>Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ. Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19). Mayo Clin Proc. 2020;95(6):1213-1221.doi: 10.1016/j.mayocp.2020.03.024.</Citation>
</Reference>
<Reference><Citation>Chorin E, Wadhwani L, Magnani S, et al. QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin. Heart Rhythm. 2020;17(9):1425-1433. doi: 10.1016/j.hrthm.2020.05.014.</Citation>
</Reference>
<Reference><Citation>Bessière F, Roccia H, Delinière A, et al. Assessment of QT intervals in a case series of patients with Coronavirus disease 2019 (COVID19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit. JAMA Cardiol. 2020;5(9):1067. 10.1001/jamacardio.2020.1787.</Citation>
</Reference>
<Reference><Citation>Maraj I, Hummel JP, Taoutel R, et al. Incidence and determinants of QT interval prolongation in COVID-19 patients treated with hydroxychloroquine and azithromycin. J Cardiovasc Electrophysiol. 2020;31(8):1904-1907.</Citation>
</Reference>
<Reference><Citation>Seymour CW, McCreary EK, Stegenga J. Sensible medicine-balancing intervention and inaction during the COVID-19 pandemic. JAMA. 2020;324(18):1827. Published online October 15, 2020. doi:10.1001/jama.2020.20271.</Citation>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000043 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000043 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= CovidChloroV1 |flux= Main |étape= Corpus |type= RBID |clé= pubmed:33959987 |texte= Medication safety in a pandemic: A multicentre point prevalence study of QTc monitoring of hydroxychloroquine for COVID-19. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:33959987" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a CovidChloroV1
![]() | This area was generated with Dilib version V0.6.38. | ![]() |