Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.
Identifieur interne : 000309 ( PubMed/Curation ); précédent : 000308; suivant : 000310Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.
Auteurs : Dieudonné Makaba Mvumbi [Oman] ; Raphael Boreux ; Rosalie Sacheli ; Mvumbi Lelo ; Bobanga Lengu ; Situakibanza Nani-Tuma ; Pierrette Melin ; Kayembe Ntumba ; Kalala Lunganza ; Patrick Demol ; Marie-Pierre HayetteSource :
- Malaria journal [ 1475-2875 ] ; 2013.
Descripteurs français
- KwdFr :
- ADN des protozoaires (), ADN des protozoaires (génétique), Analyse de séquence d'ADN, Antipaludiques (usage thérapeutique), Chloroquine (usage thérapeutique), Enfant d'âge préscolaire, Femelle, Fréquence d'allèle, Haplotypes, Humains, Mâle, Nourrisson, Nouveau-né, Paludisme à Plasmodium falciparum (parasitologie), Paludisme à Plasmodium falciparum (épidémiologie), Plasmodium falciparum (génétique), Plasmodium falciparum (isolement et purification), Protéines de protozoaire (génétique), Protéines de transport membranaire (génétique), Protéines mutantes (génétique), Réaction de polymérisation en chaine en temps réel, République démocratique du Congo (épidémiologie), Résistance aux substances.
- MESH :
- génétique : ADN des protozoaires, Plasmodium falciparum, Protéines de protozoaire, Protéines de transport membranaire, Protéines mutantes.
- isolement et purification : Plasmodium falciparum.
- parasitologie : Paludisme à Plasmodium falciparum.
- usage thérapeutique : Antipaludiques, Chloroquine.
- épidémiologie : Paludisme à Plasmodium falciparum, République démocratique du Congo.
- ADN des protozoaires, Analyse de séquence d'ADN, Enfant d'âge préscolaire, Femelle, Fréquence d'allèle, Haplotypes, Humains, Mâle, Nourrisson, Nouveau-né, Réaction de polymérisation en chaine en temps réel, Résistance aux substances.
English descriptors
- KwdEn :
- Antimalarials (therapeutic use), Child, Preschool, Chloroquine (therapeutic use), DNA, Protozoan (chemistry), DNA, Protozoan (genetics), Democratic Republic of the Congo (epidemiology), Drug Resistance, Female, Gene Frequency, Haplotypes, Humans, Infant, Infant, Newborn, Malaria, Falciparum (epidemiology), Malaria, Falciparum (parasitology), Male, Membrane Transport Proteins (genetics), Mutant Proteins (genetics), Plasmodium falciparum (genetics), Plasmodium falciparum (isolation & purification), Protozoan Proteins (genetics), Real-Time Polymerase Chain Reaction, Sequence Analysis, DNA.
- MESH :
- chemical , chemistry : DNA, Protozoan.
- chemical , genetics : DNA, Protozoan, Membrane Transport Proteins, Mutant Proteins, Protozoan Proteins.
- chemical , therapeutic use : Antimalarials, Chloroquine.
- geographic , epidemiology : Democratic Republic of the Congo.
- epidemiology : Malaria, Falciparum.
- genetics : Plasmodium falciparum.
- isolation & purification : Plasmodium falciparum.
- parasitology : Malaria, Falciparum.
- Child, Preschool, Drug Resistance, Female, Gene Frequency, Haplotypes, Humans, Infant, Infant, Newborn, Male, Real-Time Polymerase Chain Reaction, Sequence Analysis, DNA.
Abstract
In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype. This haplotype was first identified in Southeast Asia and South America but was recently reported in two African countries neighbouring DRC. These facts raised two questions: the first about the evolution of CQ resistance (CQR) in DRC and the second about the presence of the SVMNT haplotype, which would compromise the use of AQ as a partner drug for ACT.
DOI: 10.1186/1475-2875-12-459
PubMed: 24359280
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Frequency</term><term>Haplotypes</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Real-Time Polymerase Chain Reaction</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN des protozoaires</term><term>Analyse de séquence d'ADN</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Haplotypes</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Résistance aux substances</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype. This haplotype was first identified in Southeast Asia and South America but was recently reported in two African countries neighbouring DRC. These facts raised two questions: the first about the evolution of CQ resistance (CQR) in DRC and the second about the presence of the SVMNT haplotype, which would compromise the use of AQ as a partner drug for ACT.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24359280</PMID><DateCompleted><Year>2014</Year><Month>08</Month><Day>20</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1475-2875</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><PubDate><Year>2013</Year><Month>Dec</Month><Day>20</Day></PubDate></JournalIssue><Title>Malaria journal</Title><ISOAbbreviation>Malar. J.</ISOAbbreviation></Journal><ArticleTitle>Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.</ArticleTitle><Pagination><MedlinePgn>459</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1475-2875-12-459</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype. This haplotype was first identified in Southeast Asia and South America but was recently reported in two African countries neighbouring DRC. These facts raised two questions: the first about the evolution of CQ resistance (CQR) in DRC and the second about the presence of the SVMNT haplotype, which would compromise the use of AQ as a partner drug for ACT.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A total of 213 thick blood films were randomly collected in 2010 from a paediatric clinic in Kinshasa, DRC. Microscopy controls and real-time polymerase chain reaction (RT-PCR) were performed for Plasmodium species identification. Haplotypes of the pfcrt gene were determined by sequencing.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The K76T mutation was detected in 145 out of 198 P. falciparum-positive samples (73.2%). In these 145 resistant strains, only the CVIET haplotype was detected.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study is the first to assess the molecular markers of resistance to CQ and AQ after the introduction of ACT in DRC. The results suggest first that CQR is decreasing, as wild-type pfcrt haplotypes were found in only 26.8% of the samples and secondly that the SVMNT haplotype is not yet present in Kinshasa, suggesting that AQ remains valid as a partner drug for ACT in this region.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mvumbi</LastName><ForeName>Dieudonné Makaba</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Biochemistry and Molecular Biology Unit, Department of Basic Sciences, School of Medicine, University of Kinshasa, BP 190 KIN XI, Kinshasa, DR Congo. didimvumbi@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boreux</LastName><ForeName>Raphael</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Sacheli</LastName><ForeName>Rosalie</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lelo</LastName><ForeName>Mvumbi</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lengu</LastName><ForeName>Bobanga</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Nani-Tuma</LastName><ForeName>Situakibanza</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Melin</LastName><ForeName>Pierrette</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Ntumba</LastName><ForeName>Kayembe</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Lunganza</LastName><ForeName>Kalala</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>DeMol</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Hayette</LastName><ForeName>Marie-Pierre</ForeName><Initials>MP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Malar J</MedlineTA><NlmUniqueID>101139802</NlmUniqueID><ISSNLinking>1475-2875</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016054">DNA, Protozoan</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D026901">Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050505">Mutant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C416369">PfCRT protein, Plasmodium falciparum</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015800">Protozoan Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016054" MajorTopicYN="N">DNA, Protozoan</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015023" MajorTopicYN="N" Type="Geographic">Democratic Republic of the Congo</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004351" MajorTopicYN="Y">Drug Resistance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006239" MajorTopicYN="Y">Haplotypes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016778" MajorTopicYN="N">Malaria, Falciparum</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D026901" MajorTopicYN="N">Membrane Transport Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050505" MajorTopicYN="N">Mutant Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015800" MajorTopicYN="N">Protozoan Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>09</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>12</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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