Metallothionein induction by nonsteroidal antiinflammatory drugs.
Identifieur interne : 000563 ( PubMed/Corpus ); précédent : 000562; suivant : 000564Metallothionein induction by nonsteroidal antiinflammatory drugs.
Auteurs : K H Summer ; D. Klein ; N. De Ruiter ; J. AbelSource :
- Biological trace element research [ 0163-4984 ]
English descriptors
- KwdEn :
- Animals, Anti-Inflammatory Agents, Non-Steroidal (pharmacology), Female, Immunoblotting, Kidney (drug effects), Kidney (metabolism), Liver (drug effects), Liver (metabolism), Lung (drug effects), Lung (metabolism), Metallothionein (biosynthesis), Metallothionein (genetics), Mice, Mice, Inbred C57BL, RNA, Messenger (biosynthesis).
- MESH :
- chemical , biosynthesis : Metallothionein, RNA, Messenger.
- chemical , genetics : Metallothionein.
- chemical , pharmacology : Anti-Inflammatory Agents, Non-Steroidal.
- drug effects : Kidney, Liver, Lung.
- metabolism : Kidney, Liver, Lung.
- Animals, Female, Immunoblotting, Mice, Mice, Inbred C57BL.
Abstract
In the present study we report on the effects of commonly used nonsteroidal antiinflammatory drugs on metallothionein (MT) and MT-I mRNA levels. A single dose of chloroquine (100 mg/kg), diclofenac (100 mg/kg), indomethacin (10 mg/kg), or piroxicam (100 mg/kg) was administered ip to C57B1 mice. After 18 h, MT levels were determined with a Cd-saturation radioassay. MT-I mRNA levels were measured by Northern Blot analyses using a probe containing the mouse MT-I gene. All drugs tested caused an increase in the MT content of the liver but not of the kidneys and lung. The lowest and highest effects were observed with chloroquine (8 times the control value) and diclofenac (18 times), respectively. In accordance with the stimulation of MT synthesis, increased accumulation of hepatic MT-I mRNA could be demonstrated. These results indicate that elevated MT levels may contribute to the effectiveness of nonsteroidal antiinflammatory drugs in the treatment of rheumatoid arthritis (RA).
DOI: 10.1007/bf02917248
PubMed: 2484582
Links to Exploration step
pubmed:2484582Le document en format XML
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<author><name sortKey="Summer, K H" sort="Summer, K H" uniqKey="Summer K" first="K H" last="Summer">K H Summer</name>
<affiliation><nlm:affiliation>Institute of Toxicology, Gesellschaft für Strahlen- und Umweltforschung München, Neuherberg, FRG.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Klein, D" sort="Klein, D" uniqKey="Klein D" first="D" last="Klein">D. Klein</name>
</author>
<author><name sortKey="De Ruiter, N" sort="De Ruiter, N" uniqKey="De Ruiter N" first="N" last="De Ruiter">N. De Ruiter</name>
</author>
<author><name sortKey="Abel, J" sort="Abel, J" uniqKey="Abel J" first="J" last="Abel">J. Abel</name>
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<date when="????"><PubDate><MedlineDate>1989 Jul-Sep</MedlineDate>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Metallothionein induction by nonsteroidal antiinflammatory drugs.</title>
<author><name sortKey="Summer, K H" sort="Summer, K H" uniqKey="Summer K" first="K H" last="Summer">K H Summer</name>
<affiliation><nlm:affiliation>Institute of Toxicology, Gesellschaft für Strahlen- und Umweltforschung München, Neuherberg, FRG.</nlm:affiliation>
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<author><name sortKey="Klein, D" sort="Klein, D" uniqKey="Klein D" first="D" last="Klein">D. Klein</name>
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<author><name sortKey="De Ruiter, N" sort="De Ruiter, N" uniqKey="De Ruiter N" first="N" last="De Ruiter">N. De Ruiter</name>
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<author><name sortKey="Abel, J" sort="Abel, J" uniqKey="Abel J" first="J" last="Abel">J. Abel</name>
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<series><title level="j">Biological trace element research</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Anti-Inflammatory Agents, Non-Steroidal (pharmacology)</term>
<term>Female</term>
<term>Immunoblotting</term>
<term>Kidney (drug effects)</term>
<term>Kidney (metabolism)</term>
<term>Liver (drug effects)</term>
<term>Liver (metabolism)</term>
<term>Lung (drug effects)</term>
<term>Lung (metabolism)</term>
<term>Metallothionein (biosynthesis)</term>
<term>Metallothionein (genetics)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>RNA, Messenger (biosynthesis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Metallothionein</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Metallothionein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Kidney</term>
<term>Liver</term>
<term>Lung</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Kidney</term>
<term>Liver</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Immunoblotting</term>
<term>Mice</term>
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<front><div type="abstract" xml:lang="en">In the present study we report on the effects of commonly used nonsteroidal antiinflammatory drugs on metallothionein (MT) and MT-I mRNA levels. A single dose of chloroquine (100 mg/kg), diclofenac (100 mg/kg), indomethacin (10 mg/kg), or piroxicam (100 mg/kg) was administered ip to C57B1 mice. After 18 h, MT levels were determined with a Cd-saturation radioassay. MT-I mRNA levels were measured by Northern Blot analyses using a probe containing the mouse MT-I gene. All drugs tested caused an increase in the MT content of the liver but not of the kidneys and lung. The lowest and highest effects were observed with chloroquine (8 times the control value) and diclofenac (18 times), respectively. In accordance with the stimulation of MT synthesis, increased accumulation of hepatic MT-I mRNA could be demonstrated. These results indicate that elevated MT levels may contribute to the effectiveness of nonsteroidal antiinflammatory drugs in the treatment of rheumatoid arthritis (RA).</div>
</front>
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<DateCompleted><Year>1990</Year>
<Month>11</Month>
<Day>02</Day>
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<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>22</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0163-4984</ISSN>
<JournalIssue CitedMedium="Print"><Volume>21</Volume>
<PubDate><MedlineDate>1989 Jul-Sep</MedlineDate>
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<Title>Biological trace element research</Title>
<ISOAbbreviation>Biol Trace Elem Res</ISOAbbreviation>
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<ArticleTitle>Metallothionein induction by nonsteroidal antiinflammatory drugs.</ArticleTitle>
<Pagination><MedlinePgn>165-9</MedlinePgn>
</Pagination>
<Abstract><AbstractText>In the present study we report on the effects of commonly used nonsteroidal antiinflammatory drugs on metallothionein (MT) and MT-I mRNA levels. A single dose of chloroquine (100 mg/kg), diclofenac (100 mg/kg), indomethacin (10 mg/kg), or piroxicam (100 mg/kg) was administered ip to C57B1 mice. After 18 h, MT levels were determined with a Cd-saturation radioassay. MT-I mRNA levels were measured by Northern Blot analyses using a probe containing the mouse MT-I gene. All drugs tested caused an increase in the MT content of the liver but not of the kidneys and lung. The lowest and highest effects were observed with chloroquine (8 times the control value) and diclofenac (18 times), respectively. In accordance with the stimulation of MT synthesis, increased accumulation of hepatic MT-I mRNA could be demonstrated. These results indicate that elevated MT levels may contribute to the effectiveness of nonsteroidal antiinflammatory drugs in the treatment of rheumatoid arthritis (RA).</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Summer</LastName>
<ForeName>K H</ForeName>
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<AffiliationInfo><Affiliation>Institute of Toxicology, Gesellschaft für Strahlen- und Umweltforschung München, Neuherberg, FRG.</Affiliation>
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<Author ValidYN="Y"><LastName>Klein</LastName>
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<Author ValidYN="Y"><LastName>de Ruiter</LastName>
<ForeName>N</ForeName>
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<Author ValidYN="Y"><LastName>Abel</LastName>
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<MeshHeading><DescriptorName UI="D008668" MajorTopicYN="N">Metallothionein</DescriptorName>
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<ReferenceList><Reference><Citation>Acta Pharmacol Toxicol (Copenh). 1986;59 Suppl 7:365-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3022551</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Toxicol Appl Pharmacol. 1986 Sep 30;85(3):380-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3764922</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Soc Exp Biol Med. 1985 Jun;179(2):168-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3857634</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 1987 Jul 11;2(8550):95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2885586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Trace Elem Electrolytes Health Dis. 1988 Mar;2(1):43-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2980792</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 1985 Jan 21;827(1):36-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2981555</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 1985 Oct;5(10):2866-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3879767</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat New Biol. 1971 Jun 23;231(25):232-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5284360</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Toxicology. 1986 Dec 1;42(1):23-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3798457</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1979 Nov 27;18(24):5294-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">518835</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Pharmacol. 1986 Jun 15;35(12):2033-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3087367</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
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