[The inhibitory effects of chloroquine and dexamethasone on the formation of pulmonary edema in the early stage of smoke inhalation injury in rats].
Identifieur interne : 000471 ( PubMed/Curation ); précédent : 000470; suivant : 000472[The inhibitory effects of chloroquine and dexamethasone on the formation of pulmonary edema in the early stage of smoke inhalation injury in rats].
Auteurs : T. Yang [République populaire de Chine] ; Z. Yang ; Q. LuoSource :
- Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns [ 1009-2587 ] ; 2000.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Lésion par inhalation de fumée.
- usage thérapeutique : Chloroquine, Dexaméthasone.
- Animaux, Femelle, Lésion par inhalation de fumée, Mâle, Oedème pulmonaire, Rat Wistar, Rats.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Chloroquine, Dexamethasone.
- complications : Smoke Inhalation Injury.
- drug therapy : Smoke Inhalation Injury.
- prevention & control : Pulmonary Edema.
- Animals, Female, Male, Rats, Rats, Wistar.
Abstract
To explore the inhibitory effects of chloroquine and dexamethasone on the formation of pulmonary edema in the early stage of smoke inhalation injury in rats.
PubMed: 11876860
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Luo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:11876860</idno><idno type="pmid">11876860</idno><idno type="wicri:Area/PubMed/Corpus">000471</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000471</idno><idno type="wicri:Area/PubMed/Curation">000471</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000471</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[The inhibitory effects of chloroquine and dexamethasone on the formation of pulmonary edema in the early stage of smoke inhalation injury in rats].</title><author><name sortKey="Yang, T" sort="Yang, T" uniqKey="Yang T" first="T" last="Yang">T. Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anesthesia, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Z" sort="Yang, Z" uniqKey="Yang Z" first="Z" last="Yang">Z. Yang</name></author><author><name sortKey="Luo, Q" sort="Luo, Q" uniqKey="Luo Q" first="Q" last="Luo">Q. Luo</name></author></analytic><series><title level="j">Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns</title><idno type="ISSN">1009-2587</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chloroquine (therapeutic use)</term><term>Dexamethasone (therapeutic use)</term><term>Female</term><term>Male</term><term>Pulmonary Edema (prevention & control)</term><term>Rats</term><term>Rats, Wistar</term><term>Smoke Inhalation Injury (complications)</term><term>Smoke Inhalation Injury (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chloroquine (usage thérapeutique)</term><term>Dexaméthasone (usage thérapeutique)</term><term>Femelle</term><term>Lésion par inhalation de fumée ()</term><term>Lésion par inhalation de fumée (traitement médicamenteux)</term><term>Mâle</term><term>Oedème pulmonaire ()</term><term>Rat Wistar</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chloroquine</term><term>Dexamethasone</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Smoke Inhalation Injury</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Smoke Inhalation Injury</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pulmonary Edema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lésion par inhalation de fumée</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Chloroquine</term><term>Dexaméthasone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Lésion par inhalation de fumée</term><term>Mâle</term><term>Oedème pulmonaire</term><term>Rat Wistar</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To explore the inhibitory effects of chloroquine and dexamethasone on the formation of pulmonary edema in the early stage of smoke inhalation injury in rats.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11876860</PMID><DateCompleted><Year>2002</Year><Month>07</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1009-2587</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>3</Issue><PubDate><Year>2000</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns</Title><ISOAbbreviation>Zhonghua Shao Shang Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[The inhibitory effects of chloroquine and dexamethasone on the formation of pulmonary edema in the early stage of smoke inhalation injury in rats].</ArticleTitle><Pagination><MedlinePgn>150-2</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To explore the inhibitory effects of chloroquine and dexamethasone on the formation of pulmonary edema in the early stage of smoke inhalation injury in rats.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Wistar rats were used and randomly divided into 10 groups, i.e. normal control, 1 PBH (postburn hour), 3 PBH, 6 PBH, 12 PBH and 24 PBH groups of smoke inhalation injury, 6 PBH and 12 PBH groups with dexamethasone treatment, and 6 PBH and 12 PBH groups with chloroquine treatment. The lung water content (LWC), pulmonary vascular permeability (PVP) and hemorrhagic amount (PHA) were measured.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The LWC and PVP (measured by the pulmonary exudation amount of (131)I -- labelled albumin) increased obviously, peaked at 6 PBH and lasted to 24 PBH (P < 0.01) in rats injured by smoke inhalation. In groups treated with chloroquine or dexamethasone, the LWC and PVP were significantly lower at 6 PBH (P < 0.05). Similarly, the PHA in injured group exhibited remarkable, especially at 1 PBH and up to 24 PBH when the value was still higher than that in normal control group (P < 0.01). In groups treated with chloroquine or dexamethasone, PHA abated evidently at 6 PBH (P < 0.01). But there were no significant difference of the indices among groups at 12 PBH.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Both chloroquine and dexamethasone be effective in preventing and treating pulmonary edema in rats in the early stage of smoke inhalation injury.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Anesthesia, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Z</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Q</ForeName><Initials>Q</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhonghua Shao Shang Za Zhi</MedlineTA><NlmUniqueID>100959418</NlmUniqueID><ISSNLinking>1009-2587</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>7S5I7G3JQL</RegistryNumber><NameOfSubstance UI="D003907">Dexamethasone</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003907" MajorTopicYN="N">Dexamethasone</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011654" MajorTopicYN="N">Pulmonary Edema</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015208" MajorTopicYN="N">Smoke Inhalation Injury</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>3</Month><Day>6</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>7</Month><Day>13</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>3</Month><Day>6</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11876860</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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