High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Identifieur interne : 000159 ( PubMed/Curation ); précédent : 000158; suivant : 000160High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Auteurs : Guorong Zhang ; Zhiqiang Liu ; Yan Chen ; Yihang ZhangSource :
- The Tohoku journal of experimental medicine [ 1349-3329 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse multivariée, Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (sang), Cellules A549, Chloroquine (pharmacologie), Courbe ROC, Femelle, Humains, Mâle, Pronostic, Protéines et peptides de signalisation intercellulaire (sang), Quercétine (pharmacologie), Sujet âgé, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (sang), Tumeurs osseuses (sang), Tumeurs osseuses (secondaire), Études de cohortes.
- MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- pharmacologie : Chloroquine, Quercétine.
- sang : Carcinome pulmonaire non à petites cellules, Protéines et peptides de signalisation intercellulaire, Tumeurs du poumon, Tumeurs osseuses.
- secondaire : Tumeurs osseuses.
- Adulte d'âge moyen, Analyse multivariée, Cellules A549, Courbe ROC, Femelle, Humains, Mâle, Pronostic, Sujet âgé, Études de cohortes.
English descriptors
- KwdEn :
- A549 Cells, Aged, Bone Neoplasms (blood), Bone Neoplasms (secondary), Carcinoma, Non-Small-Cell Lung (blood), Carcinoma, Non-Small-Cell Lung (pathology), Chloroquine (pharmacology), Cohort Studies, Female, Humans, Intercellular Signaling Peptides and Proteins (blood), Lung Neoplasms (blood), Lung Neoplasms (pathology), Male, Middle Aged, Multivariate Analysis, Prognosis, Quercetin (pharmacology), ROC Curve.
- MESH :
- chemical , blood : Intercellular Signaling Peptides and Proteins.
- chemical , pharmacology : Chloroquine, Quercetin.
- blood : Bone Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- secondary : Bone Neoplasms.
- A549 Cells, Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Multivariate Analysis, Prognosis, ROC Curve.
Abstract
Hepatoma-derived growth factor (HDGF) is a heparin-binding protein possessing mitogenic activity and could be secreted from necrotic cells passively or actively, thereby functioning as a damage-associated molecular pattern (DAMP). The high expression of HDGF in non-small cell lung cancer (NSCLC) tissues is associated with unfavorable prognosis. However, the clinical significance of serum HDGF has not been elucidated in NSCLC yet. In the present study, we compared the serum levels of HDGF in 235 patients with NSCLC (141 adenocarcinoma and 94 squamous cell carcinoma cases) with those in 40 healthy subjects. Moreover, we explored the correlation between serum HDGF levels and clinicopathologic factors or the overall survival rates. We thus found that the serum HDGF levels were significantly higher in NSCLC patients than those in healthy subjects (P < 0.001). Moreover, there was no significant difference in the serum HDGF levels between adenocarcinoma and squamous cell carcinoma. Importantly, the higher serum levels of HDGF were significantly associated with bone metastasis and with lower overall survival rates. Thus, serum HDGF was identified as an independent prognostic factor indicating poor prognosis of NSCLC. Using A549 human lung adenocarcinoma cell line, we demonstrated that an autophagy inhibitor, chloroquine, could inhibit the HDGF secretion, while quercetin, an autophagy inducer derived from a traditional Chinese drug, could facilitate HDGF secretion. In conclusion, high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of NSCLC. We suggest that anti-HDGF therapy is potential to protect NSCLC patients with advanced stages from bone metastasis.
DOI: 10.1620/tjem.242.101
PubMed: 28592712
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Guorong Zhang<affiliation><nlm:affiliation>Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang.</nlm:affiliation><wicri:noCountry code="subField">Yidu Central Hospital of Weifang</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang.</nlm:affiliation><wicri:noCountry code="subField">Yidu Central Hospital of Weifang</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang.</nlm:affiliation><wicri:noCountry code="subField">Yidu Central Hospital of Weifang</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Orthopaedics, Shandong Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Shandong Academy of Medical Sciences</wicri:noCountry></affiliation>Le document en format XML
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Weifang</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><affiliation><nlm:affiliation>Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang.</nlm:affiliation><wicri:noCountry code="subField">Yidu Central Hospital of Weifang</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Yihang" sort="Zhang, Yihang" uniqKey="Zhang Y" first="Yihang" last="Zhang">Yihang Zhang</name><affiliation><nlm:affiliation>Department of Orthopaedics, Shandong Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Shandong Academy of Medical Sciences</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Tohoku journal of experimental medicine</title><idno type="eISSN">1349-3329</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term><term>Aged</term><term>Bone Neoplasms (blood)</term><term>Bone Neoplasms (secondary)</term><term>Carcinoma, Non-Small-Cell Lung (blood)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Chloroquine (pharmacology)</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Intercellular Signaling Peptides and Proteins (blood)</term><term>Lung Neoplasms (blood)</term><term>Lung Neoplasms (pathology)</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Prognosis</term><term>Quercetin (pharmacology)</term><term>ROC Curve</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term><term>Carcinome pulmonaire non à petites cellules (sang)</term><term>Cellules A549</term><term>Chloroquine (pharmacologie)</term><term>Courbe ROC</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Protéines et peptides de signalisation intercellulaire (sang)</term><term>Quercétine (pharmacologie)</term><term>Sujet âgé</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (sang)</term><term>Tumeurs osseuses (sang)</term><term>Tumeurs osseuses (secondaire)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Intercellular Signaling Peptides and Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term><term>Quercetin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Bone Neoplasms</term><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term><term>Quercétine</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Protéines et peptides de signalisation intercellulaire</term><term>Tumeurs du poumon</term><term>Tumeurs osseuses</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs osseuses</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Prognosis</term><term>ROC Curve</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Cellules A549</term><term>Courbe ROC</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hepatoma-derived growth factor (HDGF) is a heparin-binding protein possessing mitogenic activity and could be secreted from necrotic cells passively or actively, thereby functioning as a damage-associated molecular pattern (DAMP). The high expression of HDGF in non-small cell lung cancer (NSCLC) tissues is associated with unfavorable prognosis. However, the clinical significance of serum HDGF has not been elucidated in NSCLC yet. In the present study, we compared the serum levels of HDGF in 235 patients with NSCLC (141 adenocarcinoma and 94 squamous cell carcinoma cases) with those in 40 healthy subjects. Moreover, we explored the correlation between serum HDGF levels and clinicopathologic factors or the overall survival rates. We thus found that the serum HDGF levels were significantly higher in NSCLC patients than those in healthy subjects (P < 0.001). Moreover, there was no significant difference in the serum HDGF levels between adenocarcinoma and squamous cell carcinoma. Importantly, the higher serum levels of HDGF were significantly associated with bone metastasis and with lower overall survival rates. Thus, serum HDGF was identified as an independent prognostic factor indicating poor prognosis of NSCLC. Using A549 human lung adenocarcinoma cell line, we demonstrated that an autophagy inhibitor, chloroquine, could inhibit the HDGF secretion, while quercetin, an autophagy inducer derived from a traditional Chinese drug, could facilitate HDGF secretion. In conclusion, high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of NSCLC. We suggest that anti-HDGF therapy is potential to protect NSCLC patients with advanced stages from bone metastasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28592712</PMID><DateCompleted><Year>2018</Year><Month>03</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>03</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1349-3329</ISSN><JournalIssue CitedMedium="Internet"><Volume>242</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>06</Month></PubDate></JournalIssue><Title>The Tohoku journal of experimental medicine</Title><ISOAbbreviation>Tohoku J. Exp. Med.</ISOAbbreviation></Journal><ArticleTitle>High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.</ArticleTitle><Pagination><MedlinePgn>101-108</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1620/tjem.242.101</ELocationID><Abstract><AbstractText>Hepatoma-derived growth factor (HDGF) is a heparin-binding protein possessing mitogenic activity and could be secreted from necrotic cells passively or actively, thereby functioning as a damage-associated molecular pattern (DAMP). The high expression of HDGF in non-small cell lung cancer (NSCLC) tissues is associated with unfavorable prognosis. However, the clinical significance of serum HDGF has not been elucidated in NSCLC yet. In the present study, we compared the serum levels of HDGF in 235 patients with NSCLC (141 adenocarcinoma and 94 squamous cell carcinoma cases) with those in 40 healthy subjects. Moreover, we explored the correlation between serum HDGF levels and clinicopathologic factors or the overall survival rates. We thus found that the serum HDGF levels were significantly higher in NSCLC patients than those in healthy subjects (P < 0.001). Moreover, there was no significant difference in the serum HDGF levels between adenocarcinoma and squamous cell carcinoma. Importantly, the higher serum levels of HDGF were significantly associated with bone metastasis and with lower overall survival rates. Thus, serum HDGF was identified as an independent prognostic factor indicating poor prognosis of NSCLC. Using A549 human lung adenocarcinoma cell line, we demonstrated that an autophagy inhibitor, chloroquine, could inhibit the HDGF secretion, while quercetin, an autophagy inducer derived from a traditional Chinese drug, could facilitate HDGF secretion. In conclusion, high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of NSCLC. We suggest that anti-HDGF therapy is potential to protect NSCLC patients with advanced stages from bone metastasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Guorong</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zhiqiang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Traditional Chinese Medicine, Yidu Central Hospital of Weifang.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yihang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Orthopaedics, Shandong Academy of Medical Sciences.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Tohoku J Exp Med</MedlineTA><NlmUniqueID>0417355</NlmUniqueID><ISSNLinking>0040-8727</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D036341">Intercellular Signaling Peptides and Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C051610">hepatoma-derived growth factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9IKM0I5T1E</RegistryNumber><NameOfSubstance UI="D011794">Quercetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000072283" MajorTopicYN="N">A549 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001859" MajorTopicYN="N">Bone Neoplasms</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000556" MajorTopicYN="Y">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002289" MajorTopicYN="N">Carcinoma, Non-Small-Cell Lung</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D036341" MajorTopicYN="N">Intercellular Signaling Peptides and Proteins</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011794" MajorTopicYN="N">Quercetin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012372" MajorTopicYN="N">ROC Curve</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">hepatoma-derived growth factor</Keyword><Keyword MajorTopicYN="N">metastasis</Keyword><Keyword MajorTopicYN="N">non-small cell lung cancer</Keyword><Keyword MajorTopicYN="N">prognosis</Keyword><Keyword MajorTopicYN="N">secretion</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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