Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children.
Identifieur interne : 000424 ( PubMed/Curation ); précédent : 000423; suivant : 000425Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children.
Auteurs : S K Kabra [Inde] ; Sumit Bhargava ; Rakesh Lodha ; A. Satyavani ; M. WaliaSource :
- Indian pediatrics [ 0019-6061 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Glucocorticoïdes (usage thérapeutique), Hormones corticosurrénaliennes (usage thérapeutique), Humains, Hydroxychloroquine (usage thérapeutique), Hémosidérose (anatomopathologie), Hémosidérose (diagnostic), Hémosidérose (traitement médicamenteux), Macrophages, Maladie aigüe, Maladies pulmonaires (anatomopathologie), Maladies pulmonaires (diagnostic), Maladies pulmonaires (traitement médicamenteux), Mâle, Nourrisson, Prednisolone (usage thérapeutique), Études rétrospectives.
- MESH :
- anatomopathologie : Hémosidérose, Maladies pulmonaires.
- diagnostic : Hémosidérose, Maladies pulmonaires.
- traitement médicamenteux : Hémosidérose, Maladies pulmonaires.
- usage thérapeutique : Glucocorticoïdes, Hormones corticosurrénaliennes, Hydroxychloroquine, Prednisolone.
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Macrophages, Maladie aigüe, Mâle, Nourrisson, Études rétrospectives.
English descriptors
- KwdEn :
- Acute Disease, Adolescent, Adrenal Cortex Hormones (therapeutic use), Child, Child, Preschool, Female, Glucocorticoids (therapeutic use), Hemosiderosis (diagnosis), Hemosiderosis (drug therapy), Hemosiderosis (pathology), Humans, Hydroxychloroquine (therapeutic use), Infant, Lung Diseases (diagnosis), Lung Diseases (drug therapy), Lung Diseases (pathology), Macrophages, Male, Prednisolone (therapeutic use), Retrospective Studies.
- MESH :
- chemical , therapeutic use : Adrenal Cortex Hormones, Glucocorticoids, Hydroxychloroquine, Prednisolone.
- diagnosis : Hemosiderosis, Lung Diseases.
- drug therapy : Hemosiderosis, Lung Diseases.
- pathology : Hemosiderosis, Lung Diseases.
- Acute Disease, Adolescent, Child, Child, Preschool, Female, Humans, Infant, Macrophages, Male, Retrospective Studies.
Abstract
To describe the clinical details and follow up of children with idiopathic pulmonary hemosiderosis.
PubMed: 17536132
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Satyavani</name></author><author><name sortKey="Walia, M" sort="Walia, M" uniqKey="Walia M" first="M" last="Walia">M. Walia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17536132</idno><idno type="pmid">17536132</idno><idno type="wicri:Area/PubMed/Corpus">000424</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000424</idno><idno type="wicri:Area/PubMed/Curation">000424</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000424</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children.</title><author><name sortKey="Kabra, S K" sort="Kabra, S K" uniqKey="Kabra S" first="S K" last="Kabra">S K Kabra</name><affiliation wicri:level="1"><nlm:affiliation>Pediatric Pulmonology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India. skkabra@hotmail.com</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Pediatric Pulmonology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029</wicri:regionArea></affiliation></author><author><name sortKey="Bhargava, Sumit" sort="Bhargava, Sumit" uniqKey="Bhargava S" first="Sumit" last="Bhargava">Sumit Bhargava</name></author><author><name sortKey="Lodha, Rakesh" sort="Lodha, Rakesh" uniqKey="Lodha R" first="Rakesh" last="Lodha">Rakesh Lodha</name></author><author><name sortKey="Satyavani, A" sort="Satyavani, A" uniqKey="Satyavani A" first="A" last="Satyavani">A. Satyavani</name></author><author><name sortKey="Walia, M" sort="Walia, M" uniqKey="Walia M" first="M" last="Walia">M. Walia</name></author></analytic><series><title level="j">Indian pediatrics</title><idno type="ISSN">0019-6061</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Glucocorticoids (therapeutic use)</term><term>Hemosiderosis (diagnosis)</term><term>Hemosiderosis (drug therapy)</term><term>Hemosiderosis (pathology)</term><term>Humans</term><term>Hydroxychloroquine (therapeutic use)</term><term>Infant</term><term>Lung Diseases (diagnosis)</term><term>Lung Diseases (drug therapy)</term><term>Lung Diseases (pathology)</term><term>Macrophages</term><term>Male</term><term>Prednisolone (therapeutic use)</term><term>Retrospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Glucocorticoïdes (usage thérapeutique)</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Hémosidérose (anatomopathologie)</term><term>Hémosidérose (diagnostic)</term><term>Hémosidérose (traitement médicamenteux)</term><term>Macrophages</term><term>Maladie aigüe</term><term>Maladies pulmonaires (anatomopathologie)</term><term>Maladies pulmonaires (diagnostic)</term><term>Maladies pulmonaires (traitement médicamenteux)</term><term>Mâle</term><term>Nourrisson</term><term>Prednisolone (usage thérapeutique)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Glucocorticoids</term><term>Hydroxychloroquine</term><term>Prednisolone</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hémosidérose</term><term>Maladies pulmonaires</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hemosiderosis</term><term>Lung Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hémosidérose</term><term>Maladies pulmonaires</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hemosiderosis</term><term>Lung Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hemosiderosis</term><term>Lung Diseases</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémosidérose</term><term>Maladies pulmonaires</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Glucocorticoïdes</term><term>Hormones corticosurrénaliennes</term><term>Hydroxychloroquine</term><term>Prednisolone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Macrophages</term><term>Male</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Macrophages</term><term>Maladie aigüe</term><term>Mâle</term><term>Nourrisson</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To describe the clinical details and follow up of children with idiopathic pulmonary hemosiderosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17536132</PMID><DateCompleted><Year>2007</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0019-6061</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>5</Issue><PubDate><Year>2007</Year><Month>May</Month></PubDate></JournalIssue><Title>Indian pediatrics</Title><ISOAbbreviation>Indian Pediatr</ISOAbbreviation></Journal><ArticleTitle>Idiopathic pulmonary hemosiderosis: clinical profile and follow up of 26 children.</ArticleTitle><Pagination><MedlinePgn>333-8</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To describe the clinical details and follow up of children with idiopathic pulmonary hemosiderosis.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective case series.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Pediatric chest clinic of a tertiary care hospital.</AbstractText><AbstractText Label="SUBJECTS" NlmCategory="METHODS">Children diagnosed as suffering from idiopathic pulmonary hemosiderosis (IPH).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Charts of patients diagnosed as IPH were reviewed for clinical features and treatment regimen. Diagnosis was based on presence of iron deficiency anemia, chest radiography and demonstration of hemosiderin laden macrophages in bronchoalveolar lavage (BAL), gastric aspirate, or sputum. Treatment consisted of oral prednisolone, hydroxychloroquine (HCQ) and inhaled corticosteroids (ICS).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The common clinical features in 26 children with IPH (mean age 75 months) included: cough, breathlessness, fever, hemoptysis and wheezing in 26 (100%), 22 (85%), 19 (73%),15 (58%) and 14 (54%) children, respectively. Clubbing, hepatomegaly and splenomegaly was seen in 16 (62%), 15 (58%) and 10 (38%) children, respectively. Hemosiderin laden macrophages were documented in BAL and gastric aspirate in 92% and 30% patients, respectively. Symptoms did not recur in 17 patients who received prednisolone and HCQ initially. 5 patients had recurrence of symptoms and required short courses of oral prednisolone, 4 patients required frequent courses of prednisolone and were started on azathioprine. Older age, longer duration of illness, history of hemoptysis and jaundice were associated with poor response.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Treatment with prednisolone and hydroxychloroquine followed by inhaled corticosteroids may improve survival in children with IPH.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kabra</LastName><ForeName>S K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Pediatric Pulmonology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India. skkabra@hotmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhargava</LastName><ForeName>Sumit</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lodha</LastName><ForeName>Rakesh</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Satyavani</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Walia</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Indian Pediatr</MedlineTA><NlmUniqueID>2985062R</NlmUniqueID><ISSNLinking>0019-6061</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9PHQ9Y1OLM</RegistryNumber><NameOfSubstance UI="D011239">Prednisolone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000208" MajorTopicYN="N">Acute Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006486" MajorTopicYN="N">Hemosiderosis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008171" MajorTopicYN="N">Lung Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011239" MajorTopicYN="N">Prednisolone</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>5</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>9</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>5</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17536132</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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