ChloroquineV1, PubMed, Corpus, bibRecord, 000544

Phagolysosomal pH and dissolution of cobalt oxide particles by alveolar macrophages.

Identifieur interne : 000544 ( PubMed/Corpus ); précédent : 000543; suivant : 000545

Phagolysosomal pH and dissolution of cobalt oxide particles by alveolar macrophages.

Auteurs : M. Lundborg ; R. Falk ; A. Johansson ; W. Kreyling ; P. Camner

Source :

Environmental health perspectives [ 0091-6765 ] ; 1992.

RBID : pubmed:1396451

English descriptors

KwdEn :
- Animals, Chloroquine (pharmacology), Cobalt (pharmacokinetics), Hydrogen-Ion Concentration (drug effects), Macrophages, Alveolar (metabolism), Microscopy, Electron, Models, Biological, Oxides (pharmacokinetics), Phagosomes (chemistry), Phagosomes (ultrastructure), Rabbits, Solubility.
MESH :
- chemical , pharmacokinetics : Cobalt, Oxides.
- chemical , pharmacology : Chloroquine.
- chemistry : Phagosomes.
- drug effects : Hydrogen-Ion Concentration.
- metabolism : Macrophages, Alveolar.
- ultrastructure : Phagosomes.
- Animals, Microscopy, Electron, Models, Biological, Rabbits, Solubility.

Abstract

We studied phagolysosomal pH in rabbit alveolar macrophages (AM) incubated with 0-15 microM chloroquine. There was a dose-related increase in pH with chloroquine concentration. Electron microscopy showed that chloroquine increased lysosomal size. In a second experiment we studied dissolution of radiolabeled cobalt oxide particles by rabbit AM, phagolysosomal pH, and lysosomal size. The cells were incubated for 2 days with 0, 2.5, and 10 microM chloroquine. Size and pH increased with chloroquine concentration. Dissolution of cobalt particles by the AM did not clearly change with pH. In a third experiment, dissolution of cobalt oxide particles in 0.1 M acetate buffer in saline with pH 4.0, 5.0, and 6.0 was studied. At the same pH, dissolution in acetate buffer was faster than in the AM, and the dissolution appeared to decrease faster with increasing pH than in the AM. A simple model for dissolution of a particle in a phagolysosome was proposed. This model predicts the types of differences in dissolution between AM and buffered saline.

DOI: 10.1289/ehp.9297153
PubMed: 1396451

Links to Exploration step

pubmed:1396451

Le document en format XML

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<author><name sortKey="Lundborg, M" sort="Lundborg, M" uniqKey="Lundborg M" first="M" last="Lundborg">M. Lundborg</name>
<affiliation><nlm:affiliation>Section of Lung Medicine, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Falk, R" sort="Falk, R" uniqKey="Falk R" first="R" last="Falk">R. Falk</name>
</author>
<author><name sortKey="Johansson, A" sort="Johansson, A" uniqKey="Johansson A" first="A" last="Johansson">A. Johansson</name>
</author>
<author><name sortKey="Kreyling, W" sort="Kreyling, W" uniqKey="Kreyling W" first="W" last="Kreyling">W. Kreyling</name>
</author>
<author><name sortKey="Camner, P" sort="Camner, P" uniqKey="Camner P" first="P" last="Camner">P. Camner</name>
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<author><name sortKey="Lundborg, M" sort="Lundborg, M" uniqKey="Lundborg M" first="M" last="Lundborg">M. Lundborg</name>
<affiliation><nlm:affiliation>Section of Lung Medicine, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation>
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<author><name sortKey="Falk, R" sort="Falk, R" uniqKey="Falk R" first="R" last="Falk">R. Falk</name>
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<series><title level="j">Environmental health perspectives</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chloroquine (pharmacology)</term>
<term>Cobalt (pharmacokinetics)</term>
<term>Hydrogen-Ion Concentration (drug effects)</term>
<term>Macrophages, Alveolar (metabolism)</term>
<term>Microscopy, Electron</term>
<term>Models, Biological</term>
<term>Oxides (pharmacokinetics)</term>
<term>Phagosomes (chemistry)</term>
<term>Phagosomes (ultrastructure)</term>
<term>Rabbits</term>
<term>Solubility</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Cobalt</term>
<term>Oxides</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages, Alveolar</term>
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<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Phagosomes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Microscopy, Electron</term>
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<front><div type="abstract" xml:lang="en">We studied phagolysosomal pH in rabbit alveolar macrophages (AM) incubated with 0-15 microM chloroquine. There was a dose-related increase in pH with chloroquine concentration. Electron microscopy showed that chloroquine increased lysosomal size. In a second experiment we studied dissolution of radiolabeled cobalt oxide particles by rabbit AM, phagolysosomal pH, and lysosomal size. The cells were incubated for 2 days with 0, 2.5, and 10 microM chloroquine. Size and pH increased with chloroquine concentration. Dissolution of cobalt particles by the AM did not clearly change with pH. In a third experiment, dissolution of cobalt oxide particles in 0.1 M acetate buffer in saline with pH 4.0, 5.0, and 6.0 was studied. At the same pH, dissolution in acetate buffer was faster than in the AM, and the dissolution appeared to decrease faster with increasing pH than in the AM. A simple model for dissolution of a particle in a phagolysosome was proposed. This model predicts the types of differences in dissolution between AM and buffered saline.</div>
</front>
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<Abstract><AbstractText>We studied phagolysosomal pH in rabbit alveolar macrophages (AM) incubated with 0-15 microM chloroquine. There was a dose-related increase in pH with chloroquine concentration. Electron microscopy showed that chloroquine increased lysosomal size. In a second experiment we studied dissolution of radiolabeled cobalt oxide particles by rabbit AM, phagolysosomal pH, and lysosomal size. The cells were incubated for 2 days with 0, 2.5, and 10 microM chloroquine. Size and pH increased with chloroquine concentration. Dissolution of cobalt particles by the AM did not clearly change with pH. In a third experiment, dissolution of cobalt oxide particles in 0.1 M acetate buffer in saline with pH 4.0, 5.0, and 6.0 was studied. At the same pH, dissolution in acetate buffer was faster than in the AM, and the dissolution appeared to decrease faster with increasing pH than in the AM. A simple model for dissolution of a particle in a phagolysosome was proposed. This model predicts the types of differences in dissolution between AM and buffered saline.</AbstractText>
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Phagolysosomal pH and dissolution of cobalt oxide particles by alveolar macrophages.

Phagolysosomal pH and dissolution of cobalt oxide particles by alveolar macrophages.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki