Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis.
Identifieur interne : 000009 ( PubMed/Curation ); précédent : 000008; suivant : 000010Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis.
Auteurs : M. Drent [Pays-Bas] ; V L J. Proesmans [Pays-Bas] ; M D P. Elfferich [Pays-Bas] ; N T Jessurun [Pays-Bas] ; S M G. De Jong [Pays-Bas] ; N M Ebner [Pays-Bas] ; E D O. Lewis [Pays-Bas] ; A. Bast [Pays-Bas]Source :
- Lung [ 1432-1750 ] ; 2020.
Abstract
Clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. So far, no curative treatment exists; the disease can only be suppressed. All treatment options cause side effects affecting quality of life. The aim of this study was to establish and rank the prevalence of self-reported gastrointestinal side effects of drugs used in the treatment of sarcoidosis.
DOI: 10.1007/s00408-020-00323-8
PubMed: 31960165
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Proesmans</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Elfferich, M D P" sort="Elfferich, M D P" uniqKey="Elfferich M" first="M D P" last="Elfferich">M D P. Elfferich</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Jessurun, N T" sort="Jessurun, N T" uniqKey="Jessurun N" first="N T" last="Jessurun">N T Jessurun</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="De Jong, S M G" sort="De Jong, S M G" uniqKey="De Jong S" first="S M G" last="De Jong">S M G. De Jong</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Ebner, N M" sort="Ebner, N M" uniqKey="Ebner N" first="N M" last="Ebner">N M Ebner</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, E D O" sort="Lewis, E D O" uniqKey="Lewis E" first="E D O" last="Lewis">E D O. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Bast, A" sort="Bast, A" uniqKey="Bast A" first="A" last="Bast">A. Bast</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31960165</idno><idno type="pmid">31960165</idno><idno type="doi">10.1007/s00408-020-00323-8</idno><idno type="wicri:Area/PubMed/Corpus">000009</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000009</idno><idno type="wicri:Area/PubMed/Curation">000009</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000009</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis.</title><author><name sortKey="Drent, M" sort="Drent, M" uniqKey="Drent M" first="M" last="Drent">M. Drent</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, FHML, Maastricht University, Maastricht, The Netherlands. m.drent@antoniusziekenhuis.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pharmacology and Toxicology, FHML, Maastricht University, Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Proesmans, V L J" sort="Proesmans, V L J" uniqKey="Proesmans V" first="V L J" last="Proesmans">V L J. Proesmans</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Elfferich, M D P" sort="Elfferich, M D P" uniqKey="Elfferich M" first="M D P" last="Elfferich">M D P. Elfferich</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Jessurun, N T" sort="Jessurun, N T" uniqKey="Jessurun N" first="N T" last="Jessurun">N T Jessurun</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="De Jong, S M G" sort="De Jong, S M G" uniqKey="De Jong S" first="S M G" last="De Jong">S M G. De Jong</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Ebner, N M" sort="Ebner, N M" uniqKey="Ebner N" first="N M" last="Ebner">N M Ebner</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, E D O" sort="Lewis, E D O" uniqKey="Lewis E" first="E D O" last="Lewis">E D O. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>ild care foundation Research Team, Ede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ild care foundation Research Team, Ede</wicri:regionArea></affiliation></author><author><name sortKey="Bast, A" sort="Bast, A" uniqKey="Bast A" first="A" last="Bast">A. Bast</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein</wicri:regionArea></affiliation></author></analytic><series><title level="j">Lung</title><idno type="eISSN">1432-1750</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. So far, no curative treatment exists; the disease can only be suppressed. All treatment options cause side effects affecting quality of life. The aim of this study was to establish and rank the prevalence of self-reported gastrointestinal side effects of drugs used in the treatment of sarcoidosis.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">31960165</PMID><DateRevised><Year>2020</Year><Month>01</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1750</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jan</Month><Day>20</Day></PubDate></JournalIssue><Title>Lung</Title><ISOAbbreviation>Lung</ISOAbbreviation></Journal><ArticleTitle>Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00408-020-00323-8</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. So far, no curative treatment exists; the disease can only be suppressed. All treatment options cause side effects affecting quality of life. The aim of this study was to establish and rank the prevalence of self-reported gastrointestinal side effects of drugs used in the treatment of sarcoidosis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A cross-sectional web-based anonymous survey about complaints and side effects was conducted among sarcoidosis patients in the Netherlands, United Kingdom, and United States of America.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the participants, 70% were being treated with one or more drugs. The most important reported side effect was weight gain, associated with increased appetite among prednisone users (as monotherapy as well as in combination with other drugs). Methotrexate (MTX) users especially experienced nausea, with monotherapy as well as combination therapy. Vomiting and weight loss were most prominent among azathioprine and mycophenolate mofetil (MMF) users, whereas diarrhoea was frequently mentioned by MMF and MTX users. The reported side effects of hydroxychloroquine were generally rather mild.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The current study ranked the gastrointestinal side effects associated with pharmacotherapy in sarcoidosis patients. Pharmacotherapy does have multiple gastrointestinal side effects. The strongest association between a reported side effect and drug use was that of weight gain associated with increased appetite among prednisone users. It would therefore be useful for future research to look further into dietary interventions to counter these side effects and reduce their burden.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drent</LastName><ForeName>M</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1586-0110</Identifier><AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, FHML, Maastricht University, Maastricht, The Netherlands. m.drent@antoniusziekenhuis.nl.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands. m.drent@antoniusziekenhuis.nl.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands. m.drent@antoniusziekenhuis.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Proesmans</LastName><ForeName>V L J</ForeName><Initials>VLJ</Initials><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Venlo Campus, Maastricht University, Venlo, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elfferich</LastName><ForeName>M D P</ForeName><Initials>MDP</Initials><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jessurun</LastName><ForeName>N T</ForeName><Initials>NT</Initials><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands' Pharmacovigilance Centre Lareb, 's Hertogenbosch, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Jong</LastName><ForeName>S M G</ForeName><Initials>SMG</Initials><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Venlo Campus, Maastricht University, Venlo, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ebner</LastName><ForeName>N M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Venlo Campus, Maastricht University, Venlo, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>E D O</ForeName><Initials>EDO</Initials><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Venlo Campus, Maastricht University, Venlo, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bast</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pulmonology, ILD Center of Excellence, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ild care foundation Research Team, Ede, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Venlo Campus, Maastricht University, Venlo, The Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lung</MedlineTA><NlmUniqueID>7701875</NlmUniqueID><ISSNLinking>0341-2040</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gastrointestinal side effects</Keyword><Keyword MajorTopicYN="N">Glucocorticoids</Keyword><Keyword MajorTopicYN="N">Methotrexate</Keyword><Keyword MajorTopicYN="N">Pharmacotherapy</Keyword><Keyword MajorTopicYN="N">Sarcoidosis</Keyword><Keyword MajorTopicYN="N">Side effects</Keyword><Keyword MajorTopicYN="N">Treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>1</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31960165</ArticleId><ArticleId IdType="doi">10.1007/s00408-020-00323-8</ArticleId><ArticleId IdType="pii">10.1007/s00408-020-00323-8</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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