Failure of orally administered hydroxychloroquine sulphate to prevent venous thromboembolism following elective hip operations.
Identifieur interne : 000622 ( PubMed/Corpus ); précédent : 000621; suivant : 000623Failure of orally administered hydroxychloroquine sulphate to prevent venous thromboembolism following elective hip operations.
Auteurs : E D Cooke ; M H Dawson ; R M Ibbotson ; S A Bowcock ; M E Ainsworth ; M F PilcherSource :
- The Journal of bone and joint surgery. American volume [ 0021-9355 ] ; 1977.
English descriptors
- KwdEn :
- Administration, Oral, Aged, Arthroplasty, Body Weight, Clinical Trials as Topic, Double-Blind Method, Female, Hip Joint (surgery), Humans, Hydroxychloroquine (administration & dosage), Hydroxychloroquine (therapeutic use), Leg (blood supply), Male, Middle Aged, Placebos, Postoperative Complications (prevention & control), Pulmonary Embolism (diagnosis), Pulmonary Embolism (prevention & control), Radionuclide Imaging, Thromboembolism (diagnosis), Thromboembolism (prevention & control).
- MESH :
- chemical , administration & dosage : Hydroxychloroquine.
- blood supply : Leg.
- diagnosis : Pulmonary Embolism, Thromboembolism.
- prevention & control : Postoperative Complications, Pulmonary Embolism, Thromboembolism.
- surgery : Hip Joint.
- chemical , therapeutic use : Hydroxychloroquine.
- Administration, Oral, Aged, Arthroplasty, Body Weight, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Male, Middle Aged, Placebos, Radionuclide Imaging.
Abstract
In a double-blind, randomized trial of orally administered hydroxychloroquine sulphate in the prevention of venous thromboembolism after elective surgery on the hip, the drug or a placebo was given to fifty consecutive patients. Therapy was commenced on the day before the operation and continued for fourteen days. The diagnosis of deep venous thrombosis was made by daily thermographic scanning of the legs and confirmed by phlebography. The diagnosis of pulmonary embolism was made by perfusion lung scanning. No significant difference in the incidence of thromboembolism was found between treated and control groups. The results provide evidence that substances which reduce the incidence of thromboembolism in general surgery may not be effective in operations on the hip.
PubMed: 325009
Links to Exploration step
pubmed:325009Le document en format XML
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American volume</title><idno type="ISSN">0021-9355</idno><imprint><date when="1977" type="published">1977</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Aged</term><term>Arthroplasty</term><term>Body Weight</term><term>Clinical Trials as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Hip Joint (surgery)</term><term>Humans</term><term>Hydroxychloroquine (administration & dosage)</term><term>Hydroxychloroquine (therapeutic use)</term><term>Leg (blood supply)</term><term>Male</term><term>Middle Aged</term><term>Placebos</term><term>Postoperative Complications (prevention & control)</term><term>Pulmonary Embolism (diagnosis)</term><term>Pulmonary Embolism (prevention & control)</term><term>Radionuclide Imaging</term><term>Thromboembolism (diagnosis)</term><term>Thromboembolism (prevention & control)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Leg</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pulmonary Embolism</term><term>Thromboembolism</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Postoperative Complications</term><term>Pulmonary Embolism</term><term>Thromboembolism</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Hip Joint</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Aged</term><term>Arthroplasty</term><term>Body Weight</term><term>Clinical Trials as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Placebos</term><term>Radionuclide Imaging</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a double-blind, randomized trial of orally administered hydroxychloroquine sulphate in the prevention of venous thromboembolism after elective surgery on the hip, the drug or a placebo was given to fifty consecutive patients. Therapy was commenced on the day before the operation and continued for fourteen days. The diagnosis of deep venous thrombosis was made by daily thermographic scanning of the legs and confirmed by phlebography. The diagnosis of pulmonary embolism was made by perfusion lung scanning. No significant difference in the incidence of thromboembolism was found between treated and control groups. The results provide evidence that substances which reduce the incidence of thromboembolism in general surgery may not be effective in operations on the hip.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">325009</PMID><DateCompleted><Year>1977</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2016</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0021-9355</ISSN><JournalIssue CitedMedium="Print"><Volume>59</Volume><Issue>4</Issue><PubDate><Year>1977</Year><Month>Jun</Month></PubDate></JournalIssue><Title>The Journal of bone and joint surgery. American volume</Title><ISOAbbreviation>J Bone Joint Surg Am</ISOAbbreviation></Journal><ArticleTitle>Failure of orally administered hydroxychloroquine sulphate to prevent venous thromboembolism following elective hip operations.</ArticleTitle><Pagination><MedlinePgn>496-500</MedlinePgn></Pagination><Abstract><AbstractText>In a double-blind, randomized trial of orally administered hydroxychloroquine sulphate in the prevention of venous thromboembolism after elective surgery on the hip, the drug or a placebo was given to fifty consecutive patients. Therapy was commenced on the day before the operation and continued for fourteen days. The diagnosis of deep venous thrombosis was made by daily thermographic scanning of the legs and confirmed by phlebography. The diagnosis of pulmonary embolism was made by perfusion lung scanning. No significant difference in the incidence of thromboembolism was found between treated and control groups. The results provide evidence that substances which reduce the incidence of thromboembolism in general surgery may not be effective in operations on the hip.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cooke</LastName><ForeName>E D</ForeName><Initials>ED</Initials></Author><Author ValidYN="Y"><LastName>Dawson</LastName><ForeName>M H</ForeName><Initials>MH</Initials></Author><Author ValidYN="Y"><LastName>Ibbotson</LastName><ForeName>R M</ForeName><Initials>RM</Initials></Author><Author ValidYN="Y"><LastName>Bowcock</LastName><ForeName>S A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Ainsworth</LastName><ForeName>M E</ForeName><Initials>ME</Initials></Author><Author ValidYN="Y"><LastName>Pilcher</LastName><ForeName>M F</ForeName><Initials>MF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Bone Joint Surg Am</MedlineTA><NlmUniqueID>0014030</NlmUniqueID><ISSNLinking>0021-9355</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010919">Placebos</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001178" MajorTopicYN="N">Arthroplasty</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001835" MajorTopicYN="N">Body Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002986" MajorTopicYN="N">Clinical Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006621" MajorTopicYN="N">Hip Joint</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="N">blood supply</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010919" MajorTopicYN="N">Placebos</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011655" MajorTopicYN="N">Pulmonary Embolism</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011877" MajorTopicYN="N">Radionuclide Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013923" MajorTopicYN="N">Thromboembolism</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1977</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1977</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1977</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">325009</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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