Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells.
Identifieur interne : 000286 ( PubMed/Curation ); précédent : 000285; suivant : 000287Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells.
Auteurs : Ke Jiang ; Yingchun Li ; Qiumin Zhu ; Jiansheng Xu ; Yupeng Wang ; Wuguo Deng ; Quentin Liu ; Guirong Zhang [République populaire de Chine] ; Songshu MengSource :
- BMC cancer [ 1471-2407 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Autophagie (), Chloroquine (pharmacologie), Embryon de poulet, Humains, Lignée cellulaire tumorale, Protéines associées aux microtubules (génétique), Résistance aux médicaments antinéoplasiques (), Sirolimus (pharmacologie), Souris, Souris nude, Techniques de knock-down de gènes, Tests d'activité antitumorale sur modèle de xénogreffe, Thérapie virale de cancers (), Transplantation tumorale, Tumeurs du poumon (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Virus de la maladie de Newcastle (), Virus oncolytiques ().
- MESH :
- anatomopathologie : Tumeurs du poumon.
- génétique : Protéines associées aux microtubules, Tumeurs du poumon.
- pharmacologie : Chloroquine, Sirolimus.
- Animaux, Autophagie, Embryon de poulet, Humains, Lignée cellulaire tumorale, Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Techniques de knock-down de gènes, Tests d'activité antitumorale sur modèle de xénogreffe, Thérapie virale de cancers, Transplantation tumorale, Tumeurs du poumon, Virus de la maladie de Newcastle, Virus oncolytiques.
English descriptors
- KwdEn :
- Animals, Autophagy (drug effects), Cell Line, Tumor, Chick Embryo, Chloroquine (pharmacology), Drug Resistance, Neoplasm (drug effects), Gene Knockdown Techniques, Humans, Lung Neoplasms (genetics), Lung Neoplasms (pathology), Lung Neoplasms (therapy), Mice, Mice, Nude, Microtubule-Associated Proteins (genetics), Neoplasm Transplantation, Newcastle disease virus (drug effects), Oncolytic Virotherapy (methods), Oncolytic Viruses (drug effects), Sirolimus (pharmacology), Xenograft Model Antitumor Assays.
- MESH :
- chemical , genetics : Microtubule-Associated Proteins.
- chemical , pharmacology : Chloroquine, Sirolimus.
- drug effects : Autophagy, Drug Resistance, Neoplasm, Newcastle disease virus, Oncolytic Viruses.
- genetics : Lung Neoplasms.
- methods : Oncolytic Virotherapy.
- pathology : Lung Neoplasms.
- therapy : Lung Neoplasms.
- Animals, Cell Line, Tumor, Chick Embryo, Gene Knockdown Techniques, Humans, Mice, Mice, Nude, Neoplasm Transplantation, Xenograft Model Antitumor Assays.
Abstract
Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/FMW virotherapy of drug-resistant lung cancer cells.
DOI: 10.1186/1471-2407-14-551
PubMed: 25078870
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pubmed:25078870Le document en format XML
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<term>Chloroquine (pharmacology)</term>
<term>Drug Resistance, Neoplasm (drug effects)</term>
<term>Gene Knockdown Techniques</term>
<term>Humans</term>
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<term>Microtubule-Associated Proteins (genetics)</term>
<term>Neoplasm Transplantation</term>
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<term>Oncolytic Virotherapy (methods)</term>
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<term>Xenograft Model Antitumor Assays</term>
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<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
<term>Thérapie virale de cancers ()</term>
<term>Transplantation tumorale</term>
<term>Tumeurs du poumon ()</term>
<term>Tumeurs du poumon (anatomopathologie)</term>
<term>Tumeurs du poumon (génétique)</term>
<term>Virus de la maladie de Newcastle ()</term>
<term>Virus oncolytiques ()</term>
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<term>Sirolimus</term>
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<term>Oncolytic Viruses</term>
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<term>Sirolimus</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line, Tumor</term>
<term>Chick Embryo</term>
<term>Gene Knockdown Techniques</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Neoplasm Transplantation</term>
<term>Xenograft Model Antitumor Assays</term>
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<term>Autophagie</term>
<term>Embryon de poulet</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Résistance aux médicaments antinéoplasiques</term>
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<term>Souris nude</term>
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<term>Thérapie virale de cancers</term>
<term>Transplantation tumorale</term>
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<front><div type="abstract" xml:lang="en">Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/FMW virotherapy of drug-resistant lung cancer cells.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25078870</PMID>
<DateCompleted><Year>2015</Year>
<Month>04</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2407</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<PubDate><Year>2014</Year>
<Month>Jul</Month>
<Day>30</Day>
</PubDate>
</JournalIssue>
<Title>BMC cancer</Title>
<ISOAbbreviation>BMC Cancer</ISOAbbreviation>
</Journal>
<ArticleTitle>Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells.</ArticleTitle>
<Pagination><MedlinePgn>551</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/1471-2407-14-551</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/FMW virotherapy of drug-resistant lung cancer cells.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The effect of NDV/FMW infection on autophagy machinery in A549 lung cancer cell lines resistant to cisplatin (A549/DDP) or paclitaxel (A549/PTX) was investigated by detection of GFP-microtubule-associated protein 1 light chain 3 (GFP-LC3) puncta, formation of double-membrane vesicles and conversion of the nonlipidated form of LC3 (LC3-I) to the phosphatidylethanolamine-conjugated form (LC3-II). The effects of autophagy inhibitor chloroquine (CQ) and autophagy inducer rapamycin on NDV/FMW-mediated antitumor activity were evaluated both in culture cells and in mice bearing drug-resistant lung cancer cells.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We show that NDV/FMW triggers autophagy in A549/PTX cells via dampening the class I PI3K/Akt/mTOR/p70S6K pathway, which inhibits autophagy. On the contrary, NDV/FMW infection attenuates the autophagic process in A549/DDP cells through the activation of the negative regulatory pathway. Furthermore, combination with CQ or knockdown of ATG5 significantly enhances NDV/FMW-mediated antitumor effects on A549/DDP cells, while the oncolytic efficacy of NDV/FMW in A549/PTX cells is significantly improved by rapamycin. Interestingly, autophagy modulation does not increase virus progeny in these drug resistant cells. Importantly, CQ or rapamycin significantly potentiates NDV/FMW oncolytic activity in mice bearing A549/DDP or A549/PTX cells respectively.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results demonstrate that combination treatment with autophagy modulators is an effective strategy to augment the therapeutic activity of NDV/FMW against drug-resistant lung cancers.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Ke</ForeName>
<Initials>K</Initials>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yingchun</ForeName>
<Initials>Y</Initials>
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<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Qiumin</ForeName>
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<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Jiansheng</ForeName>
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<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yupeng</ForeName>
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<Author ValidYN="Y"><LastName>Deng</LastName>
<ForeName>Wuguo</ForeName>
<Initials>W</Initials>
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<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Quentin</ForeName>
<Initials>Q</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Guirong</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, 9 Lvshun Road South, Dalian 116044, China. zhang.lth@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meng</LastName>
<ForeName>Songshu</ForeName>
<Initials>S</Initials>
</Author>
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<Month>07</Month>
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<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
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<MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName>
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<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D009368" MajorTopicYN="N">Neoplasm Transplantation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009522" MajorTopicYN="N">Newcastle disease virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050130" MajorTopicYN="Y">Oncolytic Virotherapy</DescriptorName>
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<MeshHeading><DescriptorName UI="D050504" MajorTopicYN="N">Oncolytic Viruses</DescriptorName>
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<MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName>
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