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Constrictive Bronchiolitis in Patients With Primary Sjögren Syndrome.

Identifieur interne : 000119 ( PubMed/Curation ); précédent : 000118; suivant : 000120

Constrictive Bronchiolitis in Patients With Primary Sjögren Syndrome.

Auteurs : Elizabeth C. Wight ; Misbah Baqir [États-Unis] ; Jay H. Ryu [États-Unis]

Source :

RBID : pubmed:29596206

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Abstract

Constrictive bronchiolitis (CB) is a poorly understood pulmonary manifestation of primary Sjögren syndrome (pSS). We aimed to clarify the presenting clinicoradiologic features and clinical course of pSS-associated CB through a retrospective cohort study.

DOI: 10.1097/RHU.0000000000000771
PubMed: 29596206

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Elizabeth C. Wight
<affiliation>
<nlm:affiliation>From the Department of Internal Medicine and.</nlm:affiliation>
<wicri:noCountry code="no comma">From the Department of Internal Medicine and.</wicri:noCountry>
</affiliation>

Le document en format XML

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<nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<term>Adult</term>
<term>Aged</term>
<term>Bronchiolitis Obliterans (complications)</term>
<term>Bronchiolitis Obliterans (diagnostic imaging)</term>
<term>Bronchiolitis Obliterans (physiopathology)</term>
<term>Female</term>
<term>Forced Expiratory Volume</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Sjogren's Syndrome (complications)</term>
<term>Sjogren's Syndrome (diagnostic imaging)</term>
<term>Sjogren's Syndrome (physiopathology)</term>
<term>Tomography, X-Ray Computed</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Bronchiolite oblitérante ()</term>
<term>Bronchiolite oblitérante (imagerie diagnostique)</term>
<term>Bronchiolite oblitérante (physiopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Syndrome de Gougerot-Sjögren ()</term>
<term>Syndrome de Gougerot-Sjögren (imagerie diagnostique)</term>
<term>Syndrome de Gougerot-Sjögren (physiopathologie)</term>
<term>Tomodensitométrie</term>
<term>Volume expiratoire maximal par seconde</term>
<term>Études rétrospectives</term>
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<term>Bronchiolitis Obliterans</term>
<term>Sjogren's Syndrome</term>
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<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en">
<term>Bronchiolitis Obliterans</term>
<term>Sjogren's Syndrome</term>
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<term>Bronchiolite oblitérante</term>
<term>Syndrome de Gougerot-Sjögren</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Bronchiolite oblitérante</term>
<term>Syndrome de Gougerot-Sjögren</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Bronchiolitis Obliterans</term>
<term>Sjogren's Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Forced Expiratory Volume</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Tomography, X-Ray Computed</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Bronchiolite oblitérante</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Syndrome de Gougerot-Sjögren</term>
<term>Tomodensitométrie</term>
<term>Volume expiratoire maximal par seconde</term>
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<front>
<div type="abstract" xml:lang="en">Constrictive bronchiolitis (CB) is a poorly understood pulmonary manifestation of primary Sjögren syndrome (pSS). We aimed to clarify the presenting clinicoradiologic features and clinical course of pSS-associated CB through a retrospective cohort study.</div>
</front>
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<PMID Version="1">29596206</PMID>
<DateCompleted>
<Year>2019</Year>
<Month>12</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised>
<Year>2019</Year>
<Month>12</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1536-7355</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>25</Volume>
<Issue>2</Issue>
<PubDate>
<Year>2019</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases</Title>
<ISOAbbreviation>J Clin Rheumatol</ISOAbbreviation>
</Journal>
<ArticleTitle>Constrictive Bronchiolitis in Patients With Primary Sjögren Syndrome.</ArticleTitle>
<Pagination>
<MedlinePgn>74-77</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/RHU.0000000000000771</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Constrictive bronchiolitis (CB) is a poorly understood pulmonary manifestation of primary Sjögren syndrome (pSS). We aimed to clarify the presenting clinicoradiologic features and clinical course of pSS-associated CB through a retrospective cohort study.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We retrospectively identified 11 patients with pSS and CB (defined by mosaic pattern with air trapping on computed tomography) encountered at our institution over 9 years from 2007 to 2015. Presenting clinical features, laboratory results, radiologic findings, and clinical course were analyzed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Our patients were mostly women (91%), with a median age 53 years (range, 31-76 years) at the time of pulmonary symptom (dyspnea or cough) onset. Most (64%) were nonsmokers. Average interval between diagnosis of pSS and the onset of pulmonary symptoms was 4.4 years; in 4 patients (36%), CB was the presenting manifestation of pSS. Chest radiographs were normal (67%) or demonstrated hyperinflation (33%). Pulmonary function testing demonstrated airflow obstruction in 7 patients (63%), and 2 patients (18%) had an isolated reduction in diffusing capacity, whereas the remaining 2 patients manifested mixed physiology or normal results. Surgical lung biopsy was performed in 2 patients and confirmed the diagnosis of CB in both. Treatment was variable among our patients included glucocorticoids, hydroxychloroquine, mycophenolate mofetil, and cyclophosphamide. Among 6 patients with follow-up computed tomography and pulmonary function, the results remained stable or worsened.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Constrictive bronchiolitis is a rare extraglandular manifestation and can sometimes be the presenting manifestation of pSS. This pulmonary manifestation is associated with an indolent clinical course and does not respond well to immunosuppressive therapy.</AbstractText>
</Abstract>
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<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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